Publications by authors named "Hans Gelderblom"

100Publications

Individualized dosing of fluoropyrimidine-based chemotherapy to prevent severe fluoropyrimidine-related toxicity - What are the options?

Clin Pharmacol Ther 2020 Oct 5. Epub 2020 Oct 5.

Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1002/cpt.2069DOI Listing
October 2020

Pexidartinib: first approved systemic therapy for patients with tenosynovial giant cell tumor.

Future Oncol 2020 Oct 23;16(29):2345-2356. Epub 2020 Jul 23.

Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.2217/fon-2020-0542DOI Listing
October 2020

Current concepts in the treatment of giant cell tumour of bone.

Curr Opin Oncol 2020 Jul;32(4):332-338

Department of Medical Oncology, Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1097/CCO.0000000000000645DOI Listing
July 2020

Exposure-response analysis of endoxifen serum concentrations in early-breast cancer.

Cancer Chemother Pharmacol 2020 Jun 29;85(6):1141-1152. Epub 2020 May 29.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Albinusdreef 2, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00280-020-04089-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305085PMC
June 2020

Current concepts in the treatment of giant cell tumour of bone.

Curr Opin Oncol 2020 May 22. Epub 2020 May 22.

Department of Medical Oncology, Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1097/CCO.0000000000000645DOI Listing
May 2020

The significance of stromal collagen organization in cancer tissue: An in-depth discussion of literature.

Crit Rev Oncol Hematol 2020 Jul 4;151:102907. Epub 2020 May 4.

Department of Surgery, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.critrevonc.2020.102907DOI Listing
July 2020

Denosumab salvage therapy in a patient with a locally advanced and refractory sellar giant cell tumour of bone.

Lancet Diabetes Endocrinol 2020 04 11;8(4):348. Epub 2020 Feb 11.

Division of Endocrinology, Department of Medicine, Leiden University Medical Center, Leiden, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(20)30041-3DOI Listing
April 2020

Intrigue: Phase III study of ripretinib versus sunitinib in advanced gastrointestinal stromal tumor after imatinib.

Future Oncol 2020 Jan 22;16(1):4251-4264. Epub 2019 Nov 22.

Portland VA Health Care System & OHSU Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.2217/fon-2019-0633DOI Listing
January 2020

Home treatment of patients with cancer-associated venous thromboembolism - An evaluation of daily practice.

Thromb Res 2019 Dec 4;184:122-128. Epub 2019 Nov 4.

Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1016/j.thromres.2019.10.031DOI Listing
December 2019

Denosumab in patients with giant-cell tumour of bone: a multicentre, open-label, phase 2 study.

Lancet Oncol 2019 12 6;20(12):1719-1729. Epub 2019 Nov 6.

Chemotherapy Unit, IRCCS Istituto Ortopedico Rizzoli/Department of Experimental, Diagnostic and Specialty Medicine, Università di Bologna, Bologna, Italy. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(19)30663-1DOI Listing
December 2019

Which Factors Are Associated with Local Control and Survival of Patients with Localized Pelvic Ewing's Sarcoma? A Retrospective Analysis of Data from the Euro-EWING99 Trial.

