Hakan Mellstedt

Hakan Mellstedt

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Hakan Mellstedt

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European Perspective on Biosimilars.

Authors:
Håkan Mellstedt

J Oncol Pract 2017 09;13(9_suppl):15s-16s

Karolinska Institute, Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1200/JOP.2017.025569DOI Listing
September 2017

Clinical and Immune Effects of Lenalidomide in Combination with Gemcitabine in Patients with Advanced Pancreatic Cancer.

PLoS One 2017 18;12(1):e0169736. Epub 2017 Jan 18.

Department of Oncology-Pathology, Cancer Center Karolinska (CCK), Karolinska Institutet, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169736PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242484PMC
August 2017

T cells in chronic lymphocytic leukemia display dysregulated expression of immune checkpoints and activation markers.

Haematologica 2017 03 7;102(3):562-572. Epub 2016 Dec 7.

Immune and Gene Therapy Laboratory, Department of Oncology & Pathology, Cancer Centre Karolinska, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3324/haematol.2016.151100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394965PMC
March 2017

Ibrutinib-A double-edge sword in cancer and autoimmune disorders.

J Drug Target 2016 11;24(5):373-85. Epub 2015 Sep 11.

b Department of Oncology-Pathology, Immune and Gene therapy Lab , Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute , Stockholm , Sweden .

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http://dx.doi.org/10.3109/1061186X.2015.1086357DOI Listing
December 2016

Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.

Tumour Biol 2016 Sep 16;37(9):11947-11957. Epub 2016 Apr 16.

Department of Oncology-Pathology, Immune and Gene Therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s13277-016-5039-5DOI Listing
September 2016

Biosimilars - terms of use.

Curr Med Res Opin 2015 Dec 27;31(12):2325-30. Epub 2015 Oct 27.

c c Istituto Clinico Humanitas - IRCCS in Gastroenterology , Milan , Italy.

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http://dx.doi.org/10.1185/03007995.2015.1098601DOI Listing
December 2015

Dendritic cell regulation of NK-cell responses involves lymphotoxin-α, IL-12, and TGF-β.

Eur J Immunol 2015 Jun 17;45(6):1783-93. Epub 2015 Apr 17.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

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http://doi.wiley.com/10.1002/eji.201444885
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http://dx.doi.org/10.1002/eji.201444885DOI Listing
June 2015

The PI3K/AKT/mTOR pathway is involved in direct apoptosis of CLL cells induced by ROR1 monoclonal antibodies.

Br J Haematol 2015 May 19;169(3):455-8. Epub 2014 Nov 19.

Department of Oncology-Pathology, Immune and Gene Therapy Lab, CCK, Karolinska Institute and Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1111/bjh.13228DOI Listing
May 2015

The tyrosine kinase receptor ROR1 is constitutively phosphorylated in chronic lymphocytic leukemia (CLL) cells.

PLoS One 2013 24;8(10):e78339. Epub 2013 Oct 24.

Department of Oncology-Pathology, Immune and Gene therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institute, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078339PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813472PMC
February 2015

The receptor tyrosine kinase ROR1--an oncofetal antigen for targeted cancer therapy.

Semin Cancer Biol 2014 Dec 25;29:21-31. Epub 2014 Jul 25.

Department of Oncology-Pathology, Immune and Gene Therapy Lab, Cancer Center Karolinska (CCK), Karolinska University Hospital Solna and Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2014.07.005DOI Listing
December 2014

Telomerase (GV1001) vaccination together with gemcitabine in advanced pancreatic cancer patients.

Int J Oncol 2014 Sep 11;45(3):1293-303. Epub 2014 Jun 11.

Department of Oncology-Pathology (Radiumhemmet), Karolinska Institutet and Karolinska University Hospital Solna, SE-17176 Stockholm, Sweden.

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http://dx.doi.org/10.3892/ijo.2014.2496DOI Listing
September 2014

Therapeutic vaccines for cancer: an overview of clinical trials.

Nat Rev Clin Oncol 2014 Sep 8;11(9):509-24. Epub 2014 Jul 8.

Cancer Centre Karolinska, Department of Oncology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1038/nrclinonc.2014.111DOI Listing
September 2014

[Cheaper with biosimilars, but safety comes first].

