Hans E Krokan

Hans E Krokan

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Hans E Krokan

Hans E Krokan

Publications by authors named "Hans E Krokan"

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Uracil-DNA glycosylase UNG1 isoform variant supports class switch recombination and repairs nuclear genomic uracil.

Nucleic Acids Res 2019 May;47(9):4569-4585

Department of Clinical and Molecular Medicine, NTNU-Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.

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http://dx.doi.org/10.1093/nar/gkz145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511853PMC
May 2019

Corrigendum: Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.

Nat Genet 2017 03;49(4):651

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http://dx.doi.org/10.1038/ng0417-651aDOI Listing
March 2017

DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.

Biochem Biophys Rep 2016 Jul 22;6:9-15. Epub 2016 Feb 22.

Department of Microbiology, Division of diagnostics and intervention, Institute of Clinical Medicine, Oslo University Hospital, Rikshospitalet, NO-0027 Oslo, Norway.

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https://linkinghub.elsevier.com/retrieve/pii/S24055808163001
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http://dx.doi.org/10.1016/j.bbrep.2016.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600429PMC
July 2016

Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins.

Mol Biosyst 2016 Mar;12(3):796-805

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Norway. and PROMEC Core Facility for Proteomics and Metabolomics, Norwegian University of Science and Technology, Norway.

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http://dx.doi.org/10.1039/c5mb00744eDOI Listing
March 2016

Uracil-DNA Glycosylase UNG Promotes Tet-mediated DNA Demethylation.

J Biol Chem 2016 Jan 30;291(2):731-8. Epub 2015 Nov 30.

From the The State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai 200031, China,

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http://dx.doi.org/10.1074/jbc.M115.693861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705393PMC
January 2016

Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia.

Carcinogenesis 2015 Nov 10;36(11):1314-26. Epub 2015 Sep 10.

Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada,

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http://carcin.oxfordjournals.org/content/early/2015/09/11/ca
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635669PMC
November 2015

Cell cycle regulation of human DNA repair and chromatin remodeling genes.

DNA Repair (Amst) 2015 Jun 28;30:53-67. Epub 2015 Mar 28.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2015.03.007DOI Listing
June 2015

AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.

DNA Repair (Amst) 2015 Jan 24;25:60-71. Epub 2014 Nov 24.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.11.006DOI Listing
January 2015

Red versus blue light illumination in hexyl 5-aminolevulinate photodynamic therapy: the influence of light color and irradiance on the treatment outcome in vitro.

J Biomed Opt 2014 Aug;19(8):088002

University of Salzburg, Division of Physics and Biophysics, Department of Materials Science and Physics, Laboratory of Photodynamic Inactivation of Microorganisms, Hellbrunnerstraße 34, Salzburg 5020, Austria.

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http://biomedicaloptics.spiedigitallibrary.org/article.aspx?
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http://dx.doi.org/10.1117/1.JBO.19.8.088002DOI Listing
August 2014

Error-free versus mutagenic processing of genomic uracil--relevance to cancer.

DNA Repair (Amst) 2014 Jul 18;19:38-47. Epub 2014 Apr 18.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2014.03.028DOI Listing
July 2014

Expression and recruitment of uracil-DNA glycosylase are regulated by E2A during antibody diversification.

Mol Immunol 2014 Jul 18;60(1):23-31. Epub 2014 Apr 18.

Department of Molecular Biology, Umeå University, 90187, Umeå, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.molimm.2014.03.011DOI Listing
July 2014

Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.

Nat Genet 2014 Jul 1;46(7):736-41. Epub 2014 Jun 1.

1] Center for Genomic Medicine, Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA. [2] [3].

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http://dx.doi.org/10.1038/ng.3002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074058PMC
July 2014

Activation-induced cytidine deaminase (AID) is localized to subnuclear domains enriched in splicing factors.

Exp Cell Res 2014 Mar 13;322(1):178-92. Epub 2014 Jan 13.

Central Norway Health Authorities and Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, N-7491, Norwegian University of Science and Technology, Trondheim, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.yexcr.2014.01.004DOI Listing
March 2014

Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56,307 individuals from the HUNT study in Norway.

Eur J Hum Genet 2013 Nov 27;21(11):1293-9. Epub 2013 Feb 27.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1038/ejhg.2013.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3798835PMC
November 2013

A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported.

