Hakho Lee

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Compact and Filter-Free Luminescence Biosensor for Mobile Diagnoses.

ACS Nano 2019 Sep 6. Epub 2019 Sep 6.

Center for Systems Biology , Massachusetts General Hospital, Harvard Medical School , Boston , Massachusetts 02114 , United States.

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http://dx.doi.org/10.1021/acsnano.9b05634DOI Listing
September 2019

Physical and Molecular Landscapes of Mouse Glioma Extracellular Vesicles Define Heterogeneity.

Cell Rep 2019 Jun;27(13):3972-3987.e6

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Cancer Research Institute, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604862PMC
June 2019

Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles.

Cell Rep 2019 Apr;27(1):255-268.e6

Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193031
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http://dx.doi.org/10.1016/j.celrep.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6528836PMC
April 2019

Thermophoretically enriched detection.

Nat Biomed Eng 2019 Mar;3(3):163-164

Center for Systems Biology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41551-019-0364-9DOI Listing
March 2019

Multichannel digital heteronuclear magnetic resonance biosensor.

Biosens Bioelectron 2019 Feb 27;126:240-248. Epub 2018 Oct 27.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for NanoMedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09565663183086
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http://dx.doi.org/10.1016/j.bios.2018.10.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483068PMC
February 2019

Bioassay for monitoring the anti-aging effect of cord blood treatment.

Theranostics 2019 1;9(1):1-10. Epub 2019 Jan 1.

Department of Biotechnology, College of Life Science, CHA University, Gyeonggi-do 13488, Republic of Korea.

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http://www.thno.org/v09p0001.htm
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http://dx.doi.org/10.7150/thno.30422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332798PMC
January 2019

Computational Optics Enables Breast Cancer Profiling in Point-of-Care Settings.

ACS Nano 2018 09 20;12(9):9081-9090. Epub 2018 Aug 20.

Center for Systems Biology , Massachusetts General Hospital , Boston , Massachusetts 02114 , United States.

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http://pubs.acs.org/doi/10.1021/acsnano.8b03029
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http://dx.doi.org/10.1021/acsnano.8b03029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519708PMC
September 2018

Characterization of Extracellular Vesicles by Surface Plasmon Resonance.

Methods Mol Biol 2017 ;1660:133-141

Cancer Program, MGH Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://link.springer.com/10.1007/978-1-4939-7253-1_11
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http://dx.doi.org/10.1007/978-1-4939-7253-1_11DOI Listing
May 2018

High-throughput intensity diffraction tomography with a computational microscope.

Biomed Opt Express 2018 May 5;9(5):2130-2141. Epub 2018 Apr 5.

Department of Electrical and Computer Engineering, Boston University, Boston, MA 02215, USA.

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http://dx.doi.org/10.1364/BOE.9.002130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946776PMC
May 2018

Integrated Biosensor for Rapid and Point-of-Care Sepsis Diagnosis.

ACS Nano 2018 04 20;12(4):3378-3384. Epub 2018 Mar 20.

Department of Systems Biology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://dx.doi.org/10.1021/acsnano.7b08965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019292PMC
April 2018

New Technologies for Analysis of Extracellular Vesicles.

Chem Rev 2018 02 31;118(4):1917-1950. Epub 2018 Jan 31.

Center for Systems Biology, Massachusetts General Hospital , Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acs.chemrev.7b00534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029891PMC
February 2018

Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System.

ACS Photonics 2018 Feb 3;5(2):487-494. Epub 2017 Nov 3.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114.

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http://pubs.acs.org/doi/10.1021/acsphotonics.7b00992
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http://dx.doi.org/10.1021/acsphotonics.7b00992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966285PMC
February 2018

Multiplexed Profiling of Single Extracellular Vesicles.

ACS Nano 2018 01 4;12(1):494-503. Epub 2018 Jan 4.

Center for Systems Biology, Massachusetts General Hospital , 185 Cambridge St, CPZN 5206, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acsnano.7b07060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898240PMC
January 2018

Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection.

ACS Nano 2017 11 25;11(11):11041-11046. Epub 2017 Oct 25.

Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acsnano.7b05083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237084PMC
November 2017

Nanomagnetic System for Rapid Diagnosis of Acute Infection.

ACS Nano 2017 11 14;11(11):11425-11432. Epub 2017 Nov 14.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School , Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acsnano.7b06074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296367PMC
November 2017

Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications.