Authors:
Håkan Mellstedt

Lakartidningen 2014 May 27-Jun 10;111(22-23):1011

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August 2014

Clinical considerations for biosimilar antibodies.

Authors:
Håkan Mellstedt

EJC Suppl 2013 Dec;11(3):1-11

Professor of Oncological Biotherapy, Department of Oncology-Pathology, Karolinska Institute, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/S1359-6349(13)70001-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048039PMC
December 2013

Inhibition of the receptor tyrosine kinase ROR1 by anti-ROR1 monoclonal antibodies and siRNA induced apoptosis of melanoma cells.

PLoS One 2013 8;8(4):e61167. Epub 2013 Apr 8.

Department of Oncology-Pathology, Immune and Gene therapy Lab, Cancer Center Karolinska, Karolinska University Hospital Solna and Karolinska Institute, Stockholm, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061167PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620154PMC
November 2013

Telomere length and expression of human telomerase reverse transcriptase splice variants in chronic lymphocytic leukemia.

Exp Hematol 2013 Jul 30;41(7):615-26. Epub 2013 Mar 30.

Immune and Gene Therapy Laboratory, Department of Oncology and Pathology, Cancer Centre Karolinska, Karolinska Institutet, Stockholm, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X130012
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http://dx.doi.org/10.1016/j.exphem.2013.03.008DOI Listing
July 2013

Orphan receptor tyrosine kinases ROR1 and ROR2 in hematological malignancies.

Leuk Lymphoma 2013 Apr 9;54(4):843-50. Epub 2012 Oct 9.

Immune and Gene Therapy Laboratory, Cancer Center Karolinska, Karolinska University Hospital Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3109/10428194.2012.731599DOI Listing
April 2013

T cells from indolent CLL patients prevent apoptosis of leukemic B cells in vitro and have altered gene expression profile.

Cancer Immunol Immunother 2013 Jan 27;62(1):51-63. Epub 2012 Jun 27.

Institute of Cancer, Barts and The London School of Medicine and Dentistry, Charterhouse Square, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1007/s00262-012-1300-yDOI Listing
January 2013

Induction of IgM, IgA and IgE antibodies in colorectal cancer patients vaccinated with a recombinant CEA protein.

J Clin Immunol 2012 Aug 2;32(4):855-65. Epub 2012 Mar 2.

Department of Oncology and CancerCentreKarolinska at the Karolinska Institute, Karolinska University Hospital Solna, SE-171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s10875-012-9662-7DOI Listing
August 2012

Epithelial cell adhesion molecule expression (CD326) in cancer: a short review.

Cancer Treat Rev 2012 Feb 14;38(1):68-75. Epub 2011 May 14.

Dept. of Pathology, Azienda Ospedaliera di Melegnano, Milan, Italy.

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http://dx.doi.org/10.1016/j.ctrv.2011.04.002DOI Listing
February 2012

[Treatment of myeloma when high dose therapy is not possible. New drugs--alternatives for elderly patients].

Lakartidningen 2011 Oct 19-25;108(42):2090-4

Radiumhemmet, Karolinska universitetssjukhuset, Solna.

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December 2011

Vaccines for the treatment of non-small cell lung cancer: investigational approaches and clinical experience.

Lung Cancer 2011 Jul 6;73(1):11-7. Epub 2011 Apr 6.

Cancer Centre Karolinska, Department of Oncology, Karolinska University Hospital, Solna, SE-171 76 Stockholm, Sweden.

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http://linkinghub.elsevier.com/retrieve/pii/S016950021100166
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http://dx.doi.org/10.1016/j.lungcan.2011.02.023DOI Listing
July 2011

Gene expression analysis using long-term preserved formalin-fixed and paraffin-embedded tissue of non-small cell lung cancer.

Int J Oncol 2011 Apr 8;38(4):1075-81. Epub 2011 Feb 8.

Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3892/ijo.2011.936DOI Listing
April 2011

FcγR polymorphisms and clinical outcome in colorectal cancer patients receiving passive or active antibody treatment.

