Publications by authors named "Hana Rajhelová"

2 Publications

  • Page 1 of 1

Toxicity of the Zinc Oxide and Vermiculite/Zinc Oxide Nanomaterials.

J Nanosci Nanotechnol 2019 05;19(5):2977-2982

Nanotechnology Centre, VŠB-Technical University of Ostrava, 708 33 Ostrava-Poruba, Czech Republic.

Nanomaterials and nanocomposite materials on the base of zinc oxide (ZnO) are being produced and applied in our daily life at a rapid pace mainly as additives to the different polymer materials. The antibacterial behaviors of ZnO nanoparticles are intensively studied but related health and environmental toxicity assessments are lagging behind. The aim of this work was evaluated the toxic effect of self-synthesized samples (ZnO nanoparticles, vermiculite/ZnO nanocomposite) and one commercial sample of the ZnO nanoparticles, to induce oxidative stress via lipid peroxidation. This ability is one of the indicators of material toxicity. The toxicity results were compared with the results of titanium dioxide nanoparticles as a validated toxic standard. The effect of the major nanoparticles properties as particle and crystallite size, shape, specific phase and composition were evaluated using the dynamic laser diffraction, scanning electron microscopy and X-ray diffraction analysis. The attention was also focused on the influence of the vermiculite (as matrix of nanocomposite samples) and temperature of the nanostructured materials preparation. All samples containing vermiculite are not able to induce peroxidation of lipids in comparison to TiO₂ nanoparticles. However, samples of ZnO nanoparticles demonstrate the ability to induce oxidative stress via lipid peroxidation, which decreases with the increasing temperature of preparation and for commercial ZnO was higher than for prepared ZnO nanoparticles.
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http://dx.doi.org/10.1166/jnn.2019.15845DOI Listing
May 2019

Determination of Oxidative Potential Caused by Brake Wear Debris in Non-Cellular Systems.

J Nanosci Nanotechnol 2019 05;19(5):2869-2875

Nanotechnology Centre, VŠB-Technical University of Ostrava, 17. listopadu 15/2172, 708 33 Ostrava-Poruba, Czech Republic.

Wear debris from automotive brake systems represents a major source of non-exhaust emissions from road traffic and its production increases with number of cars worldwide. However, impact of brake wear debris on the environment and organisms is still not clear. One of the most possible ways by which these particles may affect living organisms is oxidative stress. Production of reactive oxidative species may cause damage of basic cell components, lipids, proteins, etc. Aim of this study is to perform characterization of airborne and nonairborne fractions of brake wear debris generated during standard dynamometer tests and evaluation of its potential to induce oxidative stress via lipid peroxidation and carbonylation of proteins in non-cellular system. Elemental and phase composition were determined by scanning electron microscopy, Raman microspectroscopy, and X-ray powder diffraction analysis. Carbon in amorphous form and graphite, copper, and iron in form of oxides were identified as major components in both studied fractions. Characteristic size of studied wear particles was evaluated by dynamic light scattering. Both airborne and nonairborne samples showed ability to induce oxidative stress which results from determination of carbonylated proteins.
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http://dx.doi.org/10.1166/jnn.2019.15866DOI Listing
May 2019