Haiquan Li

Haiquan Li

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Haiquan Li

Publications by authors named "Haiquan Li"

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NIR-Activated Polymeric Nanoplatform with Upper Critical Solution Temperature for Image-Guided Synergistic Photothermal Therapy and Chemotherapy.

Biomacromolecules 2019 Jun 6;20(6):2338-2349. Epub 2019 May 6.

Shanghai Key Laboratory of Functional Materials Chemistry , East China University of Science and Technology , Shanghai 200237 , China.

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http://dx.doi.org/10.1021/acs.biomac.9b00321DOI Listing
June 2019

Precision drug repurposing via convergent eQTL-based molecules and pathway targeting independent disease-associated polymorphisms.

Pac Symp Biocomput 2019 ;24:308-319

Center for Biomedical Informatics and Biostatistics (CB2), The University of Arizona, Tucson, AZ 85721, USA2Department of Medicine COM-T, The University of Arizona, Tucson, AZ 85721, USA†Authors contributed equally to this work,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425966PMC
January 2019

Convergent downstream candidate mechanisms of independent intergenic polymorphisms between co-classified diseases implicate epistasis among noncoding elements.

Pac Symp Biocomput 2018 ;23:524-535

Center for Biomedical Informatics and Biostatistics (CB2) and Departments of Medicine and of Systems and Industrial Engineering, The University of Arizona, Tucson, AZ 85721, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730078PMC
August 2018

N-of-1-pathways MixEnrich: advancing precision medicine via single-subject analysis in discovering dynamic changes of transcriptomes.

BMC Med Genomics 2017 05 24;10(Suppl 1):27. Epub 2017 May 24.

Center for Biomedical Informatics and Biostatistics, The University of Arizona, Tucson, AZ, 85721, USA.

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http://dx.doi.org/10.1186/s12920-017-0263-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461551PMC
May 2017

kMEn: Analyzing noisy and bidirectional transcriptional pathway responses in single subjects.

J Biomed Inform 2017 02 19;66:32-41. Epub 2016 Dec 19.

Center for Biomedical Informatics and Biostatistics, The University of Arizona, Tucson, AZ 85721, USA; Bio5 Institute, The University of Arizona, Tucson, AZ 85721, USA; Department of Medicine, The University of Arizona, Tucson, AZ 85721, USA; Graduate Interdisciplinary Program in Statistics, The University of Arizona, Tucson, AZ 85721, USA; University of Arizona Cancer Center, The University of Arizona, Tucson, AZ 85721, USA; Institute for Genomics and Systems Biology, The University of Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbi.2016.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316373PMC
February 2017

Analysis of aggregated cell-cell statistical distances within pathways unveils therapeutic-resistance mechanisms in circulating tumor cells.

Bioinformatics 2016 06;32(12):i80-i89

Center for Biomedical Informatics and Biostatistics (CB2) Graduate Interdisciplinary Program in Statistics Department of Medicine BIO5 Institute, The University of Arizona, Tucson, AZ 85721, USA The University of Arizona Cancer Center, Tucson, AZ 85719, USA Institute for Genomics and Systems Biology, The University of Chicago, Chicago, IL, 60637, USA.

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http://dx.doi.org/10.1093/bioinformatics/btw248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908332PMC
June 2016

Integrative genomics analyses unveil downstream biological effectors of disease-specific polymorphisms buried in intergenic regions.

NPJ Genom Med 2016;1. Epub 2016 Apr 27.

BIO5 institute, University of Arizona, Tucson, AZ, USA; Department of Medicine, University of Arizona, Tucson, AZ, USA; Department of Medicine, University of Illinois at Chicago, IL, USA; Section of Genetic Medicine, Department of Medicine, University of Chicago, IL, USA; Center for Biomedical Informatics, Department of Medicine, University of Chicago, IL, USA; Computation Institute, Argonne National Laboratory and University of Chicago, IL, USA; Institute for Genomics and Systems Biology, Argonne National Laboratory & University of Chicago, IL, USA; University of Arizona Cancer Center, University of Arizona, Tucson, AZ, USA; Section for Bioinformatics, Department of Bioengineering, University of Illinois at Chicago, IL, USA; Department of Biopharmaceutical Sciences, University of Illinois at Chicago, IL, USA.

