Publications by authors named "Hamid Reza Aghaei Meybodi"

24 Publications

  • Page 1 of 1

Personalized medicine in cardiovascular disease: review of literature.

J Diabetes Metab Disord 2021 Dec 7;20(2):1793-1805. Epub 2021 Jul 7.

Cardiology Department, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Personalized medicine (PM) is the concept of managing patients based on their characteristics, including genotypes. In the field of cardiology, advantages of PM could be found in the diagnosis and treatment of several conditions such as arrhythmias and cardiomyopathies; moreover, it may be beneficial to prevent adverse drug reactions (ADR) and select the best medication. Genetic background can help us in selecting effective treatments, appropriate dose requirements, and preventive strategies in individuals with particular genotypes.

Method: In this review, we provide examples of personalized medicine based on human genetics for the most used pharmaceutics in cardiology, including warfarin, clopidogrel, and statins. We also review cardiovascular diseases, including coronary artery disease, arrhythmia, and cardiomyopathies.

Conclusion: Genetic factors are as important as environmental factors and they should be tested and evaluated more in the future by improving in genetic testing tools.

Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-021-00840-0.
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http://dx.doi.org/10.1007/s40200-021-00840-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630142PMC
December 2021

A pharmacogenetic pilot study of common genetic variant and sulfonylureas therapeutic response in type 2 diabetes mellitus patients.

J Diabetes Metab Disord 2021 Dec 14;20(2):1513-1519. Epub 2021 Sep 14.

Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Background: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that is associated with elevated blood glucose levels. Sulfonylureas (SFUs) are the most widely used among the oral antidiabetic drugs that are highly metabolized by cytochrome P450 family 2 subfamily C member 9 (CYP2C9). The has been shown to be associated with a better glycemic response to SFUs and a lower treatment failure rate. The aim of the present study was to assess the influence of the rs1067910 gene variant on the SFUs response in a group of Iranian patients for the first time.

Methods: Blood samples were taken from 30 patients with T2DM under sulfonylurea treatment. DNA extraction was performed using Salting out method, and then genotyping was performed by polymerase chain reaction (PCR) followed by Sanger sequencing.

Results: There was no significant difference in the fasting blood sugar (FBS) between T2DM patients with different genotypes before and after the treatment with SFUs ( = 0.073 and  = 0.893, respectively). Although HbA1c was significantly different among AA, CA and CC carriers before ( = 0.001) and after ( = 0.018) treatment, no significant change was observed after treatment in all three groups.

Conclusions: In the present study based on only 30 samples in pilot survey, it is shown that the therapeutic response to SFUs was not related to rs1057910 variant.
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http://dx.doi.org/10.1007/s40200-021-00894-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630254PMC
December 2021

A systematic review of miRNAs as biomarkers in osteoporosis disease.

J Diabetes Metab Disord 2021 Dec 27;20(2):1391-1406. Epub 2021 Aug 27.

Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, No.10-Jalal-e-Ale-Ahmad Street, Chamran Highway, 1411713119 Tehran, Iran.

Background: Osteoporosis is often considered to be a disease of the elderly, which is characterized by two characteristics: low bone mineral density (BMD) and increased risk of fracture. MicroRNAs (miRNAs) have been reported to play a potential role in bone formation and resorption, bone remodeling, bone homeostasis regulation, and bone cell differentiation. Therefore, altered expression of different miRNAs may impact the pathology of bone diseases such as osteoporosis. A systematic review was conducted to extract all miRNA found to be significantly dys-regulated in the peripheral blood.

Methods: This review was carried out using a systematically search on PubMed, Scopus, Embase, Web of Science (WoS), and Cochrane databases from 1990 to 2018 to explore the diagnostic value of miRNAs as a biomarker in osteoporosis.

Results: A total of 31 studies were identified in the systematic review that indicated more than 30 kinds of up-regulated and down-regulated miRNAs in three categories; postmenopausal osteoporosis, postmenopausal osteoporosis with fracture risk, and other types of osteoporosis and fracture risk.

Conclusion: The collective data presented in this review indicate that miRNAs could serve as biomarkers for the diagnosis (onset) and prognosis (progression of osteoporosis), while the clinical application of these findings has yet to be verified.

Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-021-00873-5.
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http://dx.doi.org/10.1007/s40200-021-00873-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630174PMC
December 2021

The role of the PPARG (Pro12Ala) common genetic variant on type 2 diabetes mellitus risk.

J Diabetes Metab Disord 2021 Dec 20;20(2):1385-1390. Epub 2021 Aug 20.

Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Khaghani Avenue, Shariati St, 193951459 Tehran, Iran.

Background: Type 2 diabetes (T2DM) prevalence has been rapidly increasing in the last decades. T2DM pathogenesis is related to insulin resistance and beta-cell dysfunction. is concerned about T2DM risk through the involvement in adipocyte differentiation and energy homeostasis. The present study aimed to find the risk associated with a common genetic variant (Pro12Ala) of the gene in the development of T2DM in a group of the Iranian population.

Methods: Totally, 149 patients with T2DM and 96 healthy individuals were recruited in this case-control study. The genotyping of the genetic variant was carried out using the polymerase chain reaction (PCR) followed by Sanger sequencing.

Results: No significant difference is observed between the CG and GG genotypes frequency of the variant ( = 0.17) in T2DM patient and the control groups. Furthermore, the frequency of the G allele was similar between case and control groups. The Pro12Ala variant may decrease the risk of diabetic retinopathy (DR) which was not statistically significant. Furthermore, the Pro12Ala variant caused a 27% increase in the risk of diabetes nephropathy (DN) among patients with T2DM but was not significant.

Conclusions: Our findings showed that the variant could not impact on T2DM development and its complications.
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http://dx.doi.org/10.1007/s40200-021-00872-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630345PMC
December 2021

The associations of statin intake and the trabecular bone score and bone mineral density status in elderly Iranian individuals: a cross-sectional analysis of the Bushehr Elderly Health (BEH) program.

Arch Osteoporos 2021 09 27;16(1):144. Epub 2021 Sep 27.

Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran Universityof Medical Sciences, Tehran, Iran.

In recent years, a growing interest on the impact of statin intake on bone health has emerged, although the reported results are controversial. The results of this study revealed that BMD at lumbar spine has a significant association with statin intake. However, such association appears to be weaker regarding TBS values compared to BMD. This study was performed with the aim of evaluating associations of statin intake with BMD and TBS using data from 2426 individuals aged ≥ 60 years from the second phase of the Bushehr Elderly Health (BEH) program. We found a positive association between statin and BMD at lumbar spine, whereas association between statin and TBS was detected only in the men in the final model.

Introduction: In recent years, a growing interest has been established to evaluate the impact of statin intake on bone health, although the reported results are controversial. This study aimed to evaluate the association of statin intake with bone health status according to BMD and TBS.

Methods: This cross-sectional analysis used data from the elderly Iranian individuals who participated in the Bushehr Elderly Health (BEH) program. Dual x-ray absorptiometry (DXA) device was used to evaluate the BMD at lumbar spine (L1-L4), femoral neck, and total hip, as well as TBS at lumbar spine.

Results: Among 2426 (1260 women and 1166 men) study participants, 778 were statin users. A positive significant association, irrespective of sex, was observed between statin intake and BMD at L1-L4, even after controlling for potential variables in total population (β = 0.016, p = 0.013). The mean TBS values at L1-L4 were negatively associated with statin intake in total population (β =  - 0.009, p = 0.001), while in the full adjusted model, significant positive association between TBS and statin intake was detected only in men (β = 0.013, p = 0.02).

Conclusion: The results of this study revealed that BMD at lumbar spine has a significant association with statin intake. However, such an association appears to be weaker regarding TBS values compared to BMD.
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http://dx.doi.org/10.1007/s11657-021-00991-wDOI Listing
September 2021

Diabetic foot self-care practice in women with diabetes in Iran.

Diabetes Metab Syndr 2021 Sep-Oct;15(5):102225. Epub 2021 Jul 26.

Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background And Aims: The present study was conducted to determine the situation of foot self-care practice among Iranian women with diabetes.

Methods: In this cross-sectional study, 475 women completed the Diabetic Foot Self-Care Questionnaire (DFSQ) along with other questions. The overall and three components scores including personal care, podiatric care, and foot wearing, were calculated and their relationship with other factors was analyzed.

Results: The average total DFSQ score was 60.38 ± 9.9, and 16.98 ± 7, 5.95 ± 2.11, and 12.26 ± 3.95 for personal care, podiatric care, and footwear respectively. Education level, self-reported health status, and life satisfaction had a significant relationship with footwear score, and smoking and life satisfaction were related to personal care and podiatric care respectively. In Pearson regression, DM self-care was correlated with all three components and total DFSQ score. Also, depression and SCS (Social Capital Status) correlated with DFSQ scores except with personal self-care and footwear respectively. Body Mass Index (BMI) and Quality of Life (QoL) were significantly correlated with footwear and podiatric care scores.

