Publications by authors named "Haiyoung Jung"

62Publications

Immunotherapy in Hematologic Malignancies: Emerging Therapies and Novel Approaches.

Int J Mol Sci 2020 Oct 27;21(21). Epub 2020 Oct 27.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea.

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October 2020

Molecular Mechanisms and Emerging Therapeutics for Osteoporosis.

Int J Mol Sci 2020 Oct 15;21(20). Epub 2020 Oct 15.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea.

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October 2020

Regulation of Hematopoietic Stem Cell Fate and Malignancy.

Int J Mol Sci 2020 Jul 6;21(13). Epub 2020 Jul 6.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea.

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July 2020

The Gata1 murine megakaryocyte-erythroid progenitor cells expand robustly and alter differentiation potential.

Biochem Biophys Res Commun 2020 07 23;528(1):46-53. Epub 2020 May 23.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology Yuseong-gu, Daejeon, 34141, South Korea. Electronic address:

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July 2020

Dysregulation of Rho GTPases in Human Cancers.

Cancers (Basel) 2020 May 7;12(5). Epub 2020 May 7.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.

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May 2020

Large DNA Methylation Nadirs Anchor Chromatin Loops Maintaining Hematopoietic Stem Cell Identity.

Mol Cell 2020 05;78(3):506-521.e6

Stem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston, TX, USA; Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. Electronic address:

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May 2020

Toll-Like Receptors in Natural Killer Cells and Their Application for Immunotherapy.

J Immunol Res 2020 4;2020:2045860. Epub 2020 Jan 4.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.

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January 2020

A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy.

Biomaterials 2020 07 7;247:119960. Epub 2020 Mar 7.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon, 34113, Republic of Korea. Electronic address:

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July 2020

Anti-inflammatory activities of astringent persimmons (Diospyros kaki Thunb.) stalks of various cultivar types based on the stages of maturity in the Gyeongnam province.

BMC Complement Altern Med 2019 Sep 23;19(1):262. Epub 2019 Sep 23.

Korean Convergence Medicine major, University of Science & Technology (UST), Daejeon, 34054, Republic of Korea.

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September 2019

Protein Kinases and Their Inhibitors in Pluripotent Stem Cell Fate Regulation.

Stem Cells Int 2019 24;2019:1569740. Epub 2019 Jul 24.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.

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July 2019

Inhibition of Osteoclastogenesis by Thioredoxin-Interacting Protein-Derived Peptide (TN13).

J Clin Med 2019 Mar 29;8(4). Epub 2019 Mar 29.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, Korea.

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March 2019

Causes and Mechanisms of Hematopoietic Stem Cell Aging.

Int J Mol Sci 2019 Mar 13;20(6). Epub 2019 Mar 13.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Korea.

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March 2019

A negative feedback loop between XBP1 and Fbw7 regulates cancer development.

Oncogenesis 2019 Feb 19;8(3):12. Epub 2019 Feb 19.

Drug Development Center, DGMIF, Daegu, Republic of Korea.

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February 2019

Thioredoxin-interacting protein-derived peptide (TN13) inhibits LPS-induced inflammation by inhibiting p38 MAPK signaling.

Biochem Biophys Res Commun 2018 12 16;507(1-4):489-495. Epub 2018 Nov 16.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon, 34141, Republic of Korea. Electronic address:

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December 2018

Pharmacological Regulation of Oxidative Stress in Stem Cells.

Oxid Med Cell Longev 2018 30;2018:4081890. Epub 2018 Sep 30.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.

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November 2018

TLR4/NF-κB axis induces fludarabine resistance by suppressing TXNIP expression in acute myeloid leukemia cells.

Biochem Biophys Res Commun 2018 11 15;506(1):33-40. Epub 2018 Oct 15.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon, 34141, Republic of Korea. Electronic address:

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November 2018

TXNIP regulates AKT-mediated cellular senescence by direct interaction under glucose-mediated metabolic stress.

Aging Cell 2018 Dec 31;17(6):e12836. Epub 2018 Aug 31.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.

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December 2018

Ginsenoside Rg3 ameliorated HFD-induced hepatic steatosis through downregulation of STAT5-PPARγ.

J Endocrinol 2017 Dec;235(3):223-235

Metabolic Regulation Research CenterKorea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon Republic of Korea

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December 2017

Role of Protein Kinases and Their Inhibitors in Radiation Response of Tumor Cells.

Curr Pharm Des 2017 11;23(29):4259-4280

New Drug Development Center, DGMIF, 80 Chumbok-ro, Dong-gu, Daegu 41061, Korea.

