Publications by authors named "Hamid Kashkar"

53Publications

ATP synthase modulation leads to an increase of spare respiratory capacity in HPV associated cancers.

Sci Rep 2020 Oct 15;10(1):17339. Epub 2020 Oct 15.

Institute of Virology, University of Cologne, Medical Faculty and University Hospital Cologne, Fürst-Pückler-Str. 56, 50935, Cologne, Germany.

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http://dx.doi.org/10.1038/s41598-020-74311-6DOI Listing
October 2020

An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells.

Proc Natl Acad Sci U S A 2020 Oct 22;117(40):24957-24963. Epub 2020 Sep 22.

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.2015372117DOI Listing
October 2020

CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage.

Cell Death Dis 2020 Sep 10;11(9):740. Epub 2020 Sep 10.

Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/s41419-020-02923-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484759PMC
September 2020

Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed-Sternberg cells.

Carcinogenesis 2020 Apr 7. Epub 2020 Apr 7.

Center for Physiology and Pathophysiology, Institute of Vegetative Physiology, Medical Faculty, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1093/carcin/bgaa032DOI Listing
April 2020

Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide.

Nat Microbiol 2020 02 23;5(2):354-367. Epub 2019 Dec 23.

Institute for Medical Microbiology, Immunology and Hygiene, Centre for Molecular Medicine Cologne and Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/s41564-019-0620-5DOI Listing
February 2020

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.

Nature 2019 11 20;575(7784):683-687. Epub 2019 Nov 20.

Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), CECAD Research Center, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/s41586-019-1770-6DOI Listing
November 2019

The X-linked inhibitor of apoptosis protein (XIAP) is involved in melanoma invasion by regulating cell migration and survival.

Cell Oncol (Dordr) 2019 Jun 18;42(3):319-329. Epub 2019 Feb 18.

Department of Dermatology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

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http://dx.doi.org/10.1007/s13402-019-00427-1DOI Listing
June 2019

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages.

Cell Rep 2018 11;25(9):2354-2368.e5

Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, 81377 Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183169
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http://dx.doi.org/10.1016/j.celrep.2018.10.087DOI Listing
November 2018

Tumour-infiltrating neutrophils counteract anti-VEGF therapy in metastatic colorectal cancer.

Br J Cancer 2019 01 31;120(1):69-78. Epub 2018 Oct 31.

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC) and Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, CECAD Research Center, Joseph-Stelzmann-Str. 26, 50931, Cologne, Germany.

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http://www.nature.com/articles/s41416-018-0198-3
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http://dx.doi.org/10.1038/s41416-018-0198-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325148PMC
January 2019

PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.

Nat Cell Biol 2017 04 13;19(4):318-328. Epub 2017 Mar 13.

Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne 50931, Germany.

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http://dx.doi.org/10.1038/ncb3488DOI Listing
April 2017

B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice.

Blood 2016 06 5;127(22):2732-41. Epub 2016 Apr 5.

Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany; Center of Integrated Oncology, University Hospital of Cologne, Cologne, Germany; and Center of Molecular Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2015-11-684183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891954PMC
June 2016

Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.

Nat Commun 2016 Feb 4;7:10612. Epub 2016 Feb 4.

Institute for Genetics and CECAD Research Center, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany.

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http://dx.doi.org/10.1038/ncomms10612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4743000PMC
February 2016

IAP antagonization promotes inflammatory destruction of vascular endothelium.

EMBO Rep 2015 Jun 30;16(6):719-27. Epub 2015 Mar 30.

Center for Molecular Medicine Cologne (CMMC) and Institute for Medical Microbiology, Immunology and Hygiene (IMMIH) University of Cologne, Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany

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http://dx.doi.org/10.15252/embr.201439616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467856PMC
June 2015

Regulation of the DNA damage response by ubiquitin conjugation.

Front Genet 2015 10;6:98. Epub 2015 Mar 10.

