Hans Morreau

Hans Morreau

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Hans Morreau

Hans Morreau

Publications by authors named "Hans Morreau"

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The missing heritability of familial colorectal cancer.

Mutagenesis 2019 Oct 12. Epub 2019 Oct 12.

Department of Pathology, Leiden University Medical Center, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/mutage/gez027DOI Listing
October 2019

The complexity of screening PMS2 in DNA isolated from formalin-fixed paraffin-embedded material.

Eur J Hum Genet 2019 Oct 15. Epub 2019 Oct 15.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41431-019-0527-xDOI Listing
October 2019

Targeted Treatment Options of Recurrent Radioactive Iodine Refractory Hürthle Cell Cancer.

Cancers (Basel) 2019 Aug 15;11(8). Epub 2019 Aug 15.

Department of Pathology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.3390/cancers11081185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721552PMC
August 2019

Allelic Switching of , , and during Colorectal Cancer Tumorigenesis.

Int J Genomics 2019 10;2019:1287671. Epub 2019 Apr 10.

Department of Pathology, Leiden University Medical Center, Leiden, Netherlands.

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https://www.hindawi.com/journals/ijg/2019/1287671/
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http://dx.doi.org/10.1155/2019/1287671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481143PMC
April 2019

Unique landscape of widespread chromosomal losses in Hürthle cell carcinoma.

Endocr Relat Cancer 2018 Dec 1. Epub 2018 Dec 1.

H Morreau, Pathology, Leiden University Medica Center, Leiden, Netherlands.

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http://dx.doi.org/10.1530/ERC-18-0481DOI Listing
December 2018

High Growth Rate of Pancreatic Ductal Adenocarcinoma in Mutation Carriers.

Cancer Prev Res (Phila) 2018 09 10;11(9):551-556. Epub 2018 Jul 10.

Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1940-6207.CAPR-18-0035DOI Listing
September 2018

The tumour-stroma ratio in colon cancer: the biological role and its prognostic impact.

Histopathology 2018 Aug 24;73(2):197-206. Epub 2018 Mar 24.

Department of Surgery, Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/his.13489DOI Listing
August 2018

Diagnostic Utility of Molecular and Imaging Biomarkers in Cytological Indeterminate Thyroid Nodules.

Endocr Rev 2018 04;39(2):154-191

Department of Radiology, Section of Nuclear Medicine, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1210/er.2017-00133DOI Listing
April 2018

ROS-induced near-homozygous genomes in thyroid cancer.

Endocr Relat Cancer 2018 01 24;25(1):83-97. Epub 2017 Oct 24.

Department of Pathology Leiden University Medical CenterLeiden, Netherlands

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http://dx.doi.org/10.1530/ERC-17-0288DOI Listing
January 2018

Quantitative NMR analysis of intra- and extracellular metabolism of mammalian cells: A tutorial.

Anal Chim Acta 2017 08 24;980:1-24. Epub 2017 May 24.

Center for Proteomics and Metabolomics, Leiden University Medical Center, Albinusdreef 2, 2300RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.aca.2017.05.011DOI Listing
August 2017

Dilemmas in the management of screen-detected lesions in patients at high risk for pancreatic cancer.

Fam Cancer 2017 01;16(1):111-115

Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s10689-016-9915-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243878PMC
January 2017

Imprinted survival genes preclude loss of heterozygosity of chromosome 7 in cancer cells.

J Pathol 2016 09;240(1):72-83

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/path.4756DOI Listing
September 2016

Benefit of Surveillance for Pancreatic Cancer in High-Risk Individuals: Outcome of Long-Term Prospective Follow-Up Studies From Three European Expert Centers.

J Clin Oncol 2016 06 25;34(17):2010-9. Epub 2016 Apr 25.

