Dr. Hannah P Priyanka, M.Sc., M.Phil., Ph.D. - Institute of Advanced Research in Health Sciences, Tamil Nadu Govt Multi Super Speciality Hospital - DST Inspire Faculty

Dr. Hannah P Priyanka

M.Sc., M.Phil., Ph.D.

Institute of Advanced Research in Health Sciences, Tamil Nadu Govt Multi Super Speciality Hospital

DST Inspire Faculty

Chennai, Tamil Nadu | India

Main Specialties: Biotechnology

Additional Specialties: Neuroendocrinology and Neuroimmunology

ORCID logohttps://orcid.org/0000-0001-9555-7394


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Dr. Hannah P Priyanka, M.Sc., M.Phil., Ph.D. - Institute of Advanced Research in Health Sciences, Tamil Nadu Govt Multi Super Speciality Hospital - DST Inspire Faculty

Dr. Hannah P Priyanka

M.Sc., M.Phil., Ph.D.

Introduction

Research done so far:
Rationale: Deregulation of the bi-directional communication between the neuroendocrine-immune network leads to the development of age-associated diseases and cancer. The interplay between these systems is more complex in females due to cyclic variations in the estrogen levels with menstrual cycle and age. Stress is a potent neuroendocrine-immune modulator that mediates its effects through several mechanisms, most importantly, through sympathetic cascades involving norepinephrine and the adrenergic receptors.
Findings: Estrogen alters immune reactivity in a dose and receptor-type-dependent manner through the modulation of specific signaling molecules and cytokines. Activation of adrenergic receptors using subtype-specific agonists leads to immunosuppression irrespective of the sub-type activated, although through distinct intracellular signaling pathways. Estrogen co-treatment of adrenergic agonist-treated lymphocytes reversed adrenergic immunosuppression by ?2-AR agonist terbutaline through ER-?. In vivo studies using ovariectomised Sprague-Dawley rats supplemented with 30-day slow-release estrogen pellets have shown that estrogen exerts dose-dependent effects on splenic lymphocyte cytokine production and intracellular signaling molecules. In the lymph node lymphocytes, estrogen upregulates inflammatory signals through NF-?B, IFN-?, and nitric oxide via Akt/mTOR pathway in middle-aged female rats. In the thymus and mesenteric lymph nodes, estrogen differentially regulates the expression of tyrosine hydroxylase and nerve growth factor through free radical generation. Estrogen also triggers neuroprotective and anti-inflammatory markers in specific brain areas of middle-aged female rats. As an extension, our clinical study using peripheral blood mononuclear cells from healthy female volunteers during different phases of the menstrual cycle (follicular and luteal) and phases of reproductive aging (Young-cycling, Middle-aged Perimenopausal, Old-Post menopausal) showed age-related decline in Con A-induced lymphocyte proliferation and cytokine production, target derived growth factors (NGF, pTH) and increase in proinflammatory markers (p-NF-?B). The in vitro data obtained was used to build an in silico model using the Simbiology tool box in MATLAB and shows that the cross-talk between estrogen and adrenergic receptor mediated signaling pathways is probably mediated through p-ERK, although the exact mechanism of action needs to be determined. Unpublished data shows that breast cancer cell lines treated with adrenergic receptor-specific agonists respond differently depending upon their estrogen receptor status (ER+/-) in terms of proliferation, signaling molecules (p-ERK) and pro-angiogenic molecules (VEGF C, IL-6). Similar alterations were observed in Alzheimer’s and Rheumatoid arthritis patients. Comparative analysis of the strategies for reversing age-associated immunosenescence using synthetic drugs (donepezil and deprenyl) and natural remedies (Bacopa monnieri and Morinda citrifolia) have been shown in vitro and in vivo. Treatment of splenocytes from young, middle-aged and old F344 rats with various doses of brahmi (Bacopa monnieri) and noni (Morinda citrifolia) fruit juice or oral feeding of these compounds showed significant immunomodulatory effects in the middle-aged and old rats through modulation of MAPK signaling cascades. Finally we have also looked at the role of spirituality as a neuroendocrine-immune modulator in breast cancer patients exerting beneficial effects possibly through norepinephrine-mediated signals thereby adopting an integrative approach to cancer research. –Hannah P. Priyanka.

Primary Affiliation: Institute of Advanced Research in Health Sciences, Tamil Nadu Govt Multi Super Speciality Hospital - Chennai, Tamil Nadu , India

Specialties:

Additional Specialties:

Research Interests:


View Dr. Hannah P Priyanka’s Resume / CV

Education

Apr 2015
SRM University
Ph.D.

Experience

Aug 2015
DST INSPIRE FACULTY AWARD
DST INSPIRE FACULTY
TNGMSSH, Chennai

Publications

15Publications

91Reads

364Profile Views

46PubMed Central Citations

Estrogen-induced neuroimmunomodulation as facilitator of and barrier to reproductive aging in brain and lymphoid organs.

J Chem Neuroanat 2019 Jan 2;95:6-12. Epub 2018 Mar 2.

Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.jchemneu.2018.02.008DOI Listing
January 2019
4 Reads
2.520 Impact Factor

Noni (Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats.

J Integr Med 2018 05 12;16(3):199-207. Epub 2018 Apr 12.

Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur 603203, Tamil Nadu, India. Electronic address:

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http://dx.doi.org/10.1016/j.joim.2018.04.002DOI Listing
May 2018
4 Reads

Interrelationship between Mini-Mental State Examination scores and biochemical parameters in patients with mild cognitive impairment and Alzheimer's disease.

Geriatr Gerontol Int 2017 Oct 6;17(10):1737-1745. Epub 2016 Dec 6.

Integrative Medicine Laboratory, Department of Biotechnology, SRM University, Kattankulathur, Tamil Nadu, India.

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http://dx.doi.org/10.1111/ggi.12957DOI Listing
October 2017
5 Reads
1 Citation

Phytochemicals in Morinda citrifolia fruit selectively modulate age-associated immunity and antioxidant enzyme activities through ERK pathway in splenic lymphocytes of male F344 rats.

J Recept Signal Transduct Res 2016 8;36(2):139-51. Epub 2015 Oct 8.

a Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM University , Kattankulathur , Tamil Nadu , India and.

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http://dx.doi.org/10.3109/10799893.2015.1061001DOI Listing
November 2016
5 Reads
2.280 Impact Factor

Estrogen-induced neuroprotective and anti-inflammatory effects are dependent on the brain areas of middle-aged female rats.

Brain Res Bull 2016 06 27;124:238-53. Epub 2016 May 27.

Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603203, Tamil Nadu, India. Electronic address:

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http://dx.doi.org/10.1016/j.brainresbull.2016.05.015DOI Listing
June 2016
9 Reads
2 Citations
2.720 Impact Factor

Estrogen upregulates inflammatory signals through NF-κB, IFN-γ, and nitric oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats.

Int Immunopharmacol 2015 Dec 3;29(2):591-598. Epub 2015 Oct 3.

Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamil Nadu, India. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2015.09.024DOI Listing
December 2015
8 Reads
5 Citations
2.472 Impact Factor

Estrogen modulates β2-adrenoceptor-induced cell-mediated and inflammatory immune responses through ER-α involving distinct intracellular signaling pathways, antioxidant enzymes, and nitric oxide.

Cell Immunol 2014 Nov-Dec;292(1-2):1-8. Epub 2014 Aug 20.

Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamil Nadu, India. Electronic address:

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http://dx.doi.org/10.1016/j.cellimm.2014.08.001DOI Listing
February 2015
9 Reads
1 Citation
1.924 Impact Factor

Estrogen modulates neural-immune interactions through intracellular signaling pathways and antioxidant enzyme activity in the spleen of middle-aged ovariectomized female rats.

J Neuroimmunol 2014 Feb 12;267(1-2):7-15. Epub 2013 Nov 12.

Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603203, Tamil Nadu, India. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2013.11.003DOI Listing
February 2014
11 Reads
2.470 Impact Factor

Estrogen modulates in vitro T cell responses in a concentration- and receptor-dependent manner: effects on intracellular molecular targets and antioxidant enzymes.

Mol Immunol 2013 Dec 1;56(4):328-39. Epub 2013 Aug 1.

Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603203 Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.molimm.2013.05.226DOI Listing
December 2013
6 Reads
12 Citations
2.973 Impact Factor

Selective modulation of lymphoproliferation and cytokine production via intracellular signaling targets by α1- and α2-adrenoceptors and estrogen in splenocytes.

Int Immunopharmacol 2013 Nov 19;17(3):774-84. Epub 2013 Sep 19.

Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.intimp.2013.08.020DOI Listing
November 2013
5 Reads
1 Citation
2.472 Impact Factor

Menstrual cycle and reproductive aging alters immune reactivity, NGF expression, antioxidant enzyme activities, and intracellular signaling pathways in the peripheral blood mononuclear cells of healthy women.

Brain Behav Immun 2013 Aug 27;32:131-43. Epub 2013 Mar 27.

Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.bbi.2013.03.008DOI Listing
August 2013
9 Reads
6 Citations
5.890 Impact Factor

Diverse age-related effects of Bacopa monnieri and donepezil in vitro on cytokine production, antioxidant enzyme activities, and intracellular targets in splenocytes of F344 male rats.

Int Immunopharmacol 2013 Feb 17;15(2):260-74. Epub 2012 Dec 17.

Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamil Nadu, India.

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http://dx.doi.org/10.1016/j.intimp.2012.11.018DOI Listing
February 2013
7 Reads
1 Citation
2.472 Impact Factor

Bacopa monnieri and L-deprenyl differentially enhance the activities of antioxidant enzymes and the expression of tyrosine hydroxylase and nerve growth factor via ERK 1/2 and NF-κB pathways in the spleen of female wistar rats.

Neurochem Res 2013 Jan 18;38(1):141-52. Epub 2012 Oct 18.

Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamil Nadu, India.

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http://dx.doi.org/10.1007/s11064-012-0902-2DOI Listing
January 2013
4 Reads
7 Citations
2.593 Impact Factor

Bidirectional communication between the neuroendocrine system and the immune system: relevance to health and diseases.

Ann Neurosci 2012 Jan;19(1):40-6

Integrative Medicine Laboratory, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603203, Tamil Nadu.

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http://dx.doi.org/10.5214/ans.0972.7531.180410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117073PMC
January 2012
5 Reads
10 Citations