Publications by authors named "Hajime Nakano"

187 Publications

Case of epidermodysplasia verruciformis with a novel mutation of TMC8.

J Dermatol 2021 Aug 29. Epub 2021 Aug 29.

Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1111/1346-8138.16139DOI Listing
August 2021

Widespread kerosene dermatitis associated with rhabdomyolysis.

J Dermatol 2021 Aug 24;48(8):e386-e387. Epub 2021 May 24.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

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http://dx.doi.org/10.1111/1346-8138.15956DOI Listing
August 2021

Atypical eosinophilic annular erythema clinically resembling granuloma annulare.

Int J Dermatol 2021 Apr 13. Epub 2021 Apr 13.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Aomori, Japan.

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http://dx.doi.org/10.1111/ijd.15591DOI Listing
April 2021

Management of keratoacanthoma with perineural invasion: case reports and literature review.

Australas J Dermatol 2021 May 24;62(2):e353-e354. Epub 2021 Mar 24.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

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http://dx.doi.org/10.1111/ajd.13550DOI Listing
May 2021

Pseudosyndactyly and digital contractures in bullous pemphigoid with anti-BP180-C-terminal domain autoantibodies.

J Dermatol 2021 May 14;48(5):e229-e230. Epub 2021 Mar 14.

Department of Dermatology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.

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http://dx.doi.org/10.1111/1346-8138.15842DOI Listing
May 2021

Significance of IL36RN mutation analyses in the management of impetigo herpetiformis: A case report and review of published cases.

J Dermatol 2021 May 18;48(5):699-702. Epub 2021 Feb 18.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Impetigo herpetiformis (IH) is a rare variant of generalized pustular psoriasis (GPP), which develops during pregnancy. GPP is associated with mutations of IL36RN, but it is still unclear whether the same is true of IH. A 20-year-old Japanese woman developed erythema and pustules on her trunk during the 27th week of her first pregnancy. Within 1 month, the skin lesions spread over her whole body, accompanied by fever. Skin biopsy revealed Kogoj's spongiform pustules in the epidermis and she was diagnosed with IH. Systemic administration of prednisolone failed to resolve the skin eruption, but it was partially improved by the addition of cyclosporin. The patient gave birth to a healthy female infant. After delivery, her erythema relapsed and the effect of granulocyte and monocyte adsorption apheresis was limited. Thus, secukinumab was administrated, and since then, she has maintained complete remission. Mutation analysis revealed a homozygous c.28C>T (p.Arg10X) mutation in IL36RN. Twelve cases of IH, including that presented here, have been reported together with the results of IL36RN genetic analyses, and 10 of the 12 cases occurred in East Asia (Japan and China) despite the fact that IL36RN mutations in GPP have been reported worldwide. Among 10 IH patients of East Asian descent, seven had IL36RN mutations, all of which were founder mutations causing GPP in East Asia: c.28C>T (p.Arg10X) or c.115+6T>C (p.Arg10ArgfsX1). Thus, East Asian founder mutations may play an important role in the pathogenesis of IH. IH patients with IL36RN mutations have a tendency to require biologics to resolve postpartum flare-ups or sustained psoriatic skin lesions. Because IL36RN mutation status may help predict postpartum flare-ups in IH patients, mutation analysis should be considered to enable preparation for biologic therapy of intractable flare-ups.
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http://dx.doi.org/10.1111/1346-8138.15788DOI Listing
May 2021

Novel ATP2A2 nonsense mutation in a Japanese case with Darier's disease.

J Dermatol 2021 Mar 21;48(3):e149-e150. Epub 2021 Jan 21.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1111/1346-8138.15760DOI Listing
March 2021

Novel ATP2C1 frame-shift mutation in a mild case of early onset sporadic Hailey-Hailey disease.

J Dermatol 2021 Feb 8;48(2):e96-e97. Epub 2020 Nov 8.

Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1111/1346-8138.15689DOI Listing
February 2021

Clinical practice guide for the treatment of perforating dermatosis.

J Dermatol 2020 Dec 23;47(12):1374-1382. Epub 2020 Oct 23.

Department of Dermatology, Juntendo University Urayasu Hospital, Urayasu, Japan.

