Publications by authors named "Hal M Hoffman"

100Publications

Pediatric Recurrent Fever and Autoinflammation from the Perspective of an Allergist/Immunologist.

J Allergy Clin Immunol 2020 Sep 28. Epub 2020 Sep 28.

Division of Allergy, Immunology & Rheumatology, Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego.

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http://dx.doi.org/10.1016/j.jaci.2020.09.019DOI Listing
September 2020

Vitamin D ameliorates adipose browning in chronic kidney disease cachexia.

Sci Rep 2020 Aug 25;10(1):14175. Epub 2020 Aug 25.

Pediatric Nephrology, Rady Children's Hospital San Diego, University of California, San Diego, USA.

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http://dx.doi.org/10.1038/s41598-020-70190-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7447759PMC
August 2020

Opportunistic Invasive Infection by Group A Streptococcus During Anti-Interleukin-6 Immunotherapy.

J Infect Dis 2020 Aug 18. Epub 2020 Aug 18.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.1093/infdis/jiaa511DOI Listing
August 2020

Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis-associated cachexia.

J Cachexia Sarcopenia Muscle 2020 02 13;11(1):120-134. Epub 2019 Nov 13.

Pediatric Nephrology, Rady Children's Hospital-San Diego, University of California, San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1002/jcsm.12497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015252PMC
February 2020

Autoinflammatory disease: New mouse models and therapies.

Authors:
Hal M Hoffman

J Allergy Clin Immunol 2020 01 30;145(1):116-118. Epub 2019 Oct 30.

Division of Pediatric Allergy, Immunology, and Rheumatology, University of California at San Diego and Rady Children's Hospital of San Diego, La Jolla, Calif. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.10.016DOI Listing
January 2020

Differential Immune Activation in Fetal Macrophage Populations.

Sci Rep 2019 05 22;9(1):7677. Epub 2019 May 22.

Department of Pediatrics, University of California, San Diego, La Jolla, CA, Rady Children's Hospital, San Diego, San Diego, CA, USA.

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http://www.nature.com/articles/s41598-019-44181-8
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http://dx.doi.org/10.1038/s41598-019-44181-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531440PMC
May 2019

CAPS and NLRP3.

J Clin Immunol 2019 04 10;39(3):277-286. Epub 2019 May 10.

Division of Pediatric Allergy, Immunology, and Rheumatology, Rady Children's Hospital of San Diego, University of California, San Diego, San Diego, CA, USA.

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http://dx.doi.org/10.1007/s10875-019-00638-zDOI Listing
April 2019

Neutrophils: New insights and open questions.

Sci Immunol 2018 12 7;3(30). Epub 2018 Dec 7.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1126/sciimmunol.aat4579DOI Listing
December 2018

TLR Activation Alters Bone Marrow-Derived Macrophage Differentiation.

J Innate Immun 2019 8;11(1):99-108. Epub 2018 Nov 8.

Department of Pediatrics, University of California San Diego, Rady Children's Hospital, San Diego, California, USA,

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https://www.karger.com/Article/FullText/494070
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http://dx.doi.org/10.1159/000494070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296861PMC
February 2020

JAK inhibitors in autoinflammation.

J Clin Invest 2018 07 11;128(7):2760-2762. Epub 2018 Jun 11.

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https://www.jci.org/articles/view/121526
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http://dx.doi.org/10.1172/JCI121526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025991PMC
July 2018

Canakinumab for the Treatment of Autoinflammatory Recurrent Fever Syndromes.