Int J Oncol 2010 Dec;37(6):1599-606

Immune and Gene Therapy Laboratory, Cancer Centre Karolinska, Department of Oncology-Pathology, Karolinska Institutet, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.3892/ijo_00000814DOI Listing
December 2010

Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells.

Br J Haematol 2010 Nov 31;151(4):327-35. Epub 2010 Aug 31.

Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1365-2141.2010.08362.xDOI Listing
November 2010

Implications of the development of biosimilars for cancer treatment.

Authors:
Håkan Mellstedt

Future Oncol 2010 Jul;6(7):1065-7

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http://dx.doi.org/10.2217/fon.10.72DOI Listing
July 2010

Immunoglobulin heavy chain variable region gene usage and mutational status of the leukemic B cells in Iranian patients with chronic lymphocytic leukemia.

Cancer Sci 2009 Dec 2;100(12):2346-53. Epub 2009 Sep 2.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1111/j.1349-7006.2009.01341.xDOI Listing
December 2009

[Biosimilar products--cheaper version of biological drugs. New possibilities within several therapeutic fields].

Authors:
Håkan Mellstedt

Lakartidningen 2009 Jun 3-9;106(23):1563-6

Cancercentrum Karolinska, Karolinska Universitetssjukhuset Solna, Stockholm.

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July 2009

Systemic immune effects of adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide and/or radiotherapy in breast cancer: a longitudinal study.

Cancer Immunol Immunother 2009 Jan 17;58(1):111-20. Epub 2008 May 17.

Immune and Gene Therapy Laboratory, Cancer Centre Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00262-008-0530-5DOI Listing
January 2009

Influence of varying doses of granulocyte-macrophage colony-stimulating factor on pharmacokinetics and antibody-dependent cellular cytotoxicity.

Cancer Immunol Immunother 2008 Mar 4;57(3):379-88. Epub 2007 Aug 4.

Department of Oncology and Pathology (Radiumhemmet), Cancer Centre Karolinska, Karolinska University Hospital Solna, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00262-007-0377-1DOI Listing
March 2008

The future of cancer vaccines for non-small-cell lung cancer: ongoing trials.

Clin Lung Cancer 2008 Feb;9 Suppl 1:S37-44

Karolinska Institutet, Department of Oncology-Pathology, Cancer Centrum Karolinska, Stockholm, Sweden.

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http://dx.doi.org/10.3816/clc.2008.s.006DOI Listing
February 2008

Immune response, depression and fatigue in relation to support intervention in mammary cancer patients.

Support Care Cancer 2008 Jan 12;16(1):57-65. Epub 2007 Jun 12.

Immune and Gene Therapy Laboratory, Cancer Centre Karolinska, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://link.springer.com/10.1007/s00520-007-0275-2
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http://dx.doi.org/10.1007/s00520-007-0275-2DOI Listing
January 2008

Performance of calibration standards for antigen quantitation with flow cytometry in chronic lymphocytic leukemia.

Cytometry B Clin Cytom 2007 Nov;72(6):450-7

Department of Oncology (Radiumhemmet), Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/cyto.b.20359DOI Listing
November 2007

Long-term effects of idiotype vaccination on the specific T-cell response in peripheral blood and bone marrow of multiple myeloma patients.

Eur J Haematol 2007 Nov 3;79(5):371-81. Epub 2007 Oct 3.

Immune and Gene Therapy Laboratory, CCK, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1600-0609.2007.00962.xDOI Listing
November 2007

Analysis of HLA-G gene expression in B-lymphocytes from chronic lymphocytic leukemia patients.

Iran Biomed J 2007 Apr;11(2):125-129

Immune and Gene Therapy Lab., Cancer Center Karolinska (CCK), Karolinska University Hospital, Stockholm, Sweden.

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http://ibj.pasteur.ac.ir/files/site1/user_files_b76aeb/eng/a
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April 2007

Telomerase (hTERT 611-626) serves as a tumor antigen in B-cell chronic lymphocytic leukemia and generates spontaneously antileukemic, cytotoxic T cells.

Exp Hematol 2007 Feb;35(2):297-304

Immune and Gene Therapy Lab, Cancer Centre Karolinska, Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.exphem.2006.10.006DOI Listing
February 2007

Reconstitution of the T-cell repertoire following treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with B-cell chronic lymphocytic leukaemia.

