Publications by authors named "Hans Adomat"

61Publications

Steroidogenesis in Peripheral and Transition Zones of Human Prostate Cancer Tissue.

Int J Mol Sci 2021 Jan 6;22(2). Epub 2021 Jan 6.

The Vancouver Prostate Centre, Vancouver General Hospital, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.

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January 2021

Clusterin Deficiency Predisposes C57BL/6j Mice to Cationic Bovine Serum Albumin-Induced Glomerular Inflammation.

J Inflamm Res 2020 24;13:969-983. Epub 2020 Nov 24.

Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada.

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November 2020

A polymeric paste-drug formulation for local treatment of upper tract urothelial carcinoma.

Urol Oncol 2020 Nov 26. Epub 2020 Nov 26.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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November 2020

A polymeric paste-drug formulation for intratumoral treatment of prostate cancer.

Prostate Cancer Prostatic Dis 2020 06 25;23(2):324-332. Epub 2019 Nov 25.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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June 2020

Pharmacokinetic interaction of calcitriol with 20(S)-protopanaxadiol in mice: Determined by LC/MS analysis.

Eur J Pharm Sci 2019 Mar 14;130:173-180. Epub 2019 Jan 14.

The Vancouver Prostate Centre at Vancouver General Hospital, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada; Department of Experimental Medicine, Faculty of Medicine, University of British Columbia, Vancouver, B.C., Canada; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, B.C., Canada. Electronic address:

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March 2019

Characterization of Precursor-Dependent Steroidogenesis in Human Prostate Cancer Models.

Cancers (Basel) 2018 Sep 20;10(10). Epub 2018 Sep 20.

The Vancouver Prostate Centre at Vancouver General Hospital, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.

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September 2018

Neuropeptide Y and orexin immunoreactivity in the sparrow brain coincide with seasonal changes in energy balance and steroids.

J Comp Neurol 2019 02 30;527(2):347-361. Epub 2018 Oct 30.

Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada.

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February 2019

Paracrine sonic hedgehog signaling contributes significantly to acquired steroidogenesis in the prostate tumor microenvironment.

Int J Cancer 2017 Jan 20;140(2):358-369. Epub 2016 Oct 20.

The Vancouver Prostate Centre and the Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

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January 2017

Sex steroid profiles in zebra finches: Effects of reproductive state and domestication.

Gen Comp Endocrinol 2017 04 17;244:108-117. Epub 2016 Feb 17.

Zoology Department, University of British Columbia, Vancouver, BC, Canada; Psychology Department, University of British Columbia, Vancouver, BC, Canada; Graduate Program in Neuroscience, University of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.

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April 2017

Calcitriol and 20(S)-protopanaxadiol synergistically inhibit growth and induce apoptosis in human prostate cancer cells.

J Steroid Biochem Mol Biol 2016 Apr 17;158:207-219. Epub 2015 Dec 17.

The Vancouver Prostate Centre at Vancouver General Hospital, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada; Department of Urologic Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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April 2016

Sex steroid profiles and pair-maintenance behavior of captive wild-caught zebra finches (Taeniopygia guttata).

J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2016 Jan 26;202(1):35-44. Epub 2015 Nov 26.

Psychology Department, University of British Columbia, Vancouver, BC, Canada.

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January 2016

The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer.

Cell Rep 2015 Aug 30;12(6):922-36. Epub 2015 Jul 30.

Vancouver Prostate Centre, University of British Columbia, Vancouver, BC V6H 3Z6, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC V6H 3Z6, Canada. Electronic address:

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August 2015

Capsaicin reduces the metastatic burden in the transgenic adenocarcinoma of the mouse prostate model.

Prostate 2015 Sep 5;75(12):1300-11. Epub 2015 Jun 5.

Department of Surgery (Urology), Sunnybrook Health Sciences Center, Toronto, Ontario.

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September 2015

A low carbohydrate, high protein diet suppresses intratumoral androgen synthesis and slows castration-resistant prostate tumor growth in mice.

J Steroid Biochem Mol Biol 2015 Jun 19;150:35-45. Epub 2015 Mar 19.