Perforating dermatoses are a heterogeneous skin disease group defined by transepidermal elimination of various skin materials. Four classical forms of primary perforating dermatosis have been described, where the transepidermal elimination mechanism represents the hallmark of the disease: acquired reactive perforating collagenosis, elastosis perforans serpiginosa, Kyrle's disease and perforating folliculitis. Acquired reactive perforating collagenosis presents with transepidermal elimination of collagen fibers. Elastosis perforans serpiginosum presents with the elimination of elastic fibers. Kyrle's disease presents with transepidermal elimination of abnormal keratin. In perforating folliculitis, it is the content of the follicle. We established diagnostic criteria and severity classification. In addition, the Japanese guideline for treatment of perforating dermatoses was updated using the Medical Information Network Distribution Service (MINDS) methodology. The guideline is based on a systematic published work review completed from 1989 to 2019, and on a formal consensus and approval process. Most medical published work on the treatment is limited to individual case reports and small series of patients. The guideline covers treatment options considered relevant by the expert panel and approved in Japan at the time of the consensus conference.
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http://dx.doi.org/10.1111/1346-8138.15647DOI Listing
December 2020

Autoantibodies to BPAG1e Trigger Experimental Bullous Pemphigoid in Mice.

J Invest Dermatol 2021 May 16;141(5):1167-1176.e3. Epub 2020 Oct 16.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Bullous pemphigoid (BP) is an autoimmune blistering disease that targets the hemidesmosomal proteins BP180 and BP230/BPAG1e. Whereas the role of anti-BP180 antibodies has been extensively characterized, the pathogenicity of anti-BPAG1e antibodies remains unclear. The purpose of this study is to elucidate the role of antibodies to BPAG1e in the experimental bullous pemphigoid models. We generated Bpag1 conditional knockout mice, where the knockout of Bpag1 is restricted to keratin 5-expressing epithelial cells. Bpag1 conditional knockout mice were immunized with the C-terminal portion of BPAG1e, and the splenocytes were injected into Rag2 mice intravenously. The recipient mice presented with erosion on the feet and tails. Microscopic examination showed subepidermal blisters and a linear deposition of IgG at the dermal-epidermal junction. To assess the potential role of trauma on BP development, we inflicted surface wounds on the dorsum of the Rag2 recipient mice after adoptive transfer. The wounded Rag2 mice had increased morbidity and severity of BP-like symptoms. Moreover, the depletion of B cells from splenocytes abolished a subepidermal blistering phenotype in vivo. These findings demonstrate that antibodies to BPAG1e might play a pathogenic role in causing subepidermal blistering, and external factors, including trauma, might be a trigger for BP development.
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http://dx.doi.org/10.1016/j.jid.2020.08.031DOI Listing
May 2021

Novel TGM1 Gene Mutation in a Japanese Patient with Bathing Suit Ichthyosis.

Acta Derm Venereol 2020 Oct 6;100(17):adv00285. Epub 2020 Oct 6.

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, 683-8504 Yonago, Japan. E-mail:

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http://dx.doi.org/10.2340/00015555-3643DOI Listing
October 2020

Benign neonatal hemangiomatosis with early regression of skin lesions: A case report and review of the published work.

J Dermatol 2020 Aug 3;47(8):911-916. Epub 2020 Jun 3.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

A 2-day-old Japanese male infant was referred to our outpatient clinic for multiple cutaneous hemangiomas present since birth. Physical examination revealed 14 small, well-circumscribed red papules, scattered over the head, face, dorsum of the right hand, trunk, lower extremities, buttocks and penis. Ultrasound examination revealed no evidence of visceral involvement. Histological examination of a cutaneous lesion was consistent with infantile hemangioma, resulting in the final diagnosis of benign neonatal hemangiomatosis (BNH). The hemangiomas enlarged by 1 month of age and began to resolve at 2 months of age. Within the next month, the lesions had almost completely disappeared. BNH is a rare, non-heritable, self-limited, benign disease characterized by multiple cutaneous infantile hemangiomas and no or unremarkable visceral lesions. Generally, BNH lesions spontaneously regress within the first 1-2 years of life or within 4 months of onset. However, there have been no detailed reports about the time course of BNH. To our knowledge, 31 cases of BNH without hepatic hemangiomas, excluding this case, have been reported so far. Twenty-one of these cases demonstrated spontaneous regression of the cutaneous hemangiomas without treatment. In all cases, the cutaneous hemangiomas were present at birth. The median age at the beginning of spontaneous regression was 6.0 months (range, 1-12) and the median age at complete or almost complete regression was 15 months (range, 3-28). Cutaneous hemangiomas in BNH without hepatic hemangiomas undergo spontaneous regression within the first year of life.
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http://dx.doi.org/10.1111/1346-8138.15413DOI Listing
August 2020

Japanese case of Papillon-Lefèvre syndrome with novel compound heterozygous mutations.

