Hans A Kestler

Hans A Kestler

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Hans A Kestler

Publications by authors named "Hans A Kestler"

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Exploring Deep Physiological Models for Nociceptive Pain Recognition.

Sensors (Basel) 2019 Oct 17;19(20). Epub 2019 Oct 17.

Institute of Neural Information Processing, Ulm University, James-Franck-Ring, 89081 Ulm, Germany.

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http://dx.doi.org/10.3390/s19204503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6833075PMC
October 2019

Assessing phenotype order in molecular data.

Sci Rep 2019 Aug 13;9(1):11746. Epub 2019 Aug 13.

Institute of Medical Systems Biology, Ulm University, 89069, Ulm, Germany.

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http://dx.doi.org/10.1038/s41598-019-48150-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692304PMC
August 2019

Semantic Multi-Classifier Systems Identify Predictive Processes in Heart Failure Models across Species.

Biomolecules 2018 11 26;8(4). Epub 2018 Nov 26.

Institute of Medical Systems Biology, Ulm University, 89069 Ulm, Germany.

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http://dx.doi.org/10.3390/biom8040158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315933PMC
November 2018

3D Network exploration and visualisation for lifespan data.

BMC Bioinformatics 2018 Oct 23;19(1):390. Epub 2018 Oct 23.

Institute of Medical Systems Biology - Ulm University, Albert-Einstein-Allee 11, Ulm, 89081, Germany.

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-018-2393-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199797PMC
October 2018

Automatic Screening for Perturbations in Boolean Networks.

Front Physiol 2018 24;9:431. Epub 2018 Apr 24.

Medical Faculty, Institute of Medical Systems Biology Ulm University, Ulm, Germany.

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http://dx.doi.org/10.3389/fphys.2018.00431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928136PMC
April 2018

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

Authors:
Robert A Scott Laura J Scott Reedik Mägi Letizia Marullo Kyle J Gaulton Marika Kaakinen Natalia Pervjakova Tune H Pers Andrew D Johnson John D Eicher Anne U Jackson Teresa Ferreira Yeji Lee Clement Ma Valgerdur Steinthorsdottir Gudmar Thorleifsson Lu Qi Natalie R Van Zuydam Anubha Mahajan Han Chen Peter Almgren Ben F Voight Harald Grallert Martina Müller-Nurasyid Janina S Ried Nigel W Rayner Neil Robertson Lennart C Karssen Elisabeth M van Leeuwen Sara M Willems Christian Fuchsberger Phoenix Kwan Tanya M Teslovich Pritam Chanda Man Li Yingchang Lu Christian Dina Dorothee Thuillier Loic Yengo Longda Jiang Thomas Sparso Hans A Kestler Himanshu Chheda Lewin Eisele Stefan Gustafsson Mattias Frånberg Rona J Strawbridge Rafn Benediktsson Astradur B Hreidarsson Augustine Kong Gunnar Sigurðsson Nicola D Kerrison Jian'an Luan Liming Liang Thomas Meitinger Michael Roden Barbara Thorand Tõnu Esko Evelin Mihailov Caroline Fox Ching-Ti Liu Denis Rybin Bo Isomaa Valeriya Lyssenko Tiinamaija Tuomi David J Couper James S Pankow Niels Grarup Christian T Have Marit E Jørgensen Torben Jørgensen Allan Linneberg Marilyn C Cornelis Rob M van Dam David J Hunter Peter Kraft Qi Sun Sarah Edkins Katharine R Owen John R B Perry Andrew R Wood Eleftheria Zeggini Juan Tajes-Fernandes Goncalo R Abecasis Lori L Bonnycastle Peter S Chines Heather M Stringham Heikki A Koistinen Leena Kinnunen Bengt Sennblad Thomas W Mühleisen Markus M Nöthen Sonali Pechlivanis Damiano Baldassarre Karl Gertow Steve E Humphries Elena Tremoli Norman Klopp Julia Meyer Gerald Steinbach Roman Wennauer Johan G Eriksson Satu Mӓnnistö Leena Peltonen Emmi Tikkanen Guillaume Charpentier Elodie Eury Stéphane Lobbens Bruna Gigante Karin Leander Olga McLeod Erwin P Bottinger Omri Gottesman Douglas Ruderfer Matthias Blüher Peter Kovacs Anke Tonjes Nisa M Maruthur Chiara Scapoli Raimund Erbel Karl-Heinz Jöckel Susanne Moebus Ulf de Faire Anders Hamsten Michael Stumvoll Panagiotis Deloukas Peter J Donnelly Timothy M Frayling Andrew T Hattersley Samuli Ripatti Veikko Salomaa Nancy L Pedersen Bernhard O Boehm Richard N Bergman Francis S Collins Karen L Mohlke Jaakko Tuomilehto Torben Hansen Oluf Pedersen Inês Barroso Lars Lannfelt Erik Ingelsson Lars Lind Cecilia M Lindgren Stephane Cauchi Philippe Froguel Ruth J F Loos Beverley Balkau Heiner Boeing Paul W Franks Aurelio Barricarte Gurrea Domenico Palli Yvonne T van der Schouw David Altshuler Leif C Groop Claudia Langenberg Nicholas J Wareham Eric Sijbrands Cornelia M van Duijn Jose C Florez James B Meigs Eric Boerwinkle Christian Gieger Konstantin Strauch Andres Metspalu Andrew D Morris Colin N A Palmer Frank B Hu Unnur Thorsteinsdottir Kari Stefansson Josée Dupuis Andrew P Morris Michael Boehnke Mark I McCarthy Inga Prokopenko