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http://dx.doi.org/10.1038/npjgenmed.2016.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966659PMC
April 2016

eQTL networks unveil enriched mRNA master integrators downstream of complex disease-associated SNPs.

J Biomed Inform 2015 Dec 30;58:226-234. Epub 2015 Oct 30.

Department of Medicine, University of Arizona, Tucson, AZ, USA; Bio5 Institute, University of Arizona, Tucson, AZ, USA; Cancer Center, University of Arizona, Tucson, AZ, USA; Interdisciplinary Program in Statistics, University of Arizona, Tucson, AZ, USA.

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http://dx.doi.org/10.1016/j.jbi.2015.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4684766PMC
December 2015

[The significance of multi-criteria decision analysis for the bundle treatment of severe pneumonia].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2015 Oct;27(10):796-9

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October 2015

COPD Hospitalization Risk Increased with Distinct Patterns of Multiple Systems Comorbidities Unveiled by Network Modeling.

AMIA Annu Symp Proc 2014 14;2014:855-64. Epub 2014 Nov 14.

Department of Medicine, The University of Arizona, Tucson, AZ, USA ; Cancer Center, The University of Arizona, Tucson, AZ, USA ; Biomedical Informatics Service Group, Arizona Health Science Center, The University of Arizona, Tucson, AZ, USA ; Interdisciplinary Program in Statistics, The University of Arizona, Tucson, AZ, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419951PMC
September 2015

Dynamic changes of RNA-sequencing expression for precision medicine: N-of-1-pathways Mahalanobis distance within pathways of single subjects predicts breast cancer survival.

Bioinformatics 2015 Jun;31(12):i293-302

University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, Graduate Interdisciplinary Program in Statistics, Department of Medicine and BIO5 Institute, University of Arizona, Tucson, AZ, USA University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, Graduate Interdisciplinary Program in Statistics, Department of Medicine and BIO5 Institute, University of Arizona, Tucson, AZ, USA University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, Graduate Interdisciplinary Program in Statistics, Department of Medicine and BIO5 Institute, University of Arizona, Tucson, AZ, USA University of Arizona Center for Biomedical Informatics and Biostatistics (CB2), Tucson, AZ, USA, Graduate Interdisciplinary Program in Statistics, Department of Medicine and BIO5 Institute, University of Arizona, Tucson, AZ, USA.

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http://dx.doi.org/10.1093/bioinformatics/btv253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765863PMC
June 2015

'N-of-1-pathways' unveils personal deregulated mechanisms from a single pair of RNA-Seq samples: towards precision medicine.

J Am Med Inform Assoc 2014 Nov-Dec;21(6):1015-25. Epub 2014 Jun 12.

Department of Medicine, Bio5 Institute, UA Cancer Center, University of Arizona, Tucson, Arizona, USA Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA Institute for Translational Health Informatics, University of Illinois at Chicago, Chicago, Illinois, USA Computation Institute, Argonne National Laboratory & University of Chicago, Chicago, Illinois, USA University of Illinois Cancer Center, Chicago, Illinois, USA Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois, USA Department of Biopharmaceutical Science, College of Pharmacy, University of Illinois at Chicago, Illinois, USA Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois, USA Department of Pharmacology, University of Illinois at Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1136/amiajnl-2013-002519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215042PMC
May 2015

Prognostic implication of pulmonary function at the beginning of postoperative radiotherapy in non-small cell lung cancer.

Radiother Oncol 2014 Dec 28;113(3):374-8. Epub 2014 Nov 28.

Department of Radiation Oncology, Ajou University School of Medicine, Suwon, Republic of Korea.

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http://dx.doi.org/10.1016/j.radonc.2014.11.007DOI Listing
December 2014

Interpreting personal transcriptomes: personalized mechanism-scale profiling of RNA-seq data.

Pac Symp Biocomput 2013 :159-70

Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595401PMC
December 2013

Towards mechanism classifiers: expression-anchored Gene Ontology signature predicts clinical outcome in lung adenocarcinoma patients.

