Publications by authors named "Hang Zhao"

296 Publications

Observation of the fine structure of antennal sensilla of the stink bug, Eocanthecona furcellata (Hemiptera: Pentatomidae).

Micron 2021 Aug 28;150:103143. Epub 2021 Aug 28.

College of Plant Protection, Yunnan Agricultural University, Kunming, Yunnan, 650201, China. Electronic address:

In order to explore the mechanism underlying chemosensation in Eocanthecona furcellata, the external morphology of its antennae and the type, quantity, distribution and ultrastructure of the sensilla were observed on both sexes of adults and 5th-instar nymphs using scanning electron microscopy. The results showed that the antennae of E. furcellata consisted of three parts: scape, pedicel and flagellum. There were five types of sensilla on the antennae, which included sensilla trichoidea (ST), sensilla chaetica (SCh), sensilla coeloconica (SCo), sensilla basiconica (SB) and squamifornia denticles (SD). Further, there were 4 subtypes of ST and SB and 2 subtypes of SCo and SCh. The number of sensilla on nymphs was significantly lower than that on adults. The antennae of adults showed sexual dimorphism, as the number of sensilla on female adults was higher than that on male adults. SB4 was found only on females and SCo2 was found only on males. These inter-sexual differences may be related to chemoreception of sex pheromone and chemical predation location. The morphology and putative functions of each sensilla were compared and discussed. These results provide a reference for further study of the behavioral biology, chemical ecology and electrophysiology of insects, and also provides a scientific basis for new ways of biological control.
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http://dx.doi.org/10.1016/j.micron.2021.103143DOI Listing
August 2021

Biomaterial Cues Regulated Differentiation of Neural Stem Cells into GABAergic Neurons through Ca/c-Jun/TLX3 Signaling Promoted by Hydroxyapatite Nanorods.

Nano Lett 2021 09 23;21(17):7371-7378. Epub 2021 Aug 23.

State Key Laboratory of Crystal Materials, Shandong University, Jinan, Shandong 250100, China.

Directed differentiation enables the production of a specific cell type by manipulating signals in development. However, there is a lack of effective means to accelerate the regeneration of neurons of particular subtypes for pathogenesis and clinical therapy. In this study, we find that hydroxyapatite (HAp) nanorods promote neural differentiation of neural stem cells due to their chemical compositions. Lysosome-mediated degradation of HAp nanorods elevates intracellular calcium concentrations and accelerates GABAergic neurogenesis. As a mechanism, the enhanced activity of a Ca peak initiated by HAp nanorods leads to the activation of c-Jun and thus suppresses the expression of GABAergic/glutamatergic selection gene TLX3. We demonstrate the capability of HAp nanorods in promoting the differentiation into GABAergic neurons at both molecular and cellular function levels. Given that GABAergic neurons are responsible for various physiological and pathological processes, our findings open up enormous opportunities in efficient and precise stem cell therapy of neurodegenerative diseases.
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http://dx.doi.org/10.1021/acs.nanolett.1c02708DOI Listing
September 2021

[Advances in olfactory ensheathing cells for the treatment of spinal cord injury].

Zhongguo Gu Shang 2021 Aug;34(8):785-90

The Second Department of Orthopaedics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, Shaanxi, China.

Spinal cord injury is a highly disabled neurological disease, and there is still a lack of effective treatments. Studies have proved that olfactory ensheathing cells are one of the ideal seed cells for promoting nerve regeneration after spinal cord injury. Olfactory ensheathing cells can promote axonal germination and elongation through secretion, interaction with astrocytes, regulation of inflammatory reaction, migration characteristics, myelination, anti-oxidation, lipid regulation and other channels. Thus olfactory ensheathing cells play the role of neuroprotection and nerve repair. In recent years, some studies have used bioengineering, tissue engineering, reprogramming and other technologies to enhance the efficacy of olfactoryensheathing cells from different aspects, thereby providing new therapeutic strategies for optimizing the cell therapy of spinal cord injury. This article will summarize the mechanism of olfactory ensheathing cells in repairing spinal cord injury, and review the progress of optimizing strategy of olfactory ensheathing cells in treating spinal cord injury recently, so as to provide new research ideas for the further developing the repair potential of olfactory ensheathing cells and optimize the cell therapy effect of spinal cord injury.
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http://dx.doi.org/10.12200/j.issn.1003-0034.2021.08.018DOI Listing
August 2021

Accumulation of formaldehyde causes motor deficits in an in vivo model of hindlimb unloading.

Commun Biol 2021 08 19;4(1):933. Epub 2021 Aug 19.

Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China.

During duration spaceflight, or after their return to earth, astronauts have often suffered from gait instability and cerebellar ataxia. Here, we use a mouse model of hindlimb unloading (HU) to explore a mechanism of how reduced hindlimb burden may contribute to motor deficits. The results showed that these mice which have experienced HU for 2 weeks exhibit a rapid accumulation of formaldehyde in the gastrocnemius muscle and fastigial nucleus of cerebellum. The activation of semicarbazide-sensitive amine oxidase and sarcosine dehydrogenase induced by HU-stress contributed to formaldehyde generation and loss of the abilities to maintain balance and coordinate motor activities. Further, knockout of formaldehyde dehydrogenase (FDH) in mice caused formaldehyde accumulation in the muscle and cerebellum that was associated with motor deficits. Remarkably, formaldehyde injection into the gastrocnemius muscle led to gait instability; especially, microinfusion of formaldehyde into the fastigial nucleus directly induced the same symptoms as HU-induced acute ataxia. Hence, excessive formaldehyde damages motor functions of the muscle and cerebellum.
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http://dx.doi.org/10.1038/s42003-021-02448-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376875PMC
August 2021

Formaldehyde-Crosslinked Nontoxic Aβ Monomers to Form Toxic Aβ Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives.

ChemMedChem 2021 Aug 16. Epub 2021 Aug 16.

Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, School of Mental Health, Wenzhou Medical University, Wenzhou, 325035, China.

