Hannele Ruohola-Baker

Hannele Ruohola-Baker

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Hannele Ruohola-Baker

Hannele Ruohola-Baker

Publications by authors named "Hannele Ruohola-Baker"

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59Publications

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Metabolic Control over mTOR-Dependent Diapause-like State.

Dev Cell 2020 Jan;52(2):236-250.e7

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2019.12.018DOI Listing
January 2020

microRNAs Regulating Human and Mouse Naïve Pluripotency.

Int J Mol Sci 2019 Nov 22;20(23). Epub 2019 Nov 22.

Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA.

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http://dx.doi.org/10.3390/ijms20235864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929104PMC
November 2019

Fatty Acids Enhance the Maturation of Cardiomyocytes Derived from Human Pluripotent Stem Cells.

Stem Cell Reports 2019 10 26;13(4):657-668. Epub 2019 Sep 26.

Department of Pathology, University of Washington, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Department of Medicine/Cardiology, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Brotman Building Room 453, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.08.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829750PMC
October 2019

Enhancer Chromatin and 3D Genome Architecture Changes from Naive to Primed Human Embryonic Stem Cell States.

Stem Cell Reports 2019 05 2;12(5):1129-1144. Epub 2019 May 2.

Division of Medical Genetics, Department of Medicine, Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524944PMC
May 2019

Metabolism as an early predictor of DPSCs aging.

Sci Rep 2019 Feb 18;9(1):2195. Epub 2019 Feb 18.

Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA, 98195, USA.

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http://dx.doi.org/10.1038/s41598-018-37489-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379364PMC
February 2019

Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.

Cell Stem Cell 2018 10;23(4):586-598.e8

Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia; Centre for Cardiac and Vascular Biology, The University of Queensland, Brisbane, QLD 4072, Australia; School of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19345909183044
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http://dx.doi.org/10.1016/j.stem.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220122PMC
October 2018

Loss of rescues stem cell aging in germ line.

Elife 2017 09 19;6. Epub 2017 Sep 19.

Department of Biochemistry, University of Washington, Seattle, United States.

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https://elifesciences.org/articles/27842
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http://dx.doi.org/10.7554/eLife.27842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644957PMC
September 2017

Metabolic remodeling during the loss and acquisition of pluripotency.

Development 2017 02;144(4):541-551

Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA

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http://dx.doi.org/10.1242/dev.128389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312031PMC
February 2017

Mature Let-7 miRNAs fine tune expression of LIN28B in pluripotent human embryonic stem cells.

Stem Cell Res 2016 11 24;17(3):498-503. Epub 2016 Sep 24.

Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku 20520, Finland.

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http://dx.doi.org/10.1016/j.scr.2016.09.025DOI Listing
November 2016

Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells.

Proc Natl Acad Sci U S A 2016 10 3;113(42):E6382-E6390. Epub 2016 Oct 3.

Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle, WA 98109; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109; Department of Pharmacology, University of Washington School of Medicine, Seattle, WA 98109;

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http://dx.doi.org/10.1073/pnas.1613849113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081574PMC
October 2016

Metabolic RemodeLIN of Pluripotency.

Cell Stem Cell 2016 07;19(1):3-4

Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2016.06.016DOI Listing
July 2016

Metabolic remodeling in early development and cardiomyocyte maturation.

Semin Cell Dev Biol 2016 Apr 18;52:84-92. Epub 2016 Feb 18.

Department of Biochemistry, University of Washington, School of Medicine, Seattle, WA 98195, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, School of Medicine, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820352PMC
April 2016

Tie-mediated signal from apoptotic cells protects stem cells in Drosophila melanogaster.

Nat Commun 2015 May 11;6:7058. Epub 2015 May 11.

1] Department of Biochemistry, Institute for Stem Cell &Regenerative Medicine, University of Washington, Seattle Washington 98109, USA [2] Departments of Biology, Genome Sciences and Bioengineering, University of Washington, Seattle Washington 98109, USA.

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http://dx.doi.org/10.1038/ncomms8058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4451836PMC
May 2015

Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes.

