Hans Hilpert

Hans Hilpert

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Hans Hilpert

Hans Hilpert

Publications by authors named "Hans Hilpert"

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Identification of potent and selective cathepsin S inhibitors containing different central cyclic scaffolds.

J Med Chem 2013 Dec 22;56(23):9789-801. Epub 2013 Nov 22.

Discovery Chemistry, ‡Cardiovascular and Metabolic Diseases, §Discovery Technologies, ∥Drug Metabolism and Pharmacokinetics, ⊥Process Research and Synthesis, Pharma Research and Early Development (pRED), F. Hoffmann-La Roche Ltd. , Grenzacherstrasse 124, Basel CH-4070, Switzerland.

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http://dx.doi.org/10.1021/jm401528kDOI Listing
December 2013

Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE-/- mice.

Cardiovasc Res 2011 Jan 6;89(1):244-52. Epub 2010 Aug 6.

Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.1093/cvr/cvq260DOI Listing
January 2011

Structure-based design of indole propionic acids as novel PPARalpha/gamma co-agonists.

Bioorg Med Chem Lett 2006 Aug 5;16(15):4016-20. Epub 2006 Jun 5.

F. Hoffmann-La Roche Ltd, Discovery Research Basel, CH-4070 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bmcl.2006.05.007DOI Listing
August 2006

Efficient synthesis of novel NK1 receptor antagonists: selective 1,4-addition of grignard reagents to 6-chloronicotinic acid derivatives.

J Org Chem 2006 Mar;71(5):2000-8

F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Safety & Technical Sciences, Synthesis & Process Research, Grenzacherstrasse 124, CH-4070 Basel, Switzerland.

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http://dx.doi.org/10.1021/jo0523666DOI Listing
March 2006