Hans Clevers

Hans Clevers

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Hans Clevers

Publications by authors named "Hans Clevers"

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MET Signaling Overcomes Epidermal Growth Factor Receptor Inhibition in Normal and Colorectal Cancer Stem Cells Causing Drug Resistance.

Gastroenterology 2019 10 27;157(4):1153-1155.e1. Epub 2019 Jun 27.

Amsterdam University Medical Centers, University of Amsterdam, Department of Pathology, Cancer Center Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2019.06.029DOI Listing
October 2019

A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues.

Adv Healthc Mater 2019 Oct 12;8(19):e1900979. Epub 2019 Aug 12.

Department of Oral and Maxillofacial Surgery and Special Dental Care, University Medical Center Utrecht, Utrecht University, 3508 GA, Utrecht, the Netherlands.

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http://dx.doi.org/10.1002/adhm.201900979DOI Listing
October 2019

Modeling breast cancer using CRISPR/Cas9-mediated engineering of human breast organoids.

J Natl Cancer Inst 2019 Oct 7. Epub 2019 Oct 7.

ACRF Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.

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http://dx.doi.org/10.1093/jnci/djz196DOI Listing
October 2019

Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells.

Cell Stem Cell 2019 Sep 15;25(3):342-356.e7. Epub 2019 Aug 15.

Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK; Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK; Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC), Dr. Bohr-Gasse 3, 1030 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739486PMC
September 2019

Human Organoids: Tools for Understanding Biology and Treating Diseases.

Annu Rev Pathol 2019 Sep 24. Epub 2019 Sep 24.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, 3584 CT Utrecht, The Netherlands; email:

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http://dx.doi.org/10.1146/annurev-pathmechdis-012419-032611DOI Listing
September 2019

Xenograft and organoid model systems in cancer research.

EMBO J 2019 Aug 8;38(15):e101654. Epub 2019 Jul 8.

Oncode Institute, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.

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http://dx.doi.org/10.15252/embj.2019101654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670015PMC
August 2019

Defining Adult Stem Cell Function at Its Simplest: The Ability to Replace Lost Cells through Mitosis.

Cell Stem Cell 2019 Aug;25(2):174-183

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584 CT Utrecht, the Netherlands; Oncode Institute, 3584 CT Utrecht, the Netherlands; The Princess Maxima Center for Pediatric Oncology, 3584 CS Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.07.002DOI Listing
August 2019

T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage after Allogeneic Transplantation.

Immunity 2019 Jul 2;51(1):90-103.e3. Epub 2019 Jul 2.

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.06.003DOI Listing
July 2019

Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids.

Cell Stem Cell 2019 Jun 23;24(6):927-943.e6. Epub 2019 May 23.

Oncode Institute, Utrecht, the Netherlands; Hubrecht Institute, KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, the Netherlands; The Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands; University Medical Center Utrecht, Cancer Genomics Netherlands, 3584CX Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.04.017DOI Listing
June 2019

Cancer modeling meets human organoid technology.

Science 2019 06;364(6444):952-955

Oncode Institute and Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, 3584 Utrecht, Netherlands.

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http://dx.doi.org/10.1126/science.aaw6985DOI Listing
June 2019

Tissue-Engineering the Intestine: The Trials before the Trials.

Cell Stem Cell 2019 Jun;24(6):855-859

Specialist Neonatal and Paediatric Surgery Unit, Great Ormond Street Hospital, London, UK; Stem Cells & Regenerative Medicine Section, NIHR Biomedical Research Center, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.04.018DOI Listing
June 2019

Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer.

Cell 2019 Jun;178(1):135-151.e19

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Genetics and Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193063
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http://dx.doi.org/10.1016/j.cell.2019.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716369PMC
June 2019

Is Required for Wnt Signaling in Gastric Tumors with and Without Mutations.

Cancer Res 2019 03 8;79(5):970-981. Epub 2019 Jan 8.