Theranostics 2016 18;6(10):1603-10. Epub 2016 Jun 18.

1. Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;; 5. Massachusetts General Hospital Cancer Center, Boston, MA 02114;; 6. Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114;

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http://dx.doi.org/10.7150/thno.15534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955059PMC
October 2017

Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection.

ACS Nano 2017 10 25;11(10):10062-10069. Epub 2017 Aug 25.

Department of Systems Biology, Harvard Medical School , Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acsnano.7b04318DOI Listing
October 2017

Novel nanosensing technologies for exosome detection and profiling.

Lab Chip 2017 08;17(17):2892-2898

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1039/c7lc00247eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572557PMC
August 2017

MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.

Stem Cell Reports 2017 06 18;8(6):1497-1505. Epub 2017 May 18.

Department of Neurosurgery, Harvey Cushing Neuro-oncology Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.04.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470095PMC
June 2017

Facile silicification of plastic surface for bioassays.

Chem Commun (Camb) 2017 Feb;53(13):2134-2137

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114, USA. and Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1039/c6cc09359kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327824PMC
February 2017

Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing.

Bioconjug Chem 2017 01 7;28(1):33-37. Epub 2016 Nov 7.

Department of Systems Biology, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acs.bioconjchem.6b00524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474933PMC
January 2017

Highly sensitive detection of protein biomarkers via nuclear magnetic resonance biosensor with magnetically engineered nanoferrite particles.

Int J Nanomedicine 2016;11:5497-5503. Epub 2016 Oct 21.

Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul; Department of Biomedical Engineering, Korea University of Science and Technology, Daejeon, Republic of Korea.

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http://dx.doi.org/10.2147/IJN.S118156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5085298PMC
January 2017

Supramolecular Metallo-Bioadhesive for Minimally Invasive Use.

Adv Mater 2016 Oct 12;28(39):8675-8680. Epub 2016 Aug 12.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St., CPZN 5206, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1002/adma.201602606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144581PMC
October 2016

Design of a Microfluidic Chip for Magnetic-Activated Sorting of One-Bead-One-Compound Libraries.

ACS Comb Sci 2016 06 23;18(6):271-8. Epub 2016 May 23.

Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts 02115, United States.

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http://dx.doi.org/10.1021/acscombsci.5b00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321554PMC
June 2016

Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury.

PLoS One 2015 17;10(7):e0133417. Epub 2015 Jul 17.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, Massachusetts, United States of America; Department of Systems Biology, Harvard Medical School, 200 Longwood Ave, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133417PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506142PMC
May 2016

Rapid identification of health care-associated infections with an integrated fluorescence anisotropy system.

Sci Adv 2016 05 6;2(5):e1600300. Epub 2016 May 6.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/sciadv.1600300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565941PMC
May 2016

Digital diffraction detection of protein markers for avian influenza.

Lab Chip 2016 Apr;16(8):1340-5

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St., CPZN 5206, Boston, MA 02114, USA. and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1039/c5lc01558hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4829473PMC
April 2016

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.

Cancer Discov 2016 Apr 16;6(4):382-99. Epub 2016 Mar 16.

Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087317PMC
http://dx.doi.org/10.1158/2159-8290.CD-15-0933DOI Listing
April 2016

Sparsity-Based Pixel Super Resolution for Lens-Free Digital In-line Holography.

Sci Rep 2016 Apr 21;6:24681. Epub 2016 Apr 21.

Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1038/srep24681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838824PMC
April 2016

Challenges influencing next generation technologies for precision medicine.

Expert Rev Precis Med Drug Dev 2016 28;1(2):121-123. Epub 2016 Mar 28.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; Massachusetts General Hospital Cancer Center, Boston, MA 02114; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.

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http://dx.doi.org/10.1080/23808993.2016.1165073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5166706PMC
March 2016

On chip analysis of CNS lymphoma in cerebrospinal fluid.

Theranostics 2015 17;5(8):796-804. Epub 2015 Apr 17.

1. Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA ; 5. Department of Systems Biology, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.7150/thno.11220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440438PMC
February 2016

Bioorthogonal Radiopaque Hydrogel for Endoscopic Delivery and Universal Tissue Marking.

Adv Healthc Mater 2016 Feb 20;5(4):421-6. Epub 2015 Dec 20.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1002/adhm.201500780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811597PMC
February 2016

Integrated Magneto-Electrochemical Sensor for Exosome Analysis.