Alzheimer's disease (AD) is characterized by the presence of senile plaques in the brain. However, medicines targeting amyloid-beta (Aβ) have not achieved the expected clinical effects. This review focuses on the formation mechanism of the Aβ dimer (the basic unit of oligomers and fibrils) and its tremendous potential as a drug target. Recently, age-associated formaldehyde and Aβ-derived formaldehyde have been found to crosslink the nontoxic Aβ monomer to form the toxic dimers, oligomers and fibrils. Particularly, Aβ-induced formaldehyde accumulation and formaldehyde-promoted Aβ aggregation form a vicious cycle. Subsequently, formaldehyde initiates Aβ toxicity in both the early-and late-onset AD. These facts also explain why AD drugs targeting only Aβ do not have the desired therapeutic effects. Development of the nanoparticle-based medicines targeting both formaldehyde and Aβ dimer is a promising strategy for improving the drug efficacy by penetrating blood-brain barrier and extracellular space into the cortical neurons in AD patients.
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http://dx.doi.org/10.1002/cmdc.202100428DOI Listing
August 2021

Ultrafast hydrogen bond dynamics of liquid water revealed by terahertz-induced transient birefringence.

Light Sci Appl 2020 Aug 4;9(1):136. Epub 2020 Aug 4.

The Institute of Optics, University of Rochester, Rochester, NY, 14627, USA.

The fundamental properties of water molecules, such as their molecular polarizability, have not yet been clarified. The hydrogen bond network is generally considered to play an important role in the thermodynamic properties of water. The terahertz (THz) Kerr effect technique, as a novel tool, is expected to be useful in exploring the low-frequency molecular dynamics of liquid water. Here, we use an intense and ultrabroadband THz pulse (peak electric field strength of 14.9 MV/cm, centre frequency of 3.9 THz, and bandwidth of 1-10 THz) to resonantly excite intermolecular modes of liquid water. Bipolar THz field-induced transient birefringence signals are observed in a free-flowing water film. We propose a hydrogen bond harmonic oscillator model associated with the dielectric susceptibility and combine it with the Lorentz dynamic equation to investigate the intermolecular structure and dynamics of liquid water. We mainly decompose the bipolar signals into a positive signal caused by hydrogen bond stretching vibration and a negative signal caused by hydrogen bond bending vibration, indicating that the polarizability perturbation of water presents competing contributions under bending and stretching conditions. A Kerr coefficient equation related to the intermolecular modes of water is established. The ultrafast intermolecular hydrogen bond dynamics of water revealed by an ultrabroadband THz pump pulse can provide further insights into the transient structure of liquid water corresponding to the pertinent modes.
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http://dx.doi.org/10.1038/s41377-020-00370-zDOI Listing
August 2020

Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling.

Mediators Inflamm 2021 14;2021:5571272. Epub 2021 Jul 14.

Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004 Liaoning Province, China.

Paraquat (PQ) can cause multiorgan failure including acute kidney injury (AKI). Our prior study showed that Toll-interacting protein (TOLLIP) protected against PQ-induced acute lung injury. However, the role of TOLLIP in PQ-induced AKI remains undefined. This study was aimed at understanding the role and mechanism of TOLLIP in AKI. Six-eight-week-old male Wistar rats were intraperitoneally injected with 25 mg/kg PQ to induce AKI for 24 h . HK-2 cells were treated with 300 M PQ for 24 h to induce cellular injury or 300 M PQ and 5 M nuclear factor-B (NF-B) inhibitor BAY11-7082 for 24 h. Rats were infected with adenovirus carrying TOLLIP shRNA via tail vein injection and HK-2 cells with adenovirus carrying TOLLIP shRNA or TOLLIP 48 h before PQ exposure. Results showed that TOLLIP and Toll-like receptor 2/4 (TLR2/4) expressions were boosted in the kidney after PQ intoxication. The toxic effect of PQ on the kidney and HK-2 cells was exacerbated by TOLLIP knockdown, as evidenced by aggravated glomerulus and tubule injury, inflammatory infiltration, and cell apoptosis in the kidney and increased loss of cell viability and apoptotic cells in HK-2 cells. TOLLIP knockdown also enhanced PQ-induced NLR family pyrin domain-containing 3 (NLRP3) inflammasome activation and and TLR2/4-NF-B signaling , reflected by increased contents of proinflammatory cytokines and expressions of NLRP3 inflammasome-related proteins in the kidney and HK-2 cells and expressions of TLR2, TLR4, and nuclear NF-B p65 in HK-2 cells. However, TOLLIP overexpression inhibited PQ-induced loss of cell viability, cell apoptosis, NLRP3 inflammasome activation, and TLR2/4-NF-B signaling . Additionally, BAY11-7082 abolished TOLLIP knockdown-induced NLRP3 inflammasome activation , indicating that TOLLIP protected against NLRP3 inflammasome activation in PQ-induced AKI through inhibiting TLR2/4-NF-B signaling. This study highlights the importance of TOLLIP in AKI after PQ intoxication.
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http://dx.doi.org/10.1155/2021/5571272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8298172PMC
July 2021

Modeling Two Dimensional Touch Pointing.

Proc ACM Symp User Interface Softw Tech 2020 Oct 20;2020:858-868. Epub 2020 Oct 20.

Department of Computer Science, Stony Brook University, Stony Brook, NY, United States.

Modeling touch pointing is essential to touchscreen interface development and research, as pointing is one of the most basic and common touch actions users perform on touchscreen devices. Finger-Fitts Law [4] revised the conventional Fitts' law into a 1D (one-dimensional) pointing model for finger touch by explicitly accounting for the fat finger ambiguity (absolute error) problem which was unaccounted for in the original Fitts' law. We generalize Finger-Fitts law to 2D touch pointing by solving two critical problems. First, we extend two of the most successful 2D Fitts law forms to accommodate finger ambiguity. Second, we discovered that using nominal target width and height is a conceptually simple yet effective approach for defining amplitude and directional constraints for 2D touch pointing across different movement directions. The evaluation shows our derived 2D Finger-Fitts law models can be both principled and powerful. Specifically, they outperformed the existing 2D Fitts' laws, as measured by the regression coefficient and model selection information criteria (e.g., Akaike Information Criterion) considering the number of parameters. Finally, 2D Finger-Fitts laws also advance our understanding of touch pointing and thereby serve as the basis for touch interface designs.
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http://dx.doi.org/10.1145/3379337.3415871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318005PMC
October 2020

A biocompatible theranostic agent based on stable bismuth nanoparticles for X-ray computed tomography/magnetic resonance imaging-guided enhanced chemo/photothermal/chemodynamic therapy for tumours.

