Hans-Henrik Parving

Hans-Henrik Parving

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Hans-Henrik Parving

Hans-Henrik Parving

Publications by authors named "Hans-Henrik Parving"

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Lipoprotein(a)and renal function decline, cardiovascular disease and mortality in type 2 diabetes and microalbuminuria.

J Diabetes Complications 2020 Jul 19;34(7):107593. Epub 2020 Apr 19.

Steno Diabetes Center Copenhagen, Niels Steensensvej 2, 2820 Gentofte, Denmark; University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.jdiacomp.2020.107593DOI Listing
July 2020

Atrasentan in patients with diabetes and chronic kidney disease - Authors' reply.

Lancet 2020 01;395(10220):270

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, Netherlands.

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http://dx.doi.org/10.1016/S0140-6736(19)32995-2DOI Listing
January 2020

Proteinuria and cholesterol reduction are independently associated with less renal function decline in statin-treated patients; a post hoc analysis of the PLANET trials.

Nephrol Dial Transplant 2019 10;34(10):1699-1706

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt
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http://dx.doi.org/10.1093/ndt/gfy159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6775475PMC
October 2019

Beneficial impact of intensified multifactorial intervention on risk of stroke: outcome of 21 years of follow-up in the randomised Steno-2 Study.

Diabetologia 2019 09 1;62(9):1575-1580. Epub 2019 Jun 1.

Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Panum, Maersk Tower, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/s00125-019-4920-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6677690PMC
September 2019

A cost analysis of intensified vs conventional multifactorial therapy in individuals with type 2 diabetes: a post hoc analysis of the Steno-2 study.

Diabetologia 2019 01 6;62(1):147-155. Epub 2018 Oct 6.

Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00125-018-4739-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290682PMC
January 2019

Application of urinary proteomics as possible risk predictor of renal and cardiovascular complications in patients with type 2-diabetes and microalbuminuria.

J Diabetes Complications 2018 Dec 24;32(12):1133-1140. Epub 2018 Sep 24.

Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183074
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http://dx.doi.org/10.1016/j.jdiacomp.2018.09.012DOI Listing
December 2018

Determining the optimal dose of atrasentan by evaluating the exposure-response relationships of albuminuria and bodyweight.

Diabetes Obes Metab 2018 08 1;20(8):2019-2022. Epub 2018 May 1.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

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http://doi.wiley.com/10.1111/dom.13312
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http://dx.doi.org/10.1111/dom.13312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055665PMC
August 2018

Baseline characteristics and enrichment results from the SONAR trial.

Diabetes Obes Metab 2018 08 1;20(8):1829-1835. Epub 2018 May 1.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://doi.wiley.com/10.1111/dom.13315
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http://dx.doi.org/10.1111/dom.13315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055730PMC
August 2018

Reduced risk of heart failure with intensified multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: 21 years of follow-up in the randomised Steno-2 study.

Diabetologia 2018 08 30;61(8):1724-1733. Epub 2018 May 30.

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Blegdamsvej 3B, DK-2100, Kbh Ø, Denmark.

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http://dx.doi.org/10.1007/s00125-018-4642-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061176PMC
August 2018

High osteoprotegerin is associated with development of foot ulcer in type 1 diabetes.

J Diabetes Complications 2016 Nov - Dec;30(8):1603-1608. Epub 2016 Jul 17.

Steno Diabetes Center, Gentofte, Denmark; Health, Aarhus University, Aarhus, Denmark; Novo Nordisk Foundation Center for Metabolic Research, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.jdiacomp.2016.07.008DOI Listing
March 2018

Renin angiotensin system blockade reduces urinary levels of soluble urokinase plasminogen activator receptor (suPAR) in patients with type 2 diabetes.

J Diabetes Complications 2016 Nov - Dec;30(8):1440-1442. Epub 2016 Jul 16.

HEALTH, Aarhus University, Aarhus, Denmark; Dept. of Medical Endocrinology, Rigshospitalet, Copenhagen University Hospital, Denmark.

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http://dx.doi.org/10.1016/j.jdiacomp.2016.07.003DOI Listing
March 2018

Longitudinal Estimated GFR Trajectories in Patients With and Without Type 2 Diabetes and Nephropathy.

Am J Kidney Dis 2018 01 16;71(1):91-101. Epub 2017 Nov 16.

Department of Clinical Pharmacy & Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2017.08.010DOI Listing
January 2018

Plasma high-sensitivity troponin T predicts end-stage renal disease and cardiovascular and all-cause mortality in patients with type 1 diabetes and diabetic nephropathy.

Kidney Int 2017 11 14;92(5):1242-1248. Epub 2017 Jul 14.