Conclusion: In this study, the DFSQ result was almost acceptable, however, it highlights the importance of suitable interventions to establish better self-care practice among Iranian diabetic women.
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http://dx.doi.org/10.1016/j.dsx.2021.102225DOI Listing
July 2021

Factors associated with TBS worse than BMD in non-osteoporotic elderly population: Bushehr elderly health program.

BMC Geriatr 2021 07 27;21(1):444. Epub 2021 Jul 27.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Bone mineral density (BMD) and trabecular bone score (TBS) are moderately correlated. TBS is sometimes used as an adjuvant to BMD in the fracture risk assessment. Some individuals with normal BMD or osteopenia, have more degraded TBS. We aimed to identify factors associated with TBS worse than BMD in the non-osteoporotic elderly population.

Methods: The study subjects were selected from 2384 women and men aged ≥60 years participating in the second stage of the Bushehr Elderly Health program, a population-based prospective cohort study in Iran. The BMDs of different sites and the lumbar spine texture were measured using dual-energy X-ray absorptiometry and the TBS algorithm, respectively. Subjects were categorized based on their BMD and TBS status. Logistic regression was performed to identify the factors associated with "TBS worse than BMD" in non-osteoporotic individuals.

Results: Of 1335 participants included in the study, 112 of 457 women, and 54 of 878 men had worse TBS than BMD. In multivariable analysis, TBS worse than BMD in women was statistically significantly associated with years since menopause (OR: 1.04 (1.00-1.07)) and waist circumference (OR: 1.09 (1.05-1.14)). However, in men, the condition was statistically significantly associated with waist circumference (OR: 1.10 (1.03-1.17)), current smoking (OR: 2.54 (1.10-5.84)), and HDL-C (OR: 1.03 (1.00-1.06)).

Conclusion: The results of the study show that higher waist circumference is associated with more degraded TBS than BMD in both men and women. Years passed since menopause and current smoking, respectively in women and men, were associated with more degraded TBS. Considering TBS values in older individuals with higher waist circumference, or a history of smoking despite normal BMDs might help more accurate assessment of bone health. However, further studies are required to confirm the benefit.
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http://dx.doi.org/10.1186/s12877-021-02375-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314528PMC
July 2021

Social-capital determinants of the women with diabetes: a population-based study.

J Diabetes Metab Disord 2021 Jun 9;20(1):511-521. Epub 2021 May 9.

Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Social-capital level contributes to clinical factors and health outcomes of patients suffering from diabetes. Considering the social determinants of type 2 diabetes patients could benefit to prevention of diabetes complications especially in women population. This study aims to determine social capital determinants in women with diabetes.

Methods: Four hundred and thirty-five women with diabetes take-part in this cross-sectional, multi-centric study. The data was completed by a demographic questionnaire and the Social Capital instrument (SC-IQ). This study is investigating demographic (age, gender, BMI, marital, educational and social-economic status), and lifestyle factors (physical activity, nutrition), Diabetes status (HbA1c Level, medications, complications, duration of diabetes), general health status (life satisfaction, self-rated health, physical activity, and depression) and Social capital items (Value of life, Tolerance of Diversity, Neighborhood network, Family and Friends Connections, Work connections, Community participation, Feeling of trust and Safety and Proactivity). The descriptive statistics and linear regression models were used to assess the associations between social capital and determinants.

Results: The mean age of participants was 50 (SD: 7.7), range 28-71 year. The mean social capital score was 77.8 (SD: 15.8). In linear regression analysis, results showed that women who had the greater score in total social-capital (ß: 3.7, SE: 1.5) and Feeling of trust and Safety (ß: 0.87, SE: 0.42) had vigorous physical activity and also women who had greater score in Neighborhood Connections had moderate physical activity in comparison with patients who had low physical activity. (ß: 0.67, SE: 0.26 and ß: 0.61, SE: 0.26).Also, the findings showed that women who had had a lower score in total social-capital (ß: 6, SE: 1.47), Community participation (ß: 1.44, SE: 0.37), Value of life (ß: 1.71, SE: 0.24), Family and Friends Connections (ß: 0.88, SE: 0.25) and proactivity (ß: 0.71, SE: 0.25) had depression in comparison with patients who had no depression. The findings revealed that instead of each year increase in the duration of diabetes, the total social-capital score had decreased about the half score (ß: 0.48, SE: 0.21).

Conclusions: Important social factors that make diabetes control are alterable to health interventions. The results of the current study suggest that social capital status may determine how effectively the women with diabetes have been managed. This initial finding permits subsequent experimental investigations to identify social strategies that can be valuable to improve diabetes control.
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http://dx.doi.org/10.1007/s40200-021-00772-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212190PMC
June 2021

Association of common genetic variants of gene with the risk of type 2 diabetes mellitus.

