Publications by authors named "Hans Zischka"

77Publications

CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion.

Cell Stem Cell 2020 Nov 16. Epub 2020 Nov 16.

Physiological Genomics, Biomedical Center (BMC), Ludwig-Maximilians-Universität (LMU), Planegg-Martinsried, Germany; Institute for Stem Cell Research, Helmholtz Center Munich, BMC LMU, Planegg-Martinsried, Germany; Excellence Cluster of Systems Neurology (SYNERGY), Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2020.10.015DOI Listing
November 2020

Mitochondrial Regulation of the 26S Proteasome.

Cell Rep 2020 Aug;32(8):108059

Member of the German Center for Lung Research (DZL), Comprehensive Pneumology Center (CPC), University Hospital, Ludwig-Maximilians University, Helmholtz Zentrum München, 81377 Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2020.108059DOI Listing
August 2020

LC-ICP-MS method for the determination of "extractable copper" in serum.

Metallomics 2020 09;12(9):1348-1355

Elemental Scientific, Inc., 7277 World Communications Dr., Omaha, NE, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0mt00132eDOI Listing
September 2020

Extending the mode of action of triethylenetetramine (trientine): Autophagy besides copper chelation.

J Hepatol 2020 Oct 16;73(4):970-972. Epub 2020 Jul 16.

Centre de Recherche des Cordeliers, INSERM U1138, Team "Metabolism, Cancer & Immunity", Sorbonne Université, Université de Paris, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China; Department of Women's and Children's Health, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhep.2020.05.046DOI Listing
October 2020

Copper - a novel stimulator of autophagy.

Cell Stress 2020 Apr 24;4(5):92-94. Epub 2020 Apr 24.

Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.15698/cst2020.05.218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212532PMC
April 2020

A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol.

Nature 2020 03 4;579(7799):433-437. Epub 2020 Mar 4.

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-020-2076-4DOI Listing
March 2020

Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and .

J Cell Sci 2019 10 1;132(19). Epub 2019 Oct 1.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Zentrum München-German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.223891DOI Listing
October 2019

Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease.

Int J Mol Sci 2019 Aug 16;20(16). Epub 2019 Aug 16.

CNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-504 Coimbra, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20163987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720908PMC
August 2019

Connecting lysosomes and mitochondria - a novel role for lipid metabolism in cancer cell death.

Cell Commun Signal 2019 07 29;17(1):87. Epub 2019 Jul 29.

Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12964-019-0399-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664539PMC
July 2019

Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints.

Am J Physiol Endocrinol Metab 2019 08 18;317(2):E374-E387. Epub 2019 Jun 18.

Institute for Clinical Chemistry and Pathobiochemistry, Department for Diagnostic Laboratory Medicine, University Hospital Tuebingen, Tuebingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpendo.00088.2019DOI Listing
August 2019

Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection.

Sci Rep 2019 06 11;9(1):8492. Epub 2019 Jun 11.

Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich, 81567, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-44922-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6560178PMC
June 2019

A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease Rats.

Cell Mol Gastroenterol Hepatol 2019 23;7(3):571-596. Epub 2018 Dec 23.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Toxicology and Environmental Hygiene, Technical University Munich, Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcmgh.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407159PMC
June 2019

Mitochondrial copper homeostasis and its derailment in Wilson disease.

Int J Biochem Cell Biol 2018 09 8;102:71-75. Epub 2018 Jul 8.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biocel.2018.07.001DOI Listing
September 2018

High spatial resolution LA-ICP-MS demonstrates massive liver copper depletion in Wilson disease rats upon Methanobactin treatment.

J Trace Elem Med Biol 2018 Sep 9;49:119-127. Epub 2018 May 9.

University of Münster, Institute of Inorganic and Analytical Chemistry, Corrensstraße 30, 48149 Münster, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtemb.2018.05.009DOI Listing
September 2018

The exceptional sensitivity of brain mitochondria to copper.

Toxicol In Vitro 2018 Sep 30;51:11-22. Epub 2018 Apr 30.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany; Institute of Toxicology and Environmental Hygiene, Technical University Munich, Biedersteiner Strasse 29, D-80802 Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tiv.2018.04.012DOI Listing
September 2018

PPARα Is Necessary for Radiation-Induced Activation of Noncanonical TGFβ Signaling in the Heart.

J Proteome Res 2018 04 23;17(4):1677-1689. Epub 2018 Mar 23.

Department of Cell Biology and Core Facility Animal Models (CAM), Biomedical Center , Ludwig-Maximilians University Munich , Planegg 80539 , Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jproteome.8b00001DOI Listing
April 2018

Mitochondria in non-alcoholic fatty liver disease.

Int J Biochem Cell Biol 2018 02 26;95:93-99. Epub 2017 Dec 26.