Clin Orthop Relat Res 2020 02;478(2):290-302

D. Andreou, G. Gosheger, Department of General Orthopedics and Tumor Orthopedics, University Hospital Münster, Westfälische Wilhelms-University, Münster, Germany A. Ranft, U. Dirksen, Pediatrics III, Hematology/Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany B. Timmermann, Clinic for Particle Therapy, West German Proton Therapy Center, University Hospital Essen, Essen, Germany R. Ladenstein, Department of Studies and Statistics on Integrated Research and Projects (S2IRP), Children's Cancer Research Institute, Vienna, Austria W. Hartmann, E. Wardelmann, Gerhard-Domagk-Institute for Pathology, University Hospital Münster, Westfälische Wilhelms-University, Münster, Germany S. Bauer, Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Hospital Essen, University of Duisburg-Essen, Essen, Germany D. Baumhoer, Bone Tumor Reference Center, Institute of Pathology, University Hospital Basel, University of Basel, Basel, Switzerland H. van den Berg, Department of Pediatric Oncology, Emma Children's Hospital/Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands P. D. S. Dijkstra, Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, the Netherlands H. R. Dürr, Orthopedic Oncology, Department of Orthopedics, Ludwig-Maximilians University Munich, Campus Grosshadern, Munich, Germany H. Gelderblom, Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands J. Hardes, A Streitbürger, Department of Tumor Orthopedics and Sarcoma Surgery, University Hospital Essen, Essen, Germany L. Hjorth, Department of Paediatrics, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden J. Kreyer, Department of Orthopedic and Trauma Surgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany J. Kruseova, Department of Pediatric Hematology and Oncology, 2nd Medical School, Charles University Prague, Prague, Czech Republic A. Leithner, Department of Orthopedic Surgery, Medical University of Graz, Graz, Austria S. Scobioala, Department of Radiation Oncology, University Hospital Münster, Westfälische Wilhelms-University, Münster, Germany P-U. Tunn, Department of Orthopedic Oncology, HELIOS Klinikum Berlin-Buch, Berlin, Germany R. Windhager, Department of Orthopedics, Medical University of Vienna, Vienna, Austria H. Jürgens, Department of Paediatric Hematology and Oncology, University Hospital Münster, Westfälische Wilhelms-University, Münster, Germany.

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http://dx.doi.org/10.1097/CORR.0000000000000962DOI Listing
February 2020

Reply to C.L. Braal et al, H. Brauch et al, and M.P. Goetz et al.

J Clin Oncol 2019 08 18;37(22):1984-1985. Epub 2019 Jun 18.

Henk-Jan Guchelaar, PharmD, PhD and Anabel Sanchez-Spitman, PharmD, Leiden University Medical Center, Leiden, the Netherlands; Vincent Dezentjé, MD, PhD, Netherlands Cancer Institute/Antoni van Leeuwenhoek, Amsterdam, the Netherlands; Stefan Böhringer, PhD, MD and Jesse Swen, PharmD, PhD, Leiden University Medical Center, Leiden, the Netherlands; Patrick Neven, MD, PhD, University Hospitals Leuven, Leuven, Belgium; and Hans Gelderblom, MD, PhD, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1200/JCO.19.00932DOI Listing
August 2019

Stromal organization as predictive biomarker for the treatment of colon cancer with adjuvant bevacizumab; a post-hoc analysis of the AVANT trial.

Cell Oncol (Dordr) 2019 Oct 17;42(5):717-725. Epub 2019 May 17.

Department of Surgery, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, Netherlands.

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http://dx.doi.org/10.1007/s13402-019-00449-9DOI Listing
October 2019

Adjuvant Zoledronic Acid in High-Risk Giant Cell Tumor of Bone: A Multicenter Randomized Phase II Trial.

Oncologist 2019 07 30;24(7):889-e421. Epub 2019 Apr 30.

Department of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1634/theoncologist.2019-0280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656477PMC
July 2019

Genetic polymorphisms in ABCG2 and CYP1A2 are associated with imatinib dose reduction in patients treated for gastrointestinal stromal tumors.

Pharmacogenomics J 2019 10 4;19(5):473-479. Epub 2019 Feb 4.

Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41397-019-0079-zDOI Listing
October 2019

A cost analysis of upfront DPYD genotype-guided dose individualisation in fluoropyrimidine-based anticancer therapy.

Eur J Cancer 2019 01 11;107:60-67. Epub 2018 Dec 11.

Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183147
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http://dx.doi.org/10.1016/j.ejca.2018.11.010DOI Listing
January 2019

Diagnostic and Therapeutic Strategies for Fluoropyrimidine Treatment of Patients Carrying Multiple DPYD Variants.

Genes (Basel) 2018 Nov 28;9(12). Epub 2018 Nov 28.

Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.3390/genes9120585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316498PMC
November 2018

Influenza vaccination in patients with lung cancer receiving anti-programmed death receptor 1 immunotherapy does not induce immune-related adverse events.

Eur J Cancer 2018 11 24;104:182-187. Epub 2018 Oct 24.

Department of Thoracic Oncology, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09598049183138
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http://dx.doi.org/10.1016/j.ejca.2018.09.012DOI Listing
November 2018

DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis.

