Publications by authors named "Hannele Laivuori"

100Publications

Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.

Nat Commun 2020 11 25;11(1):5976. Epub 2020 Nov 25.

School of Life Sciences, University of Nottingham, Nottingham, UK.

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November 2020

The non-traditional and familial risk factors for preeclampsia in the FINNPEC cohort.

Pregnancy Hypertens 2020 Nov 12;23:48-55. Epub 2020 Nov 12.

Department of Obstetrics and Gynecology, Turku University Central Hospital and University of Turku, Turku, Finland.

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November 2020

Therapeutic doses of metformin do not have impact on angiogenesis in presence of sera from pre-eclamptic, IUGR and healthy pregnancies.

Pregnancy Hypertens 2020 Oct 6;22:7-13. Epub 2020 Jul 6.

Department of Obstetrics and Gynaecology, Tampere University Hospital, Tampere, Finland.

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October 2020

Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia.

EBioMedicine 2020 Sep 14;59:102872. Epub 2020 Jul 14.

Stem Cells and Metabolism Research Program, University of Helsinki, and Folkhälsan Research Center, 00290 Helsinki, Finland; Department of Biosciences and Nutrition, Karolinska Institutet, 14183 Huddinge, Sweden. Electronic address:

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September 2020

Polygenic prediction of the risk of perinatal depressive symptoms.

Depress Anxiety 2020 09 5;37(9):862-875. Epub 2020 Jul 5.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

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September 2020

Maternal Hypertensive Pregnancy Disorders and Mental Disorders in Children.

Hypertension 2020 Jun 20;75(6):1429-1438. Epub 2020 Apr 20.

From the Faculty of Medicine, Department of Psychology and Logopedics, University of Helsinki, Finland (M.L.-P., P.G., S.T., S.S., J. Lahti, K.H., J. Lipsanen, H.L., K.R.).

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June 2020

Pregnancy outcomes according to the definition of gestational diabetes.

PLoS One 2020 5;15(3):e0229496. Epub 2020 Mar 5.

PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and the University of Oulu, Finland.

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June 2020

Maternal depression and inflammation during pregnancy.

Psychol Med 2020 08 23;50(11):1839-1851. Epub 2019 Aug 23.

Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

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August 2020

Pregnancy-associated stroke -a systematic review of subsequent pregnancies and maternal health.

BMC Pregnancy Childbirth 2019 May 28;19(1):187. Epub 2019 May 28.

Department of Neurology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. Box 700, FI-00029 HUS, Helsinki, Finland.

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May 2019

The health of children conceived by ART: 'the chicken or the egg?'

Hum Reprod Update 2019 03;25(2):137-158

Fertility Clinic, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, Copenhagen, Denmark.

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March 2019

The Immunogenetic Conundrum of Preeclampsia.

Front Immunol 2018 13;9:2630. Epub 2018 Nov 13.

Medical and Clinical genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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October 2019

Impact of obesity on angiogenic and inflammatory markers in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort.

Int J Obes (Lond) 2019 05 25;43(5):1070-1081. Epub 2018 Sep 25.

Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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May 2019

Polycystic ovary syndrome and risk factors for gestational diabetes.

Endocr Connect 2018 Jul 1;7(7):859-869. Epub 2018 Jun 1.

PEDEGO Research UnitMRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

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July 2018

Angiogenic profile in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort.

Pregnancy Hypertens 2018 Oct 10;14:252-259. Epub 2018 Mar 10.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Institute for Molecular Medicine Finland, HiLIFE Unit, University of Helsinki, Helsinki, Finland; Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland; Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.

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October 2018

The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis.

Hum Reprod Update 2018 05;24(3):320-389

Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Reproductive Medicine, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.

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May 2018

Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia.

Hypertension 2018 01 4;71(1):95-102. Epub 2017 Dec 4.