University of Melbourne & Victorian Infectious Diseases Reference Laboratory, Doherty Institute of Infection and Immunity, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2095DOI Listing
March 2019

Modeling Human Digestive Diseases With CRISPR-Cas9-Modified Organoids.

Gastroenterology 2019 02 23;156(3):562-576. Epub 2018 Nov 23.

Department of Gastroenterology, Keio University School of Medicine, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.11.048DOI Listing
February 2019

Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping.

Cell 2019 Feb 31;176(5):1158-1173.e16. Epub 2019 Jan 31.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Centre (UMC) Utrecht, 3584 CT Utrecht, the Netherlands; Oncode Institute, Hubrecht Institute, 3584 CT Utrecht, the Netherlands; Princess Máxima Centre for Paediatric Oncology, 3584 CT Utrecht, the Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183164
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http://dx.doi.org/10.1016/j.cell.2018.12.029DOI Listing
February 2019

An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance.

Oncogenesis 2019 Feb 19;8(3):13. Epub 2019 Feb 19.

Cancer Genetics and Stem Cell Group, Cancer Biology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, Nottingham, NG7 2UH, UK.

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http://dx.doi.org/10.1038/s41389-019-0125-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381143PMC
February 2019

Mouse and human urothelial cancer organoids: A tool for bladder cancer research.

Proc Natl Acad Sci U S A 2019 Feb 20. Epub 2019 Feb 20.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1803595116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410883PMC
February 2019

Tales from the crypt: new insights into intestinal stem cells.

Nat Rev Gastroenterol Hepatol 2019 01;16(1):19-34

Hubrecht Institute and Oncode Institute, Royal Academy of Arts and Science (KNAW) and University Medical Centre Utrecht, Utrecht, Netherlands.

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http://dx.doi.org/10.1038/s41575-018-0081-yDOI Listing
January 2019

A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.

Cell Stem Cell 2018 12 18;23(6):882-897.e11. Epub 2018 Oct 18.

Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong; The Jockey Club Centre for Clinical Innovation and Discovery, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183048
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http://dx.doi.org/10.1016/j.stem.2018.09.016DOI Listing
December 2018

Profiling proliferative cells and their progeny in damaged murine hearts.

Proc Natl Acad Sci U S A 2018 12 7;115(52):E12245-E12254. Epub 2018 Dec 7.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, 3584 CT Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1805829115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310797PMC
December 2018

Tropism, replication competence, and innate immune responses of influenza virus: an analysis of human airway organoids and ex-vivo bronchus cultures.

Lancet Respir Med 2018 11 11;6(11):846-854. Epub 2018 Jul 11.

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(18)30236-4DOI Listing
November 2018

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids.

Cell 2018 11;175(6):1591-1606.e19

Oncode Institute, Hubrecht Institute, KNAW (Royal Netherlands Academy of Arts and Sciences), Utrecht, the Netherlands; University Medical Center Utrecht, Cancer Genomics Netherlands, 3584CX Utrecht, the Netherlands; The Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.11.013DOI Listing
November 2018

Establishment and characterization of a canine keratinocyte organoid culture system.

Vet Dermatol 2018 Oct 2;29(5):375-e126. Epub 2018 Jul 2.

Hubrecht Institute for Developmental Biology and Stem Cell Research, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Centre (UMC) Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, the Netherlands.

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http://dx.doi.org/10.1111/vde.12541DOI Listing
October 2018

ROCKin' Intestinal Cell Fate: A Potential Avenue to Improve Glucose Sensitivity.

Gastroenterology 2018 10 8;155(4):974-976. Epub 2018 Sep 8.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and Cancer Genomics Netherlands, and Princess Máxima Center, and Oncode Institute, Hubrecht Institute, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.09.005DOI Listing
October 2018

Studying cellular heterogeneity and drug sensitivity in colorectal cancer using organoid technology.

Curr Opin Genet Dev 2018 10 24;52:117-122. Epub 2018 Sep 24.