Lancet Oncol 2018 11 19;19(11):1459-1467. Epub 2018 Oct 19.

Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands; Department of Clinical Pharmacology, Division of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045183068
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http://dx.doi.org/10.1016/S1470-2045(18)30686-7DOI Listing
November 2018

High-Dose Chemotherapy and Blood Autologous Stem-Cell Rescue Compared With Standard Chemotherapy in Localized High-Risk Ewing Sarcoma: Results of Euro-E.W.I.N.G.99 and Ewing-2008.

J Clin Oncol 2018 Sep 6:JCO2018782516. Epub 2018 Sep 6.

Jeremy Whelan, University College Hospital; Ian Judson, Institute of Cancer Research, London; Bernadette Brennan, Royal Manchester Children's Hospital, Manchester; Bruce Morland, Birmingham Children's Hospital; Keith Wheatley, University of Birmingham, Birmingham; Ian Lewis, Leeds Community Healthcare National Health Service Trust, Leeds; Alan Craft, Newcastle University, Newcastle upon Tyne, United Kingdom; Marie-Cecile Le Deley and Cyril Lervat, Centre Oscar Lambret, Lille; Gwénaël Le Teuff, Nathalie Gaspar, and Odile Oberlin, Institut Gustave Roussy, Villejuif; Jean-Yves Blay, Centre Léon Bérard; Perrine Marec-Berard, Institute of Pediatric Onco-Haematology, Lyon; Marie-Pierre Castex, Centre Hospitalier Universitaire de Toulouse, Toulouse; Jean-Claude Gentet, Centre Hospitalier Universitaire La Timone, Marseille; Marta Jimenez, Unicancer; Valerie Laurence and Jean Michon, Institut Curie, Paris; France; Uta Dirksen, Sebastian Bauer, Andreas Ranft, University Hospital Essen, Essen; Susanne Amler, Institut für Biometrie und Klinische Forschung; Wolfgang Hartmann and Heribert Juergens, Universitätsklinikum, Münster, Münster; Stefan Bielack, Klinikum Stuttgart, Stuttgart; Stefan Burdach, Comprehensive Cancer Center, München; Dagmar Dilloo, University-Clinic Bonn, Bonn; Angelika Eggert, Charité University; Peter Reichardt, HELIOS Klinikum Berlin-Buch, Berlin; Wolf-Achim Hassenpflug, University Medical Center Hamburg-Eppendorf, Hamburg; Thomas Klingebiel, Childrens University Hospital, Frankfurt; Udo Kontny, University Medical Center Aachen, Aachen; Michael Paulussen, Children's and Adolescents' Hospital, Datteln; Germany; Douglas S. Hawkins, Seattle Children's Hospital, Seattle, WA; Hans Gelderblom, Leiden University Medical Center, Leiden; Hendrik van den Berg, University of Amsterdam, Amsterdam, the Netherlands; Lars Hjorth, Skane University Hospital, Lund, Sweden; Jarmila Kruseova, Faculty Hospital Motol Prague, Prague, Czech Republic; Ruth Ladenstein, St Anna Children's Hospital and Children's Cancer Research Institute, Vienna, Austria; Sandrine Marreaud, European Organisation for Research and Treatment of Cancer, Brussels, Belgium.

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http://ascopubs.org/doi/10.1200/JCO.2018.78.2516
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http://dx.doi.org/10.1200/JCO.2018.78.2516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209090PMC
September 2018

Predictive potential of tumour-stroma ratio on benefit from adjuvant bevacizumab in high-risk stage II and stage III colon cancer.

Br J Cancer 2018 07 14;119(2):164-169. Epub 2018 May 14.

Department of Surgery, Leiden University Medical Centre, Albinusdreef 2, 2300 RC, Leiden, Netherlands.

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http://dx.doi.org/10.1038/s41416-018-0083-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6048031PMC
July 2018

Rapid Viral Diagnosis of Orthopoxviruses by Electron Microscopy: Optional or a Must?

Viruses 2018 03 22;10(4). Epub 2018 Mar 22.