Hans Vasen, Isaura Ibrahim, Kristin Robbers, Anneke M. van Mil, Thomas Potjer, Bert A. Bonsing, Wilma Bergman, Martin Wasser, and Hans Morreau, Leiden University Medical Center, Leiden; Wouter H. de Vos tot Nederveen Cappel, Isala Clinics, Zwolle, the Netherlands; Carmen Guillen Ponce, Alfredo Carrato, Julie Earl, Evelina Mocci, Enrique Vazquez-Sequeiros, Alfonso Sanjuanbenito, Maria Muñoz-Beltran, and José Montans, Ramón y Cajal University Hospital, Ramón y Cajal Health Research Institute, Madrid, Spain; Emily P. Slater, Elvira Matthäi, Volker Fendrich, and Detlef K. Bartsch, University Hospital Marburg; Christoph Schicker, Martin Steinkamp, and Jens Figiel, Philipps University Marburg, Marburg; Günter Klöppel, Consultation Centre for Pancreatic and Endocrine Tumors, Technical University Munich; Peter Langer, Klinikum Hanau, Hanau, Germany; and Irene Esposito, Innsbruck University Hospital, Innsbruck, Austria.

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http://dx.doi.org/10.1200/JCO.2015.64.0730DOI Listing
June 2016

Double NF1 inactivation affects adrenocortical function in NF1Prx1 mice and a human patient.

PLoS One 2015 16;10(3):e0119030. Epub 2015 Mar 16.

Institute for Medical Genetics and Human Genetics, Charité, Universitätsmedizin Berlin, Berlin, Germany; Max Planck Institute for Molecular Genetics, FG Development & Disease, Berlin, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0119030PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361563PMC
January 2016

Randomized Comparison of Surveillance Intervals in Familial Colorectal Cancer.

J Clin Oncol 2015 Dec 2;33(35):4188-93. Epub 2015 Nov 2.

Simone D. Hennink, Andrea E. van der Meulen-de Jong, Ron Wolterbeek, A. Stijn L.P. Crobach, Roeland A. Veenendaal, Hans Morreau, and Hans F.A. Vasen, Leiden University Medical Center; Wiet F.S.J. Crobach, W. Rogier ten Hove, and Anne M.C. Witte, Diaconessenhuis, Leiden; Marco C.J.M. Becx, St Antonius Hospital, Nieuwegein; Michiel van Haastert and Hugo J. Wolters, Martini Hospital; Jan H. Kleibeuker, University Medical Center Groningen, Groningen; Maarten A.C. Meijssen, Juda Vecht, Wouter H. de Vos tot Nederveen Cappel, and Dik Westerveld, Isala Clinics, Zwolle; Fokko M. Nagengast, Radboud University Medical Center, Nijmegen; Marno C.M. Rijk, Amphia Hospital, Breda; Jan M.J.I. Salemans and Marie-Louise Verhulst, Máxima Medical Center; Arnold Stronkhorst, Catharina Hospital, Eindhoven; Hans A.R.E. Tuynman, Medical Center Alkmaar, Alkmaar; Herman Walinga, Reinier de Graaf Gasthuis, Delft; Olaf K. Weinhardt, Scheper Hospital, Emmen; and Annemieke Cats, National Cancer Institute, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1200/JCO.2015.62.2035DOI Listing
December 2015

Succinate Dehydrogenase (SDH)-Deficient Pancreatic Neuroendocrine Tumor Expands the SDH-Related Tumor Spectrum.

J Clin Endocrinol Metab 2015 Oct 10;100(10):E1386-93. Epub 2015 Aug 10.

Department of Endocrinology and Metabolic Diseases (N.D.N., E.P.M.C.), Leiden University Medical Center, 2300 RC Leiden, The Netherlands; Department of Pathology (T.G.P., E.K., L.O., W.N.M.D., R.R.d.K.) Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands; Department of Pathology (R.R.d.K.), Reinier de Graaf Hospital, 2625 AD Delft, The Netherlands; and Departments of Pathology (H.M.), Human Genetics (J.P.B.), Clinical Genetics (F.J.H.), and Otorhinolaryngology (J.C.J.), Leiden University Medical Center, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1210/jc.2015-2689DOI Listing
October 2015

Safety and efficacy of the addition of simvastatin to panitumumab in previously treated KRAS mutant metastatic colorectal cancer patients.