J Colloid Interface Sci 2021 Jul 1;604:80-90. Epub 2021 Jul 1.

College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China. Electronic address:

Cancer is a leading cause of death worldwide and seriously threatens the health of humans. The current clinical treatments for cancer are not efficient and always lead to significant side effects. Herein, a biocompatible and powerful theranostic agent ([email protected]@MnO/DOX) is fabricated using a facile stepwise reaction method. The Bi nanoparticles (NPs) are coated by mesoporous silica to protect the Bi NPs from oxidation, which guarantees the stable photothermal effect of the Bi NPs. When the [email protected]@MnO/DOX nanocomposites (NCs) accumulate in the tumour site, hyperthermia is generated by Bi NPs under near-infrared (NIR) light irradiation for photothermal therapy (PTT), and the generated heat triggers the release of DOX for chemotherapy in the tumour. In addition, the MnO of the NCs responsively catalyses endogenous HO to generate O, raising the oxygen level to enhance the effect of chemotherapy in the tumour microenvironment (TME), and consumes glutathione (GSH) to produce Mn for magnetic resonance (MR) imaging. Under acidic TME conditions, HO and Mn also produce toxic hydroxyl radical (·OH) for chemodynamic therapy (CDT). Furthermore, the Bi NPs can also be used as excellent contrast agents for X-ray computed tomography (CT) imaging of tumours with a high CT value (6.865 HU mM). The [email protected]@MnO/DOX NCs exhibit a powerful theranostic performance for CT/MR imaging-guided enhanced PTT/CDT/chemotherapy, which opens a new prospect to rationally design theranostic agents for tumour imaging.
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http://dx.doi.org/10.1016/j.jcis.2021.06.174DOI Listing
July 2021

Quantitative observation of monochromatic X-rays emitted from implosion hotspot in high spatial resolution in inertial confinement fusion.

Sci Rep 2021 Jul 14;11(1):14492. Epub 2021 Jul 14.

Research Center of Laser Fusion, China Academy of Engineering Physics, Mianyang, 621900, China.

In inertial confinement fusion, quantitative and high-spatial resolution ([Formula: see text]m) measurements of the X-rays self-emitted by the hotspot are critical for studying the physical processes of the implosion stagnation stage. Herein, the 8 ± 0.39-keV monochromatic X-ray distribution from the entire hotspot is quantitatively observed in 5-[Formula: see text]m spatial resolution using a Kirkpatrick-Baez microscope, with impacts from the responses of the diagnosis system removed, for the first time, in implosion experiments at the 100 kJ laser facility in China. Two-dimensional calculations along with 2.5% P2 drive asymmetry and 0.3 ablator self-emission are congruent with the experimental results, especially for the photon number distribution, hotspot profile, and neutron yield. Theoretical calculations enabled a better understanding of the experimental results. Furthermore, the origins of the 17.81% contour profile of the deuterium-deuterium hotspot and the accurate Gaussian source approximation of the core emission area in the implosion capsule are clarified in detail. This work is significant for quantitatively exploring the physical conditions of the hotspot and updating the theoretical model of capsule implosion.
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http://dx.doi.org/10.1038/s41598-021-93482-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280192PMC
July 2021

FNDC5/Irisin attenuates diabetic cardiomyopathy in a type 2 diabetes mouse model by activation of integrin αV/β5-AKT signaling and reduction of oxidative/nitrosative stress.

J Mol Cell Cardiol 2021 Jul 3;160:27-41. Epub 2021 Jul 3.

Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China. Electronic address:

Irisin, the cleaved form of the fibronectin type III domain containing 5 (FNDC5) protein, is involved in metabolism and inflammation. Recent findings indicated that irisin participated in cardiovascular physiology and pathology. In this study, we investigated the effects of FNDC5/irisin on diabetic cardiomyopathy (DCM) in type 2 diabetic db/db mice. Downregulation of myocardial FNDC5/irisin protein expression and plasma irisin levels was observed in db/db mice compared to db/+ controls. Moreover, echocardiography revealed that db/db mice exhibited normal cardiac systolic function and impaired diastolic function. Adverse structural remodeling, including cardiomyocyte apoptosis, myocardial fibrosis, and cardiac hypertrophy were observed in the hearts of db/db mice. Sixteen-week-old db/db mice were intramyocardially injected with adenovirus encoding FNDC5 or treated with recombinant human irisin via a peritoneal implant osmotic pump for 4 weeks. Both overexpression of myocardial FNDC5 and exogenous irisin administration attenuated diastolic dysfunction and cardiac structural remodeling in db/db mice. Results from in vitro studies revealed that FNDC5/irisin protein expression was decreased in high glucose (HG)/high fat (HF)-treated cardiomyocytes. Increased levels of inducible nitric oxide synthase (iNOS), NADPH oxidase 2 (NOX2), 3-nitrotyrosine (3-NT), reactive oxygen species (ROS), and peroxynitrite (ONOO) in HG/HF-treated H9C2 cells provided evidence of oxidative/nitrosative stress, which was alleviated by treatment with FNDC5/irisin. Moreover, the mitochondria membrane potential (ΔΨm) was decreased and cytochrome C was released from mitochondria with increased levels of cleaved caspase-3 in HG/HF-treated H9C2 cells, indicating the presence of mitochondria-dependent apoptosis, which was partially reversed by FNDC5/irisin treatment. Mechanistic studies showed that activation of integrin αVβ5-AKT signaling and attenuation of oxidative/nitrosative stress were responsible for the cardioprotective effects of FNDC5/irisin. Therefore, FNDC5/irisin mediates cardioprotection in DCM by inhibiting myocardial apoptosis, myocardial fibrosis, and cardiac hypertrophy. These findings implicate that FNDC5/irisin as a potential therapeutic intervention for DCM, especially in type 2 diabetes mellitus (T2DM).
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http://dx.doi.org/10.1016/j.yjmcc.2021.06.013DOI Listing
July 2021

[Water use characteristics of artificial sand-fixing vegetation on the southern edge of Hunshandake Sandy Land, Inner Mongolia, China].