Diabetes 2017 11 31;66(11):2888-2902. Epub 2017 May 31.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, U.K.

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http://dx.doi.org/10.2337/db16-1253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652602PMC
November 2017

Switch-like behavior enables Wnt11 concentration specific response during dorso-ventral axis formation in Xenopus laevis.

J Theor Biol 2017 09 23;429:82-94. Epub 2017 Jun 23.

Institute of Medical Systems Biology, Ulm University, 89081 Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jtbi.2017.06.027DOI Listing
September 2017

ViSiBooL-visualization and simulation of Boolean networks with temporal constraints.

Bioinformatics 2017 02;33(4):601-604

Institute of Medical Systems Biology.

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http://dx.doi.org/10.1093/bioinformatics/btw661DOI Listing
February 2017

Cool-temperature-mediated activation of phospholipase C-γ2 in the human hereditary disease PLAID.

Cell Signal 2016 09 17;28(9):1237-51. Epub 2016 May 17.

Institute of Pharmacology and Toxicology, Ulm University Medical Center, 89070 Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2016.05.010DOI Listing
September 2016

SPLIFF: A Single-Cell Method to Map Protein-Protein Interactions in Time and Space.

Methods Mol Biol 2015 ;1346:151-68

Institute of Molecular Genetics and Cell Biology, Department of Biology, Ulm University, James-Franck-Ring N27, 89081, Ulm, Germany.

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http://dx.doi.org/10.1007/978-1-4939-2987-0_11DOI Listing
August 2016

GiANT: gene set uncertainty in enrichment analysis.

Bioinformatics 2016 06 1;32(12):1891-4. Epub 2016 Feb 1.

Institute of Medical Systems Biology, Ulm University, Ulm 89069, Germany, Leibniz Institute on Ageing - Fritz Lipmann Institute and FSU Jena, Jena 07745, Germany.

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http://bioinformatics.oxfordjournals.org/content/early/2016/
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http://bioinformatics.oxfordjournals.org/content/early/2016/
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http://bioinformatics.oxfordjournals.org/lookup/doi/10.1093/
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http://dx.doi.org/10.1093/bioinformatics/btw030DOI Listing
June 2016

Predicting Variabilities in Cardiac Gene Expression with a Boolean Network Incorporating Uncertainty.

PLoS One 2015 24;10(7):e0131832. Epub 2015 Jul 24.

