Hannu Norppa

Hannu Norppa

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Hannu Norppa

Hannu Norppa

Publications by authors named "Hannu Norppa"

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In vivo toxicological evaluation of polymer brush engineered nanoceria: impact of brush charge.

Nanotoxicology 2019 Apr 22;13(3):305-325. Epub 2018 Dec 22.

c c Laboratory of Nanobiotechnology, Department of Genetics and Morphology , Institute of Biological Sciences, University of Brasília , Brasília DF , Brazil.

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http://dx.doi.org/10.1080/17435390.2018.1543469DOI Listing
April 2019

Pulmonary effects of nanofibrillated celluloses in mice suggest that carboxylation lowers the inflammatory and acute phase responses.

Environ Toxicol Pharmacol 2019 Feb 14;66:116-125. Epub 2019 Jan 14.

National Research Centre for the Working Environment (NFA), 105 Lersø Parkallé, Copenhagen Ø, Denmark; Department of Micro- and Nanotechnology, Danish Technical University (DTU), DK-2800, Kgs., Lyngby, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.etap.2019.01.003DOI Listing
February 2019

Safety Aspects of Bio-Based Nanomaterials.

Bioengineering (Basel) 2017 Dec 1;4(4). Epub 2017 Dec 1.

Work Environment, Occupational Safety, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.3390/bioengineering4040094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746761PMC
December 2017

A theoretical approach for a weighted assessment of the mutagenic potential of nanomaterials.

Nanotoxicology 2017 Oct 18;11(8):964-977. Epub 2017 Oct 18.

a Work Environment, Occupational Safety , Finnish Institute of Occupational Health , Helsinki , Finland.

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http://dx.doi.org/10.1080/17435390.2017.1382601DOI Listing
October 2017

Biomarkers of exposure, effect, and susceptibility in workers exposed to chloronitrobenzenes.

Biomarkers 2016 Dec 27;21(8):721-730. Epub 2016 Apr 27.

d Department of Environmental and Occupational Medicine, The Medical School , University of Newcastle upon Tyne , Newcastle upon Tyne , UK.

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http://dx.doi.org/10.3109/1354750X.2016.1172116DOI Listing
December 2016

Effect of particle size and dispersion status on cytotoxicity and genotoxicity of zinc oxide in human bronchial epithelial cells.

Mutat Res Genet Toxicol Environ Mutagen 2016 Jul 21;805:7-18. Epub 2016 May 21.

Finnish Institute of Occupational Health, FI-00251 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.mrgentox.2016.05.008DOI Listing
July 2016

Genotoxic and immunotoxic effects of cellulose nanocrystals in vitro.

Environ Mol Mutagen 2015 Mar 24;56(2):171-82. Epub 2014 Sep 24.

Nanosafety Research Centre, Finnish Institute of Occupational Health, Helsinki, Finland; Systems Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland; Department of Anatomy, Embryology and Genetics, University of Zaragoza, Zaragoza, Spain.

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http://dx.doi.org/10.1002/em.21913DOI Listing
March 2015

Range-finding risk assessment of inhalation exposure to nanodiamonds in a laboratory environment.

Int J Environ Res Public Health 2014 May 16;11(5):5382-402. Epub 2014 May 16.

Department of Physics, University of Helsinki, Gustaf Hällströmin Katu 2, P.O. Box 64, Helsinki FI-00014, Finland.

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http://dx.doi.org/10.3390/ijerph110505382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053885PMC
May 2014

Genotoxicity evaluation of nanosized titanium dioxide, synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes.

Toxicol In Vitro 2014 Feb 27;28(1):60-9. Epub 2013 Jun 27.

Department of Human Genetics, National Institute of Health Dr. Ricardo Jorge (INSA), Av. Padre Cruz, 1649-016 Lisbon, Portugal.

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http://dx.doi.org/10.1016/j.tiv.2013.06.009DOI Listing
February 2014

Genotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in BEAS 2B cells.

Toxicology 2013 Nov 8;313(1):38-48. Epub 2012 Nov 8.

Nanosafety Research Center and Safe New Technologies, Work Environment Development, Finnish Institute of Occupational Health, Helsinki, Finland.

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https://linkinghub.elsevier.com/retrieve/pii/S0300483X120036
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http://dx.doi.org/10.1016/j.tox.2012.09.014DOI Listing
November 2013

Genotoxicity of short single-wall and multi-wall carbon nanotubes in human bronchial epithelial and mesothelial cells in vitro.

Toxicology 2013 Nov 21;313(1):24-37. Epub 2012 Dec 21.

Nanosafety Research Center, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland; Safe New Technologies, Work Environment Development, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2012.12.008DOI Listing
November 2013

Induction of chromosomal aberrations by carbon nanotubes and titanium dioxide nanoparticles in human lymphocytes in vitro.

