Publications by authors named "Haiming Li"

56 Publications

Noninvasive prediction of residual disease for advanced high-grade serous ovarian carcinoma by MRI-based radiomic-clinical nomogram.

Eur Radiol 2021 Apr 16. Epub 2021 Apr 16.

Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China.

Objectives: To develop a preoperative MRI-based radiomic-clinical nomogram for prediction of residual disease (RD) in patients with advanced high-grade serous ovarian carcinoma (HGSOC).

Methods: In total, 217 patients with advanced HGSOC were enrolled from January 2014 to June 2019 and randomly divided into a training set (n = 160) and a validation set (n = 57). Finally, 841 radiomic features were extracted from each tumor on T2-weighted imaging (T2WI) and contrast-enhanced T1-weighted imaging (CE-T1WI) sequence, respectively. We used two fusion methods, the maximal volume of interest (MV) and the maximal feature value (MF), to fuse the radiomic features of bilateral tumors, so that patients with bilateral tumors have the same kind of radiomic features as patients with unilateral tumors. The radiomic signatures were constructed by using mRMR method and LASSO classifier. Multivariable logistic regression analysis was used to develop a radiomic-clinical nomogram incorporating radiomic signature and conventional clinico-radiological features. The performance of the nomogram was evaluated on the validation set.

Results: In total, 342 tumors from 217 patients were analyzed in this study. The MF-based radiomic signature showed significantly better prediction performance than the MV-based radiomic signature (AUC = 0.744 vs. 0.650, p = 0.047). By incorporating clinico-radiological features and MF-based radiomic signature, radiomic-clinical nomogram showed favorable prediction ability with an AUC of 0.803 in the validation set, which was significantly higher than that of clinico-radiological signature and MF-based radiomic signature (AUC = 0.623, 0.744, respectively).

Conclusions: The proposed MRI-based radiomic-clinical nomogram provides a promising way to noninvasively predict the RD status.

Key Points: • MRI-based radiomic-clinical nomogram is feasible to noninvasively predict residual disease in patients with advanced HGSOC. • The radiomic signature based on MF showed significantly better prediction performance than that based on MV. • The radiomic-clinical nomogram showed a favorable prediction ability with an AUC of 0.803.
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http://dx.doi.org/10.1007/s00330-021-07902-0DOI Listing
April 2021

Na2FePO4F/biocarbon nanocomposite hollow microspheres derived from biological cell template as high-performance cathode material for sodium-ion batteries.

Chemistry 2021 Mar 29. Epub 2021 Mar 29.

Shandong Normal University, College of Chemistry,Chemical Engineering and Materials Science, Jinan,250014, CHINA.

we successfully synthesized Na 2 FePO 4 F/biocarbon nanocomposite hollow microspheres from Fe III precursor as cathodes for sodium-ion batteries through self-assembly of yeast cell biotemplate and sol-gel technology. The carbon coating on nanoparticle surface with a mesoporous structure enhances electron diffusion into Na 2 FePO 4 F crystal particles. The improved electrochemical performance of Na 2 FePO 4 F/biocarbon nanocomposites is attributed to the larger electrode-electrolyte contact area and more active sites for Na + on the surface of hollow microspheres compared with those of Na 2 FePO 4 F/C. The Na 2 FePO 4 F/biocarbon nanocomposite exhibits a high initial discharge capacity of 114.3 mAh g -1 at 0.1 C, long-cycle stability with a capacity retention of 74.3% after 500 cycles at 5 C, and excellent rate capability (70.2 mAh g -1 at 5 C) compared with Na 2 FePO 4 F/C. This novel nanocomposite hollow microsphere structure is suitable for improving the property of other cathode materials for high-power batteries.
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http://dx.doi.org/10.1002/chem.202100096DOI Listing
March 2021

Recent advances in cellulose and its derivatives for oilfield applications.

Carbohydr Polym 2021 May 6;259:117740. Epub 2021 Feb 6.

Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin, 300457, China. Electronic address:

The purpose of this review is to summarize and discuss the recent developments in exploring cellulose and its derivatives in the applications of oilfield chemicals for petroleum drilling and exploiting. We begin with a brief introduction of cellulose and its common water-soluble derivatives, such as the carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, and amphoteric cellulose. Afterwards, the applications of cellulose derivatives in different petroleum exploitation processes, such as drilling, cementing, and fracturing, are set out in detail. Finally, the application perspectives and challenges of cellulose derivatives for oilfield applications are presented. This work demonstrates that cellulose derivatives have wide application prospects in oilfield industry in the future.
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http://dx.doi.org/10.1016/j.carbpol.2021.117740DOI Listing
May 2021

The main trunk of RCA may be the best choice of sequential vein graft distal end-to-side anastomosis.