Hubrecht Institute for Developmental Biology and Stem Cell Research, Oncode Institute, University Medical Centre Utrecht, Upsalalaan 8, 3584CT Utrecht, The Netherlands; Princess Máxima Center for Pediatric Oncology, 3584CT Utrecht, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0959437X183004
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http://dx.doi.org/10.1016/j.gde.2018.09.001DOI Listing
October 2018

The Myofibroblasts' War on Drugs.

Dev Cell 2018 09;46(6):669-670

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Uppsalalaan 8, 3584 CT Utrecht, the Netherlands; Oncode Institute, Utrecht, the Netherlands; Princess Máxima Centre, 3584 CT Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.09.008DOI Listing
September 2018

Use and application of 3D-organoid technology.

Hum Mol Genet 2018 08;27(R2):R99-R107

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, University Medical Center Utrecht and University Utrecht, The Netherlands.

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https://academic.oup.com/hmg/article/27/R2/R99/5001715
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http://dx.doi.org/10.1093/hmg/ddy187DOI Listing
August 2018

Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.

Nat Cell Biol 2018 08 23;20(8):909-916. Epub 2018 Jul 23.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, University Medical Center Utrecht , Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/s41556-018-0143-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276989PMC
August 2018

Organoids in cancer research.

Nat Rev Cancer 2018 07;18(7):407-418

Princess Máxima Centre for Paediatric Oncology, Utrecht, Netherlands.

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http://www.nature.com/articles/s41568-018-0007-6
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http://dx.doi.org/10.1038/s41568-018-0007-6DOI Listing
July 2018

Modelling Cryptosporidium infection in human small intestinal and lung organoids.

Nat Microbiol 2018 07 25;3(7):814-823. Epub 2018 Jun 25.

Hubrecht Institute, Oncode Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), UMC Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/s41564-018-0177-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027984PMC
July 2018

Defining Adult Stem Cells by Function, not by Phenotype.

Annu Rev Biochem 2018 06 1;87:1015-1027. Epub 2018 Mar 1.

Centre for Stem Cells and Regenerative Medicine, King's College London, London SE1 9RT, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-biochem-062917-012341DOI Listing
June 2018

Bioengineered bile ducts recapitulate key cholangiocyte functions.

Biofabrication 2018 06 12;10(3):034103. Epub 2018 Jun 12.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands. Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, The Netherlands.

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http://stacks.iop.org/1758-5090/10/i=3/a=034103?key=crossref
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http://dx.doi.org/10.1088/1758-5090/aac8fdDOI Listing
June 2018

Expanding Impact of Stem Cell Science.

Authors:
Hans Clevers

Stem Cell Reports 2018 05;10(5):1427-1428

ISSCR President, 2017-2018.

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http://dx.doi.org/10.1016/j.stemcr.2018.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995453PMC
May 2018

Enterovirus 71 infection of human airway organoids reveals VP1-145 as a viral infectivity determinant.

Emerg Microbes Infect 2018 May 9;7(1):84. Epub 2018 May 9.

Department of Medical Microbiology, Academic Medical Center, 1105 AZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/s41426-018-0077-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943241PMC
May 2018

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.

Nat Commun 2018 05 15;9(1):1898. Epub 2018 May 15.

Department of Clinical Pathobiochemistry, Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.

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http://dx.doi.org/10.1038/s41467-018-04188-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5954009PMC
May 2018

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins.

Blood 2018 03 6;131(9):982-994. Epub 2017 Dec 6.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2017-07
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http://dx.doi.org/10.1182/blood-2017-07-797050DOI Listing
March 2018

Automated brightfield morphometry of 3D organoid populations by OrganoSeg.

Sci Rep 2018 03 28;8(1):5319. Epub 2018 Mar 28.

Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1038/s41598-017-18815-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871765PMC
March 2018

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance.

Nat Methods 2018 02 11;15(2):134-140. Epub 2017 Dec 11.

Division of Molecular Pathology and Cancer Genomics Netherlands, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1038/nmeth.4535DOI Listing
February 2018

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures.