N Engl J Med 2018 05;378(20):1908-1919

From the Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Rome (F.D.B.), Clinica Pediatrica e Reumatologia, Unità Operativa Semplice Dipartimentale di Malattie Autoinfiammatorie e Immunodeficienze, IRCCS, Istituto G. Gaslini, Genoa (M.G.), the Pediatric Clinic, University of Brescia and Spedali Civili, Brescia (M.C.), and the Amyloidosis Research and Treatment Center, Biotechnology Research Laboratories, Fondazione IRCCS Policlinico San Matteo, Pavia (L.O.) - all in Italy; the Division of Pediatric Rheumatology, Hospital Sant Joan de Déu, Universitat de Barcelona (J.A.), and the Internal Medicine Department, Autoimmune and Systemic Diseases Unit, Hospital Vall d'Hebron (S.B.-R.), Barcelona, and the Pediatric Rheumatology Unit, Hospital Universitario y Politécnico La Fe, Valencia (I.C.P.) - all in Spain; the Rheumatology Unit, Hadassah-Hebrew University Hospital (E.B.-C.), and the Pediatric Rheumatology Unit, Shaare Zedek Medical Center (P.J.H.), Jerusalem, and Heller Institute of Medical Research and Medicine Faculty, Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv (A.L.) - all in Israel; the Division of Pediatrics, University Medical Center Utrecht, Utrecht (J.F.), and the Radboud Expertise Center for Immunodeficiency and Autoinflammation, Department of Internal Medicine, Radboud University Medical Center, Nijmegen (A. Simon) - both in the Netherlands; the Departments of Pediatrics and Medicine, University of California at San Diego and Rady Children's Hospital San Diego, San Diego (H.M.H.); the Department of Pediatric Rheumatology, Centre de Référence des Maladies Auto-inflammatoires et de l'Amylose Inflammatoire, Centre Hospitalier Universitaire (CHU) de Bicêtre, Assistance Publique-Hopitaux de Paris (APHP), Université de Paris Sud (I.K.-P.), and Paris-Descartes University, Imagine Institute, Unité d'Immuno-Hématologie et Rhumatologie Pédiatrique, Hôpital Necker-Enfants Malades, APHP (P.Q.), Paris; the National Amyloidosis Centre, University College London Division of Medicine, Royal Free Campus (H.J.L.), and University College London, Great Ormond Street Institute of Child Health, and Great Ormond Street Hospital for Children NHS Foundation Trust (P.B.), London; the Department of Pediatrics, Hacettepe University, Ankara (S.O.), and the Department of Pediatric Rheumatology, Cerrahpasa Medical School (O.K.), and Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology (A.G.), Istanbul University, Istanbul - all in Turkey; the Department of Pediatrics, Division of Pediatric Rheumatology, Cleveland Clinic, Cleveland (A.Z.); the Department of Infectious Diseases and General Internal Medicine, CHU Sart-Tilman, University of Liège, Liege (M.M.), and the Department of Infectious Diseases and Immunity, Jessa Hospital, University of Hasselt, Hasselt (J.V.H.) - both in Belgium; the Department of Clinical Immunology, Center for Pediatric Hematology, Oncology, and Immunology, Moscow (A. Shcherbina); Pediatric Rheumatology of Western Switzerland, University of Lausanne, Lausanne, (M.H.), and Novartis, Basel (K.L., A. Speziale, G.J.) - both in Switzerland; the Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan (R.H.); and the Department of Pediatrics, Semmelweis Egyetem, Budapest, Hungary (T.C.).

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http://dx.doi.org/10.1056/NEJMoa1706314DOI Listing
May 2018

Increased Neutrophil Secretion Induced by Mutation Links the Inflammasome to Azurophilic Granule Exocytosis.

Front Cell Infect Microbiol 2017 11;7:507. Epub 2017 Dec 11.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, United States.

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http://dx.doi.org/10.3389/fcimb.2017.00507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732154PMC
December 2018

Group A streptococcal M protein activates the NLRP3 inflammasome.

Nat Microbiol 2017 Oct 7;2(10):1425-1434. Epub 2017 Aug 7.

Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1038/s41564-017-0005-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5750061PMC
October 2017

The innate immune response in fetal lung mesenchymal cells targets VEGFR2 expression and activity.

