Publications by authors named "Hamid Reza Niazkar"

12 Publications

  • Page 1 of 1

A comprehensive systematic review of the therapeutic effects and mechanisms of action of quercetin in sepsis.

Phytomedicine 2021 Jun 14;86:153567. Epub 2021 Apr 14.

Nutrition Research Center, Department of Clinical Nutrition, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran; Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Several studies have indicated that flavonoids exhibit a wide variety of biological actions including free radical scavenging and antioxidant activities. Quercetin, one of the most extensively distributed flavonoids in the vegetables and fruits, presents various biological activities including modulation of oxidative stress, anti-infectious, anti-inflammatory, and neuroprotective activities.

Methods: The present systematic review was conducted according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statements. We searched Web of Sciences, Google Scholar, PubMed, Scopus, and Embase databases up to February 2021 by using the relevant keywords.

Results: Out of 672 records screened, 35 articles met the study criteria. The evidence reviewed here indicates that quercetin supplementation may exert beneficial effects on sepsis by attenuating inflammation and oxidative stress, downregulating the mRNA expression of toll-like receptors (TLRs), modulating the immune response, and alleviating sepsis-related organ dysfunctions.

Conclusion: Due to the promising therapeutic effects of quercetin on sepsis complications and the lack of clinical trials in this regard, future human randomized clinical trials are warranted.
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http://dx.doi.org/10.1016/j.phymed.2021.153567DOI Listing
June 2021

Primary omental torsion in a pediatric patient.

Clin Case Rep 2021 Mar 22;9(3):1808-1809. Epub 2021 Jan 22.

Department of Pediatrics Sabzevar University of Medical Sciences Sabzevar Iran.

Omental infarction although infrequent should be considered as a possible cause of acute abdomen precisely in those with negative appendectomy.
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http://dx.doi.org/10.1002/ccr3.3842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981644PMC
March 2021

Prevalence and Subtype Analysis of Isolated from Patients in the Northeast of Iran.

J Parasitol Res 2021 13;2021:8821885. Epub 2021 Jan 13.

Department of Microbiology, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

is the most common intestinal parasite found in humans and many other hosts. Pathogenicity of spp. remains controversial, and it has been suggested that it may be associated with specific subtypes of the organism. This study identified the subtypes and their prevalence rates in the northeast of Iran. A total of 1878 samples were collected from the northeast of Iran from January to December 2017. The patients' demographic details were recorded. Samples were examined by a wet mount, and genomic DNA was extracted from positive samples. Also, PCR was done on the positive samples, and sequencing and phylogenetic analysis were subsequently performed. From 1878 collected stool samples, 152 (8.1%) Blastocystis samples were detected by the microscopic method. Of the 152 samples, spp. were found in 53.6% of the men and 28.9% of the women who showed clinical gastrointestinal symptoms, and a significant relationship was observed between gender and clinical symptoms ( = 0.002). A meaningful relationship was found between the season and infection with this parasite ( value = 0.003). The results of the sequencing of 22 PCR products showed the dominance of ST3, which was isolated from 10 (45.45%) patients, while ST1, ST2, and ST7 were found in 4 (18.19%), 7 (31.81%), and 1 (4.55%) patients, respectively. In this study, ST7 had a low prevalence in the northeast of Iran, and similar to previous studies, ST3 was the dominant subtype.
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http://dx.doi.org/10.1155/2021/8821885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822675PMC
January 2021

A Comprehensive insight into the effect of chromium supplementation on oxidative stress indices in diabetes mellitus: A systematic review.

Clin Exp Pharmacol Physiol 2021 03 18;48(3):291-309. Epub 2021 Jan 18.

Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Diabetes mellitus is a metabolic disorder defined as an increase in blood glucose levels (hyperglycaemia) and insufficient production or action of insulin produced by the pancreas. Chronic hyperglycaemia leads to increased reactive oxygen species (ROS) production and oxidative stress, which consequently results in insulin resistance, beta cell degeneration, dyslipidaemia, and glucose intolerance in diabetic patients. Chromium has an essential role in the metabolism of proteins, lipids, and carbohydrates through increasing insulin efficiency. This systematic review aimed to evaluate chromium supplementation's potential roles in oxidative stress indices in diabetes mellitus. A systematic search was performed in PubMed, Scopus, Google Scholar, Cochrane, and Science Direct databases until November 2020. All clinical trials and animal studies that assessed chromium's effect on oxidative stress indices in diabetes mellitus and were published in English-language journals were included. Finally, only 33 out of 633 articles met the required criteria for further analysis. Among 33 papers, 25 studies were performed on animals, and eight investigations were conducted on humans. Twenty-eight studies of chromium supplementation lead to reducing oxidative stress indices. Also, 23 studies showed that chromium supplementation markedly increased antioxidant enzymes' activity and improved levels of antioxidant indices. In conclusion, chromium supplementation decreased oxidative stress in diabetes mellitus. However, further clinical trials are suggested in a bid to determine the exact mechanisms.
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http://dx.doi.org/10.1111/1440-1681.13462DOI Listing
March 2021

Assessment of Three Mathematical Prediction Models for Forecasting the COVID-19 Outbreak in Iran and Turkey.