Perfusion 2021 Feb 21:267659121990571. Epub 2021 Feb 21.

Department of Cardiac Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, China.

Objective: The purpose of this study was to investigate the effect of different anastomotic positions on the early patency of the distal end-to-side anastomosis of sequential saphenous vein grafts (SVG) in off-pump coronary artery bypass grafting (OPCAB).

Methods: A total of 259 patients who underwent OPCAB between August 2014 and August 2019 and presented for coronary computed tomography angiography (CCTA) to evaluate graft patency at 1 year post-OPCAB were analyzed. There are two kinds of distal end-to-side anastomosis of SVG, to posterior descending artery (PDA) and main trunk of right coronary artery (RCA). In all, 1044 distal coronary anastomoses on 518 grafts which included 180 left internal mammary artery (LIMA) grafts, individual 79 SVG and 259 sequential SVG were assessed using CCTA. The blood flow (BF), pulsatility index (PI), and patency of every anastomosis were recorded. Besides, comprehensive data of SV-PDA and SV-RCA patients was also compared.

Results: The mean BF of SV-RCA was significantly higher than that of SV-PDA (31.71 ± 18.60 vs 22.62 ± 14.48,  = 0.001), and the PI value of SV-RCA was significantly lower than that of SV-PDA (2.57 ± 1.17 vs 3.50 ± 1.69,  = 0.001). The patency of RCA system was significantly lower than that of the LAD and the left circumflex system (79.25% vs 90.13%, 90.23% respectively,  = 0.001). In sequential SVG, the patency of SV-PDA was significantly lower than that of SV-RCA (74.01% vs 86.59%,  = 0.001). Although, there was no significant difference in left ventricular ejective fraction, the left ventricular end-diastolic diameter (LVDd) in SV-PDA group was significantly larger than that in SV-RCA (52.67 ± 8.72 mm vs 47.34 ± 7.55,  = 0.001). In addition, the target vessel diameter in SV-PDA group was smaller than that in SV-RCA group (1.52 ± 0.41 mm vs 3.17 ± 0.88 mm,  = 0.001).

Conclusion: The early patency of sequential SVG end to RCA after OPCAB is generally superior to that of to PDA, especially for patients with large LVDd.
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http://dx.doi.org/10.1177/0267659121990571DOI Listing
February 2021

Computer-aided diagnosis of ground glass pulmonary nodule by fusing deep learning and radiomics features.

Phys Med Biol 2021 Mar 4;66(6):065015. Epub 2021 Mar 4.

Department of Radiology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, 1558 Sanhuan North Road, Huzhou, Zhejiang, 313000, People's Republic of China.

Objectives: This study aims to develop a computer-aided diagnosis (CADx) scheme to classify between benign and malignant ground glass nodules (GGNs), and fuse deep leaning and radiomics imaging features to improve the classification performance.

Methods: We first retrospectively collected 513 surgery histopathology confirmed GGNs from two centers. Among these GGNs, 100 were benign and 413 were malignant. All malignant tumors were stage I lung adenocarcinoma. To segment GGNs, we applied a deep convolutional neural network and residual architecture to train and build a 3D U-Net. Then, based on the pre-trained U-Net, we used a transfer learning approach to build a deep neural network (DNN) to classify between benign and malignant GGNs. With the GGN segmentation results generated by 3D U-Net, we also developed a CT radiomics model by adopting a series of image processing techniques, i.e. radiomics feature extraction, feature selection, synthetic minority over-sampling technique, and support vector machine classifier training/testing, etc. Finally, we applied an information fusion method to fuse the prediction scores generated by DNN based CADx model and CT-radiomics based model. To evaluate the proposed model performance, we conducted a comparison experiment by testing on an independent testing dataset.

Results: Comparing with DNN model and radiomics model, our fusion model yielded a significant higher area under a receiver operating characteristic curve (AUC) value of 0.73 ± 0.06 (P < 0.01). The fusion model generated an accuracy of 75.6%, F1 score of 84.6%, weighted average F1 score of 70.3%, and Matthews correlation coefficient of 43.6%, which were higher than the DNN model and radiomics model individually.

Conclusions: Our experimental results demonstrated that (1) applying a CADx scheme was feasible to diagnosis of early-stage lung adenocarcinoma, (2) deep image features and radiomics features provided complementary information in classifying benign and malignant GGNs, and (3) it was an effective way to build DNN model with limited dataset by using transfer learning. Thus, to build a robust image analysis based CADx model, one can combine different types of image features to decode the imaging phenotypes of GGN.
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http://dx.doi.org/10.1088/1361-6560/abe735DOI Listing
March 2021

State-of-the-Art: Applications and Industrialization of Lignin Micro/Nano Particles.