Leibniz Institute for Age Research, Fritz-Lipmann Institute, Jena, Germany; Core Unit Medical Systems Biology, Ulm University, Ulm, Germany; Neural Information Processing, Ulm University, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0131832PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514755PMC
May 2016

BiTrinA--multiscale binarization and trinarization with quality analysis.

Bioinformatics 2016 Feb 14;32(3):465-8. Epub 2015 Oct 14.

Medical Systems Biology, Ulm University, 89069 Ulm, Germany, Leibniz Institute on Aging-Fritz Lipmann Institute, 07745 Jena, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btv591DOI Listing
February 2016

Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma.

Cancer Lett 2016 Feb 23;371(1):79-89. Epub 2015 Nov 23.

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.11.025DOI Listing
February 2016

Sputnik: ad hoc distributed computation.

Bioinformatics 2015 Apr 12;31(8):1298-301. Epub 2014 Dec 12.

Core Unit Medical Systems Biology, Theoretical Computer Science, Ulm University, D-89069 Ulm, Germany and Leibniz Institute for Age Research-Fritz Lipmann Institute and FSU Jena, D-07745 Jena Core Unit Medical Systems Biology, Theoretical Computer Science, Ulm University, D-89069 Ulm, Germany and Leibniz Institute for Age Research-Fritz Lipmann Institute and FSU Jena, D-07745 Jena.

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http://dx.doi.org/10.1093/bioinformatics/btu818DOI Listing
April 2015

Cooperative development of logical modelling standards and tools with CoLoMoTo.

Bioinformatics 2015 Apr 25;31(7):1154-9. Epub 2015 Jan 25.

Center for Integrative Genomics (CIG), University of Lausanne, Lausanne, Switzerland, Instituto de Engenharia de Sistemas e Computadores-Investigação e Desenvolvimento (INESC-ID), Lisbon, Portugal, Instituto Gulbenkian de Ciência (IGC), Oeiras, Portugal, Medical Systems Biology, Ulm University, Germany, Friedrich-Schiller University Jena, Jena, Germany, Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany, Institut de Biologie de l'École Normale Supérieure (IBENS)-UMR CNRS 8197-INSERM 1024, Paris, France, Swiss-Prot & Vital-IT group, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, United Kingdom and Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, USA.

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http://dx.doi.org/10.1093/bioinformatics/btv013DOI Listing
April 2015

Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.

EMBO J 2015 Mar 21;34(5):624-40. Epub 2015 Jan 21.

Leibniz Institute for Age Research - Fritz Lipmann Institute e.V. (FLI), Jena, Germany Research Group on Stem Cell Aging, Jena University Hospital (UKJ), Jena, Germany

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http://dx.doi.org/10.15252/embj.201490700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365032PMC
March 2015

Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response.

Sci Signal 2015 Mar 24;8(369):ra30. Epub 2015 Mar 24.

Max-Planck-Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany. Institute of Biochemistry, University of Giessen, 35392 Giessen, Germany.

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http://dx.doi.org/10.1126/scisignal.2005892DOI Listing
March 2015

On the validity of time-dependent AUC estimators.

Brief Bioinform 2015 Jan 14;16(1):153-68. Epub 2013 Sep 14.

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http://dx.doi.org/10.1093/bib/bbt059DOI Listing
January 2015

Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions.

Nat Commun 2014 Aug 13;5:4599. Epub 2014 Aug 13.

Clinic of Dermatology and Allergic Diseases, University Medical Center, Albert-Einstein-Allee 23, 89081 Ulm, Germany.

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http://www.nature.com/articles/ncomms5599
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http://dx.doi.org/10.1038/ncomms5599DOI Listing
August 2014

Assessment of automated analyses of cell migration on flat and nanostructured surfaces.

Comput Struct Biotechnol J 2012 21;1:e201207004. Epub 2012 Nov 21.

Department of Micro- and Nanotechnology, Technical University of Denmark, Kgs. Lyngby, Denmark.