Ying Yong Sheng Tai Xue Bao 2021 Jun;32(6):1980-1988

Institute of Water Conservancy and Civil Engineering, Inner Mongolia Agricultural University, Hohhot 010018, China.

We examined the characteristics of water use in typical tree species of arbor and shrub in Hunshandake Sandy Land, and , in the different seasons, with the aim to provide theoretical basis for the structural optimization of the artificial shelterbelt. Samples of precipitation, soil water, groundwater and stem water of the two vegetation were collected, and their distribution characteristics of δD-δO were analyzed by hydrogen and oxygen stable isotope technology. The contribution rate of these potential water source to the arbor and shrub species were calculated using multi-source linear mixing model. The precipitation equation line in the study area was δ=7.84δ+9.12, while soil moisture lines in the dry and wet season were δ=3.56δ-41.28 and δ=4.30δ-42.02, respectively. The δD-δO of soil water and stem water in the two seasons were lower than the precipitation δD-δO, indicating that both of them were strongly affected by the evaporation. Soil water contents in the shallow layer were strongly affected by rainfall and evaporation, with substantial fluctuation. With the increases of soil depth, soil water content tended to be stable, and the hydrogen and oxygen isotope in each soil layer showed significant differences. In the dry season, mainly utilized soil water in 0-40 cm and 120-200 cm layers, with contribution rates of 50.2% and 31.5%, respectively. mainly absorbed soil water in 20-40 cm and 60-100 cm layers, and the contribution rates were 53.2% and 22.9%, respectively. In the wet season, the greatest contribution of soil water to was mainly in the 0-40 cm soil layer, accounting for 72.8%. was mainly in the 0-20 cm soil water, evenly utilized the deeper soil water and groundwater. Due to the differences in root depth and distribution of the arbor and shrub, their water use strategies differed in different seasons, which was conducive to the stability of the shelterbelt community and tree species coexistence in Hunshandake Sandy Land. We proposed that the mixed planting species with different root depth should be considered in the future planting of artificial shelterbelt, which would help rationally utilize water resources and maintain the stability of sandy land ecosystem.
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http://dx.doi.org/10.13287/j.1001-9332.202106.024DOI Listing
June 2021

Rapid prediction of deterioration risk among non-high-risk patients with acute pulmonary embolism at admission: An imaging tool.

Int J Cardiol 2021 09 15;338:229-236. Epub 2021 Jun 15.

Department of Emergency Medicine, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang, China. Electronic address:

Background: Computed tomography (CT) pulmonary angiography as the first-line diagnosis tool of acute pulmonary embolism (PE), might improve this discriminatory power. We aimed to developed a simply tool combining multi-CT parameters to complete individualized risk assessment of deterioration in non-high-risk patients with acute PE at admission.

Method: Consecutive non-high-risk patients with acute PE who were treated in a Chinese center during 2010-2021, were collected.Prognosis-related CT parameters were reviewed. Deterioration was defined as any adverse event within 30 day after admission. Eligible patients were randomized into derivation and validation cohorts. In the derivation cohort, CT parameters were screened for importance using classification tree methodology and enrolled variables was partitioned via curve-fitting and dose-response analysis. A nomogram was developed and the predictive power in both cohorts was evaluated based on the area under the receiver operating characteristic curve (AUROC) and the corresponding 95% confidence interval (CI).

Result: A total of 1001 patients were included. The preliminary analyses revealed that deterioration risk was related to the right-to-left ventricular diameter ratio at 4-chamber view, pulmonary vein filling abnormality. After a curve-fitting to deterioration risk, these parameters were partitioned and used to develop a nomogram, which had AUROC values of 0.91 (95% CI: 0.87-0.96) in the derivation cohort and 0.89 (95% CI: 0.81-0.97) in the validation cohort. A web-based version of the radiomics scoring tool was published online for use in clinical practice (https://acutepeprediction.shinyapps.io/Radiomics_Predictive_Tool/).

Conclusion: This simply tool can complete rapid estimation of deterioration risk among non-high-risk acute PE patients at admission.
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http://dx.doi.org/10.1016/j.ijcard.2021.06.013DOI Listing
September 2021

Preparation and bacteriostatic research of porous polyvinyl alcohol / biochar / nanosilver polymer gel for drinking water treatment.

Sci Rep 2021 Jun 9;11(1):12205. Epub 2021 Jun 9.

School of Chemistry and Chemical Engineering, Xi'an University of Architecture and Technology, Xi'an, 710055, Shaanxi, China.

Microbial contamination in drinking water has become an important threat to human health. There is thus an urgent need to develop antibacterial materials to treat drinking water. Here, porous silver-loaded biochar (C-Ag) was prepared using corn straw as the substrate and silver as the antibacterial agent. C-Ag was then uniformly distributed in polyvinyl alcohol gel beads of eluted calcium carbonate to prepare p-PVA/C-Ag antibacterial composite. The polymer composites were tested by FT-IR, XRD, SEM and TG-DSC. The results showed that C-Ag was more evenly distributed in the PVA gel spheres. Antibacterial experiments showed that p-PVA/C-Ag greatly inhibited Escherichia coli. Practical application tests revealed that p-PVA/C-Ag showed high and sustained bactericidal inhibition and reusability. Generally, p-PVA/C-Ag composite shows high potential to be applied to drinking water treatment.
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http://dx.doi.org/10.1038/s41598-021-91833-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190314PMC
June 2021

Specific and rapid reverse assaying protocol for detection and antimicrobial susceptibility testing of Pseudomonas aeruginosa based on dual molecular recognition.