AMIA Annu Symp Proc 2012 3;2012:1040-9. Epub 2012 Nov 3.

Center for Biomedical Informatics, Dept. of Medicine, Section of Hematology/Oncology, The University of Chicago, Chicago, IL 60637, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540430PMC
July 2013

APRIL induces tumorigenesis and metastasis of colorectal cancer cells via activation of the PI3K/Akt pathway.

PLoS One 2013 29;8(1):e55298. Epub 2013 Jan 29.

Department of Clinical Laboratory Center, Affiliated Hospital of Nantong University, School of Public Health, Nantong University, Nantong, Jiangsu, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055298PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558491PMC
July 2013

Simultaneous knockdown of APRIL via multiple shRNAs reduces the malignancy of SW480 cells.

Oncol Rep 2012 Nov 22;28(5):1613-8. Epub 2012 Aug 22.

Department of Clinical Laboratory Center, Affiliated Hospital of Nantong University, Nantong Medical College, Nantong University, Nantong 226001, PR China.

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http://dx.doi.org/10.3892/or.2012.1980DOI Listing
November 2012

The rise of translational bioinformatics.

Genome Biol 2012 Aug 31;13(8):319. Epub 2012 Aug 31.

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http://dx.doi.org/10.1186/gb-2012-13-8-319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491366PMC
August 2012

Genetic diversity and population structure of Chinese foxtail millet [Setaria italica (L.) Beauv.] landraces.

G3 (Bethesda) 2012 Jul 1;2(7):769-77. Epub 2012 Jul 1.

National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.

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http://dx.doi.org/10.1534/g3.112.002907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3385983PMC
July 2012

Complex-disease networks of trait-associated single-nucleotide polymorphisms (SNPs) unveiled by information theory.

J Am Med Inform Assoc 2012 Mar-Apr;19(2):295-305. Epub 2012 Jan 25.

Center for Biomedical Informatics, Department of Medicine, University of Chicago, Illinois, USA.

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http://dx.doi.org/10.1136/amiajnl-2011-000482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277620PMC
May 2012

Population genetics of foxtail millet and its wild ancestor.

BMC Genet 2010 Oct 11;11:90. Epub 2010 Oct 11.

The National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, the Chinese Academy of Agricultural Sciences, Beijing 100081, China.

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http://dx.doi.org/10.1186/1471-2156-11-90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964552PMC
October 2010

Genomic inventory and transcriptional analysis of Medicago truncatula transporters.

Plant Physiol 2010 Mar 18;152(3):1716-30. Epub 2009 Dec 18.

Genetics and Developmental Biology Program, Division of Plant and Soil Sciences, West Virginia University, Morgantown, West Virginia 26506, USA.

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http://dx.doi.org/10.1104/pp.109.148684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832251PMC
March 2010

TransportTP: a two-phase classification approach for membrane transporter prediction and characterization.

BMC Bioinformatics 2009 Dec 14;10:418. Epub 2009 Dec 14.

Plant Biology Division, The Samuel Roberts Noble Foundation, Inc, Ardmore, OK 73401, USA.

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http://dx.doi.org/10.1186/1471-2105-10-418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087344PMC
December 2009

A nearest neighbor approach for automated transporter prediction and categorization from protein sequences.

Bioinformatics 2008 May 12;24(9):1129-36. Epub 2008 Mar 12.

Bioinformatics Lab, Plant Biology Division, The Samuel Roberts Noble Foundation, Inc., 2510 Sam Noble Parkway, Ardmore, OK 73401, USA.

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http://dx.doi.org/10.1093/bioinformatics/btn099DOI Listing
May 2008

Role of phosphodiesterase type 3A and 3B in regulating platelet and cardiac function using subtype-selective knockout mice.

Cell Signal 2007 Aug 6;19(8):1765-71. Epub 2007 Apr 6.

Otsuka Maryland Medicinal Laboratories, Inc, 9900 Medical Center Drive, Rockville, MD 20850, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S089865680700100
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http://dx.doi.org/10.1016/j.cellsig.2007.03.012DOI Listing
August 2007

The Fab fragment of a novel anti-GPVI monoclonal antibody, OM4, reduces in vivo thrombosis without bleeding risk in rats.