From Medical and Clinical Genetics, Helsinki University Hospital (T.K., S.U., M.M.K., H.L.), Obstetrics and Gynaecology, Helsinki University Hospital (M.M.K., S.H.), Abdominal Center, Nephrology, Helsinki University Hospital (I.T.), Clinical Chemistry and Hematology, Helsinki University Hospital (P.L.), Children's Hospital, Helsinki University Central Hospital (E.K.), Molecular Neurology Research Program (J.K.), and Institute for Molecular Medicine Finland, HiLIFE Unit (H.L.), University of Helsinki, Finland; Department of Obstetrics and Gynecology, South-Karelia Central Hospital, Lappeenranta, Finland (M.M.K.); Bioinformatics Center, University of Eastern Finland, Kuopio (J.P.); Department of Clinical Chemistry, University of Turku (K.P.), and Saske Screening Center, Turku University Central Hospital (K.P.), Finland; Eastern Finland Laboratory Centre, Kuopio (K.P., J.R.); Minerva Foundation Institute for Medical Research, Helsinki, Finland (I.T., P.L.); Chronic Disease Prevention Unit (E.K.) and Department of Government Services (A.P.), National Institute for Health and Welfare, Helsinki, Finland; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Finland (E.K., A.P.); Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden (J.K.); Folkhälsan Institute of Genetics, Helsinki, Finland (J.K.); Department of Medical and Molecular Genetics, King's College London, United Kingdom (J.K.); Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (K.K.); Faculty of Medicine and Life Sciences, University of Tampere, Finland (H.L.); and Department of Obstetrics and Gynecology, Tampere University Hospital, Finland (H.L.).

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January 2018

Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population.

Hypertension 2017 08 26;70(2):365-371. Epub 2017 Jun 26.

From the Immunobiology, Research Programs Unit (A.I.L., S.M.), Molecular Neurology, Research Programs Unit (J.K.), and Institute for Molecular Medicine Finland/HiLIFE Unit (P.H., K.A., M.P., H.L.), University of Helsinki, Finland; Medical and Clinical Genetics (A.I.L., H.L.), Bacteriology and Immunology (A.I.L., S.M.), Obstetrics and Gynaecology (K.A., S.H., H.L.), and Children's Hospital (E.K), University of Helsinki and Helsinki University Hospital, Finland; Folkhälsan Institute of Genetics (J.K.), University of Helsinki, Finland; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA (E.D., M.I.K., M.D.); Department of Medicine, Division of Rheumatology (M.T., E.D.O.R., J.P.A.) and Department of Genetics (E.D.O.R.), Washington University School of Medicine, St. Louis, MO; Neurosurgery of Neuro Center, Kuopio University Hospital, Finland (M.I.K.); Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston (M.I.K.); Unit of Genetics and Biomarkers (K.A.), Department of Health (M.P., E.K.), Chronic Disease Prevention Unit, Department of Health (E.K.), and Department of Government Services (A.P.), National Institute for Health and Welfare, Helsinki, Finland; The Estonian Genome Center, University of Tartu, Estonia (M.P.); PEDEGO Research Unit, MRC Oulu, University of Oulu and Oulu University Hospital, Finland (E.K., A.P.); Department of Biosciences and Nutrition, Karolinska Institutet, Solna, Sweden (J.K.); Department of Medical and Molecular Genetics, King's College, London, United Kingdom (J.K.); Division of Cardiovascular Medicine, University of Cambridge, United Kingdom (K.K.); Department of Medicine, Hospital for Special Surgery-Weill Cornell Medicine, New York, NY (J.E.S.); and Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston (M.D.).

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August 2017

Angiogenic profile and smoking in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort.

Ann Med 2017 11 9;49(7):593-602. Epub 2017 Jun 9.

a Medical and Clinical Genetics , University of Helsinki and Helsinki University Hospital , Helsinki , Finland.

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November 2017

SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men.

BMC Med Genet 2017 04 11;18(1):41. Epub 2017 Apr 11.

The Folkhälsan Institute of Genetics and the Department of Medical Genetics, University of Helsinki, Helsinki, Finland.

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April 2017

Cohort profile: the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC).

BMJ Open 2016 11 10;6(11):e013148. Epub 2016 Nov 10.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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November 2016

First trimester serum placental growth factor and hyperglycosylated human chorionic gonadotropin are associated with pre-eclampsia: a case control study.

BMC Pregnancy Childbirth 2016 11 25;16(1):378. Epub 2016 Nov 25.