J Dermatol 2020 Aug 28;47(8):e293-e295. Epub 2020 May 28.

Department of Dermatology, Yamagata University Faculty of Medicine, Yamagata, Japan.

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http://dx.doi.org/10.1111/1346-8138.15412DOI Listing
August 2020

Partial spontaneous regression of pediatric large fibroblastic connective tissue nevus.

J Dermatol 2020 Jun 18;47(6):e232-e234. Epub 2020 Mar 18.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

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http://dx.doi.org/10.1111/1346-8138.15320DOI Listing
June 2020

Abnormal keratinization and cutaneous inflammation in Mal de Meleda.

J Dermatol 2020 May 10;47(5):554-558. Epub 2020 Mar 10.

Department of Dermatology, National Center for Global Health and Medicine, Tokyo, Japan.

Mal de Meleda (MDM) is a rare, autosomal recessive form of palmoplantar keratoderma due to mutations in the gene, encoding for secreted lymphocyte antigen 6/urokinase-type plasminogen activator receptor related protein 1 (SLURP1). We report a four-year-old Taiwanese MDM female case whose biopsy specimen of hyperkeratotic lesions showed abnormal keratinization and cutaneous inflammation with characteristic transmission electron microscopic (TEM) findings and immunostaining results. The patient presented with pruritic and severely hyperkeratotic plaques on the bilateral palms and soles whichwere fringed with erythematous scaly areas. A homozygous c.256 G>A mutation, predicting a conversion of p.Gly86Arg, in SLURP1gene was detected. Histopathological examinations showed marked hyperkeratosis, acanthosis and hypergranulosis in the epidermis, accompanied by perivascular lymphocytic infiltrates in the dermis. The whole layers of the epidermis and perivascular infiltrates of the dermis were stained positive with anti-tumor necrosis factor alpha (TNFα) antibody in the biopsy specimen from the sole and the ankle. TEM examination of the biopsy specimen from the plantar hyperkeratotic plaque showed various-sized vacuoles surrounding nuclei of many keratinocytes in the spinous layer. In addition, there were numerous irregular keratohyaline granules in the granular layer. Several microorganisms and many lipid-like droplets were found in the thickened cornified layer. SLURP1 protein is known as a marker of late differentiation, predominantly expressed in the granular layer, and also known to have an inhibitory effect on TNFα release. Our results exhibited excessive TNFα expression in keratinocytes and perivascular infiltrates of the dermis, and several characteristic morphological observations of keratinocytes in MDM.
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http://dx.doi.org/10.1111/1346-8138.15296DOI Listing
May 2020

Novel mutation of the ferrochelatase gene in a Japanese family with erythropoietic protoporphyria.

J Dermatol 2020 Apr 13;47(4):e114-e116. Epub 2020 Feb 13.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

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http://dx.doi.org/10.1111/1346-8138.15258DOI Listing
April 2020

Pedunculated aneurysmal fibrous histiocytoma with increased F-fluorodeoxyglucose uptake on positron emission tomography/computed tomography.

J Dermatol 2020 Mar 17;47(3):e100-e102. Epub 2020 Jan 17.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

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http://dx.doi.org/10.1111/1346-8138.15237DOI Listing
March 2020

Case of bullous pemphigoid following Hailey-Hailey disease with novel mutation of the ATP2C1 gene.

J Dermatol 2020 Mar 10;47(3):e79-e80. Epub 2020 Jan 10.

Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

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http://dx.doi.org/10.1111/1346-8138.15229DOI Listing
March 2020

Paraneoplastic syndrome associated with chronic myelogenous leukemia mimicking adult-onset Still's disease.

J Dermatol 2020 Feb 2;47(2):e67-e69. Epub 2019 Dec 2.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

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http://dx.doi.org/10.1111/1346-8138.15169DOI Listing
February 2020

Case of Hailey-Hailey disease with a novel missense/in-frame deletion mutation in ATP2C1 successfully treated with cyclosporine.

J Dermatol 2019 Dec 9;46(12):e482-e483. Epub 2019 Sep 9.

Department of Dermatology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.

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http://dx.doi.org/10.1111/1346-8138.15081DOI Listing
December 2019

Subcutaneous dermoid cysts on the eyebrow and neck.