Nucleosides Nucleotides Nucleic Acids 2021 14;40(5):530-541. Epub 2021 Apr 14.

Medical Genomics Research Center, Islamic Azad Tehran Medical Sciences University, Tehran, Iran.

Type 2 diabetes mellitus (T2DM) is a multifactorial polygenic disease. Potassium inwardly-rectifying channel, subfamily J, member 11 ( gene mutations can result in susceptibility of T2DM. The aim of this study is to investigate the relationship between risk of T2DM and its complications (retinopathy & renal) and polymorphisms rs5210 and rs5215 of the gene in a group of Iranian population. In this case-control study, 111 Iranian patients with T2DM and 82 control subjects were genotyped for each polymorphism by polymerase chain reaction (PCR) and Sanger Sequencing methods. Frequencies of genotypes of rs5210 polymorphism among subjects with and without diabetes mellitus were 53.15% vs. 51.22% for GG and 37.84% vs. 42.68% for AG ( = 0.7), respectively. Corresponding frequencies for rs5215 polymorphism among diabetics and non-diabetics were 13.51% vs. 13.41% for CC and 50.45% vs. 37.80% for CT ( = 0.2). G allele carriers (rs5210 polymorphism) and C allele carriers (rs5215 polymorphism) had the same frequency among diabetics and non-diabetics ( = 0.9 for G allele and  = 0.2 for C allele). Our results suggested that none of the polymorphisms of , rs5210 ( = 0.7) and rs5215 ( = 0.2), were significantly associated with T2DM. Only, the relationship between CT genotype of rs5215 and retinopathy ( = 0.01) showed a borderline significant association.
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http://dx.doi.org/10.1080/15257770.2021.1905841DOI Listing
November 2021

A narrative review of current trends in liraglutide: insights into the unmet needs in management of type 2 diabetes and obesity.

J Diabetes Metab Disord 2020 Dec 28;19(2):1863-1872. Epub 2020 Aug 28.

Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Liraglutide is a long-acting human glucagon-like peptide-1 (GLP-1) analogue and an effective treatment for patients with metabolic diseases including type 2 diabetes mellitus (T2DM) and obesity. This review focuses on the mechanism of action of liraglutide as a well-known glucagon-like peptide-1 receptor agonist (GLP-1 RA) in patients with T2DM and obesity. The lower and the higher doses of GLP-1 RAs are used for glycaemic control in T2DM and in obesity respectively. GLP-1 RAs such as liraglutide enhance insulin secretion and inhibit glucagon release via the stimulation of glucagon-like peptide-1 receptors (GLP-1Rs). Liraglutide decreases hemoglobin A1c (HbA1c) in type 2 diabetes (T2D) patients when prescribes as monotherapy or in combination with one or more antidiabetic drugs. Usually, it is well tolerated with minor hypoglycemia in combination therapy. Liraglutide reduces cardiovascular events and related risk factors including improvement of lipid profile and control of blood pressure. Accordingly, it can be cost-effective and may be a budget neutral medication option by considering its protective effect on the cardiovascular system in long-term use in the health care plan. In the near future, by pharmacogenomics approach, prediction of the highest patient's response with the lowest adverse drug reactions and also rationality of drug development will be possible. Liraglutide can be used as a desirable medicine for glycemic control and obesity. It shows extensive evidence based benefits in diabetes complications. In this narrative review, we have summarized and evaluated studies related to the role of liraglutide in clinical practice.
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http://dx.doi.org/10.1007/s40200-020-00619-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843728PMC
December 2020

Gut microbiota: a perspective of precision medicine in endocrine disorders.

J Diabetes Metab Disord 2020 Dec 12;19(2):1827-1834. Epub 2020 Aug 12.

Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Gut microbiota composition is unique in every individual, it impacts on organ functions that produce hormones. Gut microbiota composition balance is directly related to our general health status. This continual interaction between gut microbiota and endocrine organs sometimes can be considered as the etiology of diseases such as type 2 diabetes mellitus (T2DM), obesity, osteoporosis, polycystic ovary syndrome (PCOS), and thyroid diseases. Microbiota is introduced for a total collection of microbial organisms in our bodies and microbiome referred for their genome and their collective functions. Near 100 trillion microorganisms live in our body and almost all of them occupy the human gut gastrointestinal tract. Precision medicine can play a crucial role in health maintenance by affecting gut microbiota composition in every individual. It can also develop special treatments specifically for every individual. In this review, we addressed any correlation between gut microbiota and endocrine disorders including T2DM, obesity, PCOS, thyroid disorders and osteoporosis.
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http://dx.doi.org/10.1007/s40200-020-00593-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843755PMC
December 2020

Diabetes Management during the COVID-19 Pandemic: An Iranian Expert Opinion Statement.