Clinical Chemistry, University of Helsinki and Helsinki University Hospital, PB 700, 00029, Helsinki, Finland.

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November 2016

Stanniocalcin-1 Hormone in Nonpreeclamptic and Preeclamptic Pregnancy: Clinical, Life-Style, and Genetic Modulators.

J Clin Endocrinol Metab 2016 12 7;101(12):4799-4807. Epub 2016 Sep 7.

Human Molecular Genetics Research Group (P.J., K.R., T.K., M.L.), Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia; Department of Obstetrics and Gynaecology (K.R., P.V.), University of Tartu, and Women's Clinic of Tartu University Hospital (K.R., P.V.), Tartu 51014, Estonia; Medical and Clinical Genetics (H.L.), University of Helsinki and Helsinki University Hospital, and Institute for Molecular Medicine Finland (H.L.), University of Helsinki, FIN-00014 Helsinki, Finland; Obstetrics and Gynecology (H.L., S.H.) and Children's Hospital (E.K.), Helsinki University Hospital and University of Helsinki, FIN-00029 Helsinki, Finland; Chronic Disease Prevention Unit (E.K.), National Institute for Health and Welfare, FIN-00271 Helsinki, Finland; Research Unit of Pediatrics, Pediatric Neurology, Pediatric Surgery, Child Psychiatry, Dermatology, Clinical Genetics, Obstetrics and Gynecology, Otorhinolaryngology, Ophtalmology (E.K.), Medical Research Center Oulu, Oulu University Hospital and University of Oulu, FIN-90014 Oulu, Finland; and Institute of Biomedicine and Translational Medicine (M.L.), University of Tartu, Tartu 50411, Estonia.

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December 2016

An RGS2 3'UTR polymorphism is associated with preeclampsia in overweight women.

BMC Genet 2016 08 24;17(1):121. Epub 2016 Aug 24.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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August 2016

The diagnosis of pre-eclampsia using two revised classifications in the Finnish Pre-eclampsia Consortium (FINNPEC) cohort.

BMC Pregnancy Childbirth 2016 08 12;16:221. Epub 2016 Aug 12.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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August 2016

Exome sequencing in pooled DNA samples to identify maternal pre-eclampsia risk variants.

Sci Rep 2016 07 7;6:29085. Epub 2016 Jul 7.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

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July 2016

The Salivary Scavenger and Agglutinin (SALSA) in Healthy and Complicated Pregnancy.

PLoS One 2016 1;11(2):e0147867. Epub 2016 Feb 1.

Immunobiology Research Program, Research Programs Unit, and Department of Bacteriology & Immunology, Medical Faculty, University of Helsinki, Helsinki, Finland.

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July 2016

White's classification and pregnancy outcome in women with type 1 diabetes: a population-based cohort study.

Diabetologia 2016 Jan;59(1):92-100

Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 2, 00029, Helsinki, Finland.

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January 2016

Gene expression profiling of pre-eclamptic placentae by RNA sequencing.

Sci Rep 2015 09 21;5:14107. Epub 2015 Sep 21.

Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, FI-00014, Finland.

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September 2015

Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis.

Spine J 2015 Oct 15;15(10):2239-46. Epub 2015 May 15.

Department of Orthopedics, Karolinska University Hospital, K54, SE-14186, Stockholm, Sweden; Department of Clinical Sciences, Intervention and Technology (CLINTEC) Karolinska Institutet, SE-14186, Stockholm, Sweden. Electronic address:

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October 2015

Genetic analysis of membrane cofactor protein (CD46) of the complement system in women with and without preeclamptic pregnancies.

PLoS One 2015 24;10(2):e0117840. Epub 2015 Feb 24.

Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland; Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland; Finnish Institute for Molecular Medicine, University of Helsinki, Helsinki, Finland.

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November 2015

Obstetric and perinatal outcome in type 1 diabetes patients with diabetic nephropathy during 1988-2011.

Diabetologia 2015 Apr 10;58(4):678-86. Epub 2015 Jan 10.

Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Central Hospital, P.O. Box 140, Haartmaninkatu 2, 00029, Helsinki, Finland,

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April 2015

Complement activation and regulation in preeclamptic placenta.

Front Immunol 2014 9;5:312. Epub 2014 Jul 9.

Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki , Helsinki , Finland ; Immunobiology Research Program, Research Programs Unit, University of Helsinki , Helsinki , Finland ; Division of Clinical Microbiology, Helsinki University Central Hospital Laboratory (HUSLAB) , Helsinki , Finland.

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July 2014

Microsatellite polymorphism in the heme oxygenase-1 promoter is associated with nonsevere and late-onset preeclampsia.

Hypertension 2014 Jul 5;64(1):172-7. Epub 2014 May 5.

From the Haartman Institute, Medical Genetics (T.K., M.M.K., A.T., J.K., H.L.), Research Programs Unit, Molecular Neurology (A.T.), Department of Clinical Chemistry (P.L.), and Institute for Molecular Medicine Finland (H.L.), University of Helsinki, Helsinki, Finland; Departments of Obstetrics and Gynecology (M.M.K., H.L.) and Clinical Chemistry (P.L.), Helsinki University Central Hospital, Helsinki, Finland; Department of Obstetrics and Gynecology, South-Karelia Central Hospital, Lappeenranta, Finland (M.M.K.); Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland (J.U.); Department of Obstetrics and Gynecology, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland (S.H.); Department of Chronic Disease Prevention, Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland (E.K.); Department of Children, Young People, and Families, National Institute for Health and Welfare, Oulu, Finland (A.P.); Children's Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland (E.K.); Department of Obstetrics and Gynaecology, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland (E.K., A.P.); Department of Biosciences and Nutrition, and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden (J.K.); Folkhälsan Institute of Genetics, Helsinki, Finland (J.K.); Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom (K.K.); and Minerva Institute for Medical Research, Helsinki, Finland (P.L.).

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July 2014

Strategy for standardization of preeclampsia research study design.

Hypertension 2014 Jun 31;63(6):1293-301. Epub 2014 Mar 31.

Department of Obstetrics and Gynecology, Center for Pregnancy and Newborn Research, University of Texas Health Science Center, San Antonio, Mail Code 7836, 7703 Floyd Curl Dr, San Antonio, TX 78229.

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June 2014

Hypertension after preeclampsia and relation to the C1114G polymorphism (rs4606) in RGS2: data from the Norwegian HUNT2 study.

BMC Med Genet 2014 Mar 5;15:28. Epub 2014 Mar 5.

From the Department of Obstetrics and Department of Gynecology, Oslo University Hospital, Ulleval, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway.

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March 2014

Serum hyperglycosylated human chorionic gonadotrophin at 14-17 weeks of gestation does not predict preeclampsia.

Prenat Diagn 2014 Jul 17;34(7):699-705. Epub 2014 Feb 17.

Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland; University of Helsinki, Helsinki, Finland.

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July 2014

Maternal preeclampsia and bone mineral density of the adult offspring.

Am J Obstet Gynecol 2013 Nov 19;209(5):443.e1-443.e10. Epub 2013 Jun 19.

National Institute for Health and Welfare and the Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland.

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November 2013

Vasoactive agents for the prediction of early- and late-onset preeclampsia in a high-risk cohort.

BMC Pregnancy Childbirth 2013 May 12;13:110. Epub 2013 May 12.

The Research Programs Unit, Women's Health, University of Helsinki, and Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland.

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May 2013

Pitfalls in setting up genetic studies on preeclampsia.

Authors:
Hannele Laivuori

Pregnancy Hypertens 2013 Apr 6;3(2):60. Epub 2013 Jun 6.

Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland.

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April 2013

A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18.

Eur J Hum Genet 2013 Sep 6;21(9):1024-6. Epub 2013 Feb 6.

Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland.

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September 2013

Erratum to "An Obesity-Related FTO Variant and the Risk of Preeclampsia in a Finnish Study Population".

J Pregnancy 2012 24;2012:540682. Epub 2012 Jul 24.

Department of Obstetrics and Gynecology, Helsinki University Central Hospital, P.O. Box 140, 00029 Helsinki, Finland.

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October 2015