Vancouver Prostate Centre, Vancouver, British Columbia, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia V6H-3Z6, Canada. Electronic address:

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June 2015

Anticancer activity of a novel selective CYP17A1 inhibitor in preclinical models of castrate-resistant prostate cancer.

Mol Cancer Ther 2015 Jan 28;14(1):59-69. Epub 2014 Oct 28.

Vancouver Prostate Centre, Department of Urological Sciences, University of British Columbia, Vancouver, Canada.

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January 2015

Capsaicin: a novel radio-sensitizing agent for prostate cancer.

Prostate 2015 Feb 13;75(2):113-25. Epub 2014 Oct 13.

Division of Urology, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

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February 2015

Regulation of local steroidogenesis in the brain and in prostate cancer: lessons learned from interdisciplinary collaboration.

Front Neuroendocrinol 2015 Jan 16;36:108-29. Epub 2014 Sep 16.

Department of Psychology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Graduate Program in Neuroscience, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Brain Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada; Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Electronic address:

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January 2015

Next-generation steroidogenesis inhibitors, dutasteride and abiraterone, attenuate but still do not eliminate androgen biosynthesis in 22RV1 cells in vitro.

J Steroid Biochem Mol Biol 2014 Oct 6;144 Pt B:436-44. Epub 2014 Sep 6.

The Vancouver Prostate Centre at Vancouver General Hospital, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada; Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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October 2014

Discovery of small-molecule inhibitors selectively targeting the DNA-binding domain of the human androgen receptor.

J Med Chem 2014 Aug 4;57(15):6458-67. Epub 2014 Aug 4.

Vancouver Prostate Centre, University of British Columbia , 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada.

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August 2014

Reproducibility and efficiency of serum-derived exosome extraction methods.

Clin Biochem 2014 Sep 20;47(13-14):1286-92. Epub 2014 Jun 20.

Vancouver Prostate Centre, University of British Columbia, Canada; Department of Urologic Sciences, University of British Columbia, Canada; Faculty of Medicine, University of British Columbia, Canada.

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September 2014

Pomegranate extracts impact the androgen biosynthesis pathways in prostate cancer models in vitro and in vivo.

J Steroid Biochem Mol Biol 2014 Sep 22;143:19-28. Epub 2014 Feb 22.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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September 2014

Ginsenoside-mediated blockade of 1α,25-dihydroxyvitamin D3 inactivation in human liver and intestine in vitro.

J Steroid Biochem Mol Biol 2014 May 30;141:94-103. Epub 2014 Jan 30.

The Vancouver Prostate Centre at Vancouver General Hospital, 2660 Oak Street, Vancouver, BC, Canada V6H 3Z6. Electronic address:

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May 2014

Abiraterone inhibits 1α,25-dihydroxyvitamin D3 metabolism by CYP3A4 in human liver and intestine in vitro.

J Steroid Biochem Mol Biol 2014 Oct 20;144 Pt A:50-8. Epub 2013 Nov 20.

The Vancouver Prostate Centre at Vancouver General Hospital, 2660 Oak Street, Vancouver, BC, Canada V6H 3Z6. Electronic address:

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October 2014

Identification of human cytochrome P450 enzymes involved in the hepatic and intestinal biotransformation of 20(S)-protopanaxadiol.

Biopharm Drug Dispos 2014 Mar 25;35(2):104-18. Epub 2013 Nov 25.

Department of Pathology and Laboratory Science, University of British Columbia, Vancouver, BC, Canada.

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March 2014

Understanding urinary conditioning film components on ureteral stents: profiling protein components and evaluating their role in bacterial colonization.

Biofouling 2013 18;29(9):1115-22. Epub 2013 Sep 18.

a Department of Urologic Sciences , The Stone Centre at Vancouver General Hospital, University of British Columbia , Vancouver , BC , Canada .

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April 2014

Overcoming resistance to Sonic Hedgehog inhibition by targeting p90 ribosomal S6 kinase in pediatric medulloblastoma.

Pediatr Blood Cancer 2014 Jan 12;61(1):107-15. Epub 2013 Aug 12.

Department of Pediatrics, British Columbia Children's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

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January 2014

Characterization of a new class of androgen receptor antagonists with potential therapeutic application in advanced prostate cancer.

Mol Cancer Ther 2013 Nov 12;12(11):2425-35. Epub 2013 Aug 12.

