Publications by authors named "Haiping Chen"

68 Publications

Immunogenicity and safety of concomitant administration of the chinese inactivated poliovirus vaccine with the diphtheria-tetanus-acellular pertussis (DTaP) vaccine in children: A multicenter, randomized, non-inferiority, controlled trial.

Front Immunol 2022 26;13:905634. Epub 2022 Jul 26.

Medical Affairs, China National Biotec Group Company Limited, Beijing, China.

Key Point: Considering that vaccination with the sIPV and DTaP overlap at the ages of 3 and 4 months in China, to reduce the burden of treatment on parents and increase vaccination coverage rates, we designed a postmarket clinical study of co-administration.

Background: The Sabin-strain-based inactivated poliovirus vaccine (sIPV) and the diphtheria-tetanus-acellular pertussis vaccine (DTaP) have been licensed in China for many years. To conduct a clinical study on the safety and immunogenicity of the sIPV when administered concomitantly with the DTaP.

Methods: The study population was divided into three groups: group 1 was the sIPV+ DTaP concomitant administration group, group 2 was the sIPV inoculation group, and group 3 was the DTaP inoculation group. Blood samples were collected prevaccination and 30 days postvaccination, and serum antibody levels were detected.

Results: This study showed that the seropositive and seroconversion rates of type 1, 2 and 3 poliovirus in group 1 were higher than those in group 2, with no statistically significant difference after vaccination (P>0.05). Groups 1 and 3 also showed similar responses for all vaccine antigens except anti-FHA (97.65 (94.09-99.36) vs. 100 (97.89-100)). The geometric mean titers (GMTs) for the DTaP and sIPV among the groups were comparable, and the non-inferiority t test result was P<0.001. The number of local adverse events (AEs) reported in group 1 (29.91%) were larger than those in group 2 (12.39%) and group 3 (21.93%), among which the most common was redness. Similarly, the most common systemic AE was fever. All 5 severe AE (SAE) cases were determined by experts to be unrelated to the vaccines during the study.

Conclusions: The evidence of similar seroconversion and safety with co-administered DTaP and sIPV supports the co-administration supports the introduction of a strategy of simultaneous administration of both vaccines into routine infant immunization, and it could increase vaccination coverage and protect more infants from morbidity and mortality from these related diseases.

Clinical Trial Registration: https://clinicaltrials.gov/ct2/show/NCT04054882?term=NCT04054882&cntry=CN&draw=2&rank=1, identifier NCT04054882.
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http://dx.doi.org/10.3389/fimmu.2022.905634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361845PMC
August 2022

Immunogenicity and safety of an inactivated SARS-CoV-2 vaccine (Sinopharm BBIBP-CorV) coadministered with quadrivalent split-virion inactivated influenza vaccine and 23-valent pneumococcal polysaccharide vaccine in China: A multicentre, non-inferiority, open-label, randomised, controlled, phase 4 trial.

Vaccine 2022 Jul 29. Epub 2022 Jul 29.

China National Biotec Group Company Limited, Beijing, China; National Engineering Technology Research Center for Combined Vaccines, Wuhan Institute of Biological Products Company Limited, Wuhan, China. Electronic address:

Background: The safety and immunogenicity of the coadministration of an inactivated SARS-CoV-2 vaccine (Sinopharm BBIBP-CorV), quadrivalent split-virion inactivated influenza vaccine (IIV4), and 23-valent pneumococcal polysaccharide vaccine (PPV23) in adults in China is unknown.

Methods: In this open-label, non-inferiority, randomised controlled trial, participants aged ≥ 18 years were recruited from the community. Individuals were eligible if they had no history of SARS-CoV-2 vaccine or any pneumonia vaccine and had not received an influenza vaccine during the 2020-21 influenza season. Eligible participants were randomly assigned (1:1:1), using block randomization stratified, to either: SARS-CoV-2 vaccine and IIV4 followed by SARS-CoV-2 vaccine and PPV23 (SARS-CoV-2 + IIV4/PPV23 group); two doses of SARS-CoV-2 vaccine (SARS-CoV-2 vaccine group); or IIV4 followed by PPV23 (IIV4/PPV23 group). Vaccines were administered 28 days apart, with blood samples taken on day 0 and day 28 before vaccination, and on day 56.

Results: Between March 10 and March 15, 2021, 1152 participants were recruited and randomly assigned to three groups (384 per group). 1132 participants were included in the per-protocol population (375 in the SARS-CoV-2 + IIV4/PPV23 group, 380 in the SARS-CoV-2 vaccine group, and 377 in the IIV4/PPV23 group). The seroconversion rate (100 % vs 100 %) and GMT (159.13 vs 173.20; GMT ratio of 0.92 [95 % CI 0.83 to 1.02]) of SARS-CoV-2 neutralising antibodies in the SARS-CoV-2 + IIV4/PPV23 group was not inferior to those in the SARS-CoV-2 vaccine group. The SARS-CoV-2 + IIV4/PPV23 group was not inferior to the IIV4/PPV23 group in terms of seroconversion rates and GMT of influenza virus antibodies for all strains except for the seroconversion rate for the B/Yamagata strain. The SARS-CoV-2 + IIV4/PPV23 group was not inferior to the IIV4/PPV23 group regarding seroconversion rates and GMC of Streptococcus pneumoniae IgG antibodies specific to all serotypes. All vaccines were well tolerated.

Conclusions: The coadministration of the inactivated SARS-CoV-2 vaccine and IIV4/PPV23 is safe with satisfactory immunogenicity. This study is registered with ClinicalTrials.gov, NCT04790851.
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http://dx.doi.org/10.1016/j.vaccine.2022.07.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334936PMC
July 2022

ARIMA and ARIMA-ERNN models for prediction of pertussis incidence in mainland China from 2004 to 2021.

BMC Public Health 2022 07 29;22(1):1447. Epub 2022 Jul 29.

School of Public Health, Fudan University, Shanghai, 200032, China.

Objective: To compare an autoregressive integrated moving average (ARIMA) model with a model that combines ARIMA with the Elman recurrent neural network (ARIMA-ERNN) in predicting the incidence of pertussis in mainland China.

Background: The incidence of pertussis has increased rapidly in mainland China since 2016, making the disease an increasing public health threat. There is a pressing need for models capable of accurately predicting the incidence of pertussis in order to guide prevention and control measures. We developed and compared two models for predicting pertussis incidence in mainland China.

Methods: Data on the incidence of pertussis in mainland China from 2004 to 2019 were obtained from the official website of the Chinese Center for Disease Control and Prevention. An ARIMA model was established using SAS (ver. 9.4) software and an ARIMA-ERNN model was established using MATLAB (ver. R2019a) software. The performances of these models were compared.