Arch Iran Med 2020 08 1;23(8):564-567. Epub 2020 Aug 1.

Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.

The coronavirus infection is an evolving pandemic with high morbidity and mortality, especially in people with comorbidities. The case fatality rate (CFR) is 9.2% in the presence of diabetes, while it is 1.4% in those without any comorbidity. Diabetes is a prevalent disease globally; hence, healthcare professionals are highly concerned about severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic progression. Current evidence does not support higher incidence of coronavirus disease 2019 (COVID-19) in people with diabetes (PWD). However, people with diabetes are considered high risk for developing complications. Optimal metabolic control is a challenging concept, especially in the presence of an acute and severe respiratory viral infection. In this consensus, we considered the challenging issues in management of patients with diabetes during the COVID-19 pandemic. The consensus covers various aspects of outpatient as well as inpatient care based on the current evidence.
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http://dx.doi.org/10.34172/aim.2020.61DOI Listing
August 2020

PPARG (Pro12Ala) genetic variant and risk of T2DM: a systematic review and meta-analysis.

Sci Rep 2020 07 29;10(1):12764. Epub 2020 Jul 29.

Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, 1411413137, Tehran, Iran.

Type 2 diabetes mellitus (T2DM) is a complex disease caused by the interaction between genetic and environmental factors. A growing number of evidence suggests that the peroxisome proliferator-activated receptor gamma (PPARG) gene plays a major role in T2DM development. Meta-analysis of genetic association studies is an efficient tool to gain a better understanding of multifactorial diseases and potentially to provide valuable insights into gene-disease interactions. The present study was focused on assessing the association between Pro12Ala variation in the PPARG and T2DM risk through a comprehensive meta-analysis. We searched PubMed, WoS, Embase, Scopus and ProQuest from 1990 to 2017. The fixed-effect or random-effect model was used to evaluate the pooled odds ratios (ORs) and 95% confidence intervals (CIs) depending on the heterogeneity among studies. The sources of heterogeneity and publication bias among the included studies were assessed using I statistics and Egger's tests. A total of 73 studies, involving 62,250 cases and 69,613 controls were included. The results showed that the minor allele (G) of the rs1801282 variant was associated with the decreased risk of T2DM under different genetic models. Moreover, the protective effect of minor allele was detected to be significantly more in some ethnicities including the European (18%), East Asian (20%), and South East Asian (18%). And the reduction of T2DM risk in Ala12 carriers was stronger in individuals from North Europe rather than Central and South Europe. Our findings indicated that the rs1801282 variant may contribute to decrease of T2DM susceptibility in different ancestries.
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http://dx.doi.org/10.1038/s41598-020-69363-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7391673PMC
July 2020

Extremely elevated serum alkaline phosphatase level upon treatment with teriparatide: a case report.

J Med Case Rep 2020 Jul 3;14(1):87. Epub 2020 Jul 3.

Rheumatology Research Center, Tehran University of Medical Sciences (TUMS), PO-Box: 1411713137, Tehran, Iran.

Background: Teriparatide is a homolog of human parathyroid hormone (1-34), which is approved for the treatment of postmenopausal and glucocorticoid-induced osteoporosis. Several minor and transient side effects have been reported for teriparatide. However, controversial findings showed an increased risk of more significant adverse effects, including osteosarcoma in humans, although this finding has been demonstrated primarily in murine models.

Case Presentation: We present a case of a 22-year-old Persian man with a previous history of systemic lupus erythematosus and glucocorticoid-induced osteoporosis. He had a previous history of joint hypermobility, idiopathic kyphoscoliosis, mitral valve prolapse, and bilateral congenital inguinal hernia, which were probably compatible with an inherited connective tissue disease. He was treated with teriparatide for 7 months because of glucocorticoid-induced osteoporosis. He was referred with a complaint of generalized bone pain and an extremely elevated serum alkaline phosphatase concentration of 6480 U/L (normal range, 80-306). A whole-body bone scan revealed a diffuse increased osseous uptake. Furthermore, the patient's systemic lupus erythematosus was clinically inactive on the basis of laboratory findings during this period. The medication was discontinued, and the patient's serum alkaline phosphatase level began to decline.