Nat Protoc 2018 Jan 7;13(1):59-78. Epub 2017 Dec 7.

Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/nprot.2017.111DOI Listing
January 2018

Imaging organoids: a bright future ahead.

Nat Methods 2018 01;15(1):24-26

Princess Maxima Center and the Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, the Netherlands.

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http://www.nature.com/doifinder/10.1038/nmeth.4537
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http://dx.doi.org/10.1038/nmeth.4537DOI Listing
January 2018

Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy.

Proc Natl Acad Sci U S A 2018 01 8;115(4):E610-E619. Epub 2018 Jan 8.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1715911114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789932PMC
January 2018

Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes.

Circ Res 2017 Dec 10;121(12):1346-1359. Epub 2017 Oct 10.

From the Center for Cardiovascular Genetics, Institute of Molecular Medicine, The University of Texas Health Sciences Center, Houston (J.K., Q.Q.Z., R.L., J.T.W., A.J.M.); Texas Heart Institute, Houston (J.T.W., A.J.M.); Cardiovascular Research Institute, Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX (C.Y.M., X.H.T.W.); Department of Pediatrics, Texas Children Hospital, Houston (C.Y.M.); Hubrecht Institute, University Medical Center, Utrecht, The Netherlands (K.K., M.B.-H., H.C.); Royal Netherlands Academy of Arts and Sciences and Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands (H.C.); and École Normale Supérieure de Lyon, France (M.B.-H.).

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http://dx.doi.org/10.1161/CIRCRESAHA.117.311876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5722680PMC
December 2017

Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney.

Proc Natl Acad Sci U S A 2017 12 13;114(52):E11190-E11198. Epub 2017 Dec 13.

Hubrecht Institute-Royal Netherlands Academy of Arts and Sciences, 3584 CT Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1714145115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748200PMC
December 2017

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche.

Cell Rep 2017 Dec;21(11):3271-3284

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Cancer Genomics Netherlands, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.050DOI Listing
December 2017

MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.

Gastroenterology 2017 10 14;153(4):1040-1053.e4. Epub 2017 Jul 14.

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.07.008DOI Listing
October 2017

Organoid culture systems to study host-pathogen interactions.

Curr Opin Immunol 2017 Oct 9;48:15-22. Epub 2017 Aug 9.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University, Netherlands; Utrecht Medical Center, 3584 CT, Utrecht, Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09527915173008
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http://dx.doi.org/10.1016/j.coi.2017.07.012DOI Listing
October 2017

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.

Science 2017 10 14;358(6360):234-238. Epub 2017 Sep 14.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center (UMC) Utrecht, 3584CT Utrecht, Netherlands.

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http://dx.doi.org/10.1126/science.aao3130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038908PMC
October 2017

Cancer stem cells revisited.

Nat Med 2017 Oct;23(10):1124-1134

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences, University Medical Center Utrecht and Princess Maxima Center, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/nm.4409DOI Listing
October 2017

Wnt/β-catenin signaling in adult mammalian epithelial stem cells.

Dev Biol 2017 08 17;428(2):273-282. Epub 2017 May 17.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Centre (UMC) Utrecht, 3584 CT Utrecht, The Netherlands; Cancer Genomics Netherlands, UMC Utrecht, 3584 CG Utrecht, The Netherlands; Princess Máxima Centre for Pediatric Oncology, 3584 CT Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2017.05.015DOI Listing
August 2017

Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation .

Dis Model Mech 2017 08 9;10(8):971-980. Epub 2017 Jun 9.

University of Melbourne and Victorian Infectious Diseases Reference Laboratory, Doherty Institute of Infection and Immunity, Melbourne, Victoria 3000, Australia

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http://dx.doi.org/10.1242/dmm.029876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5560064PMC
August 2017

FANTOM5 CAGE profiles of human and mouse samples.