Steno Diabetes Center Copenhagen, Gentofte, Denmark; HEALTH, University of Aarhus, Aarhus, Denmark; Institute for Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.kint.2017.04.018DOI Listing
November 2017

Higher Plasma Methylglyoxal Levels Are Associated With Incident Cardiovascular Disease in Individuals With Type 1 Diabetes: A 12-Year Follow-up Study.

Diabetes 2017 08 6;66(8):2278-2283. Epub 2017 Jun 6.

Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands

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http://dx.doi.org/10.2337/db16-1578DOI Listing
August 2017

The effects of atrasentan on urinary metabolites in patients with type 2 diabetes and nephropathy.

Diabetes Obes Metab 2017 05 22;19(5):749-753. Epub 2017 Feb 22.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1111/dom.12864DOI Listing
May 2017

Comparison of exposure response relationship of atrasentan between North American and Asian populations.

Diabetes Obes Metab 2017 04 27;19(4):545-552. Epub 2017 Jan 27.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1111/dom.12851DOI Listing
April 2017

Intensified multifactorial intervention in type 2 diabetics with microalbuminuria leads to long-term renal benefits.

Kidney Int 2017 04 7;91(4):982-988. Epub 2017 Feb 7.

Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2016.11.023DOI Listing
April 2017

The potential for improvement of outcomes by personalized insulin treatment of type 1 diabetes as assessed by analysis of single-patient data from a randomized controlled cross-over insulin trial.

Diabetes Res Clin Pract 2017 Jan 16;123:143-148. Epub 2016 Nov 16.

Department of Clinical Research, Nordsjællands University Hospital, Hillerød, Denmark; Steno Diabetes Center, Gentofte, Denmark; Faculties of Health Sciences, University of Aarhus, Denmark.

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http://dx.doi.org/10.1016/j.diabres.2016.11.003DOI Listing
January 2017

Years of life gained by multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: 21 years follow-up on the Steno-2 randomised trial.

Diabetologia 2016 11 16;59(11):2298-2307. Epub 2016 Aug 16.

Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, DK-2100, Copenhagen, Denmark.

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http://dx.doi.org/10.1007/s00125-016-4065-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506099PMC
November 2016

Determining the Optimal Protocol for Measuring an Albuminuria Class Transition in Clinical Trials in Diabetic Kidney Disease.

J Am Soc Nephrol 2016 Nov 7;27(11):3405-3412. Epub 2016 Apr 7.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;

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http://dx.doi.org/10.1681/ASN.2015101150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5084894PMC
November 2016

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes.

N Engl J Med 2016 11;375(18):1800-1

University Medical Center Groningen, Groningen, the Netherlands

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http://dx.doi.org/10.1056/NEJMc1611290DOI Listing
November 2016

Serum metabolites predict response to angiotensin II receptor blockers in patients with diabetes mellitus.

J Transl Med 2016 07 5;14(1):203. Epub 2016 Jul 5.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, P. O. Box 30.001, 9700RB, Groningen, The Netherlands.

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http://dx.doi.org/10.1186/s12967-016-0960-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932762PMC
July 2016

Prevention of microalbuminuria using early intervention with renin-angiotensin system inhibitors in patients with type 2 diabetes: A systematic review.

J Renin Angiotensin Aldosterone Syst 2016 Jul 3;17(3). Epub 2016 Aug 3.

Faculty of Health Sciences, University of Aarhus, Denmark Department of Medical Endocrinology, Rigshospitalet, Copenhagen University Hospital, Denmark.

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http://dx.doi.org/10.1177/1470320316652047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843870PMC
July 2016

Renal outcomes with aliskiren in patients with type 2 diabetes: a prespecified secondary analysis of the ALTITUDE randomised controlled trial.

Lancet Diabetes Endocrinol 2016 Apr 14;4(4):309-17. Epub 2016 Jan 14.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

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http://dx.doi.org/10.1016/S2213-8587(15)00469-6DOI Listing
April 2016

The renal protective effect of angiotensin receptor blockers depends on intra-individual response variation in multiple risk markers.

Br J Clin Pharmacol 2015 Oct 28;80(4):678-86. Epub 2015 May 28.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

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http://dx.doi.org/10.1111/bcp.12655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4594704PMC
October 2015

Increased all-cause mortality in patients with type 1 diabetes and high-expression mannan-binding lectin genotypes: a 12-year follow-up study.

Diabetes Care 2015 Oct 15;38(10):1898-903. Epub 2015 Jul 15.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

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http://care.diabetesjournals.org/lookup/doi/10.2337/dc15-085
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http://dx.doi.org/10.2337/dc15-0851DOI Listing
October 2015

IGFBP-4 Fragments as Markers of Cardiovascular Mortality in Type 1 Diabetes Patients With and Without Nephropathy.

J Clin Endocrinol Metab 2015 Aug 5;100(8):3032-40. Epub 2015 Jun 5.