ACS Nano 2016 Feb 28;10(2):1802-9. Epub 2016 Jan 28.

Center for Systems Biology, Massachusetts General Hospital , 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/acsnano.5b07584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802494PMC
February 2016

Fluorescence Polarization Based Nucleic Acid Testing for Rapid and Cost-Effective Diagnosis of Infectious Disease.

Chemistry 2015 Nov 30;21(46):16359-63. Epub 2015 Sep 30.

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114 (USA).

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http://dx.doi.org/10.1002/chem.201502934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816641PMC
November 2015

Recent Developments in Magnetic Diagnostic Systems.

Chem Rev 2015 Oct 10;115(19):10690-724. Epub 2015 Aug 10.

Department of Chemistry, Yonsei University , Seoul, 120-749, Korea.

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http://dx.doi.org/10.1021/cr500698dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5791529PMC
October 2015

Nanostar Clustering Improves the Sensitivity of Plasmonic Assays.

Bioconjug Chem 2015 Aug 2;26(8):1470-4. Epub 2015 Jul 2.

†Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States.

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http://pubs.acs.org/doi/10.1021/acs.bioconjchem.5b00343
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http://dx.doi.org/10.1021/acs.bioconjchem.5b00343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292976PMC
August 2015

Nano-plasmonic exosome diagnostics.

Expert Rev Mol Diagn 2015 Jun 2;15(6):725-33. Epub 2015 May 2.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1586/14737159.2015.1041378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675626PMC
June 2015

Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone.

Proc Natl Acad Sci U S A 2015 May 13;112(18):5613-8. Epub 2015 Apr 13.

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114;

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http://dx.doi.org/10.1073/pnas.1501815112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426451PMC
May 2015

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma.

Nat Commun 2015 May 11;6:6999. Epub 2015 May 11.

1] Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, Massachusetts 02114, USA [2] Massachusetts General Hospital Cancer Center, Boston, Massachusetts 02114, USA [3] Department of Radiology, Massachusetts General Hospital, Fruit St, Boston, Massachusetts 02114, USA [4] Department of Systems Biology, Harvard Medical School, 200 Longwood Ave, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms7999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4430127PMC
May 2015

Acoustic purification of extracellular microvesicles.

ACS Nano 2015 Mar 16;9(3):2321-7. Epub 2015 Feb 16.

†Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/nn506538fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4373978PMC
March 2015

Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis.

Cell 2015 Mar 5;160(6):1246-60. Epub 2015 Mar 5.

David H. Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.02.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380877PMC
March 2015

Magnetic ligation method for quantitative detection of microRNAs.

Adv Healthc Mater 2014 Jul 14;3(7):1015-9. Epub 2014 Feb 14.

Center for Systems Biology, Massachusetts General Hospital-Harvard Medical School, 185 Cambridge St., Boston, MA, 02114, USA.

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http://dx.doi.org/10.1002/adhm.201300672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107040PMC
July 2014

Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor.

Nat Biotechnol 2014 May 20;32(5):490-5. Epub 2014 Apr 20.

Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356947PMC
May 2014

Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance.

Nanomedicine 2014 Apr 4;10(3):661-8. Epub 2013 Nov 4.

Center for Systems Biology, Massachusetts General Hospital, Boston, MA; Department of Imaging, Massachusetts General Hospital, Fruit St, Boston, MA; Department of Systems Biology, Harvard Medical School, Boston, MA; Massachusetts General Hospital Cancer Center, Boston, MA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2013.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966960PMC
April 2014

Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells.

Lab Chip 2014 Jan 8;14(1):14-23. Epub 2013 Jul 8.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1039/c3lc50621eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844052PMC
January 2014

Rare cell isolation and profiling on a hybrid magnetic/size-sorting chip.

Biomicrofluidics 2013 17;7(5):54107. Epub 2013 Sep 17.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St., CPZN 5206, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1063/1.4821923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3790798PMC
January 2014

Magnetic nanosensor for detection and profiling of erythrocyte-derived microvesicles.

ACS Nano 2013 Dec 2;7(12):11227-33. Epub 2013 Dec 2.

Center for Systems Biology, Massachusetts General Hospital , 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/nn405016yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898036PMC
December 2013

Ascites analysis by a microfluidic chip allows tumor-cell profiling.

Proc Natl Acad Sci U S A 2013 Dec 2;110(51):E4978-86. Epub 2013 Dec 2.