Comput Math Methods Med 2020 21;2020:7056285. Epub 2020 Nov 21.

Department of Mechanical Engineering, Bayburt University, Bayburt, Turkey.

COVID-19 pandemic has become a concern of every nation, and it is crucial to apply an estimation model with a favorably-high accuracy to provide an accurate perspective of the situation. In this study, three explicit mathematical prediction models were applied to forecast the COVID-19 outbreak in Iran and Turkey. These models include a recursive-based method, Boltzmann Function-based model and Beesham's prediction model. These models were exploited to analyze the confirmed and death cases of the first 106 and 87 days of the COVID-19 outbreak in Iran and Turkey, respectively. This application indicates that the three models fail to predict the first 10 to 20 days of data, depending on the prediction model. On the other hand, the results obtained for the rest of the data demonstrate that the three prediction models achieve high values for the determination coefficient, whereas they yielded to different average absolute relative errors. Based on the comparison, the recursive-based model performs the best, while it estimated the COVID-19 outbreak in Iran better than that of in Turkey. Impacts of applying or relaxing control measurements like curfew in Turkey and reopening the low-risk businesses in Iran were investigated through the recursive-based model. Finally, the results demonstrate the merit of the recursive-based model in analyzing various scenarios, which may provide suitable information for health politicians and public health decision-makers.
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http://dx.doi.org/10.1155/2020/7056285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686848PMC
January 2021

Application of artificial neural networks to predict the COVID-19 outbreak.

Glob Health Res Policy 2020 11 23;5(1):50. Epub 2020 Nov 23.

Department of Civil and Environmental Engineering, Shiraz University, Shiraz, Iran.

Background: Millions of people have been infected worldwide in the COVID-19 pandemic. In this study, we aim to propose fourteen prediction models based on artificial neural networks (ANN) to predict the COVID-19 outbreak for policy makers.

Methods: The ANN-based models were utilized to estimate the confirmed cases of COVID-19 in China, Japan, Singapore, Iran, Italy, South Africa and United States of America. These models exploit historical records of confirmed cases, while their main difference is the number of days that they assume to have impact on the estimation process. The COVID-19 data were divided into a train part and a test part. The former was used to train the ANN models, while the latter was utilized to compare the purposes. The data analysis shows not only significant fluctuations in the daily confirmed cases but also different ranges of total confirmed cases observed in the time interval considered.

Results: Based on the obtained results, the ANN-based model that takes into account the previous 14 days outperforms the other ones. This comparison reveals the importance of considering the maximum incubation period in predicting the COVID-19 outbreak. Comparing the ranges of determination coefficients indicates that the estimated results for Italy are the best one. Moreover, the predicted results for Iran achieved the ranges of [0.09, 0.15] and [0.21, 0.36] for the mean absolute relative errors and normalized root mean square errors, respectively, which were the best ranges obtained for these criteria among different countries.

Conclusion: Based on the achieved results, the ANN-based model that takes into account the previous fourteen days for prediction is suggested to predict daily confirmed cases, particularly in countries that have experienced the first peak of the COVID-19 outbreak. This study has not only proved the applicability of ANN-based model for prediction of the COVID-19 outbreak, but also showed that considering incubation period of SARS-COV-2 in prediction models may generate more accurate estimations.
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http://dx.doi.org/10.1186/s41256-020-00175-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680664PMC
November 2020

Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial.

Eur J Gastroenterol Hepatol 2020 Aug 14. Epub 2020 Aug 14.

Nutrition Research Center, Department of Biochemistry & Diet Therapy, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz.

Objective: Nonalcoholic fatty liver disease (NAFLD) is a complicated disease and is considered as a severe global health problem affecting 30% of adults worldwide. The present study aimed to evaluate changes in oxidative stress, adipokines, liver enzyme, and body composition following treatment with chromium picolinate (CrPic) among patients with NAFLD.