Am J Physiol Lung Cell Mol Physiol 2017 06 23;312(6):L861-L872. Epub 2017 Mar 23.

Department of Pediatrics, University of California, San Diego, and Rady Children's Hospital, San Diego, California; and

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http://dx.doi.org/10.1152/ajplung.00554.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495951PMC
June 2017

Editorial: It Just Takes One: Somatic Mosaicism in Autoinflammatory Disease.

Arthritis Rheumatol 2017 02;69(2):253-256

University of California at San Diego, La Jolla, and Rady Children's Hospital, San Diego, California.

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http://dx.doi.org/10.1002/art.39961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538189PMC
February 2017

The role of the inflammasome in patients with autoinflammatory diseases.

J Allergy Clin Immunol 2016 07 17;138(1):3-14. Epub 2016 May 17.

Division of Pediatric Allergy, Immunology, and Rheumatology, University of California at San Diego, and Rady Children's Hospital of San Diego, La Jolla, Calif.

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http://dx.doi.org/10.1016/j.jaci.2016.05.001DOI Listing
July 2016

IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development.

J Immunol 2016 Apr 7;196(8):3411-20. Epub 2016 Mar 7.

Department of Pediatrics, University of California, San Diego and Rady Children's Hospital, San Diego, La Jolla, CA 92093;

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http://dx.doi.org/10.4049/jimmunol.1500906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5315059PMC
April 2016

Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease-Associated Abdominal Aortic Aneurysm.

Arterioscler Thromb Vasc Biol 2016 05 3;36(5):886-97. Epub 2016 Mar 3.

From the Division of Infectious Diseases and Immunology, Department of Biomedical Sciences and Pediatrics (D.W., T.R.C., M.N.R., Y.L., S.C., K.S., M.A.), Infectious and Immunologic Diseases Research Center, Department of Biomedical Sciences (T.R.C., S.C., K.S., M.A.), Biomedical Imaging Research Institute, Department of Biomedical Sciences (S.W., D.L.), and Division of Cardiology, Oppenheimer Atherosclerosis Research Center Cedars-Sinai Heart Institute (P.K.S.), Cedars-Sinai Medical Center, Los Angeles, CA; Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan (Y.K.); Regeneron Pharmaceuticals, Tarrytown, NY (W.F., Y.B.); Pediatric Rheumatology, Hospital for Special Surgery and Weill Medical College of Cornell University, New York, NY (T.L.); Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA (M.C.F.); Departments of Pediatrics (H.M.H.) and Medicine (H.M.H.), University of California, San Diego, La Jolla; and Department of Pediatrics, Rady Children's Hospital, San Diego, CA (H.M.H.).

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http://dx.doi.org/10.1161/ATVBAHA.115.307072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850105PMC
May 2016

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Cell 2016 Feb;164(5):896-910

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.12.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769378PMC
February 2016

IL-1β is an innate immune sensor of microbial proteolysis.

Sci Immunol 2016 Aug 19;1(2). Epub 2016 Aug 19.

Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California (UC), San Diego, La Jolla, CA 92093, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1126/sciimmunol.aah3539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358671PMC
August 2016

IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse Model: Role of Both IL-1α and IL-1β.

Arterioscler Thromb Vasc Biol 2015 Dec 29;35(12):2605-16. Epub 2015 Oct 29.

From the Division of Pediatric Infectious Diseases and Immunology, Department of Pediatric, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA (Y.L., D.W., J.D., K.S., S.C., G.H., T.R.C., M.A.); Department of Rheumatology, Pediatric Rheumatology, Hospital for Special Surgery and Weill Medical College of Cornell University, New York, NY (T.J.A.L.); Department of Pathology, David Geffen School of Medicine at UCLA (M.C.F.); and Department of Pediatrics, Pediatric Rheumatology, University of California, San Diego, La Jolla (H.M.H.).