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http://dx.doi.org/10.5936/csbj.201207004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962212PMC
April 2014

RNA-Pareto: interactive analysis of Pareto-optimal RNA sequence-structure alignments.

Bioinformatics 2013 Dec 16;29(23):3102-4. Epub 2013 Sep 16.

Institute of Theoretical Computer Science, Medical Systems Biology and Biology II, Ulm University, D-89069 Ulm, Germany.

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http://bioinformatics.oxfordjournals.org/content/early/2013/
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http://bioinformatics.oxfordjournals.org/cgi/doi/10.1093/bio
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http://dx.doi.org/10.1093/bioinformatics/btt536DOI Listing
December 2013

A fluorescent reporter for mapping cellular protein-protein interactions in time and space.

Mol Syst Biol 2013 ;9:647

Department of Biology, Institute of Molecular Genetics and Cell Biology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1038/msb.2013.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619943PMC
September 2013

Structural RNA alignment by multi-objective optimization.

Bioinformatics 2013 Jul 24;29(13):1607-13. Epub 2013 Apr 24.

Institute of Theoretical Computer Science, Ulm University, 89069 Ulm, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btt188DOI Listing
July 2013

A boolean model of the cardiac gene regulatory network determining first and second heart field identity.

PLoS One 2012 2;7(10):e46798. Epub 2012 Oct 2.

Research Group Bioinformatics and Systems Biology, Institute for Neural Information Processing, Ulm University, Ulm, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0046798PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462786PMC
May 2013

A hierarchy in reprogramming capacity in different tissue microenvironments: what we know and what we need to know.

Stem Cells Dev 2013 Mar 5;22(5):695-706. Epub 2013 Jan 5.

Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.

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http://dx.doi.org/10.1089/scd.2012.0461DOI Listing
March 2013

Systems biology and bioinformatics in aging research: a workshop report.

Rejuvenation Res 2012 Dec 19;15(6):631-41. Epub 2012 Nov 19.

Institute for Biostatistics and Informatics in Medicine and Ageing Research, Department of Medicine, Rostock University, Germany.

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http://dx.doi.org/10.1089/rej.2012.1360DOI Listing
December 2012

The phosphatase of regenerating liver 3 (PRL-3) promotes cell migration through Arf-activity-dependent stimulation of integrin α5 recycling.

J Cell Sci 2012 Aug 17;125(Pt 16):3883-92. Epub 2012 May 17.

Department of Internal Medicine I, University of Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.104885
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http://dx.doi.org/10.1242/jcs.104885DOI Listing
August 2012

Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation.

Gastroenterology 2012 May 15;142(5):1229-1239.e3. Epub 2012 Feb 15.

Institute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1053/j.gastro.2012.02.009DOI Listing
May 2012

Differentiation of multiple types of pancreatico-biliary tumors by molecular analysis of clinical specimens.

J Mol Med (Berl) 2012 Apr 26;90(4):457-64. Epub 2011 Nov 26.

Division of Gastroenterology, University Hospital, Philipps-Universitaet Marburg, Marburg, Germany.

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http://dx.doi.org/10.1007/s00109-011-0832-5DOI Listing
April 2012

TimeLapseAnalyzer: multi-target analysis for live-cell imaging and time-lapse microscopy.

Comput Methods Programs Biomed 2011 Nov 25;104(2):227-34. Epub 2011 Jun 25.

Department of Gastroenterology and Endocrinology, University Hospital of Marburg, Germany.

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http://dx.doi.org/10.1016/j.cmpb.2011.06.002DOI Listing
November 2011

Inferring Boolean network structure via correlation.

Bioinformatics 2011 Jun 5;27(11):1529-36. Epub 2011 Apr 5.

Research group Bioinformatics and Systems Biology, Clinic for Internal Medicine I, University Medical Center Ulm, Ulm, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btr166DOI Listing
June 2011

Generating a Wnt switch: it's all about the right dosage.

J Cell Biol 2011 May;193(3):431-3

Institute for Neural Information Processing, Ulm University, D-89081 Ulm, Germany.