Proc Natl Acad Sci U S A 2015 May 11;112(21):E2785-94. Epub 2015 May 11.

Institute for Stem Cell and Regenerative Medicine, Seattle, WA 98109; Departments of Biochemistry, Department of Bioengineering, and Department of Genome Sciences, University of Washington, Seattle, WA 98195; Department of Biology, University of Washington, Seattle, WA 98195

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http://www.pnas.org/lookup/doi/10.1073/pnas.1424042112
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http://dx.doi.org/10.1073/pnas.1424042112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450404PMC
May 2015

Drosophila as a starting point for developing therapeutics for the rare disease Duchenne Muscular Dystrophy.

Rare Dis 2013 10;1:e24995. Epub 2013 May 10.

Department of Biochemistry; Institute for Stem Cell and Regenerative Medicine; University of Washington; Seattle, WA USA.

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http://dx.doi.org/10.4161/rdis.24995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932943PMC
July 2014

Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells.

J Mol Cell Cardiol 2014 Jul 13;72:296-304. Epub 2014 Apr 13.

Department of Pathology, University of Washington, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington, Seattle, WA 98109, USA; Department of Medicine/Cardiology, University of Washington, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041732PMC
July 2014

Hypoxia-inducible factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency.

Cell Stem Cell 2014 May 20;14(5):592-605. Epub 2014 Mar 20.

Department of Biochemistry, University of Washington School of Medicine, Seattle, WA 98109-4714, USA; Department of Biology, University of Washington, Seattle, WA 98109-4714, USA; Department of Chemistry, University of Washington, Seattle, WA 98109-4714, USA; The Institute for Stem Cell and Regenerative Medicine (ISCRM), University of Washington School of Medicine, Seattle, WA 98109-4714, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028142PMC
May 2014

Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery.

Stem Cell Res 2014 Mar 23;12(2):467-80. Epub 2013 Dec 23.

Department of Rehabilitation Medicine, University of Washington, Seattle, WA, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2013.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966181PMC
March 2014

Derivation of naive human embryonic stem cells.

Proc Natl Acad Sci U S A 2014 Mar 12;111(12):4484-9. Epub 2014 Mar 12.

Institute for Stem Cell and Regenerative Medicine, Departments of Comparative Medicine, Biology, and Biochemistry, and Divisions of Hematology, Metabolism, Endocrinology and Nutrition, and Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195.

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http://dx.doi.org/10.1073/pnas.1319738111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970494PMC
March 2014

Regulation of stem cell populations by microRNAs.

Adv Exp Med Biol 2013 ;786:329-51

Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, UW Medicine at South Lake Union, 850 Republican street, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1007/978-94-007-6621-1_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901537PMC
September 2013

Hypoxia induces re-entry of committed cells into pluripotency.

Stem Cells 2013 Sep;31(9):1737-48

Department of Biochemistry, University of Washington, Seattle, Washington, USA; Institute for Stem Cell and Regenerative Medicine University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1002/stem.1446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3921075PMC
September 2013

Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila.

Development 2013 Jan 15;140(1):136-46. Epub 2012 Nov 15.

Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1242/dev.087791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513996PMC
January 2013

Use of somatic mutations to quantify random contributions to mouse development.

BMC Genomics 2013 Jan 18;14:39. Epub 2013 Jan 18.

Department of Pathology, University of Washington, Box 358056, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1186/1471-2164-14-39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564904PMC
January 2013

Loss-of-Function Screen Reveals Novel Regulators Required for Drosophila Germline Stem Cell Self-Renewal.

G3 (Bethesda) 2012 Mar 1;2(3):343-51. Epub 2012 Mar 1.

Department of Biochemistry, Institute for Stem Cell & Regenerative Medicine, University of Washington, Seattle, Washington 98109.

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http://dx.doi.org/10.1534/g3.111.001651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291504PMC
March 2012

Assessing in vivo microRNA function in the germline stem cells of the Drosophila ovary.

Methods Mol Biol 2010 ;650:201-12

Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-1-60761-769-3_15DOI Listing
December 2010

Chronic hypoxia impairs muscle function in the Drosophila model of Duchenne's muscular dystrophy (DMD).