Sci Rep 2021 May 27;11(1):11101. Epub 2021 May 27.

Zunyi Institute for Food and Drug Control, Zunyi, 563000, China.

The worldwide emergence and spread of antimicrobial resistance is accelerated by irrational administration and use of empiric antibiotics. A key point to the crisis is a lack of rapid diagnostic protocols for antimicrobial susceptibility testing (AST), which is crucial for a timely and rational antibiotic prescription. Here, a recombinant bacteriophage tail fiber protein (TFP) was functionalized on magnetic particles to specifically capture Pseudomonas aeruginosa, while fluorescein isothiocyanate-labeled-magainin II was utilized as the indicator. For solving the magnetic particles' blocking effects, a reverse assaying protocol based on TFP recognition was developed to investigate the feasibility of detection and AST of P. aeruginosa. P. aeruginosa can be rapidly, sensitively and specifically detected within 1.5 h with a linear range of 1.0 × 10 to 1.0 × 10 colony forming units (CFU)⋅mL and a detection limit of 3.3 × 10 CFU⋅mL. Subsequently, AST results, which were consistent with broth dilution results, can be obtained within 3.5 h. Due to the high specificity of the TFP, AST can actually be conducted without the need for bacterial isolation and identification. Based on the proof-of-principle work, the detection and AST of other pathogens can be extended by expressing the TFPs of their bacteriophages.
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http://dx.doi.org/10.1038/s41598-021-90619-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159986PMC
May 2021

Reduced O-GlcNAcylation of SNAP-23 promotes cisplatin resistance by inducing exosome secretion in ovarian cancer.

Cell Death Discov 2021 May 18;7(1):112. Epub 2021 May 18.

Department of Gynecology and Obstetrics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.

Exosomes have been associated with chemoresistance in various cancers, but such a role in ovarian cancer is not yet clear. Here, using in vitro cell-based and in vivo mouse model experiments, we show that downregulation of O-GlcNAcylation, a key post-translational protein modification, promotes exosome secretion. This increases exosome-mediated efflux of cisplatin from cancer cells resulting in chemoresistance. Mechanistically, our data indicate that downregulation of O-GlcNAclation transferase (OGT) reduces O-GlcNAclation of SNAP-23. Notably, O-GlcNAcylation of SNAP-23 is vital for regulating exosome release in ovarian cancer cells. Reduced O-GlcNAclation of SNAP-23 subsequently promotes the formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex consisting of SNAP-23, VAMP8, and Stx4 proteins. This enhances exosome release causing chemoresistance by increasing the efflux of intracellular cisplatin.
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http://dx.doi.org/10.1038/s41420-021-00489-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128872PMC
May 2021

Correction: TRIM27 contributes to glomerular endothelial cell injury in lupus nephritis by mediating the FoxO1 signaling pathway.

Lab Invest 2021 Aug;101(8):1110

Department of Pathology; Center of Metabolic Diseases and Cancer Research, Institute of Medical and Health Science, Hebei Medical University; Key Laboratory of Kidney Diseases of Hebei Province, Shijiazhuang, China.

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http://dx.doi.org/10.1038/s41374-021-00602-9DOI Listing
August 2021

Autophagy induction in tumor surrounding cells promotes tumor growth in adult Drosophila intestines.

Dev Biol 2021 Aug 1;476:294-307. Epub 2021 May 1.

College of Life Sciences, Capital Normal University, Beijing, 100048, China. Electronic address:

During tumorigenesis, tumor cells interact intimately with their surrounding cells (microenvironment) for their growth and progression. However, the roles of tumor microenvironment in tumor development and progression are not fully understood. Here, using an established benign tumor model in adult Drosophila intestines, we find that non-cell autonomous autophagy (NAA) is induced in tumor surrounding neighbor cells. Tumor growth can be significantly suppressed by genetic ablation of autophagy induction in tumor neighboring cells, indicating that tumor neighboring cells act as tumor microenvironment to promote tumor growth. Autophagy in tumor neighboring cells is induced downstream of elevated ROS and activated JNK signaling in tumor cells. Interestingly, we find that active transport of nutrients, such as amino acids, from tumor neighboring cells sustains tumor growth, and increasing nutrient availability could significantly restore tumor growth. Together, these data demonstrate that tumor cells take advantage of their surrounding normal neighbor cells as nutrient sources through NAA to meet their high metabolic demand for growth and progression. Thus we provide insights into our understanding of the mechanisms underlying the interaction between tumor cells and their microenvironment in tumor development.
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http://dx.doi.org/10.1016/j.ydbio.2021.04.008DOI Listing
August 2021

Thermosensitive Vesicles from Chemically Encoded Lipid-Grafted Elastin-like Polypeptides.

Angew Chem Int Ed Engl 2021 06 26;60(27):15036-15040. Epub 2021 May 26.

University of Bordeaux, CNRS, Bordeaux INP, LCPO, UMR 5629, 33600, Pessac, France.

Biomimetic design to afford smart functional biomaterials with exquisite properties represents synthetic challenges and provides unique perspectives. In this context, elastin-like polypeptides (ELPs) recently became highly attractive building blocks in the development of lipoprotein-based membranes. In addition to the bioengineered post-translational modifications of genetically encoded recombinant ELPs developed so far, we report here a simple and versatile method to design biohybrid brush-like lipid-grafted-ELPs using chemical post-modification reactions. We have explored a combination of methionine alkylation and click chemistry to create a new class of hybrid lipoprotein mimics. Our design allowed the formation of biomimetic vesicles with controlled permeability, correlated to the temperature-responsiveness of ELPs.
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http://dx.doi.org/10.1002/anie.202102807DOI Listing
June 2021

Vitamin D Status is Independently Associated with Insulin Resistance in Patients with Type 2 Diabetes Mellitus.