Results: From 2004 to 2019, there were 104,837 reported cases of pertussis in mainland China, with an increasing incidence over time. The incidence of pertussis showed obvious seasonal characteristics, with the peak lasting from March to September every year. Compared with the mean squared error (MSE), mean absolute error (MAE), and mean absolute percentage error (MAPE) of the ARIMA model, those of the ARIMA-ERNN model were 81.43%, 95.97% and 80.86% lower, respectively, in fitting performance. In terms of prediction performance, the MAE, MSE and MAPE were 37.75%, 56.88% and 43.75% lower, respectively.

Conclusion: The fitting and prediction performances of the ARIMA-ERNN model were better than those of the ARIMA model. This provides theoretical support for the prediction of infectious diseases and should be beneficial to public health decision making.
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http://dx.doi.org/10.1186/s12889-022-13872-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9338508PMC
July 2022

Evaluation of Immunogenicity and Safety of Vero Cell-Derived Inactivated COVID-19 Vaccine in Older Patients with Hypertension and Diabetes Mellitus.

Vaccines (Basel) 2022 Jun 25;10(7). Epub 2022 Jun 25.

China National Biotech Group Co., Ltd., Beijing 100024, China.

Background: To evaluate the immunogenicity and safety of the COVID-19 vaccine (Vero cell), inactivated, in a population aged ≥60 years with hypertension or(/and) diabetes mellitus.

Methods: A total of 1440 participants were enrolled and divided into four groups, 330 in the hypertension group, 330 in the diabetes group, 300 in the hypertensive combined with diabetes group (combined disease group), and 480 in the healthy population group. Two doses of the COVID-19 vaccine (Vero cell), inactivated, were administered at a 21-day interval and blood samples were collected before vaccination and 28 days after the second dose to evaluate the immunogenicity. The adverse events and changes in blood pressure and blood glucose levels after vaccination were recorded.

Results: The seroconversion rate of the COVID-19 neutralizing antibodies was 100% for all participants. The post-inoculation geometric mean titer (GMT) in the four groups of the hypertension, diabetes, combined disease, and healthy populations were 73.41, 69.93, 73.84, and 74.86, respectively. The seroconversion rates and post-vaccination GMT in the hypertension, diabetes, and combined disease groups were non-inferior to the healthy population group. The rates of vaccine-related adverse reactions were 11.93%, 14.29%, 12.50%, and 9.38%, respectively. No serious adverse events were reported during the study. No apparent abnormal fluctuations in blood pressure and blood glucose values were observed after vaccination in participants with hypertension or(/and) diabetes.

Conclusions: The COVID-19 vaccine (Vero cell), inactivated, showed good immunogenicity and safety in patients aged ≥60 years suffering from hypertension or(/and) diabetes mellitus.
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http://dx.doi.org/10.3390/vaccines10071020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9315836PMC
June 2022

Immunogenicity and Safety of an Inactivated Enterovirus 71 Vaccine Administered Simultaneously with Hepatitis B Virus Vaccine, Group A Meningococcal Polysaccharide Vaccine, Measles-Rubella Combined Vaccine and Japanese Encephalitis Vaccine: A Multi-Center, Randomized, Controlled Clinical Trial in China.

Vaccines (Basel) 2022 Jun 2;10(6). Epub 2022 Jun 2.

Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China.

Background: The aim of this study was to investigate the immunogenicity and safety of the enterovirus 71 vaccine (EV71 vaccine) administered alone or simultaneously.

Methods: A multi-center, open-label, randomized controlled trial was performed involving 1080 healthy infants aged 6 months or 8 months from Shandong, Shanxi, Shaanxi, and Hunan provinces. These infants were divided into four simultaneous administration groups and EV71 vaccine separate administration group. Blood samples were collected from the infants before the first vaccination and after the completion of the vaccination. This trial was registered in the Clinical Trials Registry (NCT03519568).

Results: A total of 895 were included in the per-protocol analysis. The seroconversion rates of antibodies against EV71 in four simultaneous administration groups (98.44% (189/192), 94.57% (122/129), 99.47% (187/188) and 98.45% (190/193)) were non-inferior to EV71 vaccine separate administration group (97.93% [189/193]) respectively. Fever was the most common adverse event, the pairwise comparison tests showed no difference in the incidence rate of solicited, systemic or local adverse events. Three serious adverse events related to the vaccination were reported.

Conclusions: The evidence of immunogenicity and safety supports that the EV71 vaccine administered simultaneously with vaccines need to be administered during the same period of time recommended in China.
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http://dx.doi.org/10.3390/vaccines10060895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9230521PMC
June 2022

Risk Stratification for Diffuse Large B-Cell Lymphoma by Integrating Interim Evaluation and International Prognostic Index: A Multicenter Retrospective Study.

Front Oncol 2021 16;11:754964. Epub 2021 Dec 16.

Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

The baseline International Prognostic Index (IPI) is not sufficient for the initial risk stratification of patients with diffuse large B-cell lymphoma (DLBCL) treated with R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone). The aims of this study were to evaluate the prognostic relevance of early risk stratification in DLBCL and develop a new stratification system that combines an interim evaluation and IPI. This multicenter retrospective study enrolled 314 newly diagnosed DLBCL patients with baseline and interim evaluations. All patients were treated with R-CHOP or R-CHOP-like regimens as the first-line therapy. Survival differences were evaluated for different risk stratification systems including the IPI, interim evaluation, and the combined system. When stratified by IPI, the high-intermediate and high-risk groups presented overlapping survival curves with no significant differences, and the high-risk group still had >50% of 3-year overall survival (OS). The interim evaluation can also stratify patients into three groups, as 3-year OS and progression-free survival (PFS) rates in patients with stable disease (SD) and progressive disease (PD) were not significantly different. The SD and PD patients had significantly lower 3-year OS and PFS rates than complete remission and partial response patients, but the percentage of these patients was only ~10%. The IPI and interim evaluation combined risk stratification system separated the patients into low-, intermediate-, high-, and very high-risk groups. The 3-year OS rates were 96.4%, 86.7%, 46.4%, and 40%, while the 3-year PFS rates were 87.1%, 71.5%, 42.5%, and 7.2%. The OS comparison between the high-risk group and very high-risk group was marginally significant, and OS and PFS comparisons between any other two groups were significantly different. This combined risk stratification system could be a useful tool for the prognostic prediction of DLBCL patients.
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http://dx.doi.org/10.3389/fonc.2021.754964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716489PMC
December 2021

Derivation and validation of prognostic models for predicting survival outcomes in Acute-on-chronic liver failure patients.

J Viral Hepat 2021 12 15;28(12):1719-1728. Epub 2021 Oct 15.

Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

Acute-on-chronic liver failure (ACLF) is a syndrome characterized by acute decompensation of chronic liver disease associated with high bacterial infection (BI) and short-term mortality. However, many ACLF prognostic predictive modelsare complicated. The aim of this study is to develop prognostic models for ACLF patients to predict BI and mortality. We retrospective recruited 263 patients with ACLF from Shandong Provincial Hospital and Taizhou Enze Medical Center (Group) Enze Hospital. ACLF was defined according to the Asian Pacific Association for the Study of the Liver (APASL) criteria. Multivariable logistic regression was used to derive prediction models for occurring BI and 28-day mortality in ACLF patients. Ninety seven of 263 patients (37%) occurred BI and 41 of 155 (26%) died within 28 days of admission. C-reactive protein (CRP), glucose, and albumin were the independent predictors for occurring BI during the hospital stay. We also found that hepatic encephalopathy (HE), prothrombin time, activated partial thromboplastin time (APRI), and glucose were the independent predictors of 28-day mortality of ACLF patients. Using logistic regression model, we generated a new modified MELD model (M-MELD) by incorporating HE, APRI, and glucose. AUC of M-MELD model was 0.871, which were significantly higher than MELD score (AUC:0.734), MELD-Na score (AUC:0.742), and integrated MELD score (iMELD) (AUC:0.761). HE, MELD score, APRI, and blood glucose were independent risk factors for 28-day mortality of ACLF patients. The modified MELD model (M-MELD) by incorporating HE, APRI, and glucose has better discriminative performances compared with MELD in predicting 28-day mortality.
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http://dx.doi.org/10.1111/jvh.13611DOI Listing
December 2021

Oropharyngeal Probiotic ENT-K12 Prevents Respiratory Tract Infections Among Frontline Medical Staff Fighting Against COVID-19: A Pilot Study.

Front Bioeng Biotechnol 2021 24;9:646184. Epub 2021 Jun 24.

Department of Pulmonary Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Healthcare workers at the frontline are facing a substantial risk of respiratory tract infection during the COVID-19 outbreak due to an extremely stressful work schedule and public health event. A well-established first-line defense on oropharyngeal microbiome could be a promising strategy to protect individuals from respiratory tract infections including COVID-19. The most thoroughly studied oropharyngeal probiotic product which creates a stable upper respiratory tract microbiota capable of preventing upper respiratory tract infections was chosen to evaluate the safety and efficacy on reducing episodes of upper respiratory tract infections for COVID-19 healthcare workers. To our knowledge to date, this is the very first study describing the beneficial effects of oropharyngeal probiotic been administered by healthcare workers during the COVID-19 pandemic. In this randomized controlled trial, we provided the probiotics to frontline medical staff who work in the hospitals in Wuhan and had been in close contact with hospitalized COVID-19 patients for prophylactic use on a daily basis. Our finding suggests that oropharyngeal probiotic administration significantly reduced the incidence of respiratory tract infections by 64.8%, reduced the time experiencing respiratory tract infections and oral ulcer symptoms by 78%, shortened the days absent from work by 95.5%, and reduced the time under medication where there is no record of antibiotic and anti-viral drug intake in the probiotic group. Furthermore, medical staff treated with Bactoblis experienced sustained protection from respiratory tract infections since the 10th day of oropharyngeal probiotic administration resulting in an extremely low incidence rate of respiratory tract infections.
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http://dx.doi.org/10.3389/fbioe.2021.646184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264449PMC
June 2021

PSP net-based automatic segmentation network model for prostate magnetic resonance imaging.

Comput Methods Programs Biomed 2021 Aug 29;207:106211. Epub 2021 May 29.

Department of Urology, the Fifth Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 11100, China.

Purpose: Prostate cancer is a common cancer. To improve the accuracy of early diagnosis, we propose a prostate Magnetic Resonance Imaging (MRI) segmentation model based on Pyramid Scene Parsing Network (PSP Net).

Method: A total of 270 prostate MRI images were collected, and the data set was divided. Contrast limited adaptive histogram equalization (CLAHE) was enhanced in this study. We use the prostate MRI segmentation model based on PSP net, and use segmentation accuracy, under segmentation rate, over segmentation rate and receiver operating characteristic (ROC) curve evaluation index to compare the segmentation effect based on FCN and U-Net.

Results: PSP net has the highest segmentation accuracy of 0.9865, over segmentation rate of 0.0023, under segmentation rate of 0.1111, which is less than FCN and U-Net. The ROC curve of PSP net is closest to the upper left corner, AUC is 0.9427, larger than FCN and U-Net.

Conclusion: This paper proves through a large number of experimental results that the prostate MRI automatic segmentation network model based on PSP Net is able to improve the accuracy of segmentation, relieve the workload of doctors, and is worthy of further clinical promotion.
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http://dx.doi.org/10.1016/j.cmpb.2021.106211DOI Listing
August 2021

Up-regulation of matrix metalloproteinases-9 in the kidneys of diabetic rats and the association with neutrophil gelatinase-associated lipocalin.

BMC Nephrol 2021 06 3;22(1):211. Epub 2021 Jun 3.

Division of Geriatrics, Medical and Health Care Center, Beijing Friendship Hospital, Capital Medical University, No. 95, Yong'an Road, Xicheng District, 100050, Beijing, People's Republic of China.

Background: Matrix metalloproteinases-9 (MMP-9) can regulate extracellular matrix deposition in diabetic glomerular injury. However, it remains unknown whether MMP-9 is involved in the renal tubular injury. Meanwhile, neutrophil gelatinase-associated lipocalin (NGAL), defined as a biomarker of proximal tubular injury, may influence MMP-9 by forming the MMP-9/NGAL complex. The aim of this study was to investigate MMP-9 expression in proximal renal tubules and the relationship of MMP-9 and NGAL in diabetic rat model treated with Valsartan.

Methods: Sprague Dawley rats were randomly divided into three groups: Diabetic group, Control group, and Treated group. The diabetic rat model was established by injection of streptozotocin. Related indexes were measured at the end of the 2nd, 4th, 8th and 12th week post-modeling.

Results: In diabetic groups, the concentrations of MMP-9 markedly increased in the serum and urine of rats in the early stage, even before the appearance of pathological albuminuria. Markedly elevated MMP-9/NGAL complex concentrations were also tested in diabetic groups. Western blot and qPCR tests confirmed that MMP-9 expression levels in the proximal renal tubular epithelial cells of diabetic rats were significantly higher than in control groups (P < 0.05). Correlation analysis showed that MMP-9 was positively correlated with NGAL at both protein and gene expression levels. In addition, Valsartan observably reduced tubular injury as well as MMP-9 expression in diabetic rats.