DNA Repair (Amst) 2013 Sep 3;12(9):699-706. Epub 2013 Jun 3.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2013.05.002DOI Listing
September 2013

Base excision repair.

Cold Spring Harb Perspect Biol 2013 Apr 1;5(4):a012583. Epub 2013 Apr 1.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a012583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683898PMC
April 2013

Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response.

DNA Repair (Amst) 2013 Mar 29;12(3):188-95. Epub 2012 Dec 29.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2012.11.010DOI Listing
March 2013

Transcription profiling during the cell cycle shows that a subset of Polycomb-targeted genes is upregulated during DNA replication.

Nucleic Acids Res 2013 Mar 15;41(5):2846-56. Epub 2013 Jan 15.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.

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http://dx.doi.org/10.1093/nar/gks1336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597645PMC
March 2013

A combined nuclear and nucleolar localization motif in activation-induced cytidine deaminase (AID) controls immunoglobulin class switching.

J Mol Biol 2013 Jan 23;425(2):424-43. Epub 2012 Nov 23.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7491 Trondheim, Norway.

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http://dx.doi.org/10.1016/j.jmb.2012.11.026DOI Listing
January 2013

Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase.

DNA Repair (Amst) 2013 Jan 8;12(1):80-6. Epub 2012 Dec 8.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2012.10.007DOI Listing
January 2013

Base excision repair efficiency and mechanism in nuclear extracts are influenced by the ratio between volume of nuclear extraction buffer and nuclei-implications for comparative studies.

Mutat Res 2012 Aug 28;736(1-2):33-8. Epub 2011 Jun 28.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1016/j.mrfmmm.2011.06.006DOI Listing
August 2012

The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage.

Nucleic Acids Res 2012 Aug 24;40(14):6620-31. Epub 2012 Apr 24.

Department of Molecular Biosciences, University of Oslo, P.O. Box 1041 Blindern, N-0316 Oslo, Norway.

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http://dx.doi.org/10.1093/nar/gks327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413135PMC
August 2012

Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil.

DNA Repair (Amst) 2012 Jun 6;11(6):587-93. Epub 2012 Apr 6.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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https://linkinghub.elsevier.com/retrieve/pii/S15687864120007
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http://dx.doi.org/10.1016/j.dnarep.2012.03.003DOI Listing
June 2012

The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.

DNA Repair (Amst) 2012 Jun 20;11(6):559-69. Epub 2012 Apr 20.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, the FUGE Proteomics Node, Norwegian University of Science and Technology, N-7006 Trondheim, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2012.03.006DOI Listing
June 2012

Autobiographical sketch: A life in DNA repair—and beyond.

Authors:
Hans E Krokan

DNA Repair (Amst) 2012 Mar;11(3):224-35

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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March 2012

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.

Nucleic Acids Res 2011 Oct 10;39(19):8430-44. Epub 2011 Jul 10.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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http://dx.doi.org/10.1093/nar/gkr563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3201877PMC
October 2011

XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage.

Environ Mol Mutagen 2011 Oct 22;52(8):623-35. Epub 2011 Jul 22.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim.

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http://dx.doi.org/10.1002/em.20663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229989PMC
October 2011

Roles of Trm9- and ALKBH8-like proteins in the formation of modified wobble uridines in Arabidopsis tRNA.

Nucleic Acids Res 2011 Sep 7;39(17):7688-701. Epub 2011 Jun 7.

Department of Molecular Biosciences, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1093/nar/gkr406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3177185PMC
September 2011

Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways.

Photochem Photobiol Sci 2011 Jul 30;10(7):1137-45. Epub 2011 Mar 30.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.

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http://dx.doi.org/10.1039/c0pp00369gDOI Listing
July 2011

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.

J Biol Chem 2011 May 23;286(19):16669-80. Epub 2011 Mar 23.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N-7491 Trondheim, Norway.

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http://dx.doi.org/10.1074/jbc.M111.230052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089509PMC
May 2011

A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA.

Nucleic Acids Res 2011 Apr 7;39(8):e55. Epub 2011 Feb 7.

Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Oslo University Hospital, Rikshospitalet, Norway.

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http://dx.doi.org/10.1093/nar/gkr051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3082876PMC
April 2011

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA.

Nat Commun 2011 Feb 1;2:172. Epub 2011 Feb 1.

Department of Molecular Biosciences, University of Oslo, PO Box 1041 Blindern, Oslo 0316, Norway.