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http://dx.doi.org/10.1083/jcb.201103167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087014PMC
May 2011

BoolNet--an R package for generation, reconstruction and analysis of Boolean networks.

Bioinformatics 2010 May 7;26(10):1378-80. Epub 2010 Apr 7.

Institute of Neural Information Processing, University of Ulm and Department of Internal Medicine I, University Hospital Ulm, 89081 Ulm, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btq124DOI Listing
May 2010

A highly efficient multi-core algorithm for clustering extremely large datasets.

BMC Bioinformatics 2010 Apr 6;11:169. Epub 2010 Apr 6.

Institute of Neural Information Processing, University of Ulm, 89069 Ulm, Germany.

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http://dx.doi.org/10.1186/1471-2105-11-169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865495PMC
April 2010

Significantly improved precision of cell migration analysis in time-lapse video microscopy through use of a fully automated tracking system.

BMC Cell Biol 2010 Apr 8;11:24. Epub 2010 Apr 8.

Research group of Bioinformatics and Systems Biology, Institute of Neural Information Processing, Ulm University, Albert-Einstein-Allee 11, D-89081 Ulm, Germany.

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http://dx.doi.org/10.1186/1471-2121-11-24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2858025PMC
April 2010

A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotypes.

Antiviral Res 2010 Feb 22;85(2):318-27. Epub 2009 Oct 22.

Institute of Virology, University Hospital Ulm, D-89081 Ulm, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S016635420900491
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http://dx.doi.org/10.1016/j.antiviral.2009.10.004DOI Listing
February 2010

MYC stimulates EZH2 expression by repression of its negative regulator miR-26a.

Blood 2008 Nov 19;112(10):4202-12. Epub 2008 Aug 19.

Institute of Physiological Chemistry, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1182/blood-2008-03-147645DOI Listing
November 2008

Network modeling of signal transduction: establishing the global view.

Bioessays 2008 Nov;30(11-12):1110-25

Department of Internal Medicine I, Ulm University Medical Centre, Germany.

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http://dx.doi.org/10.1002/bies.20834DOI Listing
November 2008

Impact of pioglitazone on coronary endothelial function in non-diabetic patients with coronary artery disease.

Clin Res Cardiol 2008 Oct 24;97(10):726-33. Epub 2008 Apr 24.

Department of Internal Medicine II, University of Ulm, Ulm, Germany.

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http://dx.doi.org/10.1007/s00392-008-0663-8DOI Listing
October 2008

From individual Wnt pathways towards a Wnt signalling network.

Philos Trans R Soc Lond B Biol Sci 2008 Apr;363(1495):1333-47

Clinic for Internal Medicine I, Medical Centre Ulm University, Robert-Koch-Strasse 8, 89081 Ulm, Germany.

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http://dx.doi.org/10.1098/rstb.2007.2251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610122PMC
April 2008

Beta-catenin signaling contributes to stemness and regulates early differentiation in murine embryonic stem cells.

FEBS Lett 2007 Nov 15;581(27):5247-54. Epub 2007 Oct 15.

Institute for Biochemistry and Molecular Biology, Ulm University, D-89069 Ulm, Germany.

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http://dx.doi.org/10.1016/j.febslet.2007.10.012DOI Listing
November 2007

Extended analyses of the Wnt/beta-catenin pathway: robustness and oscillatory behaviour.

FEBS Lett 2007 Aug 27;581(21):4043-8. Epub 2007 Jul 27.

Internal Medicine I, Ulm University, Robert-Koch-Strasse, 8, D-89081 Ulm, Germany.

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http://dx.doi.org/10.1016/j.febslet.2007.07.043DOI Listing
August 2007

Visualization of genomic aberrations using Affymetrix SNP arrays.

Bioinformatics 2007 Feb 30;23(4):496-7. Epub 2006 Nov 30.

Internal Medicine I, University of Ulm, D-89069 Ulm, Germany.

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http://dx.doi.org/10.1093/bioinformatics/btl608DOI Listing
February 2007