Hal Drakesmith

Hal Drakesmith

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Hal Drakesmith

Hal Drakesmith

Publications by authors named "Hal Drakesmith"

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Hepcidin-guided screen-and-treat interventions against iron-deficiency anaemia in pregnancy: a randomised controlled trial in The Gambia.

Lancet Glob Health 2019 Nov;7(11):e1564-e1574

Medical Research Council (MRC) Unit The Gambia at London School of Hygiene & Tropical Medicine (LSHTM), Serrekunda, The Gambia; LSHTM, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(19)30393-6DOI Listing
November 2019

Twenty Years of Ferroportin Disease: A Review or An Update of Published Clinical, Biochemical, Molecular, and Functional Features.

Pharmaceuticals (Basel) 2019 Sep 9;12(3). Epub 2019 Sep 9.

Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.3390/ph12030132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6789780PMC
September 2019

Serum hepcidin potentially identifies iron deficiency in survivors of critical illness at the time of hospital discharge.

Br J Haematol 2019 01 24;184(2):279-281. Epub 2018 Jan 24.

MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1111/bjh.15067DOI Listing
January 2019

Erythroferrone inhibits the induction of hepcidin by BMP6.

Blood 2018 10 10;132(14):1473-1477. Epub 2018 Aug 10.

Medical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1182/blood-2018-06-857995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238155PMC
October 2018

Hemoglobinopathies in the Fetal Position.

N Engl J Med 2018 Oct;379(17):1675-1677

From the Walter and Eliza Hall Institute of Medical Research, the Department of Medical Biology, University of Melbourne, the Department of Diagnostic Haematology, Royal Melbourne Hospital, and Clinical Haematology at the Peter MacCallum Cancer Centre and the Royal Melbourne Hospital - all in Parkville, VIC, Australia (S.-R.P.); and the Weatherall Institute of Molecular Medicine, Medical Research Council Human Immunology Unit, and Haematology Theme, Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (H.D.).

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http://dx.doi.org/10.1056/NEJMcibr1809628DOI Listing
October 2018

Decreased Hepcidin Levels Are Associated with Low Steady-state Hemoglobin in Children With Sickle Cell Disease in Tanzania.

EBioMedicine 2018 Aug 25;34:158-164. Epub 2018 Jul 25.

School of Tropical Medicine & Global Health, Nagasaki University, Nagasaki, Japan; London School of Hygiene and Tropical Medicine, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116423PMC
August 2018

Reducing anaemia in low income countries: control of infection is essential.

BMJ 2018 Aug 1;362:k3165. Epub 2018 Aug 1.

MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.

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http://www.bmj.com/lookup/doi/10.1136/bmj.k3165
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http://dx.doi.org/10.1136/bmj.k3165DOI Listing
August 2018

Intravenous Irons: From Basic Science to Clinical Practice.

Pharmaceuticals (Basel) 2018 Aug 27;11(3). Epub 2018 Aug 27.

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Headington, Oxford OX3 9DS, UK.

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http://www.mdpi.com/1424-8247/11/3/82
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http://dx.doi.org/10.3390/ph11030082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161004PMC
August 2018

Role of Activins in Hepcidin Regulation during Malaria.

Infect Immun 2017 12 17;85(12). Epub 2017 Nov 17.

MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom

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http://dx.doi.org/10.1128/IAI.00191-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695100PMC
December 2017

Improving iron supplements: cooking with GOS.

Gut 2017 11 3;66(11):1881-1882. Epub 2017 Aug 3.

Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK.

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http://dx.doi.org/10.1136/gutjnl-2017-314593DOI Listing
November 2017

Serum Hepcidin Concentrations Decline during Pregnancy and May Identify Iron Deficiency: Analysis of a Longitudinal Pregnancy Cohort in The Gambia.

J Nutr 2017 06 19;147(6):1131-1137. Epub 2017 Apr 19.

MRC Unit The Gambia-MRC International Nutrition Group and London School of Hygiene and Tropical Medicine, London, United Kingdom.

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http://dx.doi.org/10.3945/jn.116.245373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443464PMC
June 2017

Short-Term versus Long-Term Blood Storage.