Conclusions: To the best of our knowledge, this is the first case of an osteoblast hyperactivation state observed during treatment with teriparatide. It appears that the osteoblastogenic effect of teriparatide might induce this condition and, most likely, osteosarcoma in certain populations. However, the potential influence of the patient's young age, systemic lupus erythematosus, underlying inherited connective tissue disease, and medication use cannot be ignored. The potential risk factors of this side effect shall be studied in specific subpopulations of patients with osteoporosis in future studies.
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http://dx.doi.org/10.1186/s13256-020-02416-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333273PMC
July 2020

common genetic variant and type 2 diabetes mellitus risk.

J Diabetes Metab Disord 2020 Jun 8;19(1):47-51. Epub 2019 Dec 8.

Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Background: Type 2 diabetes mellitus (T2DM) is a multifactorial trait that both environmental and genetic factors contribute to its pathogenesis. The most common single nucleotide polymorphism (SNP) of the gene, rs2237892, is highly associated with the risk of T2DM. The aim of the present study was to examine any association between gene rs2237892 variant and risk of T2DM in a group of Iranian patients.

Methods: Genotyping was carried out in 100 type 2 diabetic patients and 100 non-diabetic subjects using the Sanger sequencing method.

Results: The CC genotype caused more than 30% reduction in the risk of T2DM in compared with CT. Nonetheless, this association was not statistically significant and this variant had no protective effect for T2DM. A significant difference was not found in genotypes (CC, CT, and TT) and alleles (C and T) frequency of rs2237892 SNP between T2DM and control groups ( = 0.475 and  = 0.470, respectively).

Conclusions: Our investigations did not show enough evidence for the presence of an association between gene rs2237892 polymorphism and risk of T2DM among a group of Iranian patients.
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http://dx.doi.org/10.1007/s40200-019-00473-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271092PMC
June 2020

Association Analysis of the HNF4A Common Genetic Variants with Type 2 Diabetes Mellitus Risk.

Int J Mol Cell Med 2019 28;8(Suppl1):56-62. Epub 2019 Aug 28.

Medical Genomics Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Type 2 diabetes mellitus (T2DM) is a complex disease that involves a wide range of genetic and environmental factors. The carries out hepatic gluconeogenesis regulation and insulin secretion crucially, and the corresponding gene was shown to be linked to T2DM in several studies. The aim of the present study was to evaluate the association between  genetic variants (rs1884613 and rs1884614) and T2DM risk in a group of Iranian patients. This case-control study included 100 patients with T2DM and 100 control subjects. Genotyping of two single nucleotide polymorphisms (SNPs) (rs1884613 and rs1884614) of  was performed using the sequencing method. There was no statistically significant difference for allele and genotype distribution of the  common variants (rs1884613 and rs1884614) between subjects with and without T2DM (P=0.9 and P=0.9, respectively). Regarding diabetic complications, although the presence of mentioned polymorphisms increased the odds of developing ophthalmic complications and reduction of the odds of renal complications among diabetic patients, the mentioned risk was non- significant and cannot be generalized to the whole population.  It seems that rs1884613 and rs1884614 polymorphisms are not associated with T2DM or its renal and ophthalmic complications. To investigate the precise influence of these polymorphisms, prospective cohorts with larger sample sizes are required.
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http://dx.doi.org/10.22088/IJMCM.BUMS.8.2.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175614PMC
August 2019

Precision Medicine in Non Communicable Diseases.

Int J Mol Cell Med 2019 25;8(Suppl1):1-18. Epub 2019 Jul 25.

Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Non-communicable diseases (NCDs) are the leading cause of death and disease burden globally, cardiovascular diseases (CVDs) account for the major part of death related to NCDs followed by different types of cancer, chronic obstructive pulmonary disease (COPD), and diabetes. As the World Health Organization (WHO) and the United Nations have announced a 25% reduction in mortality of NCDs by 2025, different communities need to adopt preventive strategies for achieving this goal. Personalized medicine approach as a predictive and preventive strategy aims for a better therapeutic goal to the patients to maximize benefits and reduce harms. The clinical benefits of this approach are already realized in cancer targeted therapy, and its impact on other conditions needs more studies in different societies. In this review, we essentially describe the concept of personalized (or precision) medicine in association with NCDs and the future of precision medicine in prediction, prevention, and personalized treatment.
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http://dx.doi.org/10.22088/IJMCM.BUMS.8.2.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175610PMC
July 2019

The Effectiveness of a Peer Coaching Education on Control and Management of Type 2 Diabetes in Women: A Protocol for a Randomized Controlled Trial.

