Publications by authors named "Han-Ting Zhang"

86 Publications

Neuroprotective Effects of Molecular Hydrogen: A Critical Review.

Neurosci Bull 2020 Oct 20. Epub 2020 Oct 20.

Taishan Institute for Hydrogen Biomedicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, 271000, China.

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October 2020

Ischemic stroke/transient ischemic attack in adults with primary immune thrombocytopenia: a meta-analysis.

Neurol Sci 2020 Oct 2. Epub 2020 Oct 2.

Departments of Neuroscience and Behavioral Medicine & Psychiatry, the Rockefeller Neurosciences Institute, West Virginia University Health Sciences Center, Morgantown, WV, 26506, USA.

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October 2020

Phosphodiesterase 2 inhibitor Hcyb1 reverses corticosterone-induced neurotoxicity and depression-like behavior.

Psychopharmacology (Berl) 2020 Nov 14;237(11):3215-3224. Epub 2020 Sep 14.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, the State University of New York, Buffalo, NY, 14214, USA.

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November 2020

GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway.

Neural Plast 2020 1;2020:8858415. Epub 2020 Aug 1.

Departments of Neuroscience and Behavioral Medicine & Psychiatry, The Rockefeller Neurosciences Institute, West Virginia University Health Sciences Center, Morgantown, WV 26506, USA.

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August 2020

The Phosphodiesterase-4 Inhibitor Roflumilast, a Potential Treatment for the Comorbidity of Memory Loss and Depression in Alzheimer's Disease: A Preclinical Study in APP/PS1 Transgenic Mice.

Int J Neuropsychopharmacol 2020 Dec;23(10):700-711

Departments of Neuroscience and Behavioral Medicine & Psychiatry, the Rockefeller Neuroscience Institute, West Virginia University Health Sciences Center, Morgantown, West Virginia.

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December 2020

The Role of Synaptic Dysfunction in Alzheimer's Disease.

J Alzheimers Dis 2020 ;76(1):49-62

Departments of Neuroscience and Behavioral Medicine & Psychiatry, Rockefeller Neurosciences Institute, West Virginia University Health Sciences Center, Morgantown, WV, USA.

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January 2020

Brucine N-Oxide Reduces Ethanol Intake and Preference in Alcohol-Preferring Male Fawn-Hooded Rats.

Alcohol Clin Exp Res 2020 06 17;44(6):1321-1328. Epub 2020 May 17.

Department of Molecular and Cellular Pharmacology, (J-hL), School of Pharmaceutical Sciences, Peking University, Beijing, China.

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June 2020

Cdk5 Inhibitory Peptide Prevents Loss of Neurons and Alleviates Behavioral Changes in p25 Transgenic Mice.

J Alzheimers Dis 2020 ;74(4):1231-1242

Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P. R. China.

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January 2020

Homocysteine, vitamin B12, and folate levels in patients with multiple sclerosis in Chinese population: A case-control study and meta-analysis.

Mult Scler Relat Disord 2019 Nov 10;36:101395. Epub 2019 Sep 10.

Department of Histology and Embryology, Yichun University, Xuefu Road, Yichun, Jiangxi Province, 336000, PR China. Electronic address:

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November 2019

Protection from Amyloid Peptide-Induced Memory, Biochemical, and Morphological Deficits by a Phosphodiesterase-4D Allosteric Inhibitor.

J Pharmacol Exp Ther 2019 11 5;371(2):250-259. Epub 2019 Sep 5.

Department of Pharmacology, School of Basic Medical Science, Peking University, Beijing, China (S.-Y.C., Y.-H.Z.); Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, New York (S.-Y.C., M.-X.Y., V.Z., Y.X., J.M.O.); Departments of Behavioral Medicine and Psychiatry, Physiology and Pharmacology, and Neuroscience, The Rockefeller Neurosciences Institute, West Virginia University Health Sciences Center, Morgantown, West Virginia (H.-T.Z.); and Tetra Discovery Partners Inc., Grand Rapids, Michigan (M.E.G.)