Conclusions: In diabetic kidney injury, the expression of MMP-9 in the proximal renal tubular epithelial cells was significantly increased. Besides, a positive correlation was found between MMP-9 and NGAL expression, along with high levels of MMP-9/NGAL complex, which indicated that NGAL might participate in the regulation of MMP-9 expression. The administration of Valsartan may reduce this effect.
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http://dx.doi.org/10.1186/s12882-021-02396-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8176706PMC
June 2021

Immunogenicity and safety of sabin-strain based inactivated poliovirus vaccine replacing salk-strain based inactivated poliovirus vaccine: An innovative application of different strain-IPVs replacement.

Vaccine 2021 04 31;39(17):2467-2474. Epub 2021 Mar 31.

China National Biotec Group Company Limited, Beijing, China. Electronic address:

Background: A domestic Sabin strain-based inactivated poliovirus vaccine (Sabin IPV) was approved by China Food and Drug Administration in 2017 as a replacement for the Salk strain-based inactivated poliovirus vaccine (Salk IPV) that has been in use in China for over 10 years. The present post-marketing trial was implemented in China to assess the immunogenicity and safety of replacing the Salk IPV with the Sabin IPV in the last two immunizations of the standard three-dose schedule.

Methods: We conducted a randomized, controlled clinical trial with two groups that received three doses of IPVs at the age of 2, 3, and 4 months: the Salk-Sabin-Sabin group and the Salk-Salk-Salk group. Blood samples were collected before vaccination and 30-40 days after the third dose of vaccination. The seroconversion rates and antibody geometric mean titers (GMTs) were calculated and analyzed to evaluate immunogenicity. The safety of both immunization schedules was also monitored and analyzed.

Results: Of 360 recruited healthy infants, all three IPV doses were administered and blood collection was completed in 330 infants. All participants (100%) in both groups were seropositive for all three poliovirus types after the last vaccination. There were significant differences between the two groups (P < 0.001) in the GMTs for antibodies against poliovirus types 1 and 2, but no significant difference was observed for antibodies against type 3 (P = 0.009). A non-inferiority t-test showed that the post-immunization GMTs for all three types in the Salk-Sabin-Sabin group were not inferior to those in the Salk-Salk-Salk group (P < 0.001). Safety assessment indicated that there was no significant difference in the incidence of all adverse events between the two groups (P = 0.806).

Conclusions: The Salk-Sabin-Sabin IPV immunization schedule is not inferior to the Salk-Salk-Salk IPV schedule in terms of both immunogenicity and safety. Clinical trial number: NCT04051736.
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http://dx.doi.org/10.1016/j.vaccine.2021.02.073DOI Listing
April 2021

MiR-103/miR-107 inhibits enterovirus 71 replication and facilitates type I interferon response by regulating SOCS3/STAT3 pathway.

Biotechnol Lett 2021 Jul 1;43(7):1357-1369. Epub 2021 Apr 1.

Department of Pediatrics, Binhaiwan Central Hospital of Dongguan, Dongguan, China.

Background: Enterovirus71 (EV71), the major cause of hand, foot, and-mouth disease (HFMD), has increasingly become a public health challenge. Type I interferons (IFNs) can regulate innate and adaptive immune responses to pathogens. MicroRNAs (miRNAs) play regulatory roles in host innate immune responses to viral infections. However, the roles of miR-103 and miR-107 in EV71 infection remain unclear.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to determine the expression of miR-103, miR-107, suppressor of cytokine signaling 3 (SOCS3), VP1, IFN-α, and IFN-β. Virus titers were measured by 50% tissue culture infectious dose (TCID) assay. Western blot assay was conducted to detect the protein levels of VP1, IFN-α, IFN-β, SOCS3, signal transducer and activator of transcription 3 (STAT3), and phospho-STAT3 (p-STAT3). Immunofluorescence assay was used to detect the protein level of VP1. The concentrations of IFN-α and IFN-β were examined by Enzyme-linked immunosorbent assay (ELISA). The interaction between SOCS3 and miR-103/miR-107 was predicted by starBase and verified by dual-luciferase reporter assay and RNA pull-down assay.

Results: MiR-103 and miR-107 were downregulated and SOCS3 was upregulated in serum from patients with EV71 and EV71-infected cells. Overexpression of miR-103 and miR-107 repressed EV71 replication by inhibiting EV71 titers and VP1 expression. Moreover, upregulation of miR-103 and miR-107 enhanced EV71-triggered the production of type I IFNs. In addition, miR-103 and miR-107 directly targeted SOCS3, and SOCS3 upregulation reversed the effects of miR-103 and miR-107 on EV71 replication and type I IFN response. Importantly, miR-103 and miR-107 increased STAT3 phosphorylation by targeting SOCS3 after EV71 infection.

Conclusion: MiR-103 and miR-107 suppressed EV71 replication and increased the production of type I IFNs by regulating SOCS3/STAT3 pathway, which might provide a novel strategy for developing effective antiviral therapy.
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http://dx.doi.org/10.1007/s10529-021-03115-zDOI Listing
July 2021

Plant-atmosphere and soil-atmosphere temperature differences and their impact on grain yield of super hybrid rice under different irrigation conditions.

PLoS One 2020 17;15(12):e0243580. Epub 2020 Dec 17.

College of Agriculture and Biotechnology, Hunan University of Humanities, Science and Technology, Loudi, Hunan Province, PR China.

Continued drought during the late growth stage of super hybrid rice (SHR) markedly reduces yield, and management practices that use water more efficiently can contribute greatly to high and stable yields from SHR. The absolute temperature differences (ATDs) between the rice plant and the atmosphere and between the soil and the atmosphere are believed to be important determinants of grain yield. However, it has not previously been determined whether these ATDs have any effect on SHR yields under water-saving cultivation. A two-year field experiment involving two SHR varieties, Liangyoupeijiu (LYPJ) and Y-Liangyou 9000 (YLY900), evaluated the effects of reducing water supply from mid-booting to maturity on grain yield, canopy relative humidity (CRH), leaf area index (LAI), and ATDs between the ambient temperature and the leaf surface, panicles, canopy, and soil. Grain yield increased significantly under shallow water irrigation (SW), by 8.84% (YLY900) and 12.26% (LYPJ), but decreased significantly under mild water stress (MS, -20 to -30 kPa), by 14.36% (YLY900) and 9.47% (LYPJ), as well as severe water stress (SS, -40 to -50 kPa), by 35.06% (YLY900) and 28.74% (LYPJ). As water supply decreased, so did the CRH and the ATDs, with significant decreases under MS and SS. The temperature differences were significantly and positively correlated with grain yield (P < 0.01) in both cultivars. LAI was increased under SW conditions, but was significantly decreased under MS and SS. Our study suggests that the dual goal of saving water while maintaining high yield can be achieved by applying SW irrigation from mid-booting to maturity and by adopting cultivation measures that maintain high CRH and high plant-atmosphere and soil-atmosphere ATDs in order to alleviate water stress. YLY900 has a higher yield potential than LYPJ under SW conditions, suggesting that its wide cultivation may help achieve this dual goal.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243580PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746292PMC
January 2021

Study on the Preparation and Properties of Talcum-Fly Ash Based Ceramic Membrane Supports.