Pediatr Dermatol 2019 Nov 14;36(6):999-1001. Epub 2019 Aug 14.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

We report a case of dermoid cysts on the right lateral eyebrow and anterior neck. Multiple concurrent dermoid cysts, as in the present case, are very rare. The differential diagnosis of dermoid cyst includes epidermoid (epidermal inclusion) cyst, trichilemmal cyst, pilomatrixoma, lymphatic malformation, and lipoma. In particular, thyroglossal duct cyst and midline anterior neck inclusion cyst are part of the differential diagnosis when the lesion is in the anterior neck.
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http://dx.doi.org/10.1111/pde.13976DOI Listing
November 2019

Two cases of cutaneous gnathostomiasis after eating raw Salangichthys microdon (icefish, shirauo).

J Dermatol 2019 Sep 27;46(9):791-793. Epub 2019 Jun 27.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Cutaneous gnathostomiasis (CG) is a disease caused by ingestion of third-stage Gnathostoma larva in raw snakes, freshwater fish or frogs. The common causative organisms of CG in Japan include G. nipponicum, G. spinigerum, G. doloresi, G. binucleatum and G. hispidum. We report two cases of CG after eating many raw Japanese icefishes (Salangichthys microdon). In both cases, linear itchy eruptions on the trunk developed after eating many S. microdon. We performed genetic analysis in the first case, which revealed G. nipponicum. Of note, this is the first case of CG diagnosed based on genetic analysis in Japan. In Japan, eating whole small raw freshwater fish is common. The most popular types of raw small freshwater fish consumed in Japan are S. microdon (shirauo in Japanese) and Leucopsarion petersii (shirouo in Japanese). Usually, S. microdon are born in rivers, but live in both the sea and rivers. They feed on small fish and freshwater water fleas and spawn in rivers in the spring. On the other hand, L. petersii are born in rivers, but move to the sea soon after hatching. They feed on plankton such as copepod in the sea. They do not feed on anything when they return to rivers to spawn in the spring. Therefore, we hypothesize that S. microdon are more easily parasitized by G. nipponicum.
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http://dx.doi.org/10.1111/1346-8138.15002DOI Listing
September 2019

Corticosteroid Therapy in Neonatal Incontinentia Pigmenti With Asymptomatic Cerebral Lesions.

Pediatr Neurol 2019 10 18;99:85-87. Epub 2019 Apr 18.

Department of Pediatrics, Fukushima Medical University, Fukushima, Japan.

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http://dx.doi.org/10.1016/j.pediatrneurol.2019.04.003DOI Listing
October 2019

Erythropoietic Protoporphyria in a Japanese Population.

Acta Derm Venereol 2019 Jun;99(7):634-639

Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, 930-0194, Toyama, Japan.

Erythropoietic protoporphyria is caused by a partial deficiency of ferrochelatase, which is the last enzyme in the heme biosynthesis pathway. In a typical erythropoietic protoporphyria, photosensitivity initially appears, following the first exposure to the sun in early infancy or childhood. Erythropoietic protoporphyria has been reported worldwide, but there is a regional variation in its epidemiology. Approximately 20% of the Japanese patients were recognized to have symptoms of erythropoietic protoporphyria after 10 years of age. Physicians occasionally encounter Japanese patients with erythropoietic protoporphyria, mild symptoms and no FECH gene mutations. The homozygous IVS3-48C polymorphism may cause a mild phenotype of the erythropoietic protoporphyria via a slight increase in protoporphyrin. The frequency of the homozygous IVS3-48C polymorphism in the Japanese population is higher than that observed in European countries. Japanese type of erythropoietic protopor-phyria shows a characteristic phenotype of the late onset and mild symptoms compared to the Caucasian erythropoietic protoporphyria. This review describes the characteristics of erythropoietic protoporphyria in Japanese patients.
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http://dx.doi.org/10.2340/00015555-3184DOI Listing
June 2019

The first Japanese case of familial porphyria cutanea tarda diagnosed by a UROD mutation.

J Dermatol Sci 2019 01 15;93(1):65-67. Epub 2018 Nov 15.

Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2018.11.004DOI Listing
January 2019

Case of generalized anhidrosis associated with diffuse reticular hyperpigmentation and syndactyly.

J Dermatol 2019 05 16;46(5):e154-e155. Epub 2018 Nov 16.

Department of Dermatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

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http://dx.doi.org/10.1111/1346-8138.14697DOI Listing
May 2019

A case of Birt-Hogg-Dubé syndrome accompanied by colon polyposis and oral papillomatosis.

Eur J Dermatol 2018 Oct;28(5):720-721

Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma 371-8511, Japan.

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http://dx.doi.org/10.1684/ejd.2018.3394DOI Listing
October 2018
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