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http://dx.doi.org/10.1038/ncomms1173DOI Listing
February 2011

Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3.

Nucleic Acids Res 2010 Oct 4;38(19):6447-55. Epub 2010 Jun 4.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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http://dx.doi.org/10.1093/nar/gkq518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965238PMC
October 2010

Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes.

DNA Repair (Amst) 2010 Jul 13;9(7):785-95. Epub 2010 May 13.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2010.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901844PMC
July 2010

Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.

Mol Cell Biol 2010 Apr 1;30(7):1814-27. Epub 2010 Feb 1.

Center for Molecular Biology and Neuroscience and Institute of Medical Microbiology, Oslo University Hospital, and Department of Molecular Biosciences, University of Oslo, Oslo, Norway.

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http://dx.doi.org/10.1128/MCB.01602-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838068PMC
April 2010

Identification of a novel, widespread, and functionally important PCNA-binding motif.

J Cell Biol 2009 Sep;186(5):645-54

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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http://dx.doi.org/10.1083/jcb.200903138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742182PMC
September 2009

Overexpression of transcription factor AP-2 stimulates the PA promoter of the human uracil-DNA glycosylase (UNG) gene through a mechanism involving derepression.

DNA Repair (Amst) 2009 Jul 2;8(7):822-33. Epub 2009 May 2.

Department of Cancer Research and Molecular Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2009.03.008DOI Listing
July 2009

Uracil in DNA and its processing by different DNA glycosylases.

Philos Trans R Soc Lond B Biol Sci 2009 Mar;364(1517):563-8

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway.

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http://dx.doi.org/10.1098/rstb.2008.0186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2660913PMC
March 2009

Omega-3 fatty acids suppress growth of SW620 human colon cancer xenografts in nude mice.

Anticancer Res 2008 Nov-Dec;28(6A):3717-23

Department of Circulation and Medical Imaging, NTNU, N-7489 Trondheim, Norway.

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March 2009

Monitoring of hexyl 5-aminolevulinate-induced photodynamic therapy in rat bladder cancer by optical spectroscopy.

J Biomed Opt 2008 Jul-Aug;13(4):044031

Norwegian University of Science and Technology, Department of Electronics and Telecommunications, N-7034 Trondheim, Norway.

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http://dx.doi.org/10.1117/1.2967909DOI Listing
January 2009

The rate of base excision repair of uracil is controlled by the initiating glycosylase.

DNA Repair (Amst) 2008 Nov 4;7(11):1869-81. Epub 2008 Sep 4.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Erling Skjalgssons gate 1, Trondheim, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2008.07.012DOI Listing
November 2008

AlkB demethylases flip out in different ways.

DNA Repair (Amst) 2008 Nov 6;7(11):1916-23. Epub 2008 Sep 6.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Erling Skjalgssons Gate 1, Trondheim, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2008.07.015DOI Listing
November 2008

Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging.

Mech Ageing Dev 2008 Jul-Aug;129(7-8):353-65. Epub 2008 Feb 12.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1016/j.mad.2008.01.007DOI Listing
September 2008

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis.

DNA Repair (Amst) 2008 Apr 4;7(4):605-16. Epub 2008 Mar 4.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N-7006 Trondheim, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2008.01.002DOI Listing
April 2008

DNA-uracil and human pathology.

Mol Aspects Med 2007 Jun-Aug;28(3-4):276-306. Epub 2007 May 18.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7006 Trondheim, Norway.

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http://dx.doi.org/10.1016/j.mam.2007.04.006DOI Listing
February 2008

Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.

EMBO J 2008 Jan 13;27(1):51-61. Epub 2007 Dec 13.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1038/sj.emboj.7601958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2147998PMC
January 2008

RNA base damage and repair.

Curr Pharm Biotechnol 2007 Dec;8(6):326-31

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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December 2007

Uracil in DNA--general mutagen, but normal intermediate in acquired immunity.

DNA Repair (Amst) 2007 Apr 20;6(4):505-16. Epub 2006 Nov 20.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N-7006 Trondheim, Norway.

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http://linkinghub.elsevier.com/retrieve/pii/S156878640600323
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http://dx.doi.org/10.1016/j.dnarep.2006.10.014DOI Listing
April 2007

Genomic uracil and human disease.

Exp Cell Res 2006 Aug 21;312(14):2666-72. Epub 2006 Jun 21.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim.