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http://dx.doi.org/10.1161/ATVBAHA.115.306475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662607PMC
December 2015

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease.

Immunity 2015 Aug 11;43(2):264-76. Epub 2015 Aug 11.

Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Interdepartmental Immunobiology Center and Skin Disease Research Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.07.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4666005PMC
August 2015

Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.

J Immunol 2015 Jul 8;195(2):488-97. Epub 2015 Jun 8.

Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada V5Z 1M9; Child and Family Research Institute, Vancouver, British Columbia, Canada V5Z 4H4;

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http://dx.doi.org/10.4049/jimmunol.1403225DOI Listing
July 2015

Transplantation: Outcomes of prenatal immunosuppression.

Nat Rev Nephrol 2015 Jul 19;11(7):390-1. Epub 2015 May 19.

Division of Allergy, Immunology and Rheumatology, Rady Children's Hospital, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0630, USA.

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http://dx.doi.org/10.1038/nrneph.2015.78DOI Listing
July 2015

Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.

Cardiovasc Res 2015 Feb 18;105(2):203-12. Epub 2014 Dec 18.

VCU Pauley Heart Center, Virginia Commonwealth University, Box 980281, 1220 East Broad Street, Richmond, VA 23298, USA Victoria Johnson Research Center, Virginia Commonwealth University, Richmond, VA, USA.

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http://dx.doi.org/10.1093/cvr/cvu259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357795PMC
February 2015

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.

FASEB J 2015 Apr 4;29(4):1269-79. Epub 2014 Dec 4.

*Division of Bone and Mineral Diseases and Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA; and Division of Allergy, Immunology, and Rheumatology, University of California, San Diego, La Jolla, California, USA

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http://dx.doi.org/10.1096/fj.14-264804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396608PMC
April 2015

The inflammasomes and autoinflammatory syndromes.

Annu Rev Pathol 2015 19;10:395-424. Epub 2014 Nov 19.

Department of Pediatrics and.

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http://dx.doi.org/10.1146/annurev-pathol-012414-040431DOI Listing
June 2015

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy.

Proc Natl Acad Sci U S A 2014 Oct 13;111(43):15514-9. Epub 2014 Oct 13.

Department of Genetics & Complex Diseases, Harvard School of Public Health, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1414859111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217429PMC
October 2014

Possible cold autoinflammatory syndrome.

J Allergy Clin Immunol Pract 2014 Sep-Oct;2(5):642. Epub 2014 Apr 18.

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http://dx.doi.org/10.1016/j.jaip.2014.01.007DOI Listing
May 2015

cASCading specks.

Nat Immunol 2014 Aug;15(8):698-700

Department of Pediatrics, University of California, La Jolla, San Diego, California, USA, the Department of Medicine, University of California, La Jolla, San Diego, California, USA, and Rady Children's Hospital San Diego, San Diego, California, USA.

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http://dx.doi.org/10.1038/ni.2942DOI Listing
August 2014

IκB kinase activity drives fetal lung macrophage maturation along a non-M1/M2 paradigm.

J Immunol 2014 Aug 30;193(3):1184-93. Epub 2014 Jun 30.

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093; Rady Children's Hospital, San Diego, CA 92123;Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232;Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232;Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232; andDepartment of Biostatistics, Vanderbilt University, Nashville, TN 37232

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1302516
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http://dx.doi.org/10.4049/jimmunol.1302516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108541PMC
August 2014

NLRP3 inflammasome activation is required for fibrosis development in NAFLD.

J Mol Med (Berl) 2014 Oct 28;92(10):1069-82. Epub 2014 May 28.

Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, MC 0715, La Jolla, CA, 92037-0715, USA.

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http://dx.doi.org/10.1007/s00109-014-1170-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349416PMC
October 2014

The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media.

Innate Immun 2015 Feb 20;21(2):203-14. Epub 2014 Mar 20.