Participants And Methods: The current randomized, double-blind, placebo-controlled study was conducted on 46 NAFLD patients with the age range of 20-65 years. Patients were randomly classified into two groups, receiving either 400 µg CrPic tablets in two divided doses of 200 µg (23 patients) or placebo (23 patients) daily for 12 weeks. The participants' body composition and biochemical parameters were evaluated at the baseline and after 12 weeks.

Results: Serum levels of liver enzymes reduced significantly only in the CrPic group (P < 0.05 for all), but not between the groups after the intervention. Besides, there were significant differences between the study groups regarding body weight and body fat mass, total antioxidant capacity, superoxide dismutase, malondialdehyde, leptin, and adiponectin post-intervention (P = 0.017, P = 0.032, P = 0.003, P = 0.023, P = 0.012, P = 0.003, and P = 0.042, respectively). However, glutathione peroxidase and resistin levels did not differ significantly between groups (P = 0.127 and P = 0.688, respectively).

Discussion And Conclusion: This study showed that consuming 400 µg/day of CrPic for 12 weeks in patients with NAFLD causes a significant change in leptin, adiponectin, oxidative stress (expect glutathione peroxidase), and body weight, compared to baseline. Nevertheless, it does not affect liver enzymes. Therefore, the CrPic supplementation may improve adipokines, some anthropometric indices, and oxidative stress in patients with NAFLD.
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http://dx.doi.org/10.1097/MEG.0000000000001830DOI Listing
August 2020

Investigation of Infection in Aborted Fetuses of Sheep Using PCR: A Study in North Khorasan Province, Iran.

Vet Med Int 2020 20;2020:7913912. Epub 2020 Jun 20.

Student Research Committee, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

is a zoonotic obligate intracellular protozoan parasite that infects warm-blooded animals as well as humans worldwide. The purpose of this study was to delineate the prevalence of infection in aborted fetuses of sheep in North Khorasan province, Iran. Three hundred and ninety-nine samples of the liver (133 samples), placenta (133 samples), and brain (133 samples) from 133 aborted fetuses of sheep were collected from 2015 to 2017. The ages of aborted fetuses were higher than 120 days' gestational age in this study. According to the samples, sixteen out of 133 aborted fetuses of sheep were infected with . DNA was found in the placenta (68.75%) and liver (31.25%) samples of infected fetuses using the PCR method. The highest and lowest rates of infection were observed during 2016 and 2017, respectively. Shirvan and Faruj provinces were recognized as the two most infected districts among others. There was a significant difference between the year and abortion rate in sheep due to infection by the parasite ( < 0.05). Furthermore, no significant difference between the prevalence of infection and aborted fetuses was seen ( > 0.05) in different areas. According to the present study, infection can be one of the causes of fetus abortion of sheep in North Khorasan province, Iran.
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http://dx.doi.org/10.1155/2020/7913912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322599PMC
June 2020

The neurological manifestations of COVID-19: a review article.

Neurol Sci 2020 Jul 1;41(7):1667-1671. Epub 2020 Jun 1.

Department of Midwifery, Faculty of Medicine, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences, Gonabad, Iran.

Results: Various neurological manifestations have been reported in the literature associated with COVID-19, which in the current study are classified into Central Nervous System (CNS) related manifestations including headache, dizziness, impaired consciousness, acute cerebrovascular disease, epilepsy, and Peripheral Nervous System (PNS) related manifestations such as hyposmia/anosmia, hypogeusia/ageusia, muscle pain, and Guillain-Barre syndrome.

Conclusion: During the current context of COVID-19 pandemic, physicians should be aware of wide spectrum of neurological COVID-19 sign and symptoms for early diagnosis and isolation of patients. In this regard, COVID-19 has been associated with many neurological manifestations such as confusion, anosmia, and ageusia. Also, various evidences support the possible CNS roles in the COVID-19 pathophysiology. In this regard, further investigation of CNS involvement of SARS-COV-2 is suggested.
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http://dx.doi.org/10.1007/s10072-020-04486-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262683PMC
July 2020

Hb S (: c.20A>T) and α- and β-Thalassemia Coinheritance in Iranian Patients.

Hemoglobin 2020 Mar 6;44(2):109-112. Epub 2020 May 6.

Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.