Risk Manag Healthc Policy 2021 7;14:1393-1399. Epub 2021 Apr 7.

Endocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, 050051, People's Republic of China.

Purpose: This study aimed to examine whether 25-hydroxyvitamin D (25OHD) levels (an indicator of vitamin D status) are independently associated with insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM).

Patients And Methods: This was a cross-sectional study. Participants with T2DM were recruited from the Department of Endocrinology in Hebei General Hospital according to inclusion and exclusion criteria. Data on basic characteristics and blood parameters were collected. We used the IR index (20/[fasting C-peptide × fasting plasma glucose]) to evaluate IR. Potential confounding factors were selected from comparisons among different IR index groups of quartiles and were adjusted in different models.

Results: We included 172 subjects (121 men and 51 women) whose mean age was 53.2±10.6 years. Body mass index (BMI), DM course, insulin use, glycated hemoglobin (HbA1c), fasting blood glucose, fasting C-peptide, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (ApoA1), and albumin were differed among different IR-index groups (all P value <0.05). In models 1 and 2, no or some confounding factors were adjusted for, and we found that there was no relationship between 25OHD and the IR index. In model 3, when all confounding factors (DM course, insulin use, BMI, HbA1c, TG, HDL-C, ApoA1, albumin and other bone turnover markers) were adjusted for, the IR index was increased by 5.6% when 25OHD levels increased by 1 ng/mL (odds ratio: 1.056; 95% confidence interval: 1.009, 1.105).

Conclusion: Vitamin D is independently associated with IR in patients with T2DM.
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http://dx.doi.org/10.2147/RMHP.S299963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039193PMC
April 2021

TRIM27 contributes to glomerular endothelial cell injury in lupus nephritis by mediating the FoxO1 signaling pathway.

Lab Invest 2021 08 14;101(8):983-997. Epub 2021 Apr 14.

Department of Pathology; Center of Metabolic Diseases and Cancer Research, Institute of Medical and Health Science, Hebei Medical University; Key Laboratory of Kidney Diseases of Hebei Province, Shijiazhuang, China.

Tripartite motif-containing 27 (TRIM27) belongs to the triple motif (TRIM) protein family, which plays a role in a variety of biological activities. Our previous study showed that the TRIM27 protein was highly expressed in the glomerular endothelial cells of patients suffering from lupus nephritis (LN). However, whether TRIM27 is involved in the injury of glomerular endothelial cells in lupus nephritis remains to be clarified. Here, we detected the expression of the TRIM27 protein in glomerular endothelial cells in vivo and in vitro. In addition, the influence of TRIM27 knockdown on endothelial cell damage in MRL/lpr mice and cultured human renal glomerular endothelial cells (HRGECs) was explored. The results revealed that the expression of TRIM27 in endothelial cells was significantly enhanced in vivo and in vitro. Downregulating the expression of TRIM27 inhibited the breakdown of the glycocalyx and the injury of endothelial cells via the FoxO1 pathway. Moreover, HRGECs transfected with the WT-FoxO1 plasmid showed a reduction in impairment caused by LN plasma. Furthermore, suppression of the protein kinase B (Akt) pathway could attenuate damage by mediating the expression of TRIM27. Thus, the present study showed that TRIM27 participated in the injury of glomerular endothelial cells and served as a potential therapeutic target for the treatment of lupus nephritis.
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http://dx.doi.org/10.1038/s41374-021-00591-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8044289PMC
August 2021

Meta-analysis of the effect of sodium-glucose cotransporter 2 inhibitors on hepatic fibrosis in patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease.

Hepatol Res 2021 Jun 28;51(6):641-651. Epub 2021 Apr 28.

Department of Endocrinology, Hebei General Hospital, Shijiazhuang, China.

Aim: This study aimed to analyze the effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on the indexes of liver fibrosis in patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease, and also to observe the effects on liver enzymes and liver fat.

Methods: This meta-analysis was performed using RevMan 5.3 statistical software.

Results: SGLT2 inhibitors could significantly reduce the level of hepatic fibrosis index: fibrosis-4 (mean difference [MD] 0.25, 95% CI -0.39 to -0.11, p = 0.0007); serum type Ⅳ collagen 7s (MD 0.32, 95% CI -0.59 to -0.04, p = 0.02); and ferritin (MD 26.7, 95% CI 50.64, 2.76, p = 0.03). SGLT2 inhibitors could significantly reduce the level of liver enzymes: alanine aminotransferase (MD 3.49, 95% CI -5.1 to 1.58, p < 0.0001); aspartate aminotransferase (MD 3.64, 95% CI -5.10 to -2.18, p < 0.00001); and glutamate aminotransferase (MD 7.13, 95% CI -12.95 to -1.32, p = 0.02). SGLT2 inhibitors could significantly reduce the level of liver fat: liver-to-spleen attenuation ratio (MD 0.16, 95% CI 0.10-0.22, p < 0.00001); magnetic resonance imaging proton density fat fraction (MD 1.97, 95% CI -3.49 to -0.45, p = 0.01); liver controlled attenuation parameter (MD 0.29, 95% CI -26.95 to -13.64, p < 0.00001); liver fat score (MD 0.55, 95% CI 1.04 to -0.05, p = 0.03); and liver fat index (MD 11.21, 95% CI -16.53 to -5.89, p < 0.0001).

Conclusion: SGLT2 inhibitors could improve liver fibrosis, liver enzymes, liver fat, and metabolic indexes in patients with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease.
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http://dx.doi.org/10.1111/hepr.13645DOI Listing
June 2021

The Predictive Value of Visceral Adiposity Index and Lipid Accumulation Index for Microalbuminuria in Newly Diagnosed Type 2 Diabetes Patients.

Diabetes Metab Syndr Obes 2021 11;14:1107-1115. Epub 2021 Mar 11.

Endocrinology Department, Hebei General Hospital, Shijiazhuang, 050051, People's Republic of China.

Purpose: This study aims to investigate the predictive value of visceral adiposity index (VAI) and lipid accumulation index (LAP) for microalbuminuria (MAU) in patients with newly diagnosed Type 2 diabetes (T2DM).