Nanotoxicology 2012 Dec 13;6:825-36. Epub 2011 Oct 13.

Finnish Institute of Occupational Health, Nanosafety Research Center, Helsinki, Finland.

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http://dx.doi.org/10.3109/17435390.2011.625130DOI Listing
December 2012

Genotoxicity of inhaled nanosized TiO(2) in mice.

Mutat Res 2012 Jun 7;745(1-2):58-64. Epub 2011 Nov 7.

Nanosafety Research Center, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.mrgentox.2011.10.011DOI Listing
June 2012

Protein adducts as biomarkers of exposure to aromatic diisocyanates in workers manufacturing polyurethane (PUR) foam.

J Environ Monit 2011 Apr 23;13(4):957-65. Epub 2011 Feb 23.

Work Environment Development, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FI-00250 Helsinki, Finland.

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http://xlink.rsc.org/?DOI=c0em00595a
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http://dx.doi.org/10.1039/c0em00595aDOI Listing
April 2011

Nano-specific genotoxic effects.

J Biomed Nanotechnol 2011 Feb;7(1):19

Nanosafety Research Center, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland.

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February 2011

Genotoxicity testing of nanomaterials--conclusions.

Nanotoxicology 2010 Dec;4:421-4

Institute of Toxicology and Environmental Hygiene, Technical University of Munich, Berlin, Germany.

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http://dx.doi.org/10.3109/17435390.2010.518774DOI Listing
December 2010

Cytotoxicity and genotoxicity in vitro and irritation potency in vivo of two red phosphorus-based pyrotechnic smokes.

Mutat Res 2010 Aug 18;701(2):137-44. Epub 2010 Jun 18.

Explosives and NBC Defence Division, Finnish Defence Forces Technical Research Centre, P.O. Box 5, FIN 34111 Lakiala, Finland.

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http://dx.doi.org/10.1016/j.mrgentox.2010.06.007DOI Listing
August 2010

Micronucleus assay for mouse alveolar Type II and Clara cells.

Environ Mol Mutagen 2010 Mar;51(2):164-72

New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.1002/em.20520DOI Listing
March 2010

Risk assessment of engineered nanomaterials and nanotechnologies--a review.

Toxicology 2010 Mar 25;269(2-3):92-104. Epub 2010 Jan 25.

Finnish Institute of Occupational Health, New Technologies and Risks, Topeliuksenkatu 41 aA, 00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.tox.2010.01.013DOI Listing
March 2010

Genotoxicity of nanomaterials: DNA damage and micronuclei induced by carbon nanotubes and graphite nanofibres in human bronchial epithelial cells in vitro.

Toxicol Lett 2009 May 7;186(3):166-73. Epub 2008 Dec 7.

New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.toxlet.2008.11.019DOI Listing
May 2009

Chromosomal aberrations in railroad transit workers: effect of genetic polymorphisms.

Environ Mol Mutagen 2009 May;50(4):304-16

Finnish Institute of Occupational Health, Helsinki and Lappeenranta, Finland.

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http://dx.doi.org/10.1002/em.20458DOI Listing
May 2009

Characterization of chromosomes and chromosomal fragments in human lymphocyte micronuclei by telomeric and centromeric FISH.

Mutagenesis 2008 Sep 22;23(5):371-6. Epub 2008 May 22.

New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, Topeliuksenkatu 41aA, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.1093/mutage/gen027DOI Listing
September 2008

Aberrations of chromosome 19 in asbestos-associated lung cancer and in asbestos-induced micronuclei of bronchial epithelial cells in vitro.

Carcinogenesis 2008 May 13;29(5):913-7. Epub 2008 Mar 13.

Biological Mechanisms and Prevention of Work-related Diseases, Health and Work Ability, Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.1093/carcin/bgn068DOI Listing
May 2008

Genotoxic effects of fumes from asphalt modified with waste plastic and tall oil pitch.

Mutat Res 2008 May 11;653(1-2):82-90. Epub 2008 Apr 11.

New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.mrgentox.2008.03.009DOI Listing
May 2008

Micronuclei frequency induced by bleomycin in human peripheral lymphocytes: correlating BLHX polymorphism with mutagen sensitivity.

Mutat Res 2008 Mar 5;639(1-2):20-6. Epub 2007 Nov 5.

Department of Pharmacology, University of Bologna, via Irnerio 48, 40126 Bologna, Italy.

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http://dx.doi.org/10.1016/j.mrfmmm.2007.10.008DOI Listing
March 2008

Origin of nuclear buds and micronuclei in normal and folate-deprived human lymphocytes.

Mutat Res 2007 Apr 22;617(1-2):33-45. Epub 2006 Dec 22.