Int J Community Based Nurs Midwifery 2017 Apr;5(2):153-164

Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Diabetes Education by Peer Coaching is a strategy which helps the patients with diabetes in the field of behavioral and emotional problems. However, the results of studies in this field in other countries could not be generalized in our context. So, the current study aimed to examine the effectiveness of Diabetes Education by Peer Coaching on Diabetes Management.

Methods: Outcome variables for patients and peer coaches are measured at baseline and in3,6 and 12 months. The primary outcome consisted of Fasting Blood Sugar (FBS) and HbA1c. Secondary outcomes included Blood Pressure (BP), Body Mass Index (BMI,) Waist-Hip Ratio (WHR), Lipid Profile, diabetes self-care activities, diabetes-related quality of life, depression, and Social Capital levels.Initial analyses compared the frequency of baseline levels of outcome and other variables using a simple Chi-square test, t-test and the Mann-Whitney- U test. Sequential measurements in each group were evaluated by two-way analysis of variance. If significant differences in baseline characteristics were found, analyses were repeated adjusting for these differences using ANOVA and logistic regression for multivariate analyses. Additional analyses were conducted to look for the evidence of effect modification by pre-specified subgroups.

Conclusion: The fact is that self-control and self-efficacy in diabetes management and treatment of diabetes could be important components. It seems that this research in this special setting with cultural differences would provide more evidence about peer-coaching model. It seems that if the peer-coaching model improves learning situations between patients with diabetes by offering one-on-one Diabetes Self Management Education, it could be an interactive approach to diabetic education. IRCT201501128175N3.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385238PMC
April 2017

Path to Personalized Medicine for Type 2 Diabetes Mellitus: Reality and Hope.

Acta Med Iran 2017 Mar;55(3):166-174

Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Type 2 diabetes mellitus (T2DM) is recognized as a public health problem and increasingly prevalent illness. Key elements of the guideline for diabetes care are based on evidence-based medicine approach and apply for population, not individuals. However, individualized care can improve diabetes management. Personalized medicine is otherwise called precision medicine tries to find better prediction, prevention, and intervention for T2DM individuals. Precision medicine in diabetes refers to the utility of genomics data of a patient with diabetes to provide the most effective diagnosis strategies and treatment plans. Over 100 genetic loci influence susceptibility to T2DM. Genomics data together with the potential of other "Omics" and clinical evidence-based data will lead to diabetes care improvement in the context of personalized medicine in the near future. Breakthrough of technologies enables much greater improvements in the understanding of individual variations that may alter the T2DM outcome. This article represents a comprehensive review of current knowledge on the impact of personalized medicine in T2DM.
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March 2017

Vitamin D status and its relationship with bone mineral density in a healthy Iranian population.

Rev Bras Ortop 2016 Jul-Aug;51(4):454-8. Epub 2016 Feb 2.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Objectives: Considering the controversial results regarding the relationship between vitamin D levels and bone mineral density in different populations, the present study was designed to evaluate this correlation in a healthy Iranian population.

Methods: Using a random cluster sample of apparently healthy men and women, this multicenter cross-sectional study was carried out among 4450 individuals living in urban areas of five major cities in Iran. Bone mineral density (BMD) values at different sites were analyzed along with the serum levels of 25(OH)D and PTH. Analysis of variance (ANOVA) was used to estimate the main effects, through comparing the mean values of these markers based on the bone mineral density status of the study group in each sex.

Results: 25(OH)D levels were inversely correlated with BMD values at total hip (r = -0.062 in men and r = -0.057 in women) and spine (r = -0.076 in men and r = -0.107 in women). After adjusting the data for age, the inverse correlation was no longer statistically significant.

Conclusion: Serum 25(OH)D levels are inversely correlated with bone mass values in both sexes.
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http://dx.doi.org/10.1016/j.rboe.2015.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974161PMC
August 2016

Association between vitamin D levels and BMI values in an Iranian population.

Clin Lab 2014 ;60(3):383-9

Background: This study aimed to determine the relationship between vitamin D levels and body mass index (BMI) values in a group of Iranian people.

Methods: In this cross-sectional study, the anthropometric values and serum vitamin D levels were measured in more than 3500 healthy adults, representing a random sample of the Iranian population in the urban areas of five large cities of Iran. The data used in this study were from the database of the Iranian Multi-centric Osteoporosis Studies (IMOS), previously conducted to assess bone health in the country. The association between BMI values and serum level of 25(OH)D was thereafter calculated.