Patients And Methods: This study included 335 patients with newly diagnosed T2DM patients from Hebei General Hospital. All the patients aged from 18 to 65 years old include 226 males and 109 females. Patients information and blood indicators were Collected and calculated the LAP and VAI scores. All the patients were divided into males (group A) and females (group B), and these groups were then further subdivided into A1 group which arises microalbuminuria, and A2 group which does not. With the same method, women were divided into B1 group and B2 group.

Results: Baseline data analysis showed that LAP and VAI levels in A1 and B1 groups were significantly higher than those in A2 and B2 groups (P<0.05). Logistic regression analysis showed that fasting blood glucose, waist circumference, LAP, and VAI were independent risk factors for the occurrence of microalbuminuria in both males and females. ROC showed that the area under curve (AUC) of waist circumference, fasting blood glucose, LAP and VAI in male patients were 0.626, 0.676, 0.760 and 0.742, respectively, and in female patients were 0.703, 0.685, 0.787 and 0.764, respectively. In addition, the area under the curve of both LAP and VAI was higher in females than in males.

Conclusion: This study confirmed that both LAP and VAI had predictive values for the occurrence of urinary microalbumin in newly diagnosed T2DM patients. The predictive value was higher in the female group and the suggestion was more applicable to female patients.
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http://dx.doi.org/10.2147/DMSO.S302761DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961207PMC
March 2021

Fabrication of an injectable iron (III) crosslinked alginate-hyaluronic acid hydrogel with shear-thinning and antimicrobial activities.

Carbohydr Polym 2021 May 8;260:117777. Epub 2021 Feb 8.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, PR China. Electronic address:

The combination of alginate, hyaluronic acid and multivalent ions have been reported to form alginate-hyaluronic acid ionic-crosslinking hydrogels for biomedical applications. However, injectable alginate-hyaluronic acid ionic-crosslinking hydrogels with satisfactory shear-thinning property have rarely been reported. In this study, we successfully developed an ionic-crosslinked alginate-hyaluronic acid hydrogel by simple assembly of alginate-hyaluronic acid mixture and Fe complex. This hydrogel could fully recover within seconds after damaged, while displayed shear thinning behavior and good injectability which were contributed by the reversible and dynamic metal-ligand interactions formed via ferric ions and carboxyl groups of the polymers. Moreover, the local degradation of this hydrogel giving the hydrogel sustained ferric ions release property, of which led to potential long-term antibacterial activities against multiple types of bacteria including gram-negative Escherichia coli and gram-positive Staphylococcus aureus, as well as representative oral pathogenic bacteria Streptococcus mutans and Porphyromonas gingivalis.
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http://dx.doi.org/10.1016/j.carbpol.2021.117777DOI Listing
May 2021

Molecular epidemiology and genetic evolution of canine parvovirus in East China, during 2018-2020.

Infect Genet Evol 2021 06 25;90:104780. Epub 2021 Feb 25.

Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China; Key Laboratory for Veterinary Bio-Product Engineering, Ministry of Agriculture, Nanjing 210014, China. Electronic address:

Canine parvovirus type 2 (CPV-2) emerged in the late 1970s, which caused high rates of morbidity and mortality in dogs. In last decade, five genetic variants (CPV-2a, CPV-2b, CPV-2c, New CPV-2a, and New CPV-2b) were frequently reported in the dog population, and replaced the original CPV-2, rising widespread concerns. However, little is known about their recent genetic diversity and evolution. The aim of this study was to analyze the characteristics of the CPV-2 strains collected in East China from 2018 to 2020. The 57 CPV-2 strains were isolated from rectal swab samples (n=140). They belong to three different genotypes, based on VP2 protein amino acid sequence. The results revealed a high prevalence of CPV-2c (77.19%) compared to the New CPV-2a (5.26%) and New CPV-2b (17.54%) strains. Further analysis showed that nucleotide homology of the VP2 gene among the 57 CPV strains was 98.9%~100%, and the homology with 24 reference strains from different countries and regions was 98.1%~100%. The phylogenetic tree of VP2 gene sequence showed that 44 CPV-2c strains were distantly related to CPV-2, CPV-2a, CPV-2b, New CPV-2a, New CPV-2b and European/American CPV-2c strains, and were closely related to Asian CPV-2c strains. The results showed that these Asian CPV-2c strains had become the dominant strain, which renewed the knowledge of CPV-2 molecular epidemiology in East China.
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http://dx.doi.org/10.1016/j.meegid.2021.104780DOI Listing
June 2021

Long Non-coding RNA MIAT Knockdown Prevents the Formation of Intracranial Aneurysm by Downregulating ENC1 via MYC.

Front Physiol 2020 21;11:572605. Epub 2021 Jan 21.

Department of Gastroenterology, The First Hospital of China Medical University, Shenyang, China.

Intracranial aneurysm (IA) is vascular enlargement occurred on the wall of cerebral vessels and can result in fatal subarachnoid hemorrhage when ruptured. Recent studies have supported the important role of long non-coding RNAs (lncRNAs) in IA treatment. This study identified functional significance of lncRNA myocardial infarction associated transcript (MIAT) in IA. Myocardial infarction associated transcript and ectodermal-neural cortex 1 (ENC1) expression was detected by reverse transcription quantitative polymerase chain reaction. Cell counting kit 8 assay flow cytometry were conducted to detect cell viability and apoptosis of endothelial cells in IA. The interaction among MIAT, ENC1, and myelocytomatosis oncogene (MYC) was analyzed by RNA pull down, RNA immunoprecipitation assay, chromatin immunoprecipitation assay, and dual luciferase reporter assay. Intracranial aneurysm was induced by ligating the left carotid artery and the bilateral posterior branch of the renal artery in rats for studying the role of MIAT and ENC1 . Myocardial infarction associated transcript and ENC1 were upregulated in IA. Endothelial cells in IA presented a decreased cell viability and an increased apoptotic rate. Myocardial infarction associated transcript could regulate the expression of ENC1, and MYC could bind to the promoter region of ENC1. High expression of MIAT increased endothelial cell apoptosis and vascular endothelial injury, while MIAT knockdown was identified to reduce the risk of IA both and through regulating ENC1. To sum up, MIAT silencing is preventive for IA occurrence by decreasing the MYC-mediated ENC1 expression, which represents a novel therapeutic target for IA.
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http://dx.doi.org/10.3389/fphys.2020.572605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7860976PMC
January 2021

Automatic segmentation of coronary lumen and external elastic membrane in intravascular ultrasound images using 8-layer U-Net.