Medical Research Laboratory (R.H., M.B., J.F.), Department of Clinical Medicine, Faculty of Health, and Faculty of Health (L.T., H.-H.P., P.R.), Aarhus University, and Departments of Heart Diseases (A.J.) and Endocrinology and Internal Medicine (J.F.), Aarhus University Hospital, DK-8000 Aarhus, Denmark; The Danish Diabetes Academy (R.H.), DK-5000 Odense, Denmark; Steno Diabetes Center (L.T., A.J., P.R.), Gentofte, DK-2820 Copenhagen, Denmark; Nordsjællands Hospital (L.T.), DK-3400 Hillerød, Denmark; Department of Medical Endocrinology (H.-H.P.), Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark; and The Novo Nordisk Foundation Center for Basic Metabolic Research (P.R.), University of Copenhagen, DK-2300 Copenhagen, Denmark.

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http://dx.doi.org/10.1210/jc.2015-2196DOI Listing
August 2015

Effects of RAS inhibitors on diabetic retinopathy.

Lancet Diabetes Endocrinol 2015 May;3(5):315-6

Steno Diabetes Center, Gentofte 2820, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22138587150008
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http://dx.doi.org/10.1016/S2213-8587(15)00088-1DOI Listing
May 2015

Number and frequency of albuminuria measurements in clinical trials in diabetic nephropathy.

Clin J Am Soc Nephrol 2015 Mar 7;10(3):410-6. Epub 2015 Jan 7.

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, Groningen, The Netherlands;

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http://dx.doi.org/10.2215/CJN.07780814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348688PMC
March 2015

Improved prognosis of diabetic nephropathy in type 1 diabetes.

Kidney Int 2015 Feb 11;87(2):417-26. Epub 2014 Jun 11.

1] Steno Diabetes Center, Gentofte, Denmark [2] Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark [3] HEALTH, University of Aarhus, Aarhus, Denmark.

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http://dx.doi.org/10.1038/ki.2014.206DOI Listing
February 2015

Diabetic nephropathy in 2014: improved cardiorenal prognosis in diabetic nephropathy.

Nat Rev Nephrol 2015 Feb 9;11(2):68-70. Epub 2014 Dec 9.

Steno Diabetes Center Niels Steensens Vej 2, 2820 Gentofte, Denmark.

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http://dx.doi.org/10.1038/nrneph.2014.238DOI Listing
February 2015

Microalbuminuria: a parameter that has changed diabetes care.

Diabetes Res Clin Pract 2015 Jan 24;107(1):1-8. Epub 2014 Oct 24.

Steno Diabetes Center, Gentofte, Denmark; HEALTH, Aarhus University, Aarhus, Denmark; NNF Center for Basic and Metabolic Research, Copenhagen University, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.diabres.2014.10.014DOI Listing
January 2015

Visit-to-visit variability in blood pressure and kidney and cardiovascular outcomes in patients with type 2 diabetes and nephropathy: a post hoc analysis from the RENAAL study and the Irbesartan Diabetic Nephropathy Trial.

Am J Kidney Dis 2014 Nov 24;64(5):714-22. Epub 2014 Jul 24.

Department of Clinical Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2014.06.008DOI Listing
November 2014

Association of the pattern recognition molecule H-ficolin with incident microalbuminuria in an inception cohort of newly diagnosed type 1 diabetic patients: an 18 year follow-up study.

Diabetologia 2014 Oct 28;57(10):2201-7. Epub 2014 Jul 28.

Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Nørrebrogade 44, Building 2, DK-8000, Aarhus C, Denmark,

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http://link.springer.com/10.1007/s00125-014-3332-7
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http://dx.doi.org/10.1007/s00125-014-3332-7DOI Listing
October 2014

Improved survival and renal prognosis of patients with type 2 diabetes and nephropathy with improved control of risk factors.

Diabetes Care 2014 Jun 12;37(6):1660-7. Epub 2014 Mar 12.

Steno Diabetes Center, Gentofte, DenmarkFaculty of Health Science, University of Copenhagen, Copenhagen, DenmarkHEALTH, University of Aarhus, Aarhus, Denmark.

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http://dx.doi.org/10.2337/dc13-2036DOI Listing
June 2014

Commentary: microalbuminuria: past, present and glorious future.

Int J Epidemiol 2014 Feb 30;43(1):21-2. Epub 2013 Dec 30.

Department of Medical Endocrinology, Rigshospitalet, University of Copenhagen, Blegdamsvvej 7-9 DK-2100 København Ø DENMARK.

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http://dx.doi.org/10.1093/ije/dyt255DOI Listing
February 2014

Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease.

N Engl J Med 2013 Dec 9;369(26):2492-503. Epub 2013 Nov 9.

