Publications by authors named "Hannah Levavi"

2 Publications

  • Page 1 of 1

A Novel t(1;9)(p36;p24.1) JAK2 Translocation and Review of the Literature.

Acta Haematol 2019 7;142(2):105-112. Epub 2019 May 7.

Departments of Medicine and Pathology, Tumor Cytogenomics, Icahn School of Medicine at Mount Sinai Hospital, New York, New York, USA,

The JAK2V617F point mutation has been implicated in the pathogenesis of the vast majority of myeloproliferative neoplasms (MPNs), but translocations involving JAK2 have increasingly been identified in patients with JAK2V617F-negativeMPNs. Here, we present a case of a patient diagnosed with JAK2V617F-negativepolycythemia vera (PV) that transformed to the MPN-blast phase. Cytogenetic and FISH analysis revealed a novel translocation of t(1;9)(p36;p24.1), causing a PEX14-JAK2 gene fusion product. The t(1;9)(p36;p24.1) represents a new addition to the list of known translocations involving JAK2that have been identified in hematologic malignancies. Although the prognostic and treatment implications of JAK2 translocations in MPNs have not been elucidated, positive outcomes have been described in case reports describing the use of JAK inhibitors in these patients. Further research into the role of JAK2 translocations in the pathogenesis and outcomes of hematologic malignancies is warranted.
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http://dx.doi.org/10.1159/000498945DOI Listing
February 2020

Retrospective analysis of thiamine deficiency in allogeneic stem cell transplant patients.

Ann Hematol 2019 Jun 3;98(6):1499-1500. Epub 2018 Nov 3.

Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1007/s00277-018-3531-2DOI Listing
June 2019
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