Hanno Glimm

Hanno Glimm

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Hanno Glimm

Hanno Glimm

Publications by authors named "Hanno Glimm"

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Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs.

Cell Stem Cell 2018 Jul;23(1):132-146.e9

Department of Translational and Functional Cancer Genomics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Translational Medical Oncology, NCT-Dresden, University Hospital, Carl Gustav Carus, Technische Universität Dresden, Dresden and DKFZ, Heidelberg, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.06.003DOI Listing
July 2018

Stk33 is required for spermatid differentiation and male fertility in mice.

Dev Biol 2018 01 16;433(1):84-93. Epub 2017 Nov 16.

Division of Applied Functional Genomics, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT) Heidelberg, 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2017.11.007DOI Listing
January 2018

Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer.

Cell Rep 2017 Aug;20(8):1906-1920

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany; Department of Internal Medicine V, University of Heidelberg, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.005DOI Listing
August 2017

Colorectal cancer-initiating cells caught in the act.

EMBO Mol Med 2017 07;9(7):856-858

Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.15252/emmm.201707858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494518PMC
July 2017

Genome-wide Specificity of Highly Efficient TALENs and CRISPR/Cas9 for T Cell Receptor Modification.

Mol Ther Methods Clin Dev 2017 Mar 12;4:213-224. Epub 2017 Feb 12.

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.omtm.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363317PMC
March 2017

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with amplification.

Cold Spring Harb Mol Case Stud 2016 11;2(6):a001180

Department of Translational Oncology, National Center for Tumor Diseases (NCT) Heidelberg, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany;; Section for Personalized Oncology, Heidelberg University Hospital, Heidelberg 69120, Germany;; German Cancer Consortium (DKTK), Heidelberg 69120, Germany.

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http://dx.doi.org/10.1101/mcs.a001180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111004PMC
November 2016

Integrating next-generation sequencing into clinical oncology: strategies, promises and pitfalls.

ESMO Open 2016 18;1(5):e000094. Epub 2016 Nov 18.

Department of Translational Oncology , National Center for Tumor Diseases Heidelberg, German Cancer Research Center (DKFZ) , Heidelberg , Germany.

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http://dx.doi.org/10.1136/esmoopen-2016-000094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133384PMC
November 2016

Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma.

Oncoimmunology 2016 7;5(12):e1240859. Epub 2016 Oct 7.

Division of Molecular Oncology of Gastrointestinal Tumors, German Cancer Research Center, Heidelberg, Germany; Department of General, Visceral and Transplantation Surgery, Heidelberg University Hospital, Heidelberg, Germany.

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http://dx.doi.org/10.1080/2162402X.2016.1240859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215250PMC
October 2016

Phenotypic differentiation does not affect tumorigenicity of primary human colon cancer initiating cells.

Cancer Lett 2016 Feb 8;371(2):326-33. Epub 2015 Dec 8.

Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 460, 69120 Heidelberg, Germany; German Consortium for Translational Cancer Research (DKTK), Germany. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2015.11.037DOI Listing
February 2016

High-resolution analysis of the human T-cell receptor repertoire.

Nat Commun 2015 Sep 1;6:8081. Epub 2015 Sep 1.

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/ncomms9081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4569693PMC
September 2015

So rare we need to hunt for them: reframing the ethical debate on incidental findings.

Genome Med 2015 30;7(1):83. Epub 2015 Jul 30.

Department of Medical Oncology, Program for Ethics and Patient Oriented Care, National Center for Tumor Diseases (NCT), University Hospital Heidelberg, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1186/s13073-015-0198-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520017PMC
August 2015

High-throughput monitoring of integration site clonality in preclinical and clinical gene therapy studies.

Mol Ther Methods Clin Dev 2015 1;2:14061. Epub 2015 Apr 1.

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center (DKFZ) , Heidelberg, Germany.

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http://dx.doi.org/10.1038/mtm.2014.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449016PMC
June 2015

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells.

Nat Commun 2013 ;4:2610

1] German Cancer Research Center (DKFZ), Div. Signalling and Functional Genomics, and Heidelberg University, Dept. Cell and Molecular Biology, Faculty of Medicine Mannheim, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany [2].

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http://dx.doi.org/10.1038/ncomms3610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826636PMC
June 2014

Reply to: NGS library preparation may generate artifactual integration sites of AAV vectors.

Nat Med 2014 Jun;20(6):578-9

1] National Center for Tumor Diseases, Heidelberg, Germany. [2] German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1038/nm.3584DOI Listing
June 2014

Targeted resequencing for analysis of clonal composition of recurrent gene mutations in chronic lymphocytic leukaemia.

Br J Haematol 2013 Nov 27;163(4):496-500. Epub 2013 Aug 27.

Department of Translational Oncology, National Centre for Tumour Diseases (NCT) and German Cancer Research Centre (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1111/bjh.12539DOI Listing
November 2013

Next-generation sequencing of cancer consensus genes in lymphoma.

Leuk Lymphoma 2013 Aug 14;54(8):1831-5. Epub 2013 Jun 14.

Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.3109/10428194.2013.796053DOI Listing
August 2013

A largely random AAV integration profile after LPLD gene therapy.

Nat Med 2013 Jul 16;19(7):889-91. Epub 2013 Jun 16.

