Publications by authors named "Hans J P M Koenen"

64Publications

Immune responses to azacytidine in animal models of inflammatory disorders: a systematic review.

J Transl Med 2021 Jan 6;19(1):11. Epub 2021 Jan 6.

Department of Laboratory Medicine-Laboratory Medical Immunology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands.

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January 2021

Synthetic Extracellular Matrices as a Toolbox to Tune Stem Cell Secretome.

ACS Appl Mater Interfaces 2020 Dec 11;12(51):56723-56730. Epub 2020 Dec 11.

Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.

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December 2020

COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients.

Crit Care 2020 May 26;24(1):263. Epub 2020 May 26.

Department of Intensive Care Medicine, Radboud University Medical Center, Internal Mail 710, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

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May 2020

TNFα-Signaling Modulates the Kinase Activity of Human Effector Treg and Regulates IL-17A Expression.

Front Immunol 2019 21;10:3047. Epub 2020 Jan 21.

Laboratory Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

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November 2020

Metabolic Pathways Involved in Regulatory T Cell Functionality.

Front Immunol 2019 3;10:2839. Epub 2019 Dec 3.

Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

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November 2020

Intradermal injection of low dose human regulatory T cells inhibits skin inflammation in a humanized mouse model.

Sci Rep 2018 07 3;8(1):10044. Epub 2018 Jul 3.

Radboud university medical center, department of Laboratory Medicine-Medical Immunology, Nijmegen, The Netherlands.

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July 2018

MPZL2, Encoding the Epithelial Junctional Protein Myelin Protein Zero-like 2, Is Essential for Hearing in Man and Mouse.

Am J Hum Genet 2018 07 28;103(1):74-88. Epub 2018 Jun 28.

Hearing and Genes Division, Department of Otorhinolaryngology, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands; Department of Human Genetics, Radboud University Medical Center, 6500 HB Nijmegen, the Netherlands. Electronic address:

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July 2018

DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4CD25 FOXP3 Regulatory T Cells but Does Not Affect Their Suppressive Capacity.

J Immunol Res 2018 15;2018:4973964. Epub 2018 Apr 15.

Department of Laboratory Medicine-Medical Immunology, Radboud University Medical Center (Radboudumc), Nijmegen, Netherlands.

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October 2018

An Autocrine TNFα-Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability .

Front Immunol 2018 21;9:573. Epub 2018 Mar 21.

Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

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May 2019

TNF-α-induced protein 3 (TNFAIP3)/A20 acts as a master switch in TNF-α blockade-driven IL-17A expression.

J Allergy Clin Immunol 2018 08 14;142(2):517-529. Epub 2017 Dec 14.

Department of Laboratory Medicine, Laboratory of Medical Immunology (LMI), Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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August 2018

Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells.

Sci Rep 2017 02 22;7:43003. Epub 2017 Feb 22.

Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud university medical center, Nijmegen, The Netherlands.

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February 2017

A TNFR2-Agonist Facilitates High Purity Expansion of Human Low Purity Treg Cells.

PLoS One 2016 25;11(5):e0156311. Epub 2016 May 25.

Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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July 2017

Immunotherapy with G-CSF in patients with chronic mucocutaneous candidiasis.

Immunol Lett 2015 Sep 18;167(1):54-6. Epub 2015 May 18.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

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September 2015

Cytokine Release After Treatment With Rituximab in Renal Transplant Recipients.

Transplantation 2015 Sep;99(9):1907-11

1 Department of Laboratory Medicine-Medical Immunology, Radboud University Medical Center, Nijmegen, the Netherlands. 2 Department of Nephrology, Radboud University Medical Center, Nijmegen, the Netherlands.

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September 2015

Balance of Treg versus T-effector cells during systemic treatment with adalimumab and topical treatment with calcipotriol-betamethasone dipropionate ointment.

Exp Dermatol 2015 Jan 18;24(1):65-7. Epub 2014 Nov 18.

Department of Dermatology, Radboud university medical center, Nijmegen, The Netherlands; Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud university medical center, Nijmegen, The Netherlands.

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January 2015

Cellular sources of IL-17 in psoriasis: a paradigm shift?

Exp Dermatol 2014 Nov;23(11):799-803

Department of Dermatology, Radboud university medical center, Nijmegen, The Netherlands; Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud university medical center, Nijmegen, The Netherlands.

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November 2014

In vivo induction of cutaneous inflammation results in the accumulation of extracellular trap-forming neutrophils expressing RORγt and IL-17.

J Invest Dermatol 2014 May 6;134(5):1276-1284. Epub 2013 Dec 6.

Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands; Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands.

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May 2014

Targeting PKC in human T cells using sotrastaurin (AEB071) preserves regulatory T cells and prevents IL-17 production.

J Invest Dermatol 2014 Apr 5;134(4):975-983. Epub 2013 Nov 5.

Laboratory of Medical Immunology, Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address:

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April 2014

Crosstalk between keratinocytes and T cells in a 3D microenvironment: a model to study inflammatory skin diseases.

J Invest Dermatol 2014 Mar 11;134(3):719-727. Epub 2013 Oct 11.

Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Electronic address:

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March 2014

Human secondary lymphoid organs typically contain polyclonally-activated proliferating regulatory T cells.

Blood 2013 Sep 15;122(13):2213-23. Epub 2013 Aug 15.