N Engl J Med 2017 03;376(11):1092

University of Oxford, Oxford, United Kingdom

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http://dx.doi.org/10.1056/NEJMc1700464DOI Listing
March 2017

Next-Generation Biomarkers for Iron Status.

Authors:
Hal Drakesmith

Nestle Nutr Inst Workshop Ser 2016 14;84:59-69. Epub 2016 Jan 14.

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http://dx.doi.org/10.1159/000436955DOI Listing
October 2016

Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study.

Am J Trop Med Hyg 2016 10 27;95(4):817-826. Epub 2016 Jun 27.

Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.

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http://dx.doi.org/10.4269/ajtmh.16-0218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062780PMC
October 2016

Regulation of Hepcidin by Erythropoiesis: The Story So Far.

Annu Rev Nutr 2016 07 4;36:417-34. Epub 2016 May 4.

Medical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute for Molecular Medicine, University of Oxford, Oxford OX3 9DS, United Kingdom; email:

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http://dx.doi.org/10.1146/annurev-nutr-071715-050731DOI Listing
July 2016

Iron Deficiency Anemia: Problems in Diagnosis and Prevention at the Population Level.

Hematol Oncol Clin North Am 2016 Apr;30(2):309-25

MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1016/j.hoc.2015.11.003DOI Listing
April 2016

Ironing out Ferroportin.

Cell Metab 2015 Nov 1;22(5):777-87. Epub 2015 Oct 1.

Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pathology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635047PMC
November 2015

Malaria and Age Variably but Critically Control Hepcidin Throughout Childhood in Kenya.

EBioMedicine 2015 Oct 8;2(10):1478-86. Epub 2015 Aug 8.

Kenya Medical Research Institute (KEMRI) - Wellcome Trust Research Programme (KWTRP), PO Box 230-80108, Kilifi, Kenya ; Department of Medicine, Imperial College, London, UK.

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http://dx.doi.org/10.1016/j.ebiom.2015.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634196PMC
October 2015

Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans.

PLoS Negl Trop Dis 2015 Sep 22;9(9):e0004029. Epub 2015 Sep 22.

MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

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http://dx.doi.org/10.1371/journal.pntd.0004029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578949PMC
September 2015

Genetics. The battle for iron.

Science 2014 Dec;346(6215):1299-300

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, OX3 9DS, UK.

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http://dx.doi.org/10.1126/science.aaa2468DOI Listing
December 2014

Iron, anemia and hepcidin in malaria.

Front Pharmacol 2014 30;5:125. Epub 2014 May 30.

MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford Oxford, UK.

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http://dx.doi.org/10.3389/fphar.2014.00125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039013PMC
June 2014

Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children.

Blood 2014 May 4;123(21):3221-9. Epub 2014 Mar 4.

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford University Hospitals, United Kingdom;

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http://dx.doi.org/10.1182/blood-2013-10-533000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046425PMC
May 2014

Expression of the iron hormone hepcidin distinguishes different types of anemia in African children.

Sci Transl Med 2014 May;6(235):235re3

Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1126/scitranslmed.3008249DOI Listing
May 2014

Intravenous iron and vertical HIV transmission: any connection?

AIDS 2014 May;28(8):1245-6

aNorthampton General Hospital NHS Trust bNorthamptonshire Healthcare NHS Foundation Trust, Cliftonville, Northampton cGuy's and St Thomas' NHS Foundation Trust dImperial College Healthcare NHS Trust, St Mary's Hospital, London eMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. *Hal Drakesmith and Hermione Lyall contributed equally to the writing of this article.

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http://dx.doi.org/10.1097/QAD.0000000000000220DOI Listing
May 2014

Control of iron deficiency anemia in low- and middle-income countries.

Blood 2013 Apr 25;121(14):2607-17. Epub 2013 Jan 25.

Nossal Institute for Global Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Carlton, Australia.

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http://dx.doi.org/10.1182/blood-2012-09-453522DOI Listing
April 2013

Hepcidin and the iron-infection axis.

Science 2012 Nov;338(6108):768-72

Molecular Immunology Group and Medical Research Council (MRC) Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1126/science.1224577DOI Listing
November 2012

Implications of malaria on iron deficiency control strategies.