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November 2019

The Rho kinase inhibitor fasudil attenuates Aβ-induced apoptosis via the ASK1/JNK signal pathway in primary cultures of hippocampal neurons.

Metab Brain Dis 2019 12 3;34(6):1787-1801. Epub 2019 Sep 3.

Institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Medical School of Shanxi Datong University, Datong, China.

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December 2019

Adjuvant therapy with Astragalus membranaceus for post-stroke fatigue: a systematic review.

Metab Brain Dis 2020 01 22;35(1):83-93. Epub 2019 Aug 22.

Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, 271016, China.

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January 2020

Inhibitory effects of hydrogen on in vitro platelet activation and in vivo prevention of thrombosis formation.

Life Sci 2019 Sep 26;233:116700. Epub 2019 Jul 26.

Institute of Pharmacology, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, PR China. Electronic address:

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September 2019

Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice.

J Psychopharmacol 2019 05 5;33(5):568-576. Epub 2019 Mar 5.

2 Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, the State University of New York, Buffalo, NY, USA.

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May 2019

Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior.

Neuropharmacology 2018 12 27;143:176-185. Epub 2018 Sep 27.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA. Electronic address:

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December 2018

6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment partially via suppressing astrocyte overactivation.

Biomed Pharmacother 2018 Nov 5;107:1523-1529. Epub 2018 Sep 5.

Institute of Pharmacology, Taishan Medical University, Taian, Shandong, 271016, China; Departments of Behavioral Medicine & Psychiatry, Physiology & Pharmacology, and Neuroscience, The Rockefeller Neurosciences Institute, West Virginia University Health Sciences Center, Morgantown, WV, 26506, USA. Electronic address:

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November 2018

Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice.

Neuropsychopharmacology 2018 10 14;43(11):2299-2309. Epub 2018 Aug 14.

Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, 14214, USA.

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October 2018

Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors.

Biochemistry 2018 07 17;57(30):4518-4525. Epub 2018 Jul 17.

Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center , The University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599-7260 , United States.

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July 2018

Inhibition of phosphodiesterase 2 by Bay 60-7550 decreases ethanol intake and preference in mice.

Psychopharmacology (Berl) 2018 Aug 7;235(8):2377-2385. Epub 2018 Jun 7.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, the State University of New York, Buffalo, NY, 14214, USA.

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August 2018

A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.

CNS Neurosci Ther 2018 10 2;24(10):889-896. Epub 2018 May 2.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, Buffalo, NY, USA.

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October 2018

The neuroprotective and antidepressant-like effects of Hcyb1, a novel selective PDE2 inhibitor.

CNS Neurosci Ther 2018 07 27;24(7):652-660. Epub 2018 Apr 27.

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA.

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July 2018

Cyclic nucleotide phosphodiesterases: potential therapeutic targets for alcohol use disorder.

Psychopharmacology (Berl) 2018 06 16;235(6):1793-1805. Epub 2018 Apr 16.

Institute of Pharmacology, Qilu Medical University, Taian, 271016, Shandong, China.

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June 2018

Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence.

Adv Neurobiol 2017 ;17:413-444

Department of Behavioral Medicine and Psychiatry, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, WV, 26506, USA.

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January 2018

The Role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders.

Adv Neurobiol 2017 ;17:307-347

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, 14214, USA.

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January 2018

The Past, Present, and Future of Phosphodiesterase-4 Modulation for Age-Induced Memory Loss.

Adv Neurobiol 2017 ;17:169-199

Department of Behavioral Medicine and Psychiatry, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, WV, 26506, USA.

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January 2018

Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases.

Adv Neurobiol 2017 ;17:45-61

Department of Behavioral Medicine and Psychiatry, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, WV, 26506, USA.

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January 2018