Biomed Eng Online 2021 Feb 6;20(1):16. Epub 2021 Feb 6.

ArteryFlow Technology Co., Ltd., Hangzhou, China.

Background: Intravascular ultrasound (IVUS) is the golden standard in accessing the coronary lesions, stenosis, and atherosclerosis plaques. In this paper, a fully automatic approach by an 8-layer U-Net is developed to segment the coronary artery lumen and the area bounded by external elastic membrane (EEM), i.e., cross-sectional area (EEM-CSA). The database comprises single-vendor and single-frequency IVUS data. Particularly, the proposed data augmentation of MeshGrid combined with flip and rotation operations is implemented, improving the model performance without pre- or post-processing of the raw IVUS images.

Results: The mean intersection of union (MIoU) of 0.937 and 0.804 for the lumen and EEM-CSA, respectively, were achieved, which exceeded the manual labeling accuracy of the clinician.

Conclusion: The accuracy shown by the proposed method is sufficient for subsequent reconstruction of 3D-IVUS images, which is essential for doctors' diagnosis in the tissue characterization of coronary artery walls and plaque compositions, qualitatively and quantitatively.
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http://dx.doi.org/10.1186/s12938-021-00852-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866471PMC
February 2021

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets.

Front Oncol 2020 19;10:570108. Epub 2021 Jan 19.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Macropinocytosis is an important mechanism of internalizing extracellular materials and dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells. On the one hand, cells expressing RAS genes (such as K-RAS, H-RAS) under the stress of nutrient deficiency can spontaneously produce constitutive macropinocytosis to promote the growth of cancer cells by internalization of extracellular nutrients (like proteins), receptors, and extracellular vesicles(EVs). On the other hand, abnormal expression of RAS genes and drug treatment (such as MOMIPP) can induce a novel cell death associated with hyperactivated macropinocytosis: methuosis. Based on the dual effect, there is immense potential for designing anticancer therapies that target macropinocytosis in cancer cells. In view of the fact that there has been little review of the dual effect of macropinocytosis in cancer cells, herein, we systematically review the general process of macropinocytosis, its specific manifestation in cancer cells, and its application in cancer treatment, including anticancer drug delivery and destruction of macropinocytosis. This review aims to serve as a reference for studying macropinocytosis in cancers and designing macropinocytosis-targeting anticancer drugs in the future.
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http://dx.doi.org/10.3389/fonc.2020.570108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851083PMC
January 2021

Single-Atom Iron and Doped Sulfur Improve the Catalysis of Polysulfide Conversion for Obtaining High-Performance Lithium-Sulfur Batteries.

ACS Appl Mater Interfaces 2021 Feb 2;13(6):7171-7177. Epub 2021 Feb 2.

International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education, Institute of Microscale Optoeletronics, Shenzhen University, Shenzhen 518060, People's Republic of China.

Lithium-sulfur (Li-S) batteries are regarded as promising secondary energy storage devices for their high energy density and low cost. The electrochemical performance of Li-S batteries is mainly determined by the efficient and reversible conversion of lithium-polysulfides to LiS when discharging and to S when charging. Herein, a catalytic strategy is proposed to accelerate the reversible conversion of S and the discharge products in Li-S batteries. This reversible transformation is achieved with active sites of single-atom iron on nitrogen- and sulfur-doped porous carbon (FeNSC). We prove that the synergy between atomically dispersed iron and doped sulfur accelerates the reversible electrochemical conversion reactions in Li-S batteries. The FeNSC/S hybrid cathode exhibits superior long-term cycling stability even at a high current density of 1C, with only 0.047% capacity decay per cycle over 1000 cycles. This study demonstrates a novel method for improving the conversion of polysulfides based on electrocatalysis strategies to ultimately obtain high-performance Li-S batteries.
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http://dx.doi.org/10.1021/acsami.0c20446DOI Listing
February 2021

Enhanced Electromechanical Property of Silicone Elastomer Composites Containing [email protected] Core-Shell Nano-Architectures.

Polymers (Basel) 2021 Jan 25;13(3). Epub 2021 Jan 25.

Laboratoire de Mécanique des Sols, Structures et Matériaux, CNRS UMR 8579, Centrale-Supélec, Université Paris-Saclay, 8-10 rue Joliot Curie, 91190 Gif-sur-Yvette, France.

Dielectric elastomer (DE) is one type of promising field-activated electroactive polymer. However, its significant electromechanical actuated properties are always obtained under a giant electric voltage, which greatly restricts the potential applications of DE. In the present work, the well-constructed core-shell [email protected] nanoparticles were fabricated by using the classical Stöber method. A series of [email protected] nano-architectures-filled polydimethylsiloxane (PDMS) composites were prepared via solution blending and compression-molding procedures. Benefiting from the additional SiO shell, both the interfacial compatibility between fillers and matrix and core-shell interfacial interaction can be improved. The [email protected]/PDMS nanocomposites exhibit a significantly enhanced in-plane actuated strain of 6.08% under a low electric field of 30 V·μm at 16 vol.% [email protected] addition, which is 180% higher than that of neat PDMS. The experimental results reveal that the well-designed core-shell structure can play an important role in both improving the electromechanical actuated property and maintaining a good flexibility of DE composites. This research provides a promising approach for the design of the novel composites with advanced low-field actuated electromechanical property in next generation DE systems.
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http://dx.doi.org/10.3390/polym13030368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865594PMC
January 2021
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