Centre for Molecular Medicine Cologne and Institute for Medical Microbiology, Immunology and Hygiene, University Hospital of Cologne Cologne, Germany ; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University Hospital of Cologne Cologne, Germany.

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http://dx.doi.org/10.3389/fgene.2015.00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354423PMC
March 2015

The cofilin phosphatase slingshot homolog 1 (SSH1) links NOD1 signaling to actin remodeling.

PLoS Pathog 2014 Sep 4;10(9):e1004351. Epub 2014 Sep 4.

Institute for Medical Microbiology, Immunology and Hygiene, Cologne, Germany; University of Hohenheim, Institute of Nutritional Medicine, Stuttgart, Germany.

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http://dx.doi.org/10.1371/journal.ppat.1004351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154870PMC
September 2014

BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella.

EMBO J 2014 Oct 23;33(19):2171-87. Epub 2014 Jul 23.

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany

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http://dx.doi.org/10.15252/embj.201387244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4282505PMC
October 2014

Noxa and cancer therapy: Tuning up the mitochondrial death machinery in response to chemotherapy.

Mol Cell Oncol 2014 28;1(1):e29906. Epub 2014 Jul 28.

Centre for Molecular Medicine Cologne (CMMC); Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD); University of Cologne, Köln, Germany; Institute for Medical Microbiology, Immunology and Hygiene (IMMIH); University of Cologne, Köln, Germany.

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http://dx.doi.org/10.4161/mco.29906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905168PMC
June 2016

Dimethylfumarate induces apoptosis in human mast cells.

Exp Dermatol 2013 Nov;22(11):719-24

Department of Dermatology, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1111/exd.12247DOI Listing
November 2013

Obesity promotes liver carcinogenesis via Mcl-1 stabilization independent of IL-6Rα signaling.

Cell Rep 2013 Aug 15;4(4):669-80. Epub 2013 Aug 15.

Max Planck Institute for Neurological Research Cologne, Institute for Genetics, University of Cologne, 50937 Cologne, Germany.

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http://dx.doi.org/10.1016/j.celrep.2013.07.023DOI Listing
August 2013

Second mitochondria-derived activator of caspase (SMAC) mimetic potentiates tumor susceptibility toward natural killer cell-mediated killing.

Leuk Lymphoma 2014 Mar 26;55(3):645-51. Epub 2013 Jun 26.

Center for Molecular Medicine Cologne (CMMC), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) and Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), University of Cologne , Cologne , Germany.

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http://dx.doi.org/10.3109/10428194.2013.807925DOI Listing
March 2014

Ubiquitin C-terminal hydrolase-L1 potentiates cancer chemosensitivity by stabilizing NOXA.

Cell Rep 2013 Mar 14;3(3):881-91. Epub 2013 Mar 14.

Centre for Molecular Medicine Cologne and Institute for Medical Microbiology, Immunology and Hygiene, University Hospital of Cologne, 50935 Cologne, Germany.

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http://dx.doi.org/10.1016/j.celrep.2013.02.014DOI Listing
March 2013

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.

Nat Cell Biol 2011 Apr 27;13(4):434-46. Epub 2011 Mar 27.

Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, University Hospital Cologne, Max Planck Institute for Neurological Research, Zülpicher Strasse 47, D-50674 Cologne, Germany.

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http://dx.doi.org/10.1038/ncb2211DOI Listing
April 2011

X-linked inhibitor of apoptosis: a chemoresistance factor or a hollow promise.

Authors:
Hamid Kashkar

Clin Cancer Res 2010 Sep 3;16(18):4496-502. Epub 2010 Aug 3.

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Köln, Germany.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-10-1664DOI Listing
September 2010

The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack.

Cancer Res 2010 Mar 23;70(5):1825-34. Epub 2010 Feb 23.

Institute for Medical Microbiology, Immunology and Hygiene, Medical Faculty, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-3175DOI Listing
March 2010

Interleukin-6 is essential for zwitterionic polysaccharide-mediated abscess formation.