From the University of Groningen, Groningen, the Netherlands (D.Z., H.J.L.H.); Showa University School of Medicine, Tokyo (T.A.); Reata Pharmaceuticals, Irving, TX (P.A., M.C., A.G., M.K., C.J.M.); University of Chicago (G.L.B.) and AbbVie Pharmaceuticals (M.H.) - both in Chicago; Statistics Collaborative, Washington, DC (H.C.-S., J.W., D.W.); University of Glasgow, Glasgow, United Kingdom (J.J.M.); Rigshospitalet, University of Copenhagen, Copenhagen (H.-H.P.); Istituto di Ricovero e Cura a Carattere Scientifico-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy (G.R.); University of Texas Southwestern Medical Center, Dallas (R.D.T.); University of California, Irvine (N.D.V.); University of Würzburg, Würzburg, Germany (C.W.); and Stanford University, Palo Alto, CA (G.M.C.).

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http://dx.doi.org/10.1056/NEJMoa1306033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496027PMC
December 2013

Direct renin inhibition in chronic kidney disease.

Br J Clin Pharmacol 2013 Oct;76(4):580-6

Steno Diabetes Center, Gentofte, Denmark.

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http://dx.doi.org/10.1111/bcp.12072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791981PMC
October 2013

Cardiorenal end points in a trial of aliskiren for type 2 diabetes.

N Engl J Med 2012 Dec 3;367(23):2204-13. Epub 2012 Nov 3.

Department of Medical Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1056/NEJMoa1208799DOI Listing
December 2012

Baseline characteristics in the Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE).

J Renin Angiotensin Aldosterone Syst 2012 Sep 14;13(3):387-93. Epub 2012 Feb 14.

Department of Medical Endocrinology, Rigshospitalet, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1177/1470320311434818DOI Listing
September 2012

New susceptibility loci associated with kidney disease in type 1 diabetes.

PLoS Genet 2012 Sep 20;8(9):e1002921. Epub 2012 Sep 20.

Folkhälsan Institute of Genetics, Folkhälsan Research Center, Biomedicum Helsinki, Helsinki, Finland.

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http://pure.qub.ac.uk/portal/files/2407268/New_Susceptibilit
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http://dx.plos.org/10.1371/journal.pgen.1002921
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http://dx.doi.org/10.1371/journal.pgen.1002921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447939PMC
September 2012

Moderation of dietary sodium potentiates the renal and cardiovascular protective effects of angiotensin receptor blockers.

Kidney Int 2012 Aug 21;82(3):330-7. Epub 2012 Mar 21.

Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00852538155555
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http://dx.doi.org/10.1038/ki.2012.74DOI Listing
August 2012

Tubular markers are associated with decline in kidney function in proteinuric type 2 diabetic patients.

Diabetes Res Clin Pract 2012 Jul 7;97(1):71-6. Epub 2012 Mar 7.

Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark.

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http://dx.doi.org/10.1016/j.diabres.2012.02.007DOI Listing
July 2012

Impact of glycaemic control on the effect of direct renin inhibition in the AVOID study.

J Renin Angiotensin Aldosterone Syst 2012 Jun 16;13(2):250-3. Epub 2012 Feb 16.

Steno Diabetes Center, Gentofte, Denmark.

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http://dx.doi.org/10.1177/1470320312437068DOI Listing
June 2012

High YKL-40 levels predict mortality in patients with type 2 diabetes.

Diabetes Res Clin Pract 2012 Apr 31;96(1):84-9. Epub 2011 Dec 31.

Steno Diabetes Center, Niels Steensenvej 2,Gentofte, Denmark.

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http://dx.doi.org/10.1016/j.diabres.2011.12.008DOI Listing
April 2012

Impact of aliskiren treatment on urinary aldosterone levels in patients with type 2 diabetes and nephropathy: an AVOID substudy.

J Renin Angiotensin Aldosterone Syst 2012 Mar 8;13(1):118-21. Epub 2011 Aug 8.

Steno Diabetes Center, Gentofte, Denmark.

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http://dx.doi.org/10.1177/1470320311417272DOI Listing
March 2012

Renal Dysfunction in the Presence of Normoalbuminuria in Type 2 Diabetes: Results from the DEMAND Study.

Cardiorenal Med 2012 Feb 26;2(1):1-10. Epub 2011 Oct 26.

Vanderbilt University School of Medicine, Nashville, Tenn., USA.

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http://dx.doi.org/10.1159/000333249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318932PMC
February 2012

Fibulin-1 is a marker for arterial extracellular matrix alterations in type 2 diabetes.

Clin Chem 2011 Nov 16;57(11):1556-65. Epub 2011 Sep 16.

Department of Clinical Biochemistry and Pharmacology, Institute of Molecular Medicine and Clinical Institute, Odense University Hospital, University of Southern Denmark.

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http://dx.doi.org/10.1373/clinchem.2011.162966DOI Listing
November 2011