Center for Systems Biology, Massachusetts General Hospital, Boston, MA 02114.

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http://dx.doi.org/10.1073/pnas.1315370110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870756PMC
December 2013

Magnetic barcode assay for genetic detection of pathogens.

Nat Commun 2013 ;4:1752

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/ncomms2745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635151PMC
November 2013

Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and a miniaturized micro-NMR system.

Nanomedicine 2013 Oct 6;9(7):1009-17. Epub 2013 Apr 6.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.nano.2013.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330975PMC
October 2013

μHall chip for sensitive detection of bacteria.

Adv Healthc Mater 2013 Sep 12;2(9):1224-8. Epub 2013 Mar 12.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114.

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http://dx.doi.org/10.1002/adhm.201200380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340655PMC
September 2013

Oxidation Kinetics and Magnetic Properties of Elemental Iron Nanoparticles.

Part Part Syst Charact 2013 Aug;30(8):667-671

Department of Applied Bioscience, CHA University, Seoul 135-081, Republic of Korea.

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http://dx.doi.org/10.1002/ppsc.201300013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783348PMC
August 2013

A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria.

Nat Nanotechnol 2013 May 5;8(5):369-75. Epub 2013 May 5.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA.

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http://www.nature.com/articles/nnano.2013.70
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http://dx.doi.org/10.1038/nnano.2013.70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711657PMC
May 2013

Dual imaging and photoactivated nanoprobe for controlled cell tracking.

Small 2013 Jan 21;9(2):222-7. Epub 2012 Sep 21.

Center for Systems Biology, Massachusetts General Hospital/Harvard, Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/smll.201201007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552149PMC
January 2013

Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cells.

J Am Chem Soc 2012 Nov 2;134(45):18499-502. Epub 2012 Nov 2.

Center for Systems Biology, Massachusetts General Hospital/Harvard Medical, Boston, 02114, United States.

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http://dx.doi.org/10.1021/ja307689wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498844PMC
November 2012

Magnetic Nanoparticles and microNMR for Diagnostic Applications.

Theranostics 2012 1;2(1):55-65. Epub 2012 Jan 1.

1. Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114;

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http://dx.doi.org/10.7150/thno.3465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263516PMC
October 2012

Mechanism of magnetic relaxation switching sensing.

ACS Nano 2012 Aug 10;6(8):6821-8. Epub 2012 Jul 10.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1021/nn301615bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429660PMC
August 2012

A magnetic Gram stain for bacterial detection.

Angew Chem Int Ed Engl 2012 Jul 28;51(31):7752-5. Epub 2012 Jun 28.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/anie.201202982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496380PMC
July 2012

Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector.

Sci Transl Med 2012 Jul;4(141):141ra92

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/scitranslmed.3003747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603277PMC
July 2012

Microfluidic cell sorter (μFCS) for on-chip capture and analysis of single cells.

Adv Healthc Mater 2012 Jul 2;1(4):432-6. Epub 2012 May 2.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/adhm.201200046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508764PMC
July 2012

Sensitive and direct detection of circulating tumor cells by multimarker µ-nuclear magnetic resonance.

Neoplasia 2012 May;14(5):388-95

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3384426PMC
http://dx.doi.org/10.1596/neo.12696DOI Listing
May 2012

Orthogonal amplification of nanoparticles for improved diagnostic sensing.

ACS Nano 2012 Apr 23;6(4):3506-13. Epub 2012 Mar 23.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/nn300536yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337350PMC
April 2012

Supramolecular host-guest interaction for labeling and detection of cellular biomarkers.

Angew Chem Int Ed Engl 2012 Jan 24;51(2):450-4. Epub 2011 Nov 24.

Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, 185 Cambridge St., Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/anie.201105670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309171PMC
January 2012

Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance.

Bioconjug Chem 2011 Dec 7;22(12):2390-4. Epub 2011 Nov 7.

Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/bc200490rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263317PMC
December 2011

Magnetic nanoparticles for biomedical NMR-based diagnostics.

Beilstein J Nanotechnol 2010 16;1:142-54. Epub 2010 Dec 16.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, U.S.A.

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http://dx.doi.org/10.3762/bjnano.1.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045933PMC
November 2011

Multicore assemblies potentiate magnetic properties of biomagnetic nanoparticles.

Adv Mater 2011 Nov 26;23(41):4793-7. Epub 2011 Sep 26.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.

