Hans Kretzschmar

Hans Kretzschmar

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Hans Kretzschmar

Publications by authors named "Hans Kretzschmar"

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Altered Long Noncoding RNA Expression Precedes the Course of Parkinson's Disease-a Preliminary Report.

Mol Neurobiol 2017 05 28;54(4):2869-2877. Epub 2016 Mar 28.

Center for Neuropathology and Prion Research (ZNP), Ludwig-Maximilians-Universität, Feodor-Lynen-Str. 23, 81377, Munich, Bavaria, Germany.

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http://dx.doi.org/10.1007/s12035-016-9854-xDOI Listing
May 2017

Profiling of methylation and demethylation pathways during brain development and ageing.

J Neural Transm (Vienna) 2016 Mar 26;123(3):189-203. Epub 2015 Oct 26.

Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Feodor-Lynen-Str. 23, 81377, Munich, Germany.

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http://dx.doi.org/10.1007/s00702-015-1469-2DOI Listing
March 2016

Clinical findings and diagnosis in genetic prion diseases in Germany.

Eur J Epidemiol 2016 Feb 16;31(2):187-96. Epub 2015 Jun 16.

Department of Neurology, National Reference Center for TSE Surveillance, University Medical School, Georg-August University Göttingen, Robert-Koch Str. 40, 37075, Göttingen, Germany.

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http://link.springer.com/10.1007/s10654-015-0049-y
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http://dx.doi.org/10.1007/s10654-015-0049-yDOI Listing
February 2016

Loss of 5-hydroxymethylcytosine and intratumoral heterogeneity as an epigenomic hallmark of glioblastoma.

Tumour Biol 2015 Nov 29;36(11):8439-46. Epub 2015 May 29.

Center for Neuropathology and Prion Research (ZNP), Ludwig-Maximilians-University, Feodor-Lynen-Str. 23, Munich, D-81377, Germany.

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http://dx.doi.org/10.1007/s13277-015-3606-9DOI Listing
November 2015

A 59-Year-Old Man with Two Cerebellar Lesions and Disturbed Cerebellar Morphology.

Brain Pathol 2015 Nov;25(6):790-1

Center for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1111/bpa.12322DOI Listing
November 2015

Age-dependent levels of 5-methyl-, 5-hydroxymethyl-, and 5-formylcytosine in human and mouse brain tissues.

Angew Chem Int Ed Engl 2015 Oct 3;54(42):12511-4. Epub 2015 Jul 3.

Center for Integrated Protein Science at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 Munich (Germany).

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http://dx.doi.org/10.1002/anie.201502722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643189PMC
October 2015

Genetic Characterization of Ten-Eleven-Translocation Methylcytosine Dioxygenase Alterations in Human Glioma.

J Cancer 2015 15;6(9):832-42. Epub 2015 Jul 15.

Center for Neuropathology and Prion Research (ZNP), Ludwig-Maximilians-University, Feodor-Lynen-Str. 23, D-81377 Munich, Bavaria, Germany.

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http://dx.doi.org/10.7150/jca.12010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532980PMC
August 2015

Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study.

J Neural Transm (Vienna) 2015 Jul 13;122(7):1055-68. Epub 2014 Aug 13.

Wolfson Neuroscience Laboratories, Division of Brain Sciences, Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London, W12 0NN, UK.

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http://dx.doi.org/10.1007/s00702-014-1293-0DOI Listing
July 2015

5-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing.

J Neural Transm (Vienna) 2015 Jul 4;122(7):1035-43. Epub 2014 Dec 4.

Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Feodor-Lynen-Str. 23, 81377, Munich, Germany,

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http://dx.doi.org/10.1007/s00702-014-1346-4DOI Listing
July 2015

Long non-coding RNA normalisers in human brain tissue.

J Neural Transm (Vienna) 2015 Jul 21;122(7):1045-54. Epub 2014 Dec 21.

Center for Neuropathology and Prion Research (ZNP), Ludwig-Maximilians-University, Feodor-Lynen-Str. 23, 81377, Munich, Bavaria, Germany,

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http://dx.doi.org/10.1007/s00702-014-1352-6DOI Listing
July 2015

The workflow from post-mortem human brain sampling to cell microdissection: a Brain Net Europe study.