National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1038/nm.3230DOI Listing
July 2013

Stable long-term blood formation by stem cells in murine steady-state hematopoiesis.

Stem Cells 2012 Sep;30(9):1961-70

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1002/stem.1151DOI Listing
September 2012

Overexpression of EVI1 interferes with cytokinesis and leads to accumulation of cells with supernumerary centrosomes in G0/1 phase.

Cell Cycle 2012 Sep 16;11(18):3492-503. Epub 2012 Aug 16.

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg; Heidelberg, Germany.

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https://www.tandfonline.com/doi/full/10.4161/cc.21801
Publisher Site
http://dx.doi.org/10.4161/cc.21801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467026PMC
September 2012

Exploiting biological diversity and genomic aberrations in chronic lymphocytic leukemia.

Leuk Lymphoma 2012 Jun 6;53(6):1023-31. Epub 2011 Dec 6.

Division of Molecular Genetics, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.3109/10428194.2011.631638DOI Listing
June 2012

Analysis of the clonal repertoire of gene-corrected cells in gene therapy.

Methods Enzymol 2012 ;507:59-87

Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581 and 460, Heidelberg, Germany.

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http://dx.doi.org/10.1016/B978-0-12-386509-0.00004-1DOI Listing
June 2012

Insertion site pattern: global approach by linear amplification-mediated PCR and mass sequencing.

Methods Mol Biol 2012 ;859:255-65

Department of Translational Oncology, National Center of Tumor Diseases and German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1007/978-1-61779-603-6_15DOI Listing
June 2012

Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites.

Hum Gene Ther Methods 2012 Apr 4;23(2):111-8. Epub 2012 May 4.

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1089/hgtb.2011.219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015219PMC
April 2012

Can prognostic factors be used to direct therapy in chronic lymphocytic leukemia?

Curr Hematol Malig Rep 2012 Mar;7(1):3-12

Department of Medicine V, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg, Germany.

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http://dx.doi.org/10.1007/s11899-011-0110-1DOI Listing
March 2012

You can count on this: barcoded hematopoietic stem cells.

Cell Stem Cell 2011 Nov;9(5):390-2

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.stem.2011.10.013DOI Listing
November 2011

Distinct types of tumor-initiating cells form human colon cancer tumors and metastases.

Cell Stem Cell 2011 Oct;9(4):357-65

Department of Translational Oncology, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.

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http://dx.doi.org/10.1016/j.stem.2011.08.010DOI Listing
October 2011

Retroviral vectors: post entry events and genomic alterations.

Viruses 2011 05 29;3(5):429-55. Epub 2011 Apr 29.

Department of Translational Oncology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.3390/v3050429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185758PMC
May 2011

Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing.

Nat Protoc 2010 Aug 8;5(8):1379-95. Epub 2010 Jul 8.

Department of Translational Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany.

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http://www.nature.com/articles/nprot.2010.87
Publisher Site
http://dx.doi.org/10.1038/nprot.2010.87DOI Listing
August 2010

Hematopoietic activity of human short-term repopulating cells in mobilized peripheral blood cell transplants is restricted to the first 5 months after transplantation.

Blood 2010 Jun 9;115(24):5023-5. Epub 2010 Apr 9.

Department of Translational Oncology, National Center for Tumor Diseases and German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1182/blood-2010-02-271528DOI Listing
June 2010

The inherent differentiation program of short-term hematopoietic repopulating cells changes during human ontogeny.

Stem Cells Dev 2010 May;19(5):621-8

Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University, Freiburg, Germany.

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http://dx.doi.org/10.1089/scd.2009.0202DOI Listing
May 2010

Detection of retroviral integration sites by linear amplification-mediated PCR and tracking of individual integration clones in different samples.

Methods Mol Biol 2009 ;506:363-72

Department of Translational Oncology, National Center of Tumor Diseases, Heidelberg, Germany.

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http://dx.doi.org/10.1007/978-1-59745-409-4_24DOI Listing
February 2009

Constitutive expression of the ATP-binding cassette transporter ABCG2 enhances the growth potential of early human hematopoietic progenitors.

Stem Cells 2008 Mar 29;26(3):810-8. Epub 2007 Nov 29.

Department of Medicine III, Ludwig-Maximilans-University Munich-Grosshadern, Munich, Germany.

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http://dx.doi.org/10.1634/stemcells.2007-0527DOI Listing
March 2008

High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR).

Nat Methods 2007 Dec;4(12):1051-7

Department of Translational Oncology, National Center for Tumor Diseases, German Cancer Research Center, Im Neuenheimer Feld 350, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1038/nmeth1103DOI Listing
December 2007

Real-time definition of non-randomness in the distribution of genomic events.

PLoS One 2007 Jun 27;2(6):e570. Epub 2007 Jun 27.

Department of Translational Oncology, National Center for Tumor Diseases, German Cancer Research Center, Heidelberg, Germany; Department of Medical Biostatistics, Tumor Center Heidelberg-Mannheim, Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000570PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892803PMC
June 2007

Ex vivo treatment of proliferating human cord blood stem cells with stroma-derived factor-1 enhances their ability to engraft NOD/SCID mice.

Blood 2002 May;99(9):3454-7

Terry Fox Laboratory, British Columbia Cancer Agency, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1182/blood.v99.9.3454DOI Listing
May 2002