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http://dx.doi.org/10.1016/j.yexcr.2006.06.015DOI Listing
August 2006

Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice.

DNA Repair (Amst) 2005 Dec 19;4(12):1432-41. Epub 2005 Sep 19.

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim.

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http://dx.doi.org/10.1016/j.dnarep.2005.08.004DOI Listing
December 2005

Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNA.

Proc Natl Acad Sci U S A 2005 Dec 28;102(49):17711-6. Epub 2005 Nov 28.

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0504643102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1308887PMC
December 2005

Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines.

Med Sci Monit 2005 Oct 26;11(10):BR351-6. Epub 2005 Sep 26.

Department of Circulation and Imaging, Norwegian University of Science and Technology, Trondheim, Norway.

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October 2005

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.

J Exp Med 2005 Jun;201(12):2011-21

Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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http://dx.doi.org/10.1084/jem.20050042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2212036PMC
June 2005

Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization.

Photochem Photobiol Sci 2005 Apr 8;4(4):383-9. Epub 2005 Mar 8.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Olav Kyrres gt. 3, N-7489, Trondheim, Norway.

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http://dx.doi.org/10.1039/b502000jDOI Listing
April 2005

Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts.

Carcinogenesis 2005 Mar 25;26(3):547-55. Epub 2004 Nov 25.

Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1093/carcin/bgh347DOI Listing
March 2005

Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner.

J Mol Diagn 2005 Feb;7(1):36-9

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867510PMC
February 2005

Alkylation damage in DNA and RNA--repair mechanisms and medical significance.

DNA Repair (Amst) 2004 Nov;3(11):1389-407

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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http://dx.doi.org/10.1016/j.dnarep.2004.05.004DOI Listing
November 2004

Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair.

J Mol Biol 2004 Sep;342(3):787-99

Instituto de Parasitologia y Biomedicina "Lopez Neyra", Consejo Superior de Investigaciones Cientificas, C/Ventanilla 11, 18001 Granada, Spain.

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http://dx.doi.org/10.1016/j.jmb.2004.07.043DOI Listing
September 2004

Novel aspects of macromolecular repair and relationship to human disease.

J Mol Med (Berl) 2004 May 24;82(5):280-97. Epub 2004 Feb 24.

Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway.

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http://dx.doi.org/10.1007/s00109-004-0528-1DOI Listing
May 2004

Genetic analysis of the murine mu opioid receptor: increased complexity of Oprm gene splicing.

J Mol Med (Berl) 2004 Apr 9;82(4):250-5. Epub 2004 Jan 9.

Institute of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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http://dx.doi.org/10.1007/s00109-003-0514-zDOI Listing
April 2004

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.

Nat Immunol 2003 Oct 7;4(10):1023-8. Epub 2003 Sep 7.

Institut National de la Santé et de la Recherche Médicale Unité 429, Hôpital Necker-Enfants Malades, 75015 Paris, France.

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http://dx.doi.org/10.1038/ni974DOI Listing
October 2003

The interacting pathways for prevention and repair of oxidative DNA damage.

Mutat Res 2003 Oct;531(1-2):231-51

Institute of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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http://dx.doi.org/10.1016/j.mrfmmm.2003.06.002DOI Listing
October 2003

Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas.

Oncogene 2003 Aug;22(35):5381-6

Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire EN6 3LD, UK.

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http://dx.doi.org/10.1038/sj.onc.1206860DOI Listing
August 2003

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.

Nature 2003 Feb;421(6925):859-63

Institute of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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http://dx.doi.org/10.1038/nature01363DOI Listing
February 2003

Uracil in DNA--occurrence, consequences and repair.

Oncogene 2002 Dec;21(58):8935-48

Institute of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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http://dx.doi.org/10.1038/sj.onc.1205996DOI Listing
December 2002

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup.

J Biol Chem 2002 Oct 2;277(42):39926-36. Epub 2002 Aug 2.

Institute of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, N-7489 Trondheim, Norway.

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http://dx.doi.org/10.1074/jbc.M207107200DOI Listing
October 2002

Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy.

Eur J Clin Pharmacol 2002 Aug 13;58(5):353-6. Epub 2002 Jul 13.

Institute of Cancer Research and Molecular Biology, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway.

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http://dx.doi.org/10.1007/s00228-002-0490-1DOI Listing
August 2002