Department of Laboratory Medicine-Medical Immunology, Radboud University Medical Centre, Nijmegen, The Netherlands;

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September 2013

Co-culture of healthy human keratinocytes and T-cells promotes keratinocyte chemokine production and RORγt-positive IL-17 producing T-cell populations.

J Dermatol Sci 2013 Jan 17;69(1):44-53. Epub 2012 Oct 17.

Department of Laboratory Medicine - Medical Immunology, Radboud University Medical Centre, Nijmegen, The Netherlands.

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January 2013

High-dose vitamin D3 supplementation is a requisite for modulation of skin-homing markers on regulatory T cells in HIV-infected patients.

AIDS Res Hum Retroviruses 2013 Feb 29;29(2):299-306. Epub 2012 Aug 29.

Department of Laboratory Medicine, Laboratory Medical Immunology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.

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February 2013

Seasonal variation in vitamin D₃ levels is paralleled by changes in the peripheral blood human T cell compartment.

PLoS One 2012 3;7(1):e29250. Epub 2012 Jan 3.

Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

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May 2012

Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin.

J Invest Dermatol 2011 Sep 9;131(9):1853-60. Epub 2011 Jun 9.

Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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September 2011

1,25-dihydroxyvitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responses.

J Infect Dis 2011 Jan;203(1):122-30

Department of Laboratory Medicine, Radboud University Nijmegen Medical Center; 3Nijmegen Institute for Infection, Inflammation and Immunity, Nijmegen, The Netherlands.

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January 2011

Immunotherapy with regulatory T cells in transplantation.

Immunotherapy 2009 Sep;1(5):855-71

Department of Blood Transfusion & Transplantation Immunology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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September 2009

Clinical grade Treg: GMP isolation, improvement of purity by CD127 Depletion, Treg expansion, and Treg cryopreservation.

PLoS One 2008 Sep 8;3(9):e3161. Epub 2008 Sep 8.

Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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September 2008

Immunological monitoring of renal transplant recipients to predict acute allograft rejection following the discontinuation of tacrolimus.

PLoS One 2008 Jul 16;3(7):e2711. Epub 2008 Jul 16.

Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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July 2008

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells.

Blood 2008 Sep 10;112(6):2340-52. Epub 2008 Jul 10.

Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, The Netherlands.

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September 2008

Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy.

PLoS One 2008 May 21;3(5):e2233. Epub 2008 May 21.

Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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May 2008

Allogeneic stimulation of naturally occurring CD4+CD25+ T cells induces strong regulatory capacity with increased donor-reactivity.

Transpl Immunol 2007 Jun 31;17(4):237-42. Epub 2007 Jan 31.

Department of Bloodtransfusion and Transplantation Immunology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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June 2007

Antigen-specific regulatory T-cell subsets in transplantation tolerance regulatory T-cell subset quality reduces the need for quantity.

Hum Immunol 2006 Sep 27;67(9):665-75. Epub 2006 Jun 27.

Department of Blood Transfusion and Transplantation Immunology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands.

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September 2006

The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+ CD25- T cells.

Blood 2007 Jan 10;109(1):244-52. Epub 2006 Aug 10.

Radboud University Nijmegen Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

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January 2007

Ex vivo expansion of human CD4+ CD25high regulatory T cells from transplant recipients permits functional analysis of small blood samples.

J Immunol Methods 2006 Jul 28;314(1-2):103-13. Epub 2006 Jun 28.

Department of Blood Transfusion and Transplantation Immunology, Internal Postal Code 469, Radboud University Nijmegen, Medical Centre, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

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July 2006

CTLA-4 engagement and regulatory CD4+CD25+ T cells independently control CD8+-mediated responses under costimulation blockade.

J Immunol 2006 May;176(9):5240-6

Department of Bloodtransfusion and Transplantation Immunology, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands.

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May 2006

Rapamycin, and not cyclosporin A, preserves the highly suppressive CD27+ subset of human CD4+CD25+ regulatory T cells.

Blood 2006 Feb 6;107(3):1018-23. Epub 2005 Oct 6.

Department of Bloodtransfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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February 2006

Cyclosporine preserves the anergic state of human T cells induced by costimulation blockade in vitro.

Transplantation 2005 Aug;80(4):522-9

Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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August 2005

CD27/CFSE-based ex vivo selection of highly suppressive alloantigen-specific human regulatory T cells.

J Immunol 2005 Jun;174(12):7573-83

Department of Blood Transfusion and Transplantation Immunology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

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June 2005

Tolerizing effects of co-stimulation blockade rest on functional dominance of CD4+CD25+ regulatory T cells.

Transplantation 2005 Jan;79(2):147-56

Department of Bloodtransfusion and Transplantation Immunology (ABTI/OV603), University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands.

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January 2005

A novel bispecific antihuman CD40/CD86 fusion protein with t-cell tolerizing potential.

Transplantation 2004 Nov;78(10):1429-38

Department of Blood Transfusion and Transplantation Immunology (ABTI/OV603), University Medical Center Nijmegen, P-Box 9101, 6500 HB Nijmegen, The Netherlands.

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November 2004

IL-15 and cognate antigen successfully expand de novo-induced human antigen-specific regulatory CD4+ T cells that require antigen-specific activation for suppression.

J Immunol 2003 Dec;171(12):6431-41

Department for Blood Transfusion and Transplantation Immunology, University Medical Center, Nijmegen, The Netherlands.

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December 2003