Membranes (Basel) 2020 Aug 28;10(9). Epub 2020 Aug 28.

School of Energy, Power and Mechanical Engineering, North China Electric Power University, Beijing 102206, China.

Ceramic membrane method for moisture recovery from flue gas of thermal power plants is of considerable interest due to its excellent selection performance and corrosion resistance. However, manufacturing costs of commercial ceramic membranes are still relatively expensive, which promotes the development of new methods for preparing low-cost ceramic membranes. In this study, a method for the preparation of porous ceramic membrane supports is proposed. Low-cost fly ash from power plants is the main material of the membrane supports, and talcum is the additive. The fabrication process of the ceramic membrane supports is described in detail. The properties of the supports were fully characterized, including surface morphology, phase composition, pore diameter distribution, and porosity. The mechanical strength of the supports was measured. The obtained ceramic membrane supports displays a pore size of about 5 μm and porosity of 37.8%. Furthermore, the water recovery performance of the supports under different operating conditions was experimentally studied. The experimental results show that the recovered water flux varies with operating conditions. In the study, the maximum recovered water flux reaches 5.22 kg/(m·h). The findings provide a guidance for the ceramic membrane supports application of water recovery from flue gas.
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http://dx.doi.org/10.3390/membranes10090207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7557749PMC
August 2020

Immunogenicity and safety of different sequential schedules of Sabin strain-based inactivated poliovirus vaccination: A randomized, controlled, open-label, phase IV clinical trial in China.

Vaccine 2020 09 31;38(40):6274-6279. Epub 2020 Jul 31.

China National Biotec Group Company Limited, Beijing, China. Electronic address:

Background: The immunogenicity and safety of the sequential schedule of Sabin strain-based inactivated poliovirus vaccine (sIPV) and bivalent oral poliovirus vaccine (bOPV) remains poorly understood in Chinese population.

Methods: A multi-center, open-label, randomized controlled trial was performed involving 648 healthy infants aged 2 months from Inner Mongolia, Shanxi, and Hebei provinces. These participants were divided into three groups: sIPV-bOPV-bOPV, sIPV-sIPV-bOPV, and sIPV-sIPV-sIPV. Doses were administered sequentially at age 2, 3, and 4 months. Neutralisation assays were tested using sera collected at 2 months and 5 months.

Results: A total of 569 were included in the per-protocol analysis. The seroconversion rates of poliovirus type 1 and 3 were 100% in all three groups, the seroconversion rate of poliovirus type 2 was 91.53% (173/189) (95% CI: 86.62-95.08) in the sIPV-bOPV-bOPV group, 98.38% (182/185) (95% CI: 95.33-99.66) in the sIPV-sIPV-bOPV group, and 99.49% (194/195) (95% CI: 97.18-99.99) in the sIPV-sIPV-sIPV group. For the seroconversion rate of poliovirus types 1 and 3, the sIPV-bOPV-bOPV and sIPV-sIPV-bOPV groups were non-inferior to the sIPV-sIPV-sIPV group. For the seroconversion rate of poliovirus type 2, the sIPV-sIPV-bOPV group was non-inferior to the sIPV-sIPV-sIPV group, and the sIPV-bOPV-bOPV group was inferior to the sIPV-sIPV-sIPV group. All three groups exhibited good safety, with two serious adverse events reported, that were unrelated to vaccine.

Conclusions: In china, a new vaccination schedule that including 2 doses of IPV in the national immunization programs is essential. Trial registration ClinicalTrials.govNCT04054492.
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http://dx.doi.org/10.1016/j.vaccine.2020.07.042DOI Listing
September 2020

Experimental Study on Water Recovery from Flue Gas Using Macroporous Ceramic Membrane.

Materials (Basel) 2020 Feb 10;13(3). Epub 2020 Feb 10.

School of Energy, Power and Mechanical Engineering, North China Electric Power University, Beijing 102206, China.

In this work, a ceramic membrane tube with a pore size of 1 μm was used to conduct experimental research on moisture and waste heat recovery from flue gas. The length, inner/outer diameter, and porosity were 800 mm, 8/12 mm, and 27.2%, respectively. In the experiments, the flue gas, which was artificially prepared, flowed on the shell side of membrane module. The water coolant passed through the membrane counter-currently with the gas. The effects of flue gas flow rate, flue gas temperature, water coolant flux, and water coolant temperature on the membrane recovery performance were analyzed. The results indicated that, upon increasing the flue gas flow rate and its temperature, both the amount of recycled water and the recovered heat increased. The amount of recycled water, recycled water rate, recovered heat, and heat recovery rate all decreased as the water coolant temperature increased. When the water coolant temperature exceeded 30 °C, the amount of recycled water dropped sharply. The maximum amounts of recycled water, recovered heat, and total heat transfer coefficient were 2.93 kg/(m·h), 3.63 kW/m, and 224.3 W/(m·K), respectively.
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http://dx.doi.org/10.3390/ma13030804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040702PMC
February 2020

Tornado Disaster Casualties Admitted to a County Hospital in the Jiangsu Province of China.

Disaster Med Public Health Prep 2020 10 15;14(5):585-589. Epub 2020 Jan 15.

Institute of Military Health Management, Second Military Medical University, Shanghai, China.

Objective: We analyzed characteristics of tornado-related injuries and medical impact on a county-level hospital in China in June 23, 2016. The objective of this study was to describe and analyze local government rescue responses following the tornado.

Methods: County hospital medical records of 288 tornado-related injury patients were collected. Descriptive analyses to study injury characteristics and associated risk factors were performed.

Results: Of the studied population, 84% of the wounded were older than 45 years. Only 30 (10.4%) people were sent to the hospital for treatment within 3 hours following the disaster. Heavy objects or collapsing houses accounted for 191 (66.3%) of the documented injuries. The proportion of people with resulting brain injuries was 46.2% of the entire injured population, and the incidence of lower extremity injuries was 27.8%. A total of 89.6% of the wounded had skin and soft tissue injuries. Multiple injuries were found in 129 (44.8%) people and 156 had a single injury (54.2%), and 3 cases with acute stress disorder were admitted to the hospital.

Conclusions: Preparation plans, including tornado warnings, prevention, and rescue, are a basic requirement for the mitigation of tornado-related injuries. Protection awareness of tornado disasters is also critical to ensure injury prevention.
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http://dx.doi.org/10.1017/dmp.2019.86DOI Listing
October 2020

Probing the properties of lattice vibrations and surface electronic states in magnetic semiconductor CrPS.

RSC Adv 2019 Sep 30;9(53):30655-30658. Epub 2019 Sep 30.