Department of Medicine, Division of Rheumatology, Allergy and Immunology, University of California San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1177/1753425914526074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379507PMC
February 2015

Recurrent fevers and failure to thrive in an infant.

Allergy Asthma Proc 2013 Sep-Oct;34(5):473-9

Scripps Clinic, Department of Medicine, San Diego, CA 92130, USA.

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http://dx.doi.org/10.2500/aap.2013.34.3672DOI Listing
April 2014

From NAFLD to NASH to cirrhosis-new insights into disease mechanisms.

Nat Rev Gastroenterol Hepatol 2013 Nov 20;10(11):627-36. Epub 2013 Aug 20.

Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037-0715, USA.

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http://dx.doi.org/10.1038/nrgastro.2013.149DOI Listing
November 2013

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice.

Hepatology 2014 Mar 30;59(3):898-910. Epub 2014 Jan 30.

Department of Pediatrics, University of California San Diego, La Jolla, CA; Department of Gastroenterology and Hepatology, University Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1002/hep.26592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008151PMC
March 2014

ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6.

Proc Natl Acad Sci U S A 2012 Oct 24;109(41):16648-53. Epub 2012 Sep 24.

Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1204151109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478632PMC
October 2012

Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis.

J Clin Immunol 2013 Jan 29;33(1):162-71. Epub 2012 Aug 29.

Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California-San Diego, 9500 Gilman Dr. MC 0635, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1007/s10875-012-9767-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540165PMC
January 2013

Prolonged urticaria and fever in a toddler.

Allergy Asthma Proc 2012 May-Jun;33(3):297-301

Department od Medicine, University of California-San Diego, USA.

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http://www.ingentaconnect.com/content/10.2500/aap.2012.33.35
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http://dx.doi.org/10.2500/aap.2012.33.3567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490505PMC
September 2012

Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity.

J Autoimmun 2012 Dec 10;39(4):323-31. Epub 2012 May 10.

Department of Molecular and Experimental Medicine, MEM125, Scripps Research Institute, La Jolla, CA 92037, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089684111200046
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http://dx.doi.org/10.1016/j.jaut.2012.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570757PMC
December 2012

Autoinflammation: translating mechanism to therapy.

J Leukoc Biol 2011 Jul 17;90(1):37-47. Epub 2011 Feb 17.

Division of Allergy, Immunology, and Rheumatology, University of California at San Diego, School of Medicine, 9500 Gilman Dr., La Jolla, CA 92093-0635, USA.

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http://dx.doi.org/10.1189/jlb.1110616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219035PMC
July 2011

Genetic and molecular basis of inflammasome-mediated disease.

J Biol Chem 2011 Apr 4;286(13):10889-96. Epub 2011 Feb 4.

Department of Pediatrics, University of California at San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.R110.135491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064144PMC
April 2011

Recurrent fever syndromes in patients after recovery from Kawasaki syndrome.

Pediatrics 2011 Feb 10;127(2):e489-93. Epub 2011 Jan 10.

Department of Pediatrics, University of California San Diego and Rady Children’s Hospital, San Diego, California, USA.

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http://dx.doi.org/10.1542/peds.2010-1218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3025426PMC
February 2011

Inflammasome and IL-1beta-mediated disorders.

Curr Allergy Asthma Rep 2010 Jul;10(4):229-35

Division of Allergy and Immunology, University of California at San Diego and Rady Children's Hospital of San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1007/s11882-010-0109-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2892083PMC
July 2010

Therapy of autoinflammatory syndromes.

Authors:
Hal M Hoffman

J Allergy Clin Immunol 2009 Dec;124(6):1129-38; quiz 1139-40

Department of Pediatrics and Medicine, Division of Allergy, Immunology, and Rheumatology, University of California at San Diego, School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093-0635, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508191PMC
December 2009

Familial atypical cold urticaria: description of a new hereditary disease.

