Dr. Hani Harb, PhD - Boston Children's Hospital, Harvard Medical School - Division of Immunology

Dr. Hani Harb

PhD

Boston Children's Hospital, Harvard Medical School

Division of Immunology

Boston, MA | United States

Main Specialties: Allergy & Immunology

Additional Specialties: Immunology, Epigenetics, Allergolgy,

ORCID logohttps://orcid.org/0000-0001-8218-2538


Top Author

Dr. Hani Harb, PhD - Boston Children's Hospital, Harvard Medical School - Division of Immunology

Dr. Hani Harb

PhD

Introduction

I am an immunologist. I work as a Research Fellow at Boston Children's Hospital, Harvard Medical School, Boston, USA. My area of research is Asthma, Allergy and epigenetics. I study the role of fine particulate matter from diesel exhaust on airway inflammation trying to find novel biomarkers and deep mechanisms of actions, all in the context of IL-4ra mutations that are predominant in african americans.

furthermore, i study epigenetic mechanisms underlying these changes.

I look always for the next jump in my career both on the scientific as well as the managmental level.

Primary Affiliation: Boston Children's Hospital, Harvard Medical School - Boston, MA , United States

Specialties:

Additional Specialties:

Research Interests:


View Dr. Hani Harb’s Resume / CV

Education

Mar 2016
Philipps University Marburg
PhD. Immunology and Epigenetics
Suma Com Laude
Jul 2011
Philipps University Marburg
Msc. Infectious Biology
77%
Feb 2006
Amman University
Bsc. Pharmacy
84%

Experience

Apr 2017
Research Fellow
Fellow
Mar 2016
Research Assistant
Researcher
Aug 2011
Junior Research Assistant
Researcher
Aug 2011
Junior Research Assistant
Researcher

Publications

24Publications

584Reads

3446Profile Views

179PubMed Central Citations

Treatment of severe persistent asthma with IL-6 receptor blockade.

J Allergy Clin Immunol Pract 2019 Mar 15. Epub 2019 Mar 15.

Division of Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2019.02.043DOI Listing
March 2019

Histone Acetylation of Immune Regulatory Genes in Human Placenta in Association with Maternal Intake of Olive Oil and Fish Consumption.

Int J Mol Sci 2019 03 1;20(5). Epub 2019 Mar 1.

Institute of Laboratory Medicine, member of the German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center (UGMLC), and the inVIVO Planetary Health, Group of the Worldwide Universities Network (WUN), Philipps-University Marburg, 35043 Marburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20051060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429118PMC
March 2019
3 Reads
2.862 Impact Factor

A Jagged 1-Notch 4 molecular switch mediates airway inflammation induced by ultrafine particles.

J Allergy Clin Immunol 2018 Oct 5;142(4):1243-1256.e17. Epub 2018 Apr 5.

Division of Immunology, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Mass. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2018.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173656PMC
October 2018
148 Reads
1 Citation
11.480 Impact Factor

Histone modifications and their role in epigenetics of atopy and allergic diseases.

Allergy Asthma Clin Immunol 2018 23;14:39. Epub 2018 May 23.

1Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, Hans-Meerwein-Straße 3, 35043 Marburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13223-018-0259-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966915PMC
May 2018
7 Reads

Aberrant cognitive phenotypes and altered hippocampal BDNF expression related to epigenetic modifications in mice lacking the post-synaptic scaffolding protein SHANK1: Implications for autism spectrum disorder.

Hippocampus 2017 08 29;27(8):906-919. Epub 2017 May 29.

Behavioral Neuroscience, Experimental and Biological Psychology, Philipps-University of Marburg, Marburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hipo.22741DOI Listing
August 2017
37 Reads
1 Citation
4.162 Impact Factor

Chronic schistosomiasis during pregnancy epigenetically reprograms T-cell differentiation in offspring of infected mothers.

Eur J Immunol 2017 05 11;47(5):841-847. Epub 2017 Apr 11.

Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201646836DOI Listing
May 2017
33 Reads
1 Citation
4.034 Impact Factor

Epigenetics and allergy: from basic mechanisms to clinical applications.

Epigenomics 2017 04 21;9(4):539-571. Epub 2017 Mar 21.

Laboratory for Epigenetics & Environment, Centre National de Génotypage, CEA-Institut de Génomique, Evry, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/epi-2016-0162DOI Listing
April 2017
60 Reads
6 Citations

The role of PKCζ in cord blood T-cell maturation towards Th1 cytokine profile and its epigenetic regulation by fish oil.

Biosci Rep 2017 04 27;37(2). Epub 2017 Mar 27.

Department of Immunopathology, SA Pathology, Women and Children's Hospital Campus, School of Medicine; Robinson Research Institute and School of Biological Science, University of Adelaide, Adelaide, South Australia, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BSR20160485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482199PMC
April 2017
27 Reads
3 Citations
2.640 Impact Factor

The Role of Histone Protein Modifications and Mutations in Histone Modifiers in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia.

Cancers (Basel) 2017 Jan 3;9(1). Epub 2017 Jan 3.

Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz, Lodz 91-738, Poland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cancers9010002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295773PMC
January 2017
24 Reads
3 Citations

Recent developments in epigenetics of pediatric asthma.

Curr Opin Pediatr 2016 12;28(6):754-763

aInstitute for Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University Marburg, Marburg, Germany bJohn Paul II Hospital, Krakow, Poland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOP.0000000000000424DOI Listing
December 2016
25 Reads
5 Citations
2.530 Impact Factor

Draft Genome Sequence and Complete Plasmid Sequence of Acinetobacter lwoffii F78, an Isolate with Strong Allergy-Protective Properties.

Genome Announc 2016 Jul 21;4(4). Epub 2016 Jul 21.

Institute for Medical Microbiology, German Centre for Infection Research (DZIF Partner Site Giessen-Marburg-Langen), Justus-Liebig-University Giessen, Giessen, Germany

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/genomeA.00685-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956450PMC
July 2016
12 Reads

Epigenetic Regulation in Early Childhood: A Miniaturized and Validated Method to Assess Histone Acetylation.

Int Arch Allergy Immunol 2015 21;168(3):173-81. Epub 2016 Jan 21.

Institute of Laboratory Medicine, Pathobiochemistry and Molecular Diagnostics, Philipps University Marburg, Marburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000442158DOI Listing
June 2016
25 Reads
5 Citations
2.673 Impact Factor

Childhood allergic asthma is associated with increased IL-13 and FOXP3 histone acetylation.

J Allergy Clin Immunol 2015 Jul 11;136(1):200-2. Epub 2015 Mar 11.

Department of Pulmonary and Allergy, University Children's Hospital Munich, LMU, Munich, Germany; German Center for Lung Research (DZL), Munich, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2015.01.027DOI Listing
July 2015
11 Reads
5 Citations
11.480 Impact Factor

Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis.

Mucosal Immunol 2015 Mar 6;8(2):307-15. Epub 2014 Aug 6.

1] Institute for Medical Microbiology and Hygiene, Philipps University of Marburg, Marburg, Germany [2] Max Planck Institute for Infection Biology, Department of Immunology, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mi.2014.68DOI Listing
March 2015
8 Reads
2 Citations
7.374 Impact Factor

Update on epigenetics in allergic disease.

J Allergy Clin Immunol 2015 Jan;135(1):15-24

Institute for Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps-Universität Marburg, Marburg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2014.11.009DOI Listing
January 2015
27 Reads
11 Citations
11.480 Impact Factor

Epigenetics in immune development and in allergic and autoimmune diseases.

J Reprod Immunol 2014 Oct 30;104-105:43-8. Epub 2014 Jun 30.

Childhood Allergy and Immunology Research, School of Paediatrics and Child Health, University of Western Australia, Australia; Telethon Kids Institute, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jri.2014.05.003DOI Listing
October 2014
7 Reads
4 Citations
2.820 Impact Factor

Genome-wide DNA methylation profiling identifies a folate-sensitive region of differential methylation upstream of ZFP57-imprinting regulator in humans.

FASEB J 2014 Sep 2;28(9):4068-76. Epub 2014 Jun 2.

School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.13-249029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395735PMC
September 2014
14 Reads
20 Citations
5.043 Impact Factor

Bioavailability and allergoprotective capacity of milk-associated conjugated linoleic acid in a murine model of allergic airway inflammation.

Int Arch Allergy Immunol 2014 1;163(3):234-42. Epub 2014 Mar 1.

Institute for Laboratory Medicine, Pathobiochemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000358523DOI Listing
May 2014
13 Reads
1 Citation
2.673 Impact Factor

Farm-derived Gram-positive bacterium Staphylococcus sciuri W620 prevents asthma phenotype in HDM- and OVA-exposed mice.

Allergy 2013 Mar 1;68(3):322-9. Epub 2013 Feb 1.

Institute for Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Marburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/all.12094DOI Listing
March 2013
10 Reads
9 Citations
6.030 Impact Factor

Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes.

J Allergy Clin Immunol 2011 Sep 15;128(3):618-25.e1-7. Epub 2011 Jun 15.

Department of Clinical Chemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2011.04.035DOI Listing
September 2011
14 Reads
34 Citations
11.480 Impact Factor

Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma.

J Exp Med 2009 Sep 21;206(10):2191-204. Epub 2009 Sep 21.

Division of Immunology, Allergy, and Rheumatology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20091480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757875PMC
September 2009
17 Reads
26 Citations
12.520 Impact Factor

Top co-authors

Harald Renz
Harald Renz

Department of Clinical Chemistry and Molecular Diagnostics

16
Daniel P Potaczek
Daniel P Potaczek

Juntendo University School of Medicine

6
Holger Garn
Holger Garn

Philipps University of Marburg

6
Manori Amarasekera
Manori Amarasekera

School of Paediatrics and Child Health

4
Susan L Prescott
Susan L Prescott

University of Western Australia

4
David Martino
David Martino

University of Western Australia

3
Charles S Hii
Charles S Hii

Women's and Children's Hospital

2