Br J Haematol 2006 Nov 22;135(4):475-85. Epub 2006 Sep 22.

Immune and Gene Therapy Laboratory, Department of Oncology and Pathology, Cancer Centre Karolinska (CCK), Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/j.1365-2141.2006.06324.xDOI Listing
November 2006

Dendritic cells, pulsed with lysate of allogeneic tumor cells, are capable of stimulating MHC-restricted antigen-specific antitumor T cells.

Med Oncol 2006 ;23(2):273-82

Immune and Gene Therapy Lab, Cancer Center Karolinska, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1385/MO:23:2:273DOI Listing
October 2006

Clinical results of vaccine therapy for cancer: learning from history for improving the future.

Adv Cancer Res 2006 ;95:147-202

Department of Oncology, Cancer Centre Karolinska, Karolinska University, Hospital Solna, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/S0065-230X(06)95005-2DOI Listing
September 2006

Keynote comment: deliberations of a born-again cancer immunotherapist.

Authors:
Håkan Mellstedt

Lancet Oncol 2006 Sep;7(9):700-1

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http://dx.doi.org/10.1016/S1470-2045(06)70837-3DOI Listing
September 2006

Strategies in the management of alemtuzumab-related side effects.

Semin Oncol 2006 Apr;33(2 Suppl 5):S29-35

Department of Oncology and Hematology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1053/j.seminoncol.2006.01.027DOI Listing
April 2006

T and B cells in B-chronic lymphocytic leukaemia: Faust, Mephistopheles and the pact with the Devil.

Cancer Immunol Immunother 2006 Feb 19;55(2):210-20. Epub 2005 May 19.

Cancer Center Karolinska, Department of Hematology and Oncology, Karolinska University Hospital, 17176 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00262-005-0675-4DOI Listing
February 2006

[Active immunotherapy in patients with hematologic and solid neoplasms].

Onkologie 2005 Oct;28 Suppl 4:4-8

Immune and Gene Therapy Laboratory, Cancer Centre Karolinska, Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1159/000088821DOI Listing
October 2005

T-cell receptor BV gene usage in colorectal carcinoma patients immunised with recombinant Ep-CAM protein or anti-idiotypic antibody.

Cancer Immunol Immunother 2005 Jun 27;54(6):557-70. Epub 2004 Nov 27.

Immune and Gene Therapy Laboratory, Department of Oncology (Radiumhemmet), Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00262-004-0620-yDOI Listing
June 2005

Towards therapeutic vaccines for colorectal carcinoma: a review of clinical trials.

Expert Rev Vaccines 2005 Jun;4(3):329-50

Department of Oncology, Cancer Center Karolinska, Karolinska University Hospital, S-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1586/14760584.4.3.329DOI Listing
June 2005

Targeting human Ep-CAM in transgenic mice by anti-idiotype and antigen based vaccines.

Int J Cancer 2004 Nov;112(4):669-77

Immune and Gene Therapy Laboratory, Department of Oncology, (Radiumhemmet), Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ijc.20453DOI Listing
November 2004

Anti-EpCAM monoclonal antibody (MAb17-1A) based treatment combined with alpha-interferon, 5-fluorouracil and granulocyte-macrophage colony-stimulating factor in patients with metastatic colorectal carcinoma.

Int J Oncol 2004 Sep;25(3):703-11

Department of Oncology (Radiumhemmet), Immune and Gene Therapy Laboratory, Cancer Centre Karolinska, Stockholm, Sweden.

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September 2004

Spectrum of cytokeratin-positive cells in the bone marrows of colorectal carcinoma patients.

Anticancer Res 2004 Jul-Aug;24(4):2375-83

Department of Oncology/Pathology (Radiumhemmet), Karolinska, University Hospital Solna, SE-171 76 Stockholm, Sweden.

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September 2004

Functional HLA-DR T cell epitopes of CEA identified in patients with colorectal carcinoma immunized with the recombinant protein CEA.

Cancer Immunol Immunother 2004 Apr 7;53(4):331-7. Epub 2003 Nov 7.

Department of Oncology, Radiology and Clinical Immunology, Section of Oncology, Uppsala University Hospital, Uppsala, Sweden.