J Allergy Clin Immunol 2009 Dec;124(6):1245-50

Division of Rheumatology, Allergy, and Immunology, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1016/j.jaci.2009.09.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794966PMC
December 2009

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome.

J Cell Biol 2009 Oct;187(1):61-70

Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1083/jcb.200903124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762099PMC
October 2009

Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

Immunity 2009 Jun 4;30(6):875-87. Epub 2009 Jun 4.

Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.immuni.2009.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759865PMC
June 2009

Recurrent febrile syndromes: what a rheumatologist needs to know.

Nat Rev Rheumatol 2009 May;5(5):249-56

University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1038/nrrheum.2009.40DOI Listing
May 2009

Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS).

Authors:
Hal M Hoffman

Expert Opin Biol Ther 2009 Apr;9(4):519-31

University of California at San Diego, Division of Rheumatology and Allergy/Immunology, Mail Code 0635, 9500 Gilman Drive, La Jolla, CA 92093-0635, USA.

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http://dx.doi.org/10.1517/14712590902875518DOI Listing
April 2009

Cryopyrin-associated periodic syndromes: development of a patient-reported outcomes instrument to assess the pattern and severity of clinical disease activity.

Curr Med Res Opin 2008 Sep 29;24(9):2531-43. Epub 2008 Jul 29.

University of California at San Diego, La Jolla, CA 92093-0635, USA.

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http://dx.doi.org/10.1185/03007990802297495DOI Listing
September 2008

Identification of EpCAM as the gene for congenital tufting enteropathy.

Gastroenterology 2008 Aug 15;135(2):429-37. Epub 2008 May 15.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.05.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574708PMC
August 2008

Insight into the inflammasome and caspase-activating mechanisms.

Expert Rev Clin Immunol 2008 Jan;4(1):61-77

Department of Dermatology-Venereology, Geneva University Medical Center, Rue Michel-Servet 1, 1211 Geneva, Switzerland.

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http://dx.doi.org/10.1586/1744666X.4.1.61DOI Listing
January 2008

Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

Cell Host Microbe 2007 Sep;2(3):147-59

Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1016/j.chom.2007.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2083260PMC
September 2007

Hereditary immunologic disorders caused by pyrin and cryopyrin.

Authors:
Hal M Hoffman

Curr Allergy Asthma Rep 2007 Sep;7(5):323-30

Division of Rheumatology, Allergy, and Immunology, University of California at San Diego Medical School, 9500 Gilman Drive, La Jolla, CA 92093-0635, USA.

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http://dx.doi.org/10.1007/s11882-007-0049-4DOI Listing
September 2007

Association between celiac sprue and cryopyrin associated autoinflammatory disorders: a case report.

Pediatr Rheumatol Online J 2007 Jun 5;5:12. Epub 2007 Jun 5.

Dartmouth-Hitchcock Medical Center Section of Pediatric Allergy and Clinical Immunology, Lebanon, NH, USA.

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http://dx.doi.org/10.1186/1546-0096-5-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892774PMC
June 2007

Successful treatment of renal amyloidosis due to familial cold autoinflammatory syndrome using an interleukin 1 receptor antagonist.

Am J Kidney Dis 2007 Mar;49(3):477-81

Division of Nephrology, University of California Davis Medical Center, La Jolla, CA, USA.

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http://dx.doi.org/10.1053/j.ajkd.2006.10.026DOI Listing
March 2007

Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia.

J Allergy Clin Immunol 2007 Apr 22;119(4):991-6. Epub 2007 Feb 22.

Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA 92093-0635, USA.

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http://dx.doi.org/10.1016/j.jaci.2006.12.649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322003PMC
April 2007

Response to IL-1-receptor antagonist in a child with familial cold autoinflammatory syndrome.

Pediatr Dermatol 2007 Jan-Feb;24(1):85-9

Department of Dermatology, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland.

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http://dx.doi.org/10.1111/j.1525-1470.2007.00343.xDOI Listing
May 2007