Publications by authors named "Hanan Y Aati"

5 Publications

  • Page 1 of 1

Phytochemical Analysis of Leaves: Identification of Garcinamines F-H and Their Antiproliferative Activities.

Plants (Basel) 2021 Jun 2;10(6). Epub 2021 Jun 2.

Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Montesano 49, 80131 Naples, Italy.

is a medicinal plant used in the Arab region for intestinal diseases, lung and liver diseases, digestive problems, and as an antidiabetic agent. Repeated chromatographic purifications of leaves led to the isolation of three undescribed guaiane sesquiterpene derivatives, named garcinamines F-H, characterized by the presence of an amino acid unit, along with five known sesquiterpene lactones (garcinamines B-E and 9β-hydroxyparthenolide). The structures of the new compounds were established using spectroscopic (1D and 2D NMR) and spectrometric methods (ESIMS). Garcinamine H possesses a double bond at the Δ position, a structural feature rarely reported in guaianolide-type sesquiterpenes. The antiproliferative activity of the isolated sesquiterpenes was screened against three different cancer cell lines, and 9β-hydroxyparthenolide and garcinamines C and D displayed significant effects against lung carcinoma (A549), colon carcinoma (LoVo), and breast carcinoma (MCF7) cell lines.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/plants10061130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229242PMC
June 2021

Sterols and Triterpenes from Growing in Saudi Arabia and Their Cytotoxic Activity.

Plants (Basel) 2021 Jan 8;10(1). Epub 2021 Jan 8.

Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

A new lupane caffeoyl ester, lup-20(29)-ene 3β-caffeate-30-al (), and a new oleanane-type triterpene, 3-hydroxyolean-13(18)-en-12-one (), were isolated from the aerial parts of (Forssk), along with ten known triterpenes, including seven lupane-type lupeol (), 30-nor-lup-3-ol-20-one (), ∆-lupenone (), lup-20(29)-en-3,30-diol (), lupeol caffeate (), 30-hydroxy lup-20(29)-ene 3-caffeate (), and betunaldehyde (); three oleanane-type compounds were also identified, comprising -amyrone (), -amyrin (), and 11-oxo--amyrin (); together with six sterols, comprising -sitosterol (), stigmasterol (), 7-hydroxy--sitosterol (), 7-hydroxy-stigmasterol (), 7-keto--sitosterol (), and 7-keto-stigmasterol (). Their structures were elucidated using a variety of spectroscopic techniques, including 1D (H, C, and DEPT-135 C) and 2D (H-H COSY, H-C HSQC, and H-C HMBC) nuclear magnetic resonance (NMR) and accurate mass spectroscopy. Subsequently, the different plant extracts and some of the isolated compounds (, and ) were investigated for their possible cytotoxic activity in comparison to cisplatin against a wide array of aggressive cancer cell lines, such as colorectal cancer (HCT-116), hepatocellular carcinoma (HepG-2), and prostate cancer (PC-3) cell lines. Compound displayed broad cytotoxicity against all of the tested cell lines (IC ≅ 8 µg/mL in all cases), and a high safety margin against normal cells (IC = 70 µg/mL), suggesting that may be a highly selective and effective anticancer agent candidate. Notably, the evidence indicated that the mode of action of compound could possibly consist of the inhibition of phosphodiesterase I (80.2% enzyme inhibition observed at 2 µM compound concentration).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/plants10010119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827382PMC
January 2021

Coronavirus nCOVID-19: A pandemic disease and the Saudi precautions.

Saudi Pharm J 2020 Jul 18;28(7):888-897. Epub 2020 Jun 18.

Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 22452, Riyadh 11495, Saudi Arabia.

Now nCOVID-19 has a foothold in many countries, and the threat of a pandemic situation has risen. Recently a novel coronavirus (nCOVID-19) has first emerged in China, causing multiple symptoms in humans and closely related to those caused by SARS (Severe Acute Respiratory Syndrome) and MERS (Middle East Respiratory Syndrome). The nCOVID-19 has reported in Wuhan city of China has recently infected over six million people and at least 0.4 million confirmed deaths all over the world, while 2.8 million people has recovered from this deadly virus. Many instances of this respiratory syndrome coronavirus infection have already reported in more than 216 countries and territories. In contrast, the majority of cases reported in the USA, Brazil, Russia, Spain, UK, Italy, France and many more countries. In today's context, the coronavirus is one of the significant issues faced by the world with plenty of cases. In these circumstances, rapid reviews which recommended by WHO (World Health Organization), and these recommendations are very significant, helpful and cover current data with different preventive measures developed by the Saudi CDC (Saudi Centre for Disease Prevention and Control). This review article describes the possible modes of transmission so that proper preventive actions should be taking. Importantly, this work mentioned the animal reservoir through which may infect humans, and it must be identified to break the transmission chain. In additions, this review paper briefly discussed the spread of the coronavirus in the Arabian Peninsula and what precaution measures are in place by each country to limit the spreading of this virus. Finally, since the number of infected people specifically those with close contact with nCOVID-19 patients is increasing daily and appears unstoppable, we used the preventive measures by pharmacists as part of health care professions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsps.2020.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299861PMC
July 2020

Antibacterial and Antifungal Sesquiterpenoids from Aerial Parts of .

Molecules 2020 Apr 9;25(7). Epub 2020 Apr 9.

Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy.

Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia-11(13)en-12,6α-olide (), and germacrane, 9β-hydroxyparthenolide-9--β-D-glucopyranoside (), classes have been isolated from the leaves of the Saudi medicinal plant along with seven known compounds (-). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of - were screened against seven different pathogenic microbes, and compounds - showed a potent antifungal activity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules25071730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180898PMC
April 2020

The Phytochemical and Biological Investigation of Root Native to the Kingdom of Saudi Arabia.

Molecules 2018 Jul 28;23(8). Epub 2018 Jul 28.

Department of Pharmacognosy, Faculty of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.

Extensive phytochemical analysis of different root fractions of Courb. (Euphorbiaceae) has resulted in the isolation and identification of 22 secondary metabolites. 6-hydroxy-8-methoxycoumarin-7--β-d-glycopyranoside () and 2-hydroxymethyl -methyltryptamine () were isolated and identified as new compounds along with the known diterpenoid (, , , and ), triterpenoid ( and ), flavonoid (, , , , and ), coumarinolignan (⁻), coumarin (), pyrimidine (), indole (, ), and tyramine-derived molecules (⁻). The anti-inflammatory, analgesic, and antipyretic activities were evaluated for fifteen of the adequately available isolated compounds (⁻, ⁻, , , , , and ). Seven (, , , , , and of the tested compounds showed a significant analgesic effect ranging from 40% to 80% at 10 mg/kg in two in vivo models. Compound could also prove its analgesic property (67.21%) when it was evaluated on a third in vivo model at the same dose. The in vitro anti-inflammatory activity was also recorded where all compounds showed the ability to scavenge nitric oxide (NO) radical in a dose-dependent manner. However, eight compounds (, , , , , , , and ) out of the fifteen tested compounds exhibited considerable in vivo anti-inflammatory activity which reached 64.91% for compound at a dose of 10 mg/kg. Moreover, the tested compounds exhibited an antipyretic effect in a yeast-induced hyperthermia in mice. The activity was found to be highly pronounced with compounds , , , , , and which decreased the rectal temperature to about 37 °C after 2 h of the induced hyperthermia (~39 °C) at a dose of 10 mg/kg. This study could provide scientific evidence for the traditional use of as an anti-inflammatory, analgesic, and antipyretic.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/molecules23081892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222854PMC
July 2018
-->