Anticancer Drugs 2015 Sep;26(8):872-7

Departments of aClinical Oncology bClinical Pharmacy and Toxicology cPathology, Leiden University Medical Center dDepartment of Internal Medicine, Diaconessenhuis Leiden, Leiden eDepartment of Internal Medicine, Reinier de Graaf Hospital, Delft fDepartment of Internal Medicine and Clinical Oncology, Haga Hospital, The Hague, The Netherlands.

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http://dx.doi.org/10.1097/CAD.0000000000000255DOI Listing
September 2015

Current State and Future Challenges of Mass Spectrometry Imaging for Clinical Research.

Anal Chem 2015 Jul 7;87(13):6426-33. Epub 2015 Apr 7.

†Center for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1021/acs.analchem.5b00416DOI Listing
July 2015

Transforming Growth Factor β Signaling in Colorectal Cancer Cells With Microsatellite Instability Despite Biallelic Mutations in TGFBR2.

Gastroenterology 2015 Jun 28;148(7):1427-37.e8. Epub 2015 Feb 28.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2015.02.052DOI Listing
June 2015

Age-dependent clinical prognostic value of histone modifications in colorectal cancer.

Transl Res 2015 May 13;165(5):578-88. Epub 2014 Nov 13.

Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2014.11.001DOI Listing
May 2015

Towards imaging metabolic pathways in tissues.

Anal Bioanal Chem 2015 Mar 9;407(8):2167-76. Epub 2014 Nov 9.

Department of Medical Oncology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00216-014-8305-7DOI Listing
March 2015

Target-enriched next-generation sequencing reveals differences between primary and secondary ovarian tumors in formalin-fixed, paraffin-embedded tissue.

J Mol Diagn 2015 Mar 26;17(2):193-200. Epub 2014 Dec 26.

Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2014.10.006DOI Listing
March 2015

Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion.

J Clin Endocrinol Metab 2015 Feb 11;100(2):E360-4. Epub 2014 Nov 11.

Laboratory of Cancer Epigenome (W.Y., H.L.H., A.G., D.H., S.L.P., C.K.O., B.T.T.), Division of Medical Sciences, National Cancer Centre Singapore, 169610 Singapore; Division of Cancer and Stem Cell Biology (W.Y., J.R.M., H.L.H., D.H., S.L.P., C.K.O., S.G.R., P.T., B.T.T.), Duke-National University of Singapore Graduate Medical School, 169857 Singapore; National University of Singapore Graduate School for Integrative Sciences and Engineering (W.Y.), 117456 Singapore; Academic Endocrine Unit, Nuffield Department of Clinical Medicine (M.S., P.N., R.V.T.), Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, OX3 7LJ Oxford, United Kingdom; Department of Pathology (R.v.E., D.R., T.v.W., H.M.), Leiden University Medical Center, 2333 ZA Leiden, The Netherlands; Molecular Endocrinology Group, Molecular Pathobiology Research Centre Unit (U.I.P.M.) (B.C.) of the Portuguese Institute of Oncology from Lisbon Francisco Gentil (IPOLFG) and Chronic Diseases Research Centre (CEDOC), Faculty of Medical Sciences (FCM), New University of Lisbon (UNL), 1099-023 Lisbon, Portugal; Genome Institute of Singapore (P.T.), 138672 Singapore; and Cancer Science Institute of Singapore (P.T., B.T.T.), National University of Singapore, 117599 Singapore.

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http://dx.doi.org/10.1210/jc.2014-3238DOI Listing
February 2015

MicroRNA classifier and nomogram for metastasis prediction in colon cancer.