Authors:
Shuhei Noguchi Takahiro Arakawa Shiro Fukuda Masaaki Furuno Akira Hasegawa Fumi Hori Sachi Ishikawa-Kato Kaoru Kaida Ai Kaiho Mutsumi Kanamori-Katayama Tsugumi Kawashima Miki Kojima Atsutaka Kubosaki Ri-Ichiroh Manabe Mitsuyoshi Murata Sayaka Nagao-Sato Kenichi Nakazato Noriko Ninomiya Hiromi Nishiyori-Sueki Shohei Noma Eri Saijyo Akiko Saka Mizuho Sakai Christophe Simon Naoko Suzuki Michihira Tagami Shoko Watanabe Shigehiro Yoshida Peter Arner Richard A Axton Magda Babina J Kenneth Baillie Timothy C Barnett Anthony G Beckhouse Antje Blumenthal Beatrice Bodega Alessandro Bonetti James Briggs Frank Brombacher Ailsa J Carlisle Hans C Clevers Carrie A Davis Michael Detmar Taeko Dohi Albert S B Edge Matthias Edinger Anna Ehrlund Karl Ekwall Mitsuhiro Endoh Hideki Enomoto Afsaneh Eslami Michela Fagiolini Lynsey Fairbairn Mary C Farach-Carson Geoffrey J Faulkner Carmelo Ferrai Malcolm E Fisher Lesley M Forrester Rie Fujita Jun-Ichi Furusawa Teunis B Geijtenbeek Thomas Gingeras Daniel Goldowitz Sven Guhl Reto Guler Stefano Gustincich Thomas J Ha Masahide Hamaguchi Mitsuko Hara Yuki Hasegawa Meenhard Herlyn Peter Heutink Kelly J Hitchens David A Hume Tomokatsu Ikawa Yuri Ishizu Chieko Kai Hiroshi Kawamoto Yuki I Kawamura Judith S Kempfle Tony J Kenna Juha Kere Levon M Khachigian Toshio Kitamura Sarah Klein S Peter Klinken Alan J Knox Soichi Kojima Haruhiko Koseki Shigeo Koyasu Weonju Lee Andreas Lennartsson Alan Mackay-Sim Niklas Mejhert Yosuke Mizuno Hiromasa Morikawa Mitsuru Morimoto Kazuyo Moro Kelly J Morris Hozumi Motohashi Christine L Mummery Yutaka Nakachi Fumio Nakahara Toshiyuki Nakamura Yukio Nakamura Tadasuke Nozaki Soichi Ogishima Naganari Ohkura Hiroshi Ohno Mitsuhiro Ohshima Mariko Okada-Hatakeyama Yasushi Okazaki Valerio Orlando Dmitry A Ovchinnikov Robert Passier Margaret Patrikakis Ana Pombo Swati Pradhan-Bhatt Xian-Yang Qin Michael Rehli Patrizia Rizzu Sugata Roy Antti Sajantila Shimon Sakaguchi Hiroki Sato Hironori Satoh Suzana Savvi Alka Saxena Christian Schmidl Claudio Schneider Gundula G Schulze-Tanzil Anita Schwegmann Guojun Sheng Jay W Shin Daisuke Sugiyama Takaaki Sugiyama Kim M Summers Naoko Takahashi Jun Takai Hiroshi Tanaka Hideki Tatsukawa Andru Tomoiu Hiroo Toyoda Marc van de Wetering Linda M van den Berg Roberto Verardo Dipti Vijayan Christine A Wells Louise N Winteringham Ernst Wolvetang Yoko Yamaguchi Masayuki Yamamoto Chiyo Yanagi-Mizuochi Misako Yoneda Yohei Yonekura Peter G Zhang Silvia Zucchelli Imad Abugessaisa Erik Arner Jayson Harshbarger Atsushi Kondo Timo Lassmann Marina Lizio Serkan Sahin Thierry Sengstag Jessica Severin Hisashi Shimoji Masanori Suzuki Harukazu Suzuki Jun Kawai Naoto Kondo Masayoshi Itoh Carsten O Daub Takeya Kasukawa Hideya Kawaji Piero Carninci Alistair R R Forrest Yoshihide Hayashizaki

Sci Data 2017 08 29;4:170112. Epub 2017 Aug 29.