Department of Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteur 3 Str., 02-093 Warsaw, Poland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biocel.2017.12.019DOI Listing
February 2018

Copper Directly Affects Intestinal Lipid Turnover.

Gastroenterology 2018 01 21;154(1):15-17. Epub 2017 Nov 21.

Institute of Molecular Toxicology and Pharmacology (HMGU) and Institute of Toxicology and Environmental Hygiene (Technical University Munich), Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2017.11.016DOI Listing
January 2018

Spatial investigation of the elemental distribution in Wilson's disease liver after d-penicillamine treatment by LA-ICP-MS.

J Trace Elem Med Biol 2017 Dec 29;44:26-31. Epub 2017 May 29.

Institute of Inorganic and Analytical Chemistry, University of Münster, Corrensstraße 30, 48149 Münster, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtemb.2017.05.008DOI Listing
December 2017

Mitochondrial adaptation in steatotic mice.

Mitochondrion 2018 05 19;40:1-12. Epub 2017 Sep 19.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Institute of Toxicology and Environmental Hygiene, Technical University of Munich, 80802 Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mito.2017.08.015DOI Listing
May 2018

Downregulation of hepatic multi-drug resistance protein 1 (MDR1) after copper exposure.

Metallomics 2017 09;9(9):1279-1287

Klinik für Transplantationsmedizin, Universitätsklinikum Münster, Albert-Schweitzer-Campus 1, Gebäude A14, 48149 Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c7mt00189dDOI Listing
September 2017

Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death.

Free Radic Biol Med 2017 11 31;112:253-266. Epub 2017 Jul 31.

Institute of Biotechnology, Czech Academy of Sciences, BIOCEV, Vestec, Prague-West, Czech Republic. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.freeradbiomed.2017.07.033DOI Listing
November 2017

A TonB-Dependent Transporter Is Responsible for Methanobactin Uptake by Methylosinus trichosporium OB3b.

Appl Environ Microbiol 2016 Jan 15;82(6):1917-1923. Epub 2016 Jan 15.

Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/AEM.03884-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784032PMC
January 2016

Isolation of mitochondria from cultured cells and liver tissue biopsies for molecular and biochemical analyses.

Methods Mol Biol 2015 ;1295:87-97

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, Neuherberg, 85764, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-2550-6_8DOI Listing
December 2015

A protocol for the parallel isolation of intact mitochondria from rat liver, kidney, heart, and brain.

Methods Mol Biol 2015 ;1295:75-86

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, Neuherberg, 85764, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-2550-6_7DOI Listing
December 2015

Why to compare absolute numbers of mitochondria.

Mitochondrion 2014 Nov 23;19 Pt A:113-23. Epub 2014 Jun 23.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, D-85764 Neuherberg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mito.2014.06.005DOI Listing
November 2014

Pathological mitochondrial copper overload in livers of Wilson's disease patients and related animal models.

Ann N Y Acad Sci 2014 May 12;1315:6-15. Epub 2014 Feb 12.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/nyas.12347DOI Listing
May 2014

A semi-automated method for isolating functionally intact mitochondria from cultured cells and tissue biopsies.

Anal Biochem 2013 Dec 19;443(1):66-74. Epub 2013 Aug 19.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, D-85764 Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2013.08.007DOI Listing
December 2013

Progressive stages of mitochondrial destruction caused by cell toxic bile salts.

Biochim Biophys Acta 2013 Sep 17;1828(9):2121-33. Epub 2013 May 17.

Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, D-85764 Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamem.2013.05.007DOI Listing
September 2013

Ionising radiation induces persistent alterations in the cardiac mitochondrial function of C57BL/6 mice 40 weeks after local heart exposure.

Radiother Oncol 2013 Mar 20;106(3):404-10. Epub 2013 Mar 20.

Institute of Radiation Biology, German Research Center for Environmental Health, Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.radonc.2013.01.017DOI Listing
March 2013

Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction.

J Biol Chem 2013 Apr 19;288(15):10792-804. Epub 2013 Feb 19.

Institut für Pharmakologie und Klinische Pharmazie, Fachbereich Pharmazie, Philipps-Universität Marburg, D-35032 Marburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.453522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624460PMC
April 2013

Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition.

J Biol Chem 2013 Jan 20;288(2):1385-96. Epub 2012 Nov 20.

Department of Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University, 81377 Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M112.412007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543021PMC
January 2013

Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential.

Biochem Biophys Res Commun 2012 Aug 15;424(4):758-64. Epub 2012 Jul 15.

Medical Department II, Klinikum Grosshadern, University of Munich, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2012.07.029DOI Listing
August 2012

A mathematical model of mitochondrial swelling.

BMC Res Notes 2010 Mar 11;3:67. Epub 2010 Mar 11.