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November 2017

MicroRNA-150 controls differentiation of intraepithelial lymphocytes through TGF-β receptor II regulation.

J Allergy Clin Immunol 2018 04 7;141(4):1382-1394.e14. Epub 2017 Aug 7.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, Korea. Electronic address:

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April 2018

MicroRNA-150 modulates intracellular Ca levels in naïve CD8 T cells by targeting TMEM20.

Sci Rep 2017 06 1;7(1):2623. Epub 2017 Jun 1.

Departments of Immunology and Medicine, University of Washington School of Medicine and Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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June 2017

Suppressor of Cytokine Signaling 2 Negatively Regulates NK Cell Differentiation by Inhibiting JAK2 Activity.

Sci Rep 2017 04 6;7:46153. Epub 2017 Apr 6.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, Republic of Korea.

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April 2017

Macrophage migration inhibitory factor interacts with thioredoxin-interacting protein and induces NF-κB activity.

Cell Signal 2017 06 18;34:110-120. Epub 2017 Mar 18.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, Republic of Korea; Department of Functional Genomics, University of Science and Technology, Yuseong-gu, Daejeon 34113, Republic of Korea. Electronic address:

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June 2017

Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity.

Nat Commun 2016 12 8;7:13674. Epub 2016 Dec 8.

Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong-gu, Daejeon 34141, Republic of Korea.

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December 2016

Identification of proteins suppressing the functions of oncogenic phosphatase of regenerating liver 1 and 3.

Exp Ther Med 2016 Nov 20;12(5):2974-2982. Epub 2016 Sep 20.

New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 701-310, Republic of Korea.

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November 2016

Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS.

Biochem Biophys Res Commun 2015 Aug 15;463(4):1184-9. Epub 2015 Jun 15.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon, Republic of Korea; Department of Functional Genomics, University of Science and Technology, Yuseong-gu, Daejeon, Republic of Korea. Electronic address:

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August 2015

Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody.

Biomaterials 2015 May 17;51:119-128. Epub 2015 Feb 17.

Functional Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea; Department of Biomolecular Science, University of Science & Technology, Daejeon, Republic of Korea. Electronic address:

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May 2015

Integrated mRNA-microRNA profiling of human NK cell differentiation identifies MiR-583 as a negative regulator of IL2Rγ expression.

PLoS One 2014 14;9(10):e108913. Epub 2014 Oct 14.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea; Department of Functional Genomics, Korea University of Science and Technology, Daejeon, Republic of Korea.

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June 2015

An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression.

Hum Reprod 2014 Oct 17;29(10):2176-89. Epub 2014 Jul 17.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon 305-806, Republic of Korea Department of Functional Genomics, University of Science & Technology, Yuseong-gu, Daejeon 305-350, Republic of Korea

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October 2014

Thioredoxin-interacting protein, hematopoietic stem cells, and hematopoiesis.

Curr Opin Hematol 2014 Jul;21(4):265-70

aImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology bDepartment of Functional Genomics, University of Science and Technology, Yuseong-gu, Daejeon, Republic of Korea.

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July 2014

TXNIP deficiency exacerbates endotoxic shock via the induction of excessive nitric oxide synthesis.

PLoS Pathog 2013 3;9(10):e1003646. Epub 2013 Oct 3.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon, Republic of Korea ; Department of Functional Genomics, University of Science and Technology, Yuseong-gu, Daejeon, Republic of Korea.

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May 2014

TXNIP interacts with hEcd to increase p53 stability and activity.

Biochem Biophys Res Commun 2013 Aug 21;438(2):264-9. Epub 2013 Jul 21.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon 305-806, Republic of Korea.

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August 2013

VDUP1 exacerbates bacteremic shock in mice infected with Pseudomonas aeruginosa.

Cell Immunol 2012 Nov 29;280(1):1-9. Epub 2012 Nov 29.

Immunotherapy Research Center, Korea Research of Bioscience and Biotechnology, Yuseong, Daejeon, Republic of Korea.

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November 2012

Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation.

Biochem Biophys Res Commun 2012 Aug 26;425(2):340-7. Epub 2012 Jul 26.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yoosunggu, Daejeon 305-600, Republic of Korea.

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August 2012

PDK1 protein phosphorylation at Thr354 by murine protein serine-threonine kinase 38 contributes to negative regulation of PDK1 protein activity.

J Biol Chem 2012 Jun 27;287(25):20811-22. Epub 2012 Apr 27.

Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361-763, Republic of Korea.

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June 2012

IL-22 producing NKp46+ innate lymphoid cells can differentiate from hematopoietic precursor cells.