Cancer Epidemiol Biomarkers Prev 2015 Jan 14;24(1):187-97. Epub 2014 Oct 14.

Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1055-9965.EPI-14-0544-TDOI Listing
January 2015

Near-haploidization significantly associates with oncocytic adrenocortical, thyroid, and parathyroid tumors but not with mitochondrial DNA mutations.

Genes Chromosomes Cancer 2014 Oct 7;53(10):833-44. Epub 2014 Jun 7.

Department of Pathology, Leiden University Medical Center, RC, Leiden, Netherlands.

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http://dx.doi.org/10.1002/gcc.22194DOI Listing
October 2014

Automatic generic registration of mass spectrometry imaging data to histology using nonlinear stochastic embedding.

Anal Chem 2014 Sep 26;86(18):9204-11. Epub 2014 Aug 26.

Division of Image Processing, Department of Radiology, ‡Center for Proteomics and Metabolomics, §Department of Human Genetics, ∥Department of Neurology, and ⊥Department of Pathology, Leiden University Medical Center , 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1021/ac502170fDOI Listing
September 2014

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

Gastroenterology 2014 Jul 3;147(1):196-208.e13. Epub 2014 Apr 3.

Department of Gastroenterology and Hepatology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2014.03.052DOI Listing
July 2014

Anticancer activity of novel pyrido[2,3-b]indolizine derivatives: the relevance of phenolic substituents.

Anticancer Res 2014 Apr;34(4):1673-7

Albinusdreef 2, 2333ZA Leiden, The Netherlands.

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April 2014

Assessment of a fully automated high-throughput DNA extraction method from formalin-fixed, paraffin-embedded tissue for KRAS, and BRAF somatic mutation analysis.

Exp Mol Pathol 2013 Feb 29;94(1):121-5. Epub 2012 Jun 29.

Department of Pathology, Leiden University Medical Center, P.O.box 9600, L1-Q, Albinusdreef 2, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.yexmp.2012.06.004DOI Listing
February 2013

Variation in precursor lesions of pancreatic cancer among high-risk groups.

Clin Cancer Res 2013 Jan 21;19(2):442-9. Epub 2012 Nov 21.

Departments of Gastroenterology & Hepatology, Radiology, Pathology, and Surgery, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2730DOI Listing
January 2013

BRAF mutation-specific promoter methylation of FOX genes in colorectal cancer.

Clin Epigenetics 2013 Jan 16;5(1). Epub 2013 Jan 16.

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/1868-7083-5-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3599401PMC
January 2013

Ovarian metastases of colorectal and duodenal cancer in familial adenomatous polyposis.

Fam Cancer 2012 Dec;11(4):671-3

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s10689-012-9565-zDOI Listing
December 2012

A review of the genetic background and tumour profiling in familial colorectal cancer.

Mutagenesis 2012 Mar;27(2):239-45

Department of Pathology, LUMC, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.1093/mutage/ger071DOI Listing
March 2012

Role of the microenvironment in the tumourigenesis of microsatellite unstable and MUTYH-associated polyposis colorectal cancers.

Mutagenesis 2012 Mar;27(2):247-53

Department of Pathology, Leiden University Medical Centre, Albinusdreef 2, 2300 RC Leiden, The Netherlands.

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https://academic.oup.com/mutage/article-lookup/doi/10.1093/m
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http://dx.doi.org/10.1093/mutage/ger077DOI Listing
March 2012

Transanal endoscopic microsurgery for T1 rectal cancer: size matters!

Surg Endosc 2012 Feb 13;26(2):551-7. Epub 2011 Oct 13.

Department of Surgery, IJsselland Hospital, Prins Constantijnweg 2, 2906 ZC, Capelle aan den IJssel, The Netherlands.

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http://dx.doi.org/10.1007/s00464-011-1918-4DOI Listing
February 2012