J Neural Transm (Vienna) 2015 Jul 16;122(7):975-91. Epub 2015 May 16.

INSERM U1028; CNRS UM5292; Lyon Neuroscience Research Center, Neuro-oncology and Neuro-inflammation Team, 69000, Lyon, France,

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http://dx.doi.org/10.1007/s00702-015-1378-4DOI Listing
July 2015

Biological tumor volume in 18FET-PET before radiochemotherapy correlates with survival in GBM.

Neurology 2015 Feb 21;84(7):710-9. Epub 2015 Jan 21.

From the Departments of Neurosurgery (B.S., F.W.K., J.C.T.), Nuclear Medicine (N.L.J.), Neuroradiology (J.L., H.J.), and Neuropathology (H.K., S.E.), Ludwig-Maximilians University Munich; Department of Neurosurgery (M.S.), University of Bonn; Department of Nuclear Medicine (G.P.), Katharinenhospital Stuttgart; Department of Nuclear Medicine (C.l.F.), University of Tuebingen, Germany; and Department of Neurology (M.W.), University Hospital Zurich, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000001262DOI Listing
February 2015

Identification of Stably Expressed lncRNAs as Valid Endogenous Controls for Profiling of Human Glioma.

J Cancer 2015 1;6(2):111-9. Epub 2015 Jan 1.

Center for Neuropathology and Prion Research (ZNP), Ludwig-Maximilians-University, Feodor-Lynen-Str. 23, D-81377 Munich, Bavaria, Germany.

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http://www.jcancer.org/v06p0111.htm
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http://dx.doi.org/10.7150/jca.10867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280393PMC
January 2015

Analyses of the similarity and difference of global gene expression profiles in cortex regions of three neurodegenerative diseases: sporadic Creutzfeldt-Jakob disease (sCJD), fatal familial insomnia (FFI), and Alzheimer's disease (AD).

Mol Neurobiol 2014 Oct 7;50(2):473-81. Epub 2014 Jun 7.

State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changbai Rd 155, Beijing, 102206, People's Republic of China.

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http://dx.doi.org/10.1007/s12035-014-8758-xDOI Listing
October 2014

First symptom and initial diagnosis in sporadic CJD patients in Germany.

J Neurol 2014 Sep 15;261(9):1811-7. Epub 2014 Jul 15.

Department of Neurology, University Medical Center, National Reference Center for TSE Surveillance, Georg-August-Universität Göttingen and German Center for Neurodegenerative Diseases (DZNE), Robert-Koch Str. 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00415-014-7410-zDOI Listing
September 2014

Molecular stereotactic biopsy technique improves diagnostic accuracy and enables personalized treatment strategies in glioma patients.

Acta Neurochir (Wien) 2014 Aug 3;156(8):1427-40. Epub 2014 May 3.

Center for Neuropathology and Prion Research, University of Munich Medical Center - Grosshadern, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany.

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http://link.springer.com/10.1007/s00701-014-2073-1
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http://dx.doi.org/10.1007/s00701-014-2073-1DOI Listing
August 2014

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease.

EMBO J 2014 Aug 7;33(15):1667-80. Epub 2014 Jul 7.

German Center for Neurodegenerative Diseases, Munich, Germany Adolf Butenandt Institute, Biochemistry, Ludwig-Maximilians-University Munich, Munich, Germany Munich Cluster of Systems Neurology (SyNergy), Munich, Germany

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http://dx.doi.org/10.15252/embj.201387576DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194100PMC
August 2014

Diffuse leukoencephalopathy with spheroids: biopsy findings and a novel mutation.

Clin Neurol Neurosurg 2014 Jul 4;122:113-5. Epub 2014 May 4.

Department of Neurology, Ludwig-Maximilians-Universität, Munich, Germany; German Research Center for Neurodegenerative Diseases (DZNE), Ludwig-Maximilians-Universität, Munich, Germany.

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http://dx.doi.org/10.1016/j.clineuro.2014.04.022DOI Listing
July 2014

Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo.