Innate Immun 2010 Oct 6;16(5):310-21. Epub 2009 Nov 6.

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne Medical Centre, Cologne, Germany.

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http://dx.doi.org/10.1177/1753425909346974DOI Listing
October 2010

Riboflavin kinase couples TNF receptor 1 to NADPH oxidase.

Nature 2009 Aug 29;460(7259):1159-63. Epub 2009 Jul 29.

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/nature08206DOI Listing
August 2009

Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes.

Nat Immunol 2009 Jul 14;10(7):761-8. Epub 2009 Jun 14.

Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Germany.

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http://dx.doi.org/10.1038/ni.1757DOI Listing
July 2009

Overexpression of TOSO in CLL is triggered by B-cell receptor signaling and associated with progressive disease.

Blood 2008 Nov 15;112(10):4213-9. Epub 2008 Aug 15.

Laboratory of Cellular Immunotherapy, Clinic I of Internal Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2008-05-157255DOI Listing
November 2008

PtdIns(4,5)P-restricted plasma membrane localization of FAN is involved in TNF-induced actin reorganization.

EMBO J 2007 Jul 28;26(14):3308-21. Epub 2007 Jun 28.

Institute for Medical Microbiology, Immunology and Hygiene, Medical Faculty, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1038/sj.emboj.7601778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933409PMC
July 2007

Serpin-6 expression protects embryonic stem cells from lysis by antigen-specific CTL.

J Immunol 2007 Mar;178(6):3390-9

Institute for Medical Microbiology, Immunology and Hygiene, Medical Center, University of Cologne, Goldenfelsstrasse 19-21, 50935 Cologne, Germany.

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http://dx.doi.org/10.4049/jimmunol.178.6.3390DOI Listing
March 2007

NF-kappaB-independent down-regulation of XIAP by bortezomib sensitizes HL B cells against cytotoxic drugs.

Blood 2007 May 21;109(9):3982-8. Epub 2006 Dec 21.

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19-21, 50935 Köln, Germany.

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http://dx.doi.org/10.1182/blood-2006-10-053959DOI Listing
May 2007

Staphylococcus aureus subvert autophagy for induction of caspase-independent host cell death.

J Biol Chem 2007 Jan 29;282(4):2695-706. Epub 2006 Nov 29.

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, 50935 Cologne, Germany.

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http://dx.doi.org/10.1074/jbc.M609784200DOI Listing
January 2007

XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack.

Blood 2006 Nov 25;108(10):3434-40. Epub 2006 Jul 25.

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19-21, 50935 Köln, Germany.

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http://dx.doi.org/10.1182/blood-2006-05-021675DOI Listing
November 2006

Novel tumor necrosis factor-responsive mammalian neutral sphingomyelinase-3 is a C-tail-anchored protein.

J Biol Chem 2006 May 3;281(19):13784-93. Epub 2006 Mar 3.

Institute for Medical Microbiology, Immunology, and Hygiene, Center for Molecular Medicine--Cologne, University of Cologne, 50935 Köln, Germany.

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http://dx.doi.org/10.1074/jbc.M511306200DOI Listing
May 2006

Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane.

J Biol Chem 2005 May 1;280(21):20804-13. Epub 2005 Mar 1.

Institute for Medical Microbiology, Immunology and Hygiene and Center for Molecular Medicine Cologne, University of Cologne, 50935 Cologne, Germany.

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http://dx.doi.org/10.1074/jbc.M410869200DOI Listing
May 2005

XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells.

J Exp Med 2003 Jul;198(2):341-7

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Goldenfelsstrasse 19-21, 50935 Cologne, Germany.

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http://jem.rupress.org/content/198/2/341.full.pdf
Web Search
http://www.jem.org/lookup/doi/10.1084/jem.20021279
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http://dx.doi.org/10.1084/jem.20021279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2194071PMC
July 2003