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http://doi.wiley.com/10.1002/adma.201102948
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http://dx.doi.org/10.1002/adma.201102948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224986PMC
November 2011

Nanoparticle-mediated measurement of target-drug binding in cancer cells.

ACS Nano 2011 Nov 13;5(11):9216-24. Epub 2011 Oct 13.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1021/nn203450pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297118PMC
November 2011

Ubiquitous detection of gram-positive bacteria with bioorthogonal magnetofluorescent nanoparticles.

ACS Nano 2011 Nov 10;5(11):8834-41. Epub 2011 Oct 10.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1021/nn2029692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222727PMC
November 2011

Multiplexed magnetic labeling amplification using oligonucleotide hybridization.

Adv Mater 2011 Sep 22;23(36):H254-7. Epub 2011 Jul 22.

Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/adma.201101401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584698PMC
September 2011

Miniature magnetic resonance system for point-of-care diagnostics.

Lab Chip 2011 Jul 5;11(13):2282-7. Epub 2011 May 5.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA.

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http://dx.doi.org/10.1039/c1lc20177hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115660PMC
July 2011

Molecular detection of biomarkers and cells using magnetic nanoparticles and diagnostic magnetic resonance.

Methods Mol Biol 2011 ;726:33-49

Center for Systems Biology, Department of Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-61779-052-2_3DOI Listing
June 2011

Highly magnetic core-shell nanoparticles with a unique magnetization mechanism.

Angew Chem Int Ed Engl 2011 May 14;50(20):4663-6. Epub 2011 Apr 14.

Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, Boston, 02114, USA.

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http://dx.doi.org/10.1002/anie.201100101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3334859PMC
May 2011

Probing intracellular biomarkers and mediators of cell activation using nanosensors and bioorthogonal chemistry.

ACS Nano 2011 Apr 8;5(4):3204-13. Epub 2011 Mar 8.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, Massachusetts 02114, USA.

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http://pubs.acs.org/doi/10.1021/nn200333m
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088084PMC
April 2011

Micro-NMR for rapid molecular analysis of human tumor samples.

Sci Transl Med 2011 Feb;3(71):71ra16

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1126/scitranslmed.3002048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086073PMC
February 2011

Self-assembled magnetic filter for highly efficient immunomagnetic separation.

Lab Chip 2011 Jan 14;11(1):147-51. Epub 2010 Oct 14.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA.

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http://dx.doi.org/10.1039/c0lc00149jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005961PMC
January 2011

Carboxymethylated polyvinyl alcohol stabilizes doped ferrofluids for biological applications.

Adv Mater 2010 Dec;22(45):5168-72

Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA.

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http://dx.doi.org/10.1002/adma.201002219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993874PMC
December 2010

Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection.

Nat Nanotechnol 2010 Sep 1;5(9):660-5. Epub 2010 Aug 1.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nnano.2010.148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934903PMC
September 2010

Magnetic nanoparticle biosensors.

Wiley Interdiscip Rev Nanomed Nanobiotechnol 2010 May-Jun;2(3):291-304

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/wnan.84DOI Listing
July 2010

Ultrasensitive detection of bacteria using core-shell nanoparticles and an NMR-filter system.

Angew Chem Int Ed Engl 2009 ;48(31):5657-60

Center for Systems Biology, Massachusetts General Hospital/Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1002/anie.200901791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2453069PMC
October 2009

Rapid detection and profiling of cancer cells in fine-needle aspirates.

Proc Natl Acad Sci U S A 2009 Jul 20;106(30):12459-64. Epub 2009 Jul 20.

Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge Street, CPZN 5206, Boston, MA 02114, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0902365106
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http://dx.doi.org/10.1073/pnas.0902365106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718371PMC
July 2009

Chip-NMR biosensor for detection and molecular analysis of cells.

Nat Med 2008 Aug 6;14(8):869-74. Epub 2008 Jul 6.

Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1038/nm.1711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729055PMC
August 2008

Incorporation of iron oxide nanoparticles and quantum dots into silica microspheres.

ACS Nano 2008 Feb;2(2):197-202

Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1021/nn700344xDOI Listing
February 2008

Integrated cell manipulation system--CMOS/microfluidic hybrid.

Lab Chip 2007 Mar 1;7(3):331-7. Epub 2007 Feb 1.

Department of Physics, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1039/b700373kDOI Listing
March 2007