Adv Nutr 2012 Jul 1;3(4):570-8. Epub 2012 Jul 1.

Laboratory of Malaria Immunology and Vaccinology, NIAID, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.3945/an.111.001156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649728PMC
July 2012

Superinfection in malaria: Plasmodium shows its iron will.

EMBO Rep 2011 Dec 1;12(12):1233-42. Epub 2011 Dec 1.

Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Avenue Prof. Egas Moniz, 1649-028 Lisboa, Portugal.

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http://dx.doi.org/10.1038/embor.2011.213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245699PMC
December 2011

Hepcidin regulation by innate immune and infectious stimuli.

Blood 2011 Oct 26;118(15):4129-39. Epub 2011 Aug 26.

Molecular Immunology Group, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK.

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http://dx.doi.org/10.1182/blood-2011-04-351957DOI Listing
October 2011

Host-mediated regulation of superinfection in malaria.

Nat Med 2011 Jun 15;17(6):732-7. Epub 2011 May 15.

Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.

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http://dx.doi.org/10.1038/nm.2368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200394PMC
June 2011

Ferroportin: lack of evidence for multimers.

Blood Cells Mol Dis 2008 May-Jun;40(3):360-9. Epub 2007 Oct 31.

Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford, UK OX3 9DS, UK.

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http://dx.doi.org/10.1016/j.bcmd.2007.09.007DOI Listing
August 2008

Reflecting on a quarter century of HIV research.

Nat Immunol 2008 Aug;9(8):823-6

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1038/ni0808-823DOI Listing
August 2008

Viral infection and iron metabolism.

Nat Rev Microbiol 2008 Jul;6(7):541-52

Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital and Oxford University, Oxford OX3 9DS, UK.

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http://www.nature.com/doifinder/10.1038/nrmicro1930
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http://dx.doi.org/10.1038/nrmicro1930DOI Listing
July 2008

Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication.

Nat Immunol 2007 Jun 13;8(6):569-77. Epub 2007 May 13.

Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK.

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http://www.nature.com/articles/ni1470
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http://dx.doi.org/10.1038/ni1470DOI Listing
June 2007

Localisation of proteins of iron metabolism in the human placenta and liver.

Br J Haematol 2006 Sep;134(5):532-43

Molecular Immunology Group, Weatherall Institute of Molecular Medicine, Oxford University, John Radcliffe Hospital.

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http://doi.wiley.com/10.1111/j.1365-2141.2006.06216.x
Publisher Site
http://dx.doi.org/10.1111/j.1365-2141.2006.06216.xDOI Listing
September 2006

HIV-1 down-regulates the expression of CD1d via Nef.

Eur J Immunol 2006 Feb;36(2):278-86

MRC Human Immunology Unit and Molecular Immunology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, UK.

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http://dx.doi.org/10.1002/eji.200535487DOI Listing
February 2006

Multifactorial iron man.

Digestion 2005 10;72(1):22-4. Epub 2005 Aug 10.

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http://dx.doi.org/10.1159/000087399DOI Listing
November 2005

HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis.

Proc Natl Acad Sci U S A 2005 Aug 25;102(31):11017-22. Epub 2005 Jul 25.

Molecular Immunology Group and Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0504823102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180511PMC
August 2005

In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations.

Blood 2005 May 3;105(10):4096-102. Epub 2005 Feb 3.

Molecular Immunology Group, Weatherall Institute of Molecular Medicine, Headley Way, Oxford, OX3 9DS, United Kingdom.

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http://dx.doi.org/10.1182/blood-2004-11-4502DOI Listing
May 2005

The hemochromatosis protein HFE inhibits iron export from macrophages.

Proc Natl Acad Sci U S A 2002 Nov 12;99(24):15602-7. Epub 2002 Nov 12.

Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom.

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http://dx.doi.org/10.1073/pnas.242614699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137763PMC
November 2002

Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload.

Lancet 2002 Mar;359(9308):786-90

Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford University, Oxford OX3 9DS, UK.

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http://dx.doi.org/10.1016/S0140-6736(02)07885-6DOI Listing
March 2002