School of Mechanics and Optoelectronic Physics, Anhui University of Science and Technology Huainan 232001 P. R. China

Searching for multifunctional materials with magnetism and semiconductivity is one of the goals of research into two-dimensional (2D) systems. Herein, we report a chemical vapor transport method to successfully synthesize a layered magnetic semiconductor, CrPS. Under parallel and perpendicular polarization configurations, the anisotropic optical response of the (001) surface was investigated by polarized Raman spectroscopy; the Raman peak intensity was recorded with the crystal rotated from 0° to 360°, taking the symmetry of the Raman tensor into account; the A or B vibrational mode of different Raman peaks can be clearly distinguished. Moreover, the electronic state of the (001) single-crystal surface was investigated by ultraviolet photoelectron spectroscopy (UPS), which reveals the valence band position and work function of the (001) surface.
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http://dx.doi.org/10.1039/c9ra05861cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072214PMC
September 2019

Underutilization of Mental Health Services among American Elders: Two-Dimensional Policy Evaluation Model.

Soc Work Public Health 2019 22;34(6):457-467. Epub 2019 Jun 22.

a Department of Sociology, Peking University , Beijing , China.

Mental illnesses of American elders have posed serious public health challenges to today's U.S. society. Due to prevalent social stigma against both aging and mental illnesses, the mismatch between needs of American elders and provisions of mental health care, and the fragmented mental health service delivery, American elders have still been an underserved population in urgent needs of mental health care. Given that policies pervade every aspect of human life, the authors developed a two-dimensional policy evaluation model and then applied this model to the underutilization of mental health services among American elders. The vertical dimension represents a chronological approach (time). The horizontal dimension represents a SPECI analysis (space and being). Using this model, this article aims to understand which factors contribute to the underutilization of mental health services among American elders. Finally, implications for social work practice with mentally ill American elders are discussed.
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http://dx.doi.org/10.1080/19371918.2019.1629141DOI Listing
April 2020

[Citron Rho-interacting serine/threonine kinase knockdown suppresses prostate cancer cell proliferation and metastasis by blocking Hippo-YAP pathway].

Nan Fang Yi Ke Da Xue Xue Bao 2019 Mar;39(3):257-263

Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

Objective: Citron Rho-interacting serine/threonine kinase (CIT) was identified recently as an oncogene involved in the progression of various malignant tumors, but its role in prostate cancer (PCa) remains unclear. In this study, we aimed to investigate the biological functions of CIT in PCa.

Methods: We analyzed the expression of CIT in PCa tissues and its clinical correlations based on the Cancer Genome Atlas (TCGA) and Memorial Sloan-Kettering Cancer Center (MSKCC) dataset. We then examined the effects of RNA interference-mediated CIT silencing on the proliferation, migration and invasion of PC-3 cells using cell counting kit-8, wound healing assay and Transwell assay. We also investigated the effect of CIT silencing on epithelial-mesenchymal transition (EMT) and Hippo-Yap signaling pathway in the cells using Western blotting.

Results: CIT expression was significantly elevated in PCa tissues from TCGA cohort ( < 0.05). MSKCC dataset analysis showed that an elevated expression of CIT was significantly correlated with N stage (=0.001), distant metastasis ( < 0.001), Gleason score (=0.010) and PSA (=0.004). In cultured PC-3 cells, knockdown of CIT significantly inhibited cell proliferation, migration and invasion, reversed the EMT phenotype and decreased the expression and activity of YAP.

Conclusions: CIT might function as an oncogene in PCa by modulating the Hippo-YAP signaling pathway and serve as a candidate therapeutic target for PCa.
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http://dx.doi.org/10.12122/j.issn.1673-4254.2019.03.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765676PMC
March 2019

Clinical evidence for the immunogenicity and immune persistence of vaccination with yellow fever virus strain 17D in Chinese peacekeepers deployed to Africa.

Antiviral Res 2019 02 6;162:1-4. Epub 2018 Dec 6.

Jinan Military Region Center for Disease Control and Prevention, 36 Wenhua Road East, Lixia District, Jinan, Shandong, China.

Yellow fever is a serious disease caused by infection with the yellow fever virus (YFV). A live-attenuated YFV vaccine strain, 17D (YFV-17D) is the only virus strain available for the production of the YFV vaccine. This study evaluated the immunogenicity and immune persistence of vaccination with YFV-17D and identified their influencing factors in Chinese peacekeepers deployed to Africa. Serum specimens were collected before and ≥21 days after primary vaccination with YFV-17D in 349 Chinese peacekeepers who were subsequently deployed to Africa for the first time from 2016 to 2017 (population 1). Serum specimens were collected from 1 to 11 years after vaccination with YFV-17D in 2062 returned Chinese peacekeepers who were deployed to Africa from 2005 to 2015 (population 2). We found that YFV-17D exhibited an excellent protective effect in the Chinese peacekeepers deployed to Africa early following vaccination. In the Chinese peacekeepers one year after vaccination, the serum antibody titer against YFV increased with increasing age at vaccination; in those two or more years after vaccination, the serum antibody titer against YFV decreased over years and was similar to but greater than the minimum protective level 11 years after vaccination. The number of peacekeeping missions exhibited an almost negligible influence on the serum antibody titer against YFV. (This study has been registered at International Clinical Trials Registry Platform (http://www.who.int/ictrp/en/) under registration Nos. ChiCTR1800017024.).
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http://dx.doi.org/10.1016/j.antiviral.2018.12.001DOI Listing
February 2019

Bilateral renal cryodenervation decreases arterial pressure and improves insulin sensitivity in fructose-fed Sprague-Dawley rats.

Am J Physiol Regul Integr Comp Physiol 2018 09 30;315(3):R529-R538. Epub 2018 May 30.

Department of Internal Medicine, Wayne State University School of Medicine , Detroit, Michigan.