RIKEN Omics Science Center, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1038/sdata.2017.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574368PMC
August 2017

Stem cell-derived organoids and their application for medical research and patient treatment.

J Mol Med (Berl) 2017 07 8;95(7):729-738. Epub 2017 Apr 8.

Hubrecht Institute, Uppsalalaan 8, 3584 CT, Utrecht, The Netherlands.

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http://link.springer.com/10.1007/s00109-017-1531-7
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http://dx.doi.org/10.1007/s00109-017-1531-7DOI Listing
July 2017

Beyond growth signaling: Paneth cells metabolically support ISCs.

Cell Res 2017 07 21;27(7):851-852. Epub 2017 Apr 21.

Hubrecht Institute, Royal Academy of Arts and Science (KNAW) and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/cr.2017.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518985PMC
July 2017

Stem Cells in Repair of Gastrointestinal Epithelia.

Physiology (Bethesda) 2017 07;32(4):278-289

Hubrecht Institute for Developmental Biology and Stem Cell Research, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, The Netherlands; and.

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http://dx.doi.org/10.1152/physiol.00005.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5545610PMC
July 2017

Origins of lymphatic and distant metastases in human colorectal cancer.

Science 2017 Jul;357(6346):55-60

Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/science.aai8515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536201PMC
July 2017

SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells.

Stem Cell Reports 2017 06 11;8(6):1472-1478. Epub 2017 May 11.

Institute for Immunology, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5469944PMC
June 2017

Oncogene-inducible organoids as a miniature platform to assess cancer characteristics.

J Cell Biol 2017 06 16;216(6):1505-1507. Epub 2017 May 16.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, 3584CT Utrecht, Netherlands.

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http://dx.doi.org/10.1083/jcb.201704014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461034PMC
June 2017

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.

Cell 2017 Jun;169(6):985-999

Hubrecht Institute, University Medical Center Utrecht, Princess Maxima Center for Pediatric Oncology, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00928674173054
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http://dx.doi.org/10.1016/j.cell.2017.05.016DOI Listing
June 2017

How the Gut Feels, Smells, and Talks.

Cell 2017 06;170(1):10-11

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Uppsalalaan 8, 3584 CT, Utrecht, the Netherlands; Cancer Genomics Netherlands, UMC Utrecht, 3584 GC, Utrecht, the Netherlands; Princess Máxima Centre, 3584 CT, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.023DOI Listing
June 2017

Disease Modeling in Stem Cell-Derived 3D Organoid Systems.

Trends Mol Med 2017 05 21;23(5):393-410. Epub 2017 Mar 21.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands; Princess Máxima Center for Pediatric Oncology, 3584 CT, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2017.02.007DOI Listing
May 2017

Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling.

Nature 2017 05 3;545(7653):234-237. Epub 2017 May 3.

Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, and Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature22306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5815871PMC
May 2017

Everything has its time: Id2 clocks embryonic specification of Lgr5 gut stem cells.

EMBO J 2017 04 15;36(7):837-839. Epub 2017 Mar 15.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Centre (UMC) Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.15252/embj.201796482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376976PMC
April 2017

Translational applications of adult stem cell-derived organoids.

Development 2017 03;144(6):968-975

Cancer Genomics Netherlands, UMC Utrecht, Utrecht 3584CG, The Netherlands.

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http://dx.doi.org/10.1242/dev.140566DOI Listing
March 2017

Intestinal epithelial organoids fuse to form self-organizing tubes in floating collagen gels.

Development 2017 03;144(6):1107-1112

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), and University Medical Center Utrecht, Uppsalalaan 8, Utrecht 3584 CT, The Netherlands

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http://dx.doi.org/10.1242/dev.143933DOI Listing
March 2017