New Technologies and Risks, Work Environment Development, Finnish Institute of Occupational Health, Topeliuksenkatu 41aA, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.mrfmmm.2006.12.002DOI Listing
April 2007

Copy number gains on 5p15, 6p11-q11, 7p12, and 8q24 are rare in sputum cells of individuals at high risk of lung cancer.

Lung Cancer 2006 Nov 28;54(2):169-76. Epub 2006 Aug 28.

Finnish Institute of Occupational Health, Centre of Expertise for Health and Work Ability, Topeliuksenkatu 41 a A, FI-00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.lungcan.2006.07.009DOI Listing
November 2006

In vivo micronuclei in uncultured T-lymphocytes of male railroad transit workers and referents.

Environ Mol Mutagen 2006 Jun;47(5):345-51

Finnish Institute of Occupational Health, Helsinki and Lappeenranta, Finland.

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http://dx.doi.org/10.1002/em.20213DOI Listing
June 2006

Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes.

Cancer Epidemiol Biomarkers Prev 2006 Mar;15(3):559-66

Institute of Environmental and Occupational Toxicology, Casella Postale 108, 6780 Airolo, Switzerland.

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http://dx.doi.org/10.1158/1055-9965.EPI-05-0677DOI Listing
March 2006

Influence of DNA repair gene polymorphisms on the yield of chromosomal aberrations.

Environ Mol Mutagen 2005 Oct;46(3):198-205

Department of Research and Environmental Surveillance, STUK-Radiation and Nuclear Safety Authority, FIN-00881 Helsinki, Finland.

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http://dx.doi.org/10.1002/em.20155DOI Listing
October 2005

DNA damage in bronchial epithelial and mesothelial cells with and without associated crocidolite asbestos fibers.

Environ Mol Mutagen 2004 ;44(5):477-82

Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland.

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http://dx.doi.org/10.1002/em.20066DOI Listing
March 2005

Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: effects on levels of sister chromatid exchanges and chromosomal aberrations.

Mutat Res 2004 Oct;554(1-2):319-33

Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FIN-00250 Helsinki.

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http://linkinghub.elsevier.com/retrieve/pii/S002751070400176
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http://dx.doi.org/10.1016/j.mrfmmm.2004.05.009DOI Listing
October 2004

Cytogenetic biomarkers.

Authors:
Hannu Norppa

IARC Sci Publ 2004 (157):179-205

Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki.

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April 2004

Cytogenetic biomarkers and genetic polymorphisms.

Authors:
Hannu Norppa

Toxicol Lett 2004 Apr;149(1-3):309-34

Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, FIN-00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.toxlet.2003.12.042DOI Listing
April 2004

Impact of types of lymphocyte chromosomal aberrations on human cancer risk: results from Nordic and Italian cohorts.

Cancer Res 2004 Mar;64(6):2258-63

Department of Occupational and Environmental Medicine, Lund University Hospital, SE-221 85 Lund, Sweden.

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March 2004

Genetic susceptibility, biomarker respones, and cancer.

Authors:
Hannu Norppa

Mutat Res 2003 Nov;544(2-3):339-48

Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FIN-00250 Helsinki, Finland.

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http://dx.doi.org/10.1016/j.mrrev.2003.09.006DOI Listing
November 2003

What do human micronuclei contain?

Mutagenesis 2003 May;18(3):221-33

Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN-00250 Helsinki, Finland.

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http://dx.doi.org/10.1093/mutage/18.3.221DOI Listing
May 2003

Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity.

Carcinogenesis 2002 Jun;23(6):1003-8

Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, FIN-00250 Helsinki, Finland.

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http://dx.doi.org/10.1093/carcin/23.6.1003DOI Listing
June 2002

Influence of GSTM1 and GSTT1 genotypes on sister chromatid exchange induction by styrene in cultured human lymphocytes.

Carcinogenesis 2002 May;23(5):893-7

Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN-00250 Helsinki, Finland.

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http://dx.doi.org/10.1093/carcin/23.5.893DOI Listing
May 2002

N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk.

Pharmacogenetics 2002 Apr;12(3):227-33

Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland.

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April 2002

Sister chromatid exchanges and micronuclei in peripheral lymphocytes of shoe factory workers exposed to solvents.

Environ Health Perspect 2002 Apr;110(4):399-404

Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Edifici Cn, Universitat Autònoma de Barcelona, Bellaterra, Spain.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.02110399
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240803PMC
http://dx.doi.org/10.1289/ehp.02110399DOI Listing
April 2002

Nature of anaphase laggards and micronuclei in female cytokinesis-blocked lymphocytes.

Mutagenesis 2002 Mar;17(2):111-7

Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN-00250 Helsinki, Finland.

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http://dx.doi.org/10.1093/mutage/17.2.111DOI Listing
March 2002