Immunol Lett 2011 Dec 30;141(1):61-7. Epub 2011 Jul 30.

Cell Therapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Republic of Korea.

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December 2011

IL-15-induced IL-10 increases the cytolytic activity of human natural killer cells.

Mol Cells 2011 Sep 29;32(3):265-72. Epub 2011 Jul 29.

Cell Therapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.

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September 2011

Heterogeneous spectrum of CFTR gene mutations in Korean patients with cystic fibrosis.

Korean J Lab Med 2011 Jul 28;31(3):219-24. Epub 2011 Jun 28.

Department of Laboratory Medicine & Genetics, Samsung Medical Center and Sungkyunkwan University School of Medicine, Seoul, Korea.

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July 2011

Positive regulation of apoptosis signal-regulating kinase 1 signaling by ZPR9 protein, a zinc finger protein.

J Biol Chem 2011 Sep 19;286(36):31123-35. Epub 2011 Jul 19.

Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361-763, Republic of Korea.

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September 2011

The essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability.

Biochem Biophys Res Commun 2011 Mar 12;406(2):305-9. Epub 2011 Feb 12.

Graduate School of Medical Science and Engineering, Biomedical Research Center, KAIST, Daejeon 305-701, Republic of Korea.

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March 2011

TOX regulates the differentiation of human natural killer cells from hematopoietic stem cells in vitro.

Immunol Lett 2011 Apr 30;136(1):29-36. Epub 2010 Nov 30.

Cell Therapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon 305-806, Republic of Korea.

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April 2011

Blood chimerism in a dizygotic dichorionic pregnancy.

Korean J Lab Med 2010 Oct;30(5):521-4

Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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October 2010

Immature platelet fraction: establishment of a reference interval and diagnostic measure for thrombocytopenia.

Korean J Lab Med 2010 Oct;30(5):451-9

Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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October 2010

[Evaluation of MicroScan Synergies plus Positive Combo 3 Panels for identification and antimicrobial susceptibility testing of Staphylococcus aureus and Enterococcus species].

Korean J Lab Med 2010 Aug;30(4):373-80

Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

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August 2010

Murine protein serine/threonine kinase 38 stimulates TGF-beta signaling in a kinase-dependent manner via direct phosphorylation of Smad proteins.

J Biol Chem 2010 Oct 21;285(40):30959-70. Epub 2010 Jul 21.

Department of Biochemistry, School of Life Sciences, Chungbuk National University, Cheongju 361-763, Republic of Korea.

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October 2010

Reciprocal negative regulation of PDK1 and ASK1 signaling by direct interaction and phosphorylation.

J Biol Chem 2010 Jan 17;285(4):2397-414. Epub 2009 Nov 17.

Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361-763, Republic of Korea.

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January 2010

Serine-threonine kinase receptor-associated protein inhibits apoptosis signal-regulating kinase 1 function through direct interaction.

J Biol Chem 2010 Jan 30;285(1):54-70. Epub 2009 Oct 30.

Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361-763, Korea.

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January 2010

Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation.

J Biol Chem 2008 Dec 23;283(50):34541-53. Epub 2008 Oct 23.

Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361-763, Republic of Korea.

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December 2008

Direct interaction between NM23-H1 and macrophage migration inhibitory factor (MIF) is critical for alleviation of MIF-mediated suppression of p53 activity.

J Biol Chem 2008 Nov 24;283(47):32669-79. Epub 2008 Sep 24.

Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361-763, Republic of Korea.

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November 2008

Critical role of cysteine residue 81 of macrophage migration inhibitory factor (MIF) in MIF-induced inhibition of p53 activity.

J Biol Chem 2008 Jul 23;283(29):20383-96. Epub 2008 May 23.

Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju, Republic of Korea.

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July 2008

NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function.

J Biol Chem 2007 Nov 3;282(48):35293-307. Epub 2007 Oct 3.

Department of Biochemistry, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361-763, Republic of Korea.

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November 2007

3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.

J Biol Chem 2007 Apr 27;282(16):12272-89. Epub 2007 Feb 27.

Department of Biochemistry, Research Center for Bioresource and Health, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361-763, Republic of Korea.

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April 2007

NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling.

J Biol Chem 2007 Apr 21;282(16):12075-96. Epub 2007 Feb 21.

Department of Biochemistry, Research Center for Bioresource and Health, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361-763, Republic of Korea.

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April 2007

Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.

J Biol Chem 2005 Dec 26;280(52):42897-908. Epub 2005 Oct 26.

Department of Biochemistry, Research Center for Bioresource and Health, Biotechnology Research Institute, School of Life Sciences, Chungbuk National University, Cheongju 361-763.

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December 2005