Corresponding Author: Artem Cherkasov, Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6.

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November 2013

Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.

J Neurochem 2013 Dec 15;127(6):852-67. Epub 2013 Jul 15.

Centre for Molecular Medicine & Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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December 2013

IGF2 increases de novo steroidogenesis in prostate cancer cells.

Endocr Relat Cancer 2013 Apr 22;20(2):173-86. Epub 2013 Mar 22.

Institute of Health and Biomedical Innovation, Australian Prostate Cancer Research Centre - Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia.

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April 2013

Exosomes as biomarker enriched microvesicles: characterization of exosomal proteins derived from a panel of prostate cell lines with distinct AR phenotypes.

Mol Cell Proteomics 2012 Oct 21;11(10):863-85. Epub 2012 Jun 21.

Department of Experimental Medicine, University of British Columbia, Vancouver, British Columbia, V6H 3Z6, Canada.

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October 2012

Cytochrome P450 3A-mediated microsomal biotransformation of 1α,25-dihydroxyvitamin D3 in mouse and human liver: drug-related induction and inhibition of catabolism.

Drug Metab Dispos 2012 May 2;40(5):907-18. Epub 2012 Feb 2.

The Vancouver Prostate Centre at Vancouver General Hospital, 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6.

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May 2012

Fluorescent adducts formed by reaction of oxidized unsaturated fatty acids with amines increase macrophage viability.

Free Radic Biol Med 2011 Nov 1;51(10):1926-36. Epub 2011 Sep 1.

Department of Medicine, University of British Columbia, and Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.

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November 2011

Insulin increases de novo steroidogenesis in prostate cancer cells.

Cancer Res 2011 Sep 11;71(17):5754-64. Epub 2011 Jul 11.

Australian Prostate Cancer Research Centre, Queensland University of Technology, Brisbane, Queensland, Australia.

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September 2011

Genistein increases epidermal growth factor receptor signaling and promotes tumor progression in advanced human prostate cancer.

PLoS One 2011 16;6(5):e20034. Epub 2011 May 16.

Experimental Therapeutics, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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October 2011

Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts.

J Steroid Biochem Mol Biol 2009 Jul 5;115(3-5):126-36. Epub 2009 Apr 5.

The Prostate Centre at Vancouver General Hospital and Department of Urologic Sciences, University of British Columbia, British Columbia, Canada.

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July 2009

A novel communication role for CYP17A1 in the progression of castration-resistant prostate cancer.

Prostate 2009 Jun;69(9):928-37

Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada.

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June 2009

Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer.

Cancer Res 2008 Aug;68(15):6407-15

Department of Urologic Sciences, University of British Columbia, The Prostate Centre at Vancouver General Hospital, Vancouver, British Columbia, Canada.

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August 2008

Intravesical chemotherapy of high-grade bladder cancer with HTI-286, a synthetic analogue of the marine sponge product hemiasterlin.

Clin Cancer Res 2008 Mar;14(5):1510-8

The Prostate Centre at Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

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March 2008

Assessing the therapeutic and toxicological effects of cesium chloride following administration to nude mice bearing PC-3 or LNCaP prostate cancer xenografts.

Cancer Chemother Pharmacol 2007 Nov;60(6):821-9

Urologic Sciences, The Prostate Center at Vancouver General Hospital, 2660 Oak Street, Vancouver, BC, Canada V6H 3Z4.

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November 2007

Evidence for contamination of herbal erectile dysfunction products with phosphodiesterase type 5 inhibitors.

J Urol 2005 Aug;174(2):636-41; discussion 641; quiz 801

Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada.

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August 2005

Hypoxia in the androgen-dependent Shionogi model for prostate cancer at three stages.

Radiat Res 2004 Nov;162(5):547-53

Advanced Therapeutics, BC Cancer Research Centre, Vancouver, British Columbia, V5Z 1L3, Canada.

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November 2004

Enhanced radiation sensitivity in prostate cancer by inhibition of the cell survival protein clusterin.

Clin Cancer Res 2002 Oct;8(10):3276-84

The Prostate Centre, Vancouver General Hospital, Vancouver, British Columbia V6H 3Z6, Canada.

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October 2002