Publications by authors named "Hans-Joerg Martus"

17 Publications

  • Page 1 of 1

Summary of major conclusions from the 7th International Workshop on Genotoxicity Testing (IWGT), Tokyo, Japan.

Authors:
Hans-Joerg Martus Roland Froetschl Bhaskar Gollapudi Masamitsu Honma Francesco Marchetti Stefan Pfuhler Rita Schoeny Yoshifumi Uno Carole Yauk David J Kirkland

Mutat Res 2020 04 13;852:503134. Epub 2020 Jan 13.

Kirkland Consulting, PO Box 79, Tadcaster, LS24 0AS, UK.

View Article and Find Full Text PDF
April 2020

In vivo genotoxicity testing strategies: Report from the 7th International workshop on genotoxicity testing (IWGT).

Authors:
David Kirkland Yoshifumi Uno Mirjam Luijten Carol Beevers Jan van Benthem Brian Burlinson Stephen Dertinger George R Douglas Shuichi Hamada Katsuyoshi Horibata David P Lovell Mugimane Manjanatha Hans-Joerg Martus Nan Mei Takeshi Morita Wakako Ohyama Andrew Williams

Mutat Res 2019 11 25;847:403035. Epub 2019 Apr 25.

Environmental Health Science Research Bureau, Health Canada, Ottawa, K1A 0K9, Canada.

View Article and Find Full Text PDF
November 2019

X-ray Structures and Feasibility Assessment of CLK2 Inhibitors for Phelan-McDermid Syndrome.

Authors:
Joerg Kallen Christian Bergsdorf Bertrand Arnaud Mario Bernhard Murielle Brichet Amanda Cobos-Correa Azeddine Elhajouji Felix Freuler Ivan Galimberti Christel Guibourdenche Simon Haenni Sandra Holzinger Juerg Hunziker Aude Izaac Markus Kaufmann Lukas Leder Hans-Joerg Martus Peter von Matt Valery Polyakov Patrik Roethlisberger Guglielmo Roma Nikolaus Stiefl Marianne Uteng Andreas Lerchner

ChemMedChem 2018 09 16;13(18):1997-2007. Epub 2018 Aug 16.

Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Campus, 4002, Basel, Switzerland.

View Article and Find Full Text PDF
September 2018

Derisking Drug-Induced Carcinogenicity for Novel Therapeutics.

Authors:
Jonathan G Moggs Timothy MacLachlan Hans-Joerg Martus Philip Bentley

Trends Cancer 2016 08 30;2(8):398-408. Epub 2016 Jul 30.

Preclinical Safety, Translational Medicine, Novartis Institutes for BioMedical Research, Basel CH-4057, Switzerland.

View Article and Find Full Text PDF
August 2016

Setting Occupational Exposure Limits for Genotoxic Substances in the Pharmaceutical Industry.

Authors:
Ester Lovsin Barle Gian Christian Winkler Susanne Glowienke Azeddine Elhajouji Jana Nunic Hans-Joerg Martus

Toxicol Sci 2016 05;151(1):2-9

Novartis Pharma AG NIBR, Postfach, CH-4002 Basel, Switzerland; and.

View Article and Find Full Text PDF
May 2016

Evaluation of methyl methanesulfonate, 2,6-diaminotoluene and 5-fluorouracil: Part of the Japanese center for the validation of alternative methods (JaCVAM) international validation study of the in vivo rat alkaline comet assay.

Authors:
Ulla Plappert-Helbig Ursula Junker-Walker Hans-Joerg Martus

Mutat Res Genet Toxicol Environ Mutagen 2015 Jul 17;786-788:120-4. Epub 2015 Apr 17.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, Switzerland.

View Article and Find Full Text PDF
July 2015

Summary of major conclusions from the 6th International Workshop on Genotoxicity Testing (IWGT), Foz do Iguaçu, Brazil.

Authors:
Hans-Joerg Martus Makoto Hayashi Masamitsu Honma Peter Kasper Bhaskar Gollapudi Lutz Mueller Rita Schoeny Yoshifumi Uno David J Kirkland

Mutat Res Genet Toxicol Environ Mutagen 2015 May 26;783:1-5. Epub 2015 Feb 26.

Kirkland Consulting, PO Box 79, Tadcaster LS24 0AS, UK.

View Article and Find Full Text PDF
May 2015

Compilation and use of genetic toxicity historical control data.

Authors:
Makoto Hayashi Kerry Dearfield Peter Kasper David Lovell Hans-Joerg Martus Veronique Thybaud

Mutat Res 2011 Aug 8;723(2):87-90. Epub 2010 Oct 8.

Biosafety Research Center, Foods, Drugs and Pesticides, Iwata, Japan.

View Article and Find Full Text PDF
August 2011

High-content micronucleus assay in genotoxicity profiling: initial-stage development and some applications in the investigative/lead-finding studies in drug discovery.