Arterioscler Thromb Vasc Biol 2007 May 22;27(5):1199-205. Epub 2007 Feb 22.

Department of Cardiology and Thrombosis, Otsuka Maryland Medicinal Laboratories Inc, 9900 Medical Center Drive, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1161/ATVBAHA.107.140590DOI Listing
May 2007

Discovering motif pairs at interaction sites from protein sequences on a proteome-wide scale.

Bioinformatics 2006 Apr 29;22(8):989-96. Epub 2006 Jan 29.

Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore 119613, Singapore.

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http://dx.doi.org/10.1093/bioinformatics/btl020DOI Listing
April 2006

Discovery of stable and significant binding motif pairs from PDB complexes and protein interaction datasets.

Bioinformatics 2005 Feb 16;21(3):314-24. Epub 2004 Sep 16.

Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore 119613.

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http://dx.doi.org/10.1093/bioinformatics/bti019DOI Listing
February 2005

Antiplatelet and antithrombotic activity of cilostazol is potentiated by dipyridamole in rabbits and dissociated from bleeding time prolongation.

Cardiovasc Drugs Ther 2005 Jan;19(1):41-8

Department of Cardiology, Otsuka Maryland Medicinal Laboratories, LLC, 9900 Medical Center Drive, Rockville, Maryland 20850, USA.

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http://dx.doi.org/10.1007/s10557-005-6896-0DOI Listing
January 2005

In vivo measurement and imaging of tumor oxygenation using coembedded paramagnetic particulates.

Magn Reson Med 2004 Sep;52(3):650-7

Center for Biomedical EPR Spectroscopy and Imaging, Davis Heart and Lung Research Institute, Department of Internal Medicine, Ohio State University, Columbus, USA.

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http://dx.doi.org/10.1002/mrm.20188DOI Listing
September 2004

Nitric oxide protects cardiac sarcolemmal membrane enzyme function and ion active transport against ischemia-induced inactivation.

J Biol Chem 2003 Oct 6;278(43):41798-803. Epub 2003 Aug 6.

Department of Medicine, Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21224, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M306865200
Publisher Site
http://dx.doi.org/10.1074/jbc.M306865200DOI Listing
October 2003

Effect of carbogen-breathing on redox status of the RIF-1 tumor.

Adv Exp Med Biol 2003 ;510:13-7

EPR Center, Division of Cardiology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21224, USA.

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http://dx.doi.org/10.1007/978-1-4615-0205-0_3DOI Listing
August 2003

Mapping ischemic risk region and necrosis in the isolated heart using EPR imaging.

Magn Reson Med 2003 Jun;49(6):1181-7

Center for Biomedical EPR Spectroscopy and Imaging, Columbus, Ohio, USA.

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http://dx.doi.org/10.1002/mrm.10473DOI Listing
June 2003

In vivo measurement of tumor redox environment using EPR spectroscopy.

Mol Cell Biochem 2002 May-Jun;234-235(1-2):393-8

The EPR Center, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA.

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February 2003

In vivo measurement of regional oxygenation and imaging of redox status in RIF-1 murine tumor: effect of carbogen-breathing.

Magn Reson Med 2002 Oct;48(4):723-30

EPR Center, Division of Cardiology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1002/mrm.10254DOI Listing
October 2002

Polynitroxyl-albumin (PNA) enhances myocardial infarction therapeutic effect of tempol in rat hearts subjected to regional ischemia-reperfusion.

Free Radic Biol Med 2002 Apr;32(8):712-9

Division of Cardiology and the EPR Center, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/s0891-5849(02)00762-1DOI Listing
April 2002

Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels.

Cancer Res 2002 Jan;62(1):307-12

The EPR Center and Division of Cardiology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21224, USA.

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January 2002

A naphthalocyanine-based EPR probe for localized measurements of tissue oxygenation.

Free Radic Biol Med 2002 Jan;32(2):139-47

The EPR Center, Division of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/s0891-5849(01)00784-5DOI Listing
January 2002