Hb S (: c.20A>T) and α- and/or β-thalassemia (α- and/or β-thal) coinheritance is a common genetic disorder in regions with a high prevalence of thalassemia and sickle cell disease. The clinical manifestations of this coinheritance vary from mild to severe complications. Iran is a country with a high incidence of thalassemia and sickle cell disease. This study aimed to evaluate the coinheritance of sickle cell disease with α- and/or β-thal in Iranian patients. In this cross-sectional study from 2018-2019, a total of 47 participants with the Hb S abnormality, who were referred to the Zafar Thalassemia Clinic (Tehran, Iran), were selected as a study group. Molecular analysis for the evaluation of α and β gene mutations was performed in all participants. Hb SS, Hb S/β-thal and Hb S/Hb D-Punjab (also known as Hb D-Los Angeles, Hb D-Chicago, Hb D-North Carolina, Hb D-Portugal and Hb Oak Ridge) (: c.364G>C) were detected in 21 (44.7%), 23 (48.9%) and three (6.4%) patients, respectively. α Gene mutations were also detected in five patients with Hb S/β-thal, four patients with sickle cell disease and one patient with Hb S/Hb D-Punjab. In the current study, -α/αα with β gene abnormalities was the most common genotype. Our study showed that the coinheritance of sickle cell disease with α- and β-thal is common and evaluation of these disorders, especially in pre marriage screening is important for diagnosis and management strategies.
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http://dx.doi.org/10.1080/03630269.2020.1757462DOI Listing
March 2020

First-time Blood Donors Are Double-edged Swords for Blood Transfusion Centers: A Retrospective Study in Southwest Iran

Turk J Haematol 2020 02 2;37(1):30-35. Epub 2019 Sep 2.

Yasuj University of Medical Sciences, Cellular and Molecular Research Center, Yasuj, Iran

Objective: First-time blood donors are the most common group of blood donors. They usually have different motivations for blood donation, some of which provoke the donors to hide risk factors of transfusion-transmissible infections (TTIs). Therefore, detection of TTIs among first-time donors is crucial and can decrease the rate of TTIs among blood recipients. This study aimed to evaluate the prevalence of TTIs among first-time donors in the transfusion center of Kohgiluyeh and Boyer-Ahmad Province (KBTC), Iran.

Materials And Methods: This retrospective study was conducted with volunteer blood donors in 2004-2014 in the KBTC. Various data, including sex, confidential unit exclusion (CUE), previous donation history, and the laboratory findings of confirmatory tests, were extracted from blood donor software. Data were analyzed by SPSS using the chi-square test.

Results: Among 198,501 blood donors, 52,527 (26.46%) were first-time donors, while 145,974 donors (73.54%) were repeat and regular donors. Most of the donors (94.5%) were male, while a minority (5.5%) were female. The CUE option was chosen by 2,237 (1.13%) donors. The incidence of hepatitis B surface antigen (HBsAg) and hepatitis C virus (HCV) was 247 (0.13%) and 134 (0.07%) among the entire study population, respectively. Three donors (0.002%) had confirmed human immunodeficiency virus (HIV), while none of the blood donors were positive for syphilis. Most of the donors with positive HBsAg (95.8%), HCV (86.6%), and HIV (100%) infection were first-time donors.

Conclusion: Since TTIs are more common among first-time blood donors than regular and repeat donors, special considerations should be taken into account for this common group of blood donors.
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http://dx.doi.org/10.4274/tjh.galenos.2019.2019.0166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057759PMC
February 2020

Isolation and genotyping of Acanthamoeba strains from water sources of Kermanshah, Iran

Ann Parasitol 2019 ;65(4):397–402

Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran

Acanthamoeba spp. are free-living amoeba commonly found in environmental sources such as soil, water, and dust. This ubiquitous amoeba is the causative agent of amoebic keratitis (AK) and encephalitis. The present study aimed to investigate the presence of Acanthamoeba spp. in the water sources of Kermanshah city, Iran. Sixty water samples were taken from different localities of Kermanshah including agricultural canals, rivers, and swimming pools. Filtration and cultivation were carried out on non-nutrient agar medium (NNA). The axenic cultivation was performed for all of the positive isolates. PCR analysis was performed on positive samples. Sequencing was done for 12 PCR products. Genotypes were identified by blast search and homology analysis. The obtained data were analyzed using Statistical Package for the Social Sciences (SPSS 16) software. Acanthamoeba spp. was found in 46 (76.66%) water samples and amoebae were grown in the TYI-S-33 medium. Sequencing of 12 samples proved that Acanthamoeba belonged to T4 (75%), T2 (8.34%), T5 (8.33%) and T11 (8.33%) genotypes. In this study, Acanthamoeba T4 (75%), T2 (8.34%), T5 (8.33%) and T11 (8.33%) genotypes were isolated from the water of Kermanshah city. Thus, hygiene consideration is recommended to prevent the contamination.
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April 2020
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