Biochem Biophys Res Commun 2014 Feb 3;445(1):23-9. Epub 2014 Feb 3.

Institute of Novel and Emerging Infectious Diseases at the Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.01.122DOI Listing
February 2014

Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations.

Acta Neuropathol 2013 Dec 6;126(6):859-79. Epub 2013 Oct 6.

Department of Pathology, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1007/s00401-013-1181-yDOI Listing
December 2013

Brain banking for neurological disorders.

Lancet Neurol 2013 Nov 25;12(11):1096-105. Epub 2013 Sep 25.

Division of Clinical Neurosciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

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http://dx.doi.org/10.1016/S1474-4422(13)70202-3DOI Listing
November 2013

Report about four novel mutations in the prion protein gene.

Dement Geriatr Cogn Disord 2013 5;35(3-4):229-37. Epub 2013 Mar 5.

Department of Neurology, Clinical Dementia Center, Georg August University Goettingen, Goettingen, Germany. epicjd @ med.uni-goettingen.de

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https://epub.ub.uni-muenchen.de/21777/1/10_1159_000345991.pd
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http://www.karger.com/doi/10.1159/000345991
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http://dx.doi.org/10.1159/000345991DOI Listing
October 2013

Analyses of protease resistance and aggregation state of abnormal prion protein across the spectrum of human prions.

J Biol Chem 2013 Sep 29;288(39):27972-85. Epub 2013 Jul 29.

From the Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto delle Scienze Neurologiche di Bologna, 40139 Bologna, Italy.

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http://dx.doi.org/10.1074/jbc.M113.477547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784711PMC
September 2013

Magnetic resonance imaging in E200K and V210I mutations of the prion protein gene.

Alzheimer Dis Assoc Disord 2013 Jan-Mar;27(1):87-90

Department of Neurology, National TSE Reference Center, Georg-August University Goettingen, Goettingen, Germany.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/WAD.0b013e31824d578aDOI Listing
August 2013

Comparative analysis of gene expression profiles between cortex and thalamus in Chinese fatal familial insomnia patients.

Mol Neurobiol 2013 Aug 21;48(1):36-48. Epub 2013 Feb 21.

State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Chang-Bai Rd 155, Beijing, 102206, People's Republic of China.

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http://dx.doi.org/10.1007/s12035-013-8426-6DOI Listing
August 2013

Sox2 requirement in sonic hedgehog-associated medulloblastoma.

Cancer Res 2013 Jun 17;73(12):3796-807. Epub 2013 Apr 17.

Center for Neuropathology, Ludwig Maximilians University Munich, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0238DOI Listing
June 2013

Rapidly progressive Alzheimer's disease: a multicenter update.

J Alzheimers Dis 2012 ;30(4):751-6

National Reference Center for TSE Surveillance, Department of Neurology, Georg-August-University, Goettingen, Germany.

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http://dx.doi.org/10.3233/JAD-2012-120007DOI Listing
May 2013

Prion disease: a tale of folds and strains.

Brain Pathol 2013 May;23(3):321-32

Institut für Neuropathologie, München, Germany.

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http://dx.doi.org/10.1111/bpa.12045DOI Listing
May 2013

The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS.

Science 2013 Mar 7;339(6125):1335-8. Epub 2013 Feb 7.

Adolf Butenandt-Institute, Biochemistry, Ludwig-Maximilians University (LMU) Munich, Munich, Germany.

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http://dx.doi.org/10.1126/science.1232927DOI Listing
March 2013

Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.

J Cell Mol Med 2013 Feb 5;17(2):293-302. Epub 2013 Feb 5.

Department of Translational Brain Research, DZNE - German Center for Neurodegenerative Diseases, Munich, Germany.

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http://dx.doi.org/10.1111/jcmm.12008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822592PMC
February 2013

Amyloid plaque formation precedes dendritic spine loss.

Acta Neuropathol 2012 Dec 21;124(6):797-807. Epub 2012 Sep 21.

Center for Neuropathology, Ludwig-Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1007/s00401-012-1047-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508278PMC
December 2012

Headache in patients with pituitary adenoma: clinical and paraclinical findings.