Authors:
Madhu S Mondal Joseph Gabriels Claudia McGinnis Maria Magnifico Thomas H Marsilje Laszlo Urban Alan Collis Dejan Bojanic Scott A Biller Wilfried Frieauff Hans-Joerg Martus Willi Suter Philip Bentley

Toxicol Sci 2010 Nov 14;118(1):71-85. Epub 2010 Jul 14.

Preclinical Safety Profiling, CPC, Novartis Institutes of Biomedical Research, Inc., Cambridge, Massachusetts 02139, USA.

View Article and Find Full Text PDF
November 2010

Mutation research, genetic toxicology and environmental mutagenesis.

Authors:
Hans-Joerg Martus Willi Suter

Mutat Res 2009 Jan 14;672(2):135. Epub 2008 Nov 14.

View Article and Find Full Text PDF
January 2009

Interlaboratory evaluation of genomic signatures for predicting carcinogenicity in the rat.

Authors:
Mark R Fielden Alex Nie Michael McMillian Chandi S Elangbam Bruce A Trela Yi Yang Robert T Dunn Yvonne Dragan Ronny Fransson-Stehen Matthew Bogdanffy Stephen P Adams William R Foster Shen-Jue Chen Phil Rossi Peter Kasper David Jacobson-Kram Kay S Tatsuoka Patrick J Wier Jeremy Gollub Donald N Halbert Alan Roter Jamie K Young Joseph F Sina Jennifer Marlowe Hans-Joerg Martus Jiri Aubrecht Andrew J Olaharski Nigel Roome Paul Nioi Ingrid Pardo Ron Snyder Richard Perry Peter Lord William Mattes Bruce D Car

Toxicol Sci 2008 May 14;103(1):28-34. Epub 2008 Feb 14.

Roche Palo Alto, Palo Alto, California 94304, USA.

View Article and Find Full Text PDF
May 2008

Strategy for genotoxicity testing--metabolic considerations.

Authors:
Warren W Ku Anita Bigger Giovanni Brambilla Hansruedi Glatt Elmar Gocke Peggy J Guzzie Atsushi Hakura Masamitsu Honma Hans-Joerg Martus R Scott Obach Stanley Roberts

Mutat Res 2007 Feb 1;627(1):59-77. Epub 2006 Dec 1.

Pfizer Global Research and Development, Drug Safety Research and Development, Groton, CT 06340, USA.

View Article and Find Full Text PDF
February 2007

Methylphenidate is not clastogenic in cultured human lymphocytes and in the mouse bone-marrow micronucleus test.

Authors:
Willi Suter Hans-Joerg Martus Azeddine Elhajouji

Mutat Res 2006 Sep 7;607(2):153-9. Epub 2006 Jul 7.

Safety Assessment and Profiling, Exploratory Development, Novartis Pharma AG, MUT-2881.2.35, CH4002 Basel, Switzerland.

View Article and Find Full Text PDF
September 2006

Structure-activity considerations and in vitro approaches to assess the genotoxicity of 19 methane-, benzene- and toluenesulfonic acid esters.

Authors:
Susanne Glowienke Wilfried Frieauff Thomas Allmendinger Hans-Joerg Martus Willi Suter Lutz Mueller

Mutat Res 2005 Mar 21;581(1-2):23-34. Epub 2004 Dec 21.

Preclinical Safety Europe, Novartis Pharma AG, MUT-2881.2.29, CH 4002 Basel, Basel, Switzerland.

View Article and Find Full Text PDF
March 2005

Induction of A:T to G:C transition mutations by 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), an antiviral pyrimidine nucleoside analogue, in the bone marrow of Muta Mouse.

Authors:
Frank Staedtler Willi Suter Hans-Joerg Martus

Mutat Res 2004 Dec;568(2):211-20

Biomarker Development, Novartis Pharma AG, Klybeckstrasse 41, CH-4002 Basel, Switzerland.

View Article and Find Full Text PDF
December 2004

Induction of gene mutations by 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), an antiviral pyrimidine nucleoside analogue.

Authors:
Willi Suter Ulla Plappert-Helbig Susanne Glowienke Franziska Poetter-Locher Frank Staedtler Robert Racine Hans-Joerg Martus

Mutat Res 2004 Dec;568(2):195-209

Preclinical Safety, Novartis Pharma AG, MUT 2881.2.35, CH 4002 Basel, Switzerland.

View Article and Find Full Text PDF
December 2004

Treatment and sampling protocols for transgenic mutation assays.

Authors:
John A Heddle Hans-Joerg Martus George R Douglas

Environ Mol Mutagen 2003 ;41(1):1-6

Department of Biology, York University, Toronto, Ontario M3J 1P3, Canada.

View Article and Find Full Text PDF
March 2003