Consumption of food high in fructose is prevalent in modern diets. One week of moderately high fructose intake combined with high salt diet has been shown to increase blood pressure and failed to suppress plasma renin activity (PRA). We tested the hypothesis that the hypertension and high PRA are consequences of elevated renal sympathetic nerve activity (RSNA). In protocol 1, we assessed RSNA by telemetry in conscious Sprague-Dawley rats given 20% fructose or 20% glucose in drinking water on a 0.4% NaCl diet (NS) for 1 wk and then transitioned to a 4% NaCl diet (HS). After an additional week, mean arterial pressure (MAP) and RSNA increased significantly in fructose-fed but not glucose-fed HS rats. In protocol 2, fructose (Fruc)- or glucose (Glu)-fed rats on NS or HS diet for 3 wk underwent sham denervation (shamDNX) or bilateral renal denervation using cryoablation (cryoDNX). MAP was higher in Fruc-HS rats compared with Glu-NS, Glu-HS, or Fruc-NS rats and decreased after cryoDNX ( P < 0.01). MAP did not change in Fruc-HS shamDNX rats. Renal norepinephrine content decreased by 85% in cryoDNX ( P < 0.01 vs. shamDNX). PRA significantly decreased after cryoDNX in both Fruc-NS and Fruc-HS rats. Nonfasting blood glucose levels were similar among the four groups. Glucose-to-insulin ratio significantly increased in Fruc-HS cryoDNX rats, consistent with greater insulin sensitivity. Taken together, these studies show that renal sympathoexcitation is, at least in part, responsible for salt-dependent increases in MAP, increased PRA, and decreased insulin sensitivity in rats fed a moderately high fructose diet for as little as 3 wk.
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http://dx.doi.org/10.1152/ajpregu.00020.2018DOI Listing
September 2018

Research of an emergency medical system for mass casualty incidents in Shanghai, China: a system dynamics model.

Patient Prefer Adherence 2018 31;12:207-222. Epub 2018 Jan 31.

Department of Military Health Service Management, College of Military Health Service Management, Second Military Medical University, Shanghai, People's Republic of China.

Objectives: Emergency medical system for mass casualty incidents (EMS-MCIs) is a global issue. However, China lacks such studies extremely, which cannot meet the requirement of rapid decision-support system. This study aims to realize modeling EMS-MCIs in Shanghai, to improve mass casualty incident (MCI) rescue efficiency in China, and to provide a possible method of making rapid rescue decisions during MCIs.

Methods: This study established a system dynamics (SD) model of EMS-MCIs using the Vensim DSS program. Intervention scenarios were designed as adjusting scales of MCIs, allocation of ambulances, allocation of emergency medical staff, and efficiency of organization and command.

Results: Mortality increased with the increasing scale of MCIs, medical rescue capability of hospitals was relatively good, but the efficiency of organization and command was poor, and the prehospital time was too long. Mortality declined significantly when increasing ambulances and improving the efficiency of organization and command; triage and on-site first-aid time were shortened if increasing the availability of emergency medical staff. The effect was the most evident when 2,000 people were involved in MCIs; however, the influence was very small under the scale of 5,000 people.

Conclusion: The keys to decrease the mortality of MCIs were shortening the prehospital time and improving the efficiency of organization and command. For small-scale MCIs, improving the utilization rate of health resources was important in decreasing the mortality. For large-scale MCIs, increasing the number of ambulances and emergency medical professionals was the core to decrease prehospital time and mortality. For super-large-scale MCIs, increasing health resources was the premise.
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http://dx.doi.org/10.2147/PPA.S155603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798575PMC
January 2018

Effects of voluntary exercise on blood pressure, angiotensin II, aldosterone, and renal function in two-kidney, one-clip hypertensive rats.

Integr Blood Press Control 2017 29;10:41-51. Epub 2017 Nov 29.

Department of Internal Medicine.

Spontaneous dynamic exercise promotes sympathoinhibition and decreases arterial pressure in two-kidney, one-clip (2K-1C) hypertensive rats. Renal sympathetic nerves stimulate renin secretion and increase renal tubular sodium reabsorption. We hypothesized that daily voluntary wheel running exercise by 2K-1C rats will decrease mean arterial pressure (MAP), plasma angiotensin II (Ang II), and aldosterone as well as normalize urinary sodium and potassium excretion independent of changes in glomerular filtration rate (GFR). Five-week-old male Sprague Dawley rats underwent sham clipping (Sham) or right renal artery clipping (2K-1C). Rats were randomized to standard caging (SED) or cages with running wheels (EX). After 12 weeks, rats were assigned to either collection of aortic blood for measurement of Ang II and aldosterone or assessment of inulin clearances and excretory function. Running distances were comparable in both EX groups. MAP was lower in 2K-1C EX vs 2K-1C SED rats (<0.05). Plasma Ang II and aldosterone were significantly higher in 2K-1C SED rats and decreased in 2K-1C EX rats to levels similar to Sham SED or Sham EX rats. Clipped kidney weights were significantly lower in both 2K-1C groups, but GFR and urine flow rates were no different from right and left kidneys among the four groups. Total and fractional sodium excretion rates from the unclipped kidney of 2K-1C SED rats were higher vs either Sham group (<0.05). Values in 2K-1C EX rats were similar to the Sham groups. Potassium excretion paralleled sodium excretion. These studies show that voluntary dynamic exercise in 2K-1C rats decreases plasma Ang II and aldosterone, which contribute to the lower arterial pressure without deleterious effects on GFR. The effects on sodium excretion underscore the impact of pressure natriuresis despite elevated plasma Ang II and aldosterone in sedentary 2K-1C rats. In contrast, potassium excretion is primarily regulated by circulating aldosterone and distal sodium delivery.
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http://dx.doi.org/10.2147/IBPC.S147122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5713705PMC
November 2017

Multiscale regeneration scaffold in vitro and in vivo.

J Biomed Mater Res B Appl Biomater 2018 04 3;106(3):1218-1225. Epub 2017 Jun 3.

School of Mechanical Engineering, Henan University of Science and Technology, Luoyang, 471003, China.

Biocompatible scaffolds play an important role in modulating tissue growth. A gelatin and sodium alginate scaffold with a unique structure produced by a combination of 3-D printing, electrospinning, and vacuum freeze-drying has been developed for tissue engineering. The scaffold is composed of a macrostructure, a honeycomb microporous surface morphology, and nanofibers. This structure meets the design criteria for an ideal tissue engineering scaffold. The scaffold degrades and has low cytotoxicity. The biocompatibility of the scaffold is improved by the favorable cell-matrix interaction; cells attach to the scaffold well and secrete large amounts of extracellular matrix in vitro. Rats with the scaffold implanted survived without signs of complications and the host cells infiltrated the interior of the scaffold. After 2 months in vivo, the scaffold was vascularized and contained collagen fibers. This multiscale regeneration scaffold may be suitable for tissue engineering because of its unique structure, degradation, mechanical properties, and lower cytotoxicity, which support cell infiltration and growth, and promote vascularization and generation of granulation tissue in vivo. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1218-1225, 2018.
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http://dx.doi.org/10.1002/jbm.b.33926DOI Listing
April 2018

Comparison of influencing factors on outcomes of single and multiple road traffic injuries: A regional study in Shanghai, China (2011-2014).

PLoS One 2017 11;12(5):e0176907. Epub 2017 May 11.

Department of Military Health Service Management, College of Military Health Service Management, Second Military Medical University, Shanghai, China.

Introduction: To identify key intervention factors and reduce road traffic injury (RTI)-associated mortality, this study compared outcomes and influencing factors of single and multiple road traffic injuries (RTIs) in Shanghai.