Cephalalgia 2012 Dec 11;32(16):1198-207. Epub 2012 Oct 11.

Department of Neurology, University of Munich Hospital - Grosshadern, Germany.

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http://dx.doi.org/10.1177/0333102412462639DOI Listing
December 2012

Human and rat brain lipofuscin proteome.

Proteomics 2012 Aug;12(15-16):2445-54

Department of Neuropathology, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1002/pmic.201100668DOI Listing
August 2012

Genome-wide study links MTMR7 gene to variant Creutzfeldt-Jakob risk.

Neurobiol Aging 2012 Jul 2;33(7):1487.e21-8. Epub 2011 Dec 2.

Neurology Department, University Hospital Marqués de Valdecilla, Fundación Marqués de Valdecilla (University of Cantabria) IFIMAV and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Santander, Spain.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.10.011DOI Listing
July 2012

Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state.

Biophys J 2012 Apr 3;102(7):1646-55. Epub 2012 Apr 3.

Neurologische Klinik, Klinikum Großhadern, Ludwig-Maximilians-Universität, Munich, Germany.

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http://dx.doi.org/10.1016/j.bpj.2012.01.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318129PMC
April 2012

Lack of Pur-alpha alters postnatal brain development and causes megalencephaly.

Hum Mol Genet 2012 Feb 18;21(3):473-84. Epub 2011 Oct 18.

Center of Neuropathology and Prion Research, Ludwig-Maximilians-Universität and German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.

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http://dx.doi.org/10.1093/hmg/ddr476DOI Listing
February 2012

Next-generation sequencing reveals regional differences of the α-synuclein methylation state independent of Lewy body disease.

Neuromolecular Med 2011 Dec 1;13(4):310-20. Epub 2011 Nov 1.

The Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Feodor-Lynen-Str. 23, 81377, Munich, Germany.

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http://link.springer.com/10.1007/s12017-011-8163-9
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http://dx.doi.org/10.1007/s12017-011-8163-9DOI Listing
December 2011

Atypical prion diseases in humans and animals.

Top Curr Chem 2011 ;305:23-50

Norwegian School of Veterinary Science, Oslo, Norway.

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http://dx.doi.org/10.1007/128_2011_161DOI Listing
November 2011

Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients.

Clin Cancer Res 2011 Nov 14;17(21):6791-801. Epub 2011 Sep 14.

Center for Neuropathology, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1214DOI Listing
November 2011

α-Internexin in the diagnosis of oligodendroglial tumors and association with 1p/19q status.

J Neuropathol Exp Neurol 2011 Nov;70(11):970-8

Center for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1097/NEN.0b013e3182333ef5DOI Listing
November 2011

MiRNA expression patterns predict survival in glioblastoma.

Radiat Oncol 2011 Nov 10;6:153. Epub 2011 Nov 10.

Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Marchioninistr, 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1186/1748-717X-6-153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235977PMC
November 2011

Diphenylpyrazole-derived compounds increase survival time of mice after prion infection.

Antimicrob Agents Chemother 2011 Oct 11;55(10):4774-81. Epub 2011 Jul 11.

Institute for Novel and Emerging Infectious Diseases at the Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health Südufer 10, 17493 Greifswald-Insel Riems, Germany.

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http://aac.asm.org/lookup/doi/10.1128/AAC.00151-11
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http://dx.doi.org/10.1128/AAC.00151-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186986PMC
October 2011

From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease.

ChemMedChem 2011 Oct 13;6(10):1928-37. Epub 2011 Jul 13.

Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute for Novel and Emerging Infectious Diseases, Suedufer 10, 17493 Greifswald-Insel Riems, Germany.

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http://dx.doi.org/10.1002/cmdc.201100119DOI Listing
October 2011

Single particle analysis of tau oligomer formation induced by metal ions and organic solvents.

Biochem Biophys Res Commun 2011 Jul 24;411(1):190-6. Epub 2011 Jun 24.

Zentrum für Neuropathologie und Prionforschung, Ludwig-Maximilians-Universität, München, Germany.

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http://dx.doi.org/10.1016/j.bbrc.2011.06.135DOI Listing
July 2011