Results: About 46% of the studied 3669 subjects had moderate to severe vitamin D deficiency regardless of their gender. About 43.2% of the overweight individuals and 45.2% of the obese had moderate-to-severe vitamin D deficiency. A linear but weak increasing trend was reported in the serum levels of 25(OH)D based on increasing BMI values. The significance of the value, however, disappeared after the data was adjusted for the possible confounders.

Conclusions: A statistically positive association found between serum levels of 25(OH)D and BMI values raised concerns over the available data, suggesting that more studies should be performed in this regard.
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April 2014

Prevalence of hypertension in an Iranian population.

Ren Fail 2014 Feb 13;36(1):87-91. Epub 2013 Sep 13.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences , Tehran , Iran .

Background: The prevalence of HTN varies considerably worldwide. This study was carried out to illustrate the prevalence of hypertension in a group of Iranian population based on the data gathered for Iranian Multi-centric Osteoporosis Studies (IMOS).

Methods: This study analyzes the systolic and diastolic blood pressure from the IMOS, a multi-centric cross-sectional study carried out on apparently healthy men and women in urban areas of major Iranian cities to study bone health.

Results: Overall, 26.21% of the studied cases were estimated to be hypertensive; the condition was more prevalent among older males. Each year increase in age was associated with 1.070 higher risk of developing hypertension.

Conclusion: Hypertension is quite prevalent among Iranian population and the prevalence of the condition is rising in the context of progressive rise in age and BMI.
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http://dx.doi.org/10.3109/0886022X.2013.832315DOI Listing
February 2014

Traumatic brain injury and adrenal insufficiency: morning cortisol and cosyntropin stimulation tests.

Arch Med Sci 2013 Feb 8;9(1):68-73. Epub 2012 Oct 8.

Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Adrenal insufficiency (AI) has a great impact on the prognosis of patients with traumatic brain injury. There is a lack of consensus regarding the diagnostic criteria of AI. In these patients with acute stress we compared fasting cortisol, low and high dose cosyntropin stimulation tests to assess adrenal function in patients with moderate to severe traumatic brain injury.

Material And Methods: This multicenter, cross-sectional study recruited 50 consecutive patients (aged between 15 and 70 years old) with moderate to severe traumatic brain injury who survived more than 5 days after the event. The patients' adrenal function was assessed using the fasting cortisol, 1 and 250-µg ACTH stimulation tests.

Results: More cases of AI were detected by the 1-µg ACTH stimulation test compared to those detected by the basal serum cortisol level and 250-µg ACTH stimulation test. The κ test showed no agreement between these tests. The incidence of AI in the first 10 days after traumatic brain injury varied from 34% to 82% according to the various definitions of AI. The incidence of hypotension and need for vasopressors was higher in the patients diagnosed by the 250-µg ACTH stimulation test (p < 0.0001).

Conclusions: The incidence of secondary AI in moderate to severe traumatic brain injury seems to be high. A combination of stimulation test (either 250 or 1 µg) and basal cortisol level may improve diagnostic ability compared to either test alone. Hence performing both tests for the assessment of adrenal function in patients with traumatic brain injury is recommended.
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http://dx.doi.org/10.5114/aoms.2012.30833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598134PMC
February 2013

The discriminative value of various biochemical parameters in detecting varying degrees of vitamin D deficiency in the Iranian population.

Clin Lab 2011 ;57(3-4):163-70

Endocrinology & Metabolism Research Center (EMRC), Tehran University of Medical Sciences, Tehran, Iran.

Background: The present study was designed to assess the status and the discriminatory ability of serum Alk-Ph, Ca, P, and PTH in detecting hypovitaminosis D in some selected Iranian populations.

Methods: Using a random cluster sample of apparently healthy men and women, this multi-centric cross-sectional study was carried out among the Iranian urban population of five large cities (Tehran, Tabriz, Mashhad, Shiraz, and Booshehr). Serum levels of 25(OH)D, PTH, Alk-Ph, Ca, and P levels were analyzed. Analysis of variance (ANOVA) was used to estimate the main effects by comparing the mean values of serum PTH, Alk-Ph, Ca, and P at different 25(OH)D levels. The discriminative value of the studied biochemical markers in detecting hypovitaminosis D was assessed by ROC curve analysis.

Results: From among the studied subjects, 2164 (57.5%) had moderate to severe vitamin D deficiency. The areas under the ROC curves showed the low accuracy of PTH (0.579), Alk-Ph (0.478), Ca (0.496), and P (0.406) in detecting subjects with a vitamin D concentration < 20 ng/mL.

Conclusions: Abnormalities in routine markers of bone profile such as PTH, Alk-Ph, Ca, and P are not adequate enough to discriminate patients with hypovitaminosis D.
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June 2011
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