Methods: Based on the design of National Trauma Data Bank, this study collected demographic, injury, and outcome data from RTI patients treated at the four largest trauma centers in Shanghai from January 2011 to January 2015. Data were analyzed with descriptive statistics, univariate analysis, and hierarchical logistic regression analysis.

Results: Among 2397 participants, 59.4% had a single injury, and 40.6% had multiple injuries. Most patients' outcome was cure or improvement. For single-RTI patients, length of stay, body region, central nervous system injury, acute renal failure, multiple organ dysfunction syndrome, bacterial infection, and coma were significantly related to outcome. For multiple-RTI patients, age, admission pathway, prehospital time, length of stay, number of body regions, body region, injury condition, injury severity score, and coma were significantly related to outcome.

Conclusions: Emergency rescue in road traffic accidents should focus on high-risk groups (the elderly), high-incidence body regions (head, thorax, pelvis) and number of injuries, injury condition (central nervous system injury, coma, complications, admission pathway), injury severity (critically injured patients), and time factors (particularly prehospital time).
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0176907PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426634PMC
September 2017

Study on the Health Status and Health Service Utilization of the Elderly of a Remote and Poor Village in a Mountainous Area in Jinzhai, Anhui.

Int J Environ Res Public Health 2017 04 12;14(4). Epub 2017 Apr 12.

Institute of Health Management, Second Military Medical University, Shanghai 200433, China.

: Despite the rapid development of China's economy, a number of poor areas in China continue to exist. The health status of the elderly in the poor areas is a matter of concern. This study aims to explore the status of the elderly in terms of their health status, health service needs, and utilization among rural residents of a remote and poor village in a mountainous area in Jinzhai, Anhui. Furthermore, this study aims to explore the differences between the nation rural area average level and the remote and poor village in the mountainous area in terms of health status and health service utilization. : Cluster sampling was used to obtain the sample. A total of 110 elderly people were selected from the village, and face-to-face interviews were conducted with questionnaires by trained investigators to collect data. : All items except vision, language disability, and self-care disability were found to be higher than the national average level. In terms of mental health, Zishu Village has a ratio of 44.1% for the symptoms of anxiety and depression, which is higher than the average for the national rural areas. The two-week prevalence rate, prevalence of chronic diseases, and non-hospitalization rate of those who need hospitalization (%) in Zishu Village was 62.7%, 88.2%, and 47.6% respectively, which was higher than the rural values of the National Survey (2008). Most of the outpatient visits were to the village clinics, while the hospitalizations were mainly to county hospitals. The two-week visiting rate was 24.1%, which was lower than 2008. The hospitalization rate in Zishu Village was 10.8%, which is similar to the level of 2008. : The health level and the utilization of health services of the people in Zishu Village, Jinzhai, are generally lower than the national average. Financial difficulties continue to remain the major factor affecting the utilization of hospitalization services of this remote and poor village in Jinzhai, Anhui.
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http://dx.doi.org/10.3390/ijerph14040408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409609PMC
April 2017

Civic Engagement of Older Adults in Mainland China.

Int J Aging Hum Dev 2017 07 28;85(2):204-226. Epub 2016 Dec 28.

1 Indiana University School of Social Work, Katy, TX, USA.

Due to great challenges resulting from China's rapid population aging, Chinese elders are mobilized to address problems caused by this demographic trend through civic engagement. Based on an integrative review of policy, research, and practice, this article reveals that today's Chinese elders have a higher level and wider scope of civic engagement than previous cohorts. A set of factors contributing to such improvement are further identified, including the reform of the national economy, transformation of governmental functions, and the use of effective strategies applied to concrete programs. However, several constraints limiting Chinese elders' equal, active engagement in civic life remain, including the social stratification of older adults, preferential selection of participants due to the nation's socioeconomic development strategy, and family care work competing with other types of civic activities. Finally, future directions for policy, research, and practice are proposed in order to increase Chinese elders' civic engagement.
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http://dx.doi.org/10.1177/0091415016685326DOI Listing
July 2017

Room-temperature ferromagnetism in the two-dimensional layered CuMoS nanosheets.

Phys Chem Chem Phys 2017 Jan;19(3):1735-1739

National Synchrotron Radiation Laboratory, CAS Center for Excellence in Nanoscience, University of Science and Technology of China, Hefei, Anhui 230029, China.

A room-temperature ferromagnetic behavior was observed in a ternary layered-CuMoS nanosheet. Both the coercivity and magnetization saturation increased with a decrease in temperature. The electron paramagnetic resonance spectroscopy confirmed a high g value. Combined with atomic structural observations, our first principle calculations revealed that the ferromagnetism originated from the edged molybdenum atoms.
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http://dx.doi.org/10.1039/c6cp07270dDOI Listing
January 2017

Factors influencing the perception of medical staff and outpatients of dual practice in Shanghai, People's Republic of China.

Patient Prefer Adherence 2016 29;10:1667-78. Epub 2016 Aug 29.

Department of Military Health Management, College of Health Service, Second Military Medical University, Shanghai, People's Republic of China.

Objective: Dual practice is defined as a physician's performance of medical activities in different health care institutions (two or more) simultaneously. This study aimed to examine the perception and acceptance of medical staff and outpatients of dual practice and explore the possible factors affecting people's perception.

Methods: A cross-sectional study was conducted in 13 public hospitals in Shanghai. Participants included medical staff and outpatients. We distributed 1,000 questionnaires to each participant group, and the response rates were 66.7% and 69.4%, respectively. Statistical differences in variables were tested, and multinomial logistic regression methods were employed for statistical analysis.

Results: The study included two parts: medical staff survey and outpatient survey. The results of medical staff survey showed that 63.0% of the respondents supported dual practice. Medical staff who belonged to the surgical department or held positive belief of dual practice were more willing to participate in dual practice. Moreover, the publicity activities of dual practice and hospitals' human resource management system were important factors affecting the willingness of the medical staff. The results of outpatient survey showed that 44.5% of respondents believed that dual practice could reduce difficulty in consulting a doctor. Regarding the perceived benefits of dual practice, the proportion of outpatients who believed that dual practice could meet the demand for health convenience, minor illness, and chronic disease were 45.4%, 42.4%, and 53.7%, respectively. Additionally, demographic characteristics significantly influenced the perception of outpatients.

Conclusion: This study confirmed that both medical staff and outpatients generally held positive attitudes toward dual practice. Medical staff who belonged to the surgical department or held positive belief of dual practice were more willing to participate in dual practice. Moreover, the existence of publicity activities and more flexible management system of hospitals' human resource would promote physicians' willingness to participate in dual practice. In addition, perception of outpatients of dual practice was affected by demographic characteristics.
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http://dx.doi.org/10.2147/PPA.S110091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010167PMC
September 2016
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