PLoS One 2010 Oct 20;5(10):e13450. Epub 2010 Oct 20.

Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013450PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958114PMC
October 2010

PIWI goes solo in the soma.

Dev Cell 2009 May;16(5):627-8

Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.devcel.2009.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925128PMC
May 2009

Genetic modifier screens reveal new components that interact with the Drosophila dystroglycan-dystrophin complex.

PLoS One 2008 Jun 11;3(6):e2418. Epub 2008 Jun 11.

Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002418PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2398783PMC
June 2008

Small RNAs: keeping stem cells in line.

Cell 2008 Feb;132(4):563-6

Department of Biochemistry and Institute for Stem Cell and Regenerative Medicine, University of Washington, 1705 NE Pacific Street, Health Science Building, Room J-587, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.cell.2008.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925130PMC
February 2008

microRNA and stem cell function.

Cell Tissue Res 2008 Jan 7;331(1):57-66. Epub 2007 Nov 7.

Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1007/s00441-007-0530-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925125PMC
January 2008

Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary.

Cell Stem Cell 2007 Dec;1(6):698-709

Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.stem.2007.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211735PMC
December 2007

Dissecting muscle and neuronal disorders in a Drosophila model of muscular dystrophy.

EMBO J 2007 Jan 11;26(2):481-93. Epub 2007 Jan 11.

Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1038/sj.emboj.7601503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783456PMC
January 2007

Stem cells signal to the niche through the Notch pathway in the Drosophila ovary.

Curr Biol 2006 Dec 2;16(23):2352-8. Epub 2006 Nov 2.

Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, School of Medicine, Box 357350, 1959 NE Pacific Street, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1016/j.cub.2006.10.022DOI Listing
December 2006

Border of Notch activity establishes a boundary between the two dorsal appendage tube cell types.

Dev Biol 2006 Sep 24;297(2):461-70. Epub 2006 May 24.

Department of Biochemistry, University of Washington, Box 357350, Seattle, WA 98195-7350, USA.

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http://dx.doi.org/10.1016/j.ydbio.2006.05.021DOI Listing
September 2006

Fringe-dependent notch activation and tramtrack function are required for specification of the polar cells in Drosophila oogenesis.

Dev Dyn 2005 Apr;232(4):1013-20

Department of Biochemistry, University of Washington, Seattle, WA 98195-7350, USA.

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http://doi.wiley.com/10.1002/dvdy.20361
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http://dx.doi.org/10.1002/dvdy.20361DOI Listing
April 2005

Genome wide analysis of transcript levels after perturbation of the EGFR pathway in the Drosophila ovary.

Dev Dyn 2005 Mar;232(3):709-24

Department of Biochemistry, University of Washington, Seattle, Washington 98195-7350, USA.

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http://dx.doi.org/10.1002/dvdy.20318DOI Listing
March 2005

The mitotic-to-endocycle switch in Drosophila follicle cells is executed by Notch-dependent regulation of G1/S, G2/M and M/G1 cell-cycle transitions.

Development 2004 Jul 2;131(13):3169-81. Epub 2004 Jun 2.

Department of Biochemistry, University of Washington, J591, HSB, Seattle, WA 98195-7350, USA.

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http://dx.doi.org/10.1242/dev.01172DOI Listing
July 2004

Notch-dependent Fizzy-related/Hec1/Cdh1 expression is required for the mitotic-to-endocycle transition in Drosophila follicle cells.

Curr Biol 2004 Apr;14(7):630-6

Department of Biochemistry, University of Washington, J591 Health Science Building, Seattle, WA 98195-7350, USA.

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http://dx.doi.org/10.1016/j.cub.2004.03.040DOI Listing
April 2004

Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage.

Development 2003 Mar;130(5):859-71

Department of Biochemistry, Box 357350, University of Washington, Seattle, WA 98195-7350, USA.

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http://dx.doi.org/10.1242/dev.00310DOI Listing
March 2003

Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila.

Development 2003 Jan;130(1):173-84

Department of Biochemistry, Box 357350, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1242/dev.00199DOI Listing
January 2003