Institute of Biomathematics and Biometry, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1756-0500-3-67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850912PMC
March 2010

Mitochondrial gateways to cancer.

Mol Aspects Med 2010 Feb 19;31(1):1-20. Epub 2009 Aug 19.

INSERM, U848, Institut Gustave Roussy, PR1, 39 Rue Camille Desmoulins, F-94805 Villejuif, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mam.2009.08.002DOI Listing
February 2010

16-BAC/SDS-PAGE analysis of membrane proteins of yeast mitochondria purified by free flow electrophoresis.

Methods Mol Biol 2009 ;528:83-107

GSF-National Research Centre for Environment and Health, Institute of Human Genetics, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-60327-310-7_6DOI Listing
March 2009

Electrophoretic analysis of the mitochondrial outer membrane rupture induced by permeability transition.

Anal Chem 2008 Jul 30;80(13):5051-8. Epub 2008 May 30.

Institute of Toxicology, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Oberschleissheim, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ac800173rDOI Listing
July 2008

Purification of Saccharomyces cerevisiae mitochondria by zone electrophoresis in a free flow device.

Methods Mol Biol 2008 ;432:51-64

GSF-National Research Center for Environment and Health, Institute of Toxicology, Munich-Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-028-7_4DOI Listing
August 2008

Mechanisms of Cdc48/VCP-mediated cell death: from yeast apoptosis to human disease.

Biochim Biophys Acta 2008 Jul 2;1783(7):1418-35. Epub 2008 Feb 2.

Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Munich-Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2008.01.015DOI Listing
July 2008

Membrane-initiated effects of progesterone on calcium dependent signaling and activation of VEGF gene expression in retinal glial cells.

Glia 2007 Aug;55(10):1061-73

Institute of Human Genetics, GSF National-Research Center for Environment and Health, Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/glia.20523DOI Listing
August 2007

Differential analysis of Saccharomyces cerevisiae mitochondria by free flow electrophoresis.

Mol Cell Proteomics 2006 Nov 17;5(11):2185-200. Epub 2006 Aug 17.

Institutes of Human Genetics and Toxicology, GSF-National Research Center for Environment and Health, 85764 Munich-Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/mcp.T600018-MCP200DOI Listing
November 2006

Crucial mitochondrial impairment upon CDC48 mutation in apoptotic yeast.

J Biol Chem 2006 Sep 5;281(35):25757-67. Epub 2006 Jul 5.

GSF-National Research Center for Environment and Health, Institute of Human Genetics, Ingolstaedter Landstrasse 1, Munich-Neuherberg D-85764, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M513699200DOI Listing
September 2006

Insights into the membrane proteome of rat liver peroxisomes: microsomal glutathione-S-transferase is shared by both subcellular compartments.

Proteomics 2006 Feb;6(3):804-16

Department of Anatomy and Cell Biology II, University of Heidelberg, Heidelberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200401347DOI Listing
February 2006

The membrane proteome of Halobacterium salinarum.

Proteomics 2005 Jan;5(1):180-97

Abteilung für Membranbiochemie, Max-Planck-Institut für Biochemie, D-82152 Martinsried, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200400943DOI Listing
January 2005

FGF23 is processed by proprotein convertases but not by PHEX.

Bone 2004 Aug;35(2):455-62

Institute of Human Genetics, GSF National Research Center, 85764 München-Neuherberg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bone.2004.04.002DOI Listing
August 2004

Improved proteome analysis of Saccharomyces cerevisiae mitochondria by free-flow electrophoresis.

Proteomics 2003 Jun;3(6):906-16

GSF Research Centre for Environment and Health, Institute of Human Genetics, Oberschleissheim, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200300376DOI Listing
June 2003

Proteome analysis of the thermoreceptive pit membrane of the western diamondback rattlesnake Crotalus atrox.

Proteomics 2003 Jan;3(1):78-86

Max-Planck-Institut für Biochemie, Department of Membrane Biochemistry Martinsried, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/pmic.200390012DOI Listing
January 2003

Hisactophilin is involved in osmoprotection in Dictyostelium.

BMC Biochem 2002 May 7;3:10. Epub 2002 May 7.

Max-Planck-Institute for Biochemistry, 82152 Martinsried, Germany.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC115871PMC
http://dx.doi.org/10.1186/1471-2091-3-10DOI Listing
May 2002

Role of the N- and C-terminal regions of the PufX protein in the structural organization of the photosynthetic core complex of Rhodobacter sphaeroides.

Eur J Biochem 2002 Apr;269(7):1877-85

Department of Membrane Biochemistry Max-Planck-Institute for Biochemistry, Martinsried, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1046/j.1432-1033.2002.02834.xDOI Listing
April 2002