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http://link.springer.com/content/pdf/10.1007/s00262-003-0441
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http://link.springer.com/10.1007/s00262-003-0441-4
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http://dx.doi.org/10.1007/s00262-003-0441-4DOI Listing
April 2004

Signalling molecules and cytokine production in T cells of multiple myeloma-increased abnormalities with advancing stage.

Br J Haematol 2004 Feb;124(3):315-24

Immune and Gene Therapy Laboratory, Cancer Centre Karolinska, Karolinska Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1046/j.1365-2141.2003.04789.xDOI Listing
February 2004

Idiotype vaccination in multiple myeloma induced a reduction of circulating clonal tumor B cells.

Blood 2003 Jun 6;101(11):4607-10. Epub 2003 Feb 6.

Herlev Hospital, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1182/blood-2002-06-1925DOI Listing
June 2003

Leukemia-associated monoclonal and oligoclonal TCR-BV use in patients with B-cell chronic lymphocytic leukemia.

Blood 2003 Feb 3;101(3):1063-70. Epub 2002 Oct 3.

Immune and Gene Therapy Laboratory, Cancer Center Karolinska, the Department of Oncology (Radiumhemmet), Karolinska Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1182/blood-2002-03-0746DOI Listing
February 2003

BK virus (BKV) quantification in urine samples of bone marrow transplanted patients is helpful for diagnosis of hemorrhagic cystitis, although wide individual variations exist.

J Clin Virol 2003 Jan;26(1):71-7

Department of Oncology-Pathology, Karolinska Institute, Cancer Center Karolinska, CCK R8:01, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/s1386-6532(02)00040-9DOI Listing
January 2003

Clinical effects of alemtuzumab (Campath-1H) in B-cell chronic lymphocytic leukemia.

Med Oncol 2002 ;19 Suppl:S21-6

Karolinska Hospital, Department of Hematology and Oncology, Stockholm, Sweden.

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http://dx.doi.org/10.1385/mo:19:2s:s21DOI Listing
December 2002

Treatment with GM-CSF and IL-2 in patients with metastatic colorectal carcinoma induced high serum levels of neopterin and sIL-2R, an indicator of immune suppression.

Cancer Immunol Immunother 2002 Jul 18;51(5):255-62. Epub 2002 Apr 18.

Department of Oncology (Radiumhemmet) and Cancer Center Karolinska, Karolinska Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00262-002-0279-1DOI Listing
July 2002

Immunogenic regions of the GA733-2 tumour-associated antigen recognised by autoantibodies of patients with colorectal carcinoma.

Cancer Immunol Immunother 2002 Jun 10;51(4):209-18. Epub 2002 Apr 10.

Immune and Gene Therapy Laboratory, Cancer Centre Karolinska, Karolinska Hospital, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00262-002-0272-8DOI Listing
June 2002

Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B-CLL).

Eur J Haematol 2002 May;68(5):299-306

Immune and Gene Therapy Laboratory, Cancer Center Karolinska, Karolinska Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1034/j.1600-0609.2002.01612.xDOI Listing
May 2002

MAb17-1A and cytokines for the treatment of patients with colorectal carcinoma.

Hybrid Hybridomics 2002 Apr;21(2):99-101

Department of Oncology (Radiumhemmet), Division of Oncologic Biotherapy, CancerCentrumKarolinska, Karolinska Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1089/153685902317401681DOI Listing
April 2002

Induction of IgG subclass responses in colorectal carcinoma patients vaccinated with recombinant carcinoembryonic antigen.

Cancer Res 2002 Mar;62(5):1364-9

Department of Oncology, Radiology, and Clinical Immunology, Section of Oncology, Uppsala University Hospital, SE-75185 Uppsala, Sweden .

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March 2002

Significance of phosphotyrosine proteins, Bcl-2 and p53 for apoptosis in resting B-chronic lymphocytic leukemia (CLL) cells.

Int J Cancer 2002 Jan;97(3):344-8

Department of Oncology Research Laboratory, Clinical Research Center, Huddinge University Hospital, SE-141 86 Stockholm, Sweden.

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http://dx.doi.org/10.1002/ijc.1616DOI Listing
January 2002