(ret) University of Newcastle upon Tyne, Burnfoot, Stocksfield, Northumberland, NE43 7TN, UK.

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http://dx.doi.org/10.3390/v10040142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923436PMC
March 2018

Telatinib Is an Effective Targeted Therapy for Pseudomyogenic Hemangioendothelioma.

Clin Cancer Res 2018 06 6;24(11):2678-2687. Epub 2018 Mar 6.

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3512DOI Listing
June 2018

The tumour-stroma ratio in colon cancer: the biological role and its prognostic impact.

Histopathology 2018 Aug 24;73(2):197-206. Epub 2018 Mar 24.

Department of Surgery, Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1111/his.13489DOI Listing
August 2018

A remarkable response to pazopanib, despite recurrent liver toxicity, in a patient with a high grade endometrial stromal sarcoma, a case report.

BMC Cancer 2018 01 22;18(1):92. Epub 2018 Jan 22.

Department of Medical Oncology, Leiden University Medical Centre, Albinusdreef 2, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s12885-018-3999-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778698PMC
January 2018

Are pathological high-risk features in locally advanced rectal cancer a useful selection tool for adjuvant chemotherapy?

Eur J Cancer 2018 01 7;89:1-8. Epub 2017 Dec 7.

Department of Pathology, Radboud University Medical Centre, Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.11.006DOI Listing
January 2018

Perioperative Management of Extremity Soft Tissue Sarcomas.

J Clin Oncol 2018 01 8;36(2):118-124. Epub 2017 Dec 8.

Rick L. Haas, The Netherlands Cancer Institute, Amsterdam; Rick L. Haas, Michiel A.J. van de Sande, and Hans Gelderblom, Leiden University Medical Centre, Leiden, the Netherlands; Alessandro Gronchi, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy; Elizabeth H. Baldini, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA; Christina Messiou, The Royal Marsden Hospital and The Institute of Cancer Research, London, United Kingdom; Eva Wardelmann, University Hospital Münster, Münster, Germany; Axel Le Cesne, Institut Gustave Roussy, Villejuif, France.

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http://ascopubs.org/doi/10.1200/JCO.2017.74.7527
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http://dx.doi.org/10.1200/JCO.2017.74.7527DOI Listing
January 2018

Elderly patients with gastrointestinal stromal tumour (GIST) receive less treatment irrespective of performance score or comorbidity - A retrospective multicentre study in a large cohort of GIST patients.

Eur J Cancer 2017 11 23;86:318-325. Epub 2017 Oct 23.

Netherlands Cancer Institute / Antoni van Leeuwenhoek Hospital, Department of Medical Oncology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.09.017DOI Listing
November 2017

Early Evaluation of Response Using F-FDG PET Influences Management in Gastrointestinal Stromal Tumor Patients Treated with Neoadjuvant Imatinib.

J Nucl Med 2018 02 28;59(2):194-196. Epub 2017 Sep 28.

Department of Medical Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

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http://dx.doi.org/10.2967/jnumed.117.196642DOI Listing
February 2018

The effect of rs5758550 on CYP2D6*2 phenotype and formation of endoxifen in breast cancer patients using tamoxifen.

Pharmacogenomics 2017 Aug 26;18(12):1125-1132. Epub 2017 Jul 26.

Leiden Network for Personalised Therapeutics, Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.2217/pgs-2017-0080DOI Listing
August 2017

Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases.

Case Rep Orthop 2017 28;2017:7402570. Epub 2017 Jun 28.

Orthopaedic Surgery, Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.1155/2017/7402570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5506462PMC
June 2017

Does a glass of Coke boost the exposure to imatinib in gastrointestinal stromal tumour patients after gastrectomy?

Br J Clin Pharmacol 2017 10 4;83(10):2312-2314. Epub 2017 Jul 4.

Department of Pharmacy and Radboud Institute of Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1111/bcp.13333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595978PMC
October 2017

Evaluation of Quality of Life at Progression in Patients with Soft Tissue Sarcoma.

Sarcoma 2017 23;2017:2372135. Epub 2017 Apr 23.

Department of Medical Oncology, Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.1155/2017/2372135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420413PMC
April 2017