ChemSusChem 2021 Mar 26;14(5):1284-1294. Epub 2021 Jan 26.

School of Light Industry and Chemical Engineering, Dalian Polytechnic University, Liaoning Key Laboratory of Lignocellulose Chemistry and BioMaterials, No.1 Qinggongyuan, Ganjingzi District, Dalian, 116034, P. R. China.

As a new product of high-value utilization of lignin, lignin micro/nano particles (LMNPs) have attracted the attention of researchers due to their non-toxicity, corrosion-resistance, UV resistance, and other excellent characteristics and potential application value. This article outlined the main preparation methods of LMNPs at the current stage, summarized and compared them from three perspectives of preparation technology, final product state and product composition. Subsequently, based on the different focuses of the properties of LMNPs, their application research progress as fillers, UV blockers, drug delivery carriers, among others, were introduced. Then a concise analysis of the technical and economic assessment and life cycle assessment of LMNPs in the process of industrialization was made. Finally, the main problems at present and the future development directions were analyzed and prospected to provide references for the deep processing of forest resources and the development of bio-based nanomaterials.
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http://dx.doi.org/10.1002/cssc.202002441DOI Listing
March 2021

Transparent films by ionic liquid welding of cellulose nanofibers and polylactide: Enhanced biodegradability in marine environments.

J Hazard Mater 2021 01 22;402:124073. Epub 2020 Sep 22.

Bioproducts Institute, Departments of Chemical and Biological Engineering, Chemistry and Wood Science, University of British Columbia, Vancouver, BC V6T 1Z3, Canada; Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, Espoo FI-00076, Finland. Electronic address:

We introduce a green and facile method to compatibilize hydrophobic polylactide (PLA) with hydrophilic cellulose nanofibers (CNF) by using ionic liquid ([DBNH][OAc]) welding with a cosolvent system (gamma-valerolactone). Such welding affords strong (230 MPa tensile strength), flexible (13% elongation at break), transparent (>90%) and defect-free CNF/PLA films. The films are biodegradable in marine environments (70% degradation in 7 weeks), facilitating the otherwise slow PLA decomposition. Physical, chemical and structural features of the films before and after welding are compared and factored in the trends observed for degradation in seawater. The results point to the possibility of PLA-based films forming a co-continuous system with nanocellulose to achieve an improved performance. The role of film morphology, hydrophobicity, and crystallinity is discussed to add to the prospects for packaging materials that simultaneously display accelerated degradability in marine environments.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124073DOI Listing
January 2021

Preparation of carbon dots from waste cellulose diacetate as a sensor for tetracycline detection and fluorescence ink.

Int J Biol Macromol 2020 Dec 3;164:4289-4298. Epub 2020 Sep 3.

Liaoning Key Laboratory of Pulp and Paper Engineering, Dalian Polytechnic University, 1#Ganjingzi District, Dalian 116034, China.

As one type of the solid wastes, the increasing contamination of waste cellulose diacetate (CDA) from discarded cigarette filters is a growing problem worldwide. Finding a facile and suitable approach to convert the CDA into value-added materials is of significance. Herein, we reported a green, simple and effective method to reuse CDA as precursor for preparing fluorescence N-doped carbon dots (N-CDs) via one-pot hydrothermal carbonization in aqueous solution with low-cost ammonium hydroxide as the passivation agent. The N-CDs showed a quantum yield up to 22.4% with a maximum emission at 415 nm and excitation at 320 nm. Interestingly, the N-CDs exhibited high selectivity toward tetracycline (TC) as their fluorescence was obviously quenched by TC as a result of inner-filter effect. A linear relationship was fabricated over concentration range of 0-80 μM with a detection limit of 0.06 μM. Moreover, the N-CDs could also be applied as fluorescent ink for anti-forgery.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.08.243DOI Listing
December 2020

Hetero-aggregation of goethite and ferrihydrite nanoparticles controlled by goethite nanoparticles with elongated morphology.

Sci Total Environ 2020 Dec 6;748:141536. Epub 2020 Aug 6.

Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, Tianjin 300191, China; College of Natural Resources and Environment, South China Agricultural University, Guangzhou 510642, China.

The dispersities of goethite nanoparticles (GTNPs) and ferrihydrite nanoparticles (FHNPs) affect the transport and retention of nanoparticle-associated contaminants. However, the effects of interaction on nanoparticle stability under varying environmental conditions have not been previously investigated. This study utilized settling experiments, a semi-empirical model, and the Derjaguin-Landau-Verwey-Overbeek (DLVO) theory to study the homo-aggregation and hetero-aggregation of GTNPs and FHNPs. The pure system of GTNPs tended to aggregate more easily than that of FHNPs, especially under the conditions of high pH (7.0-9.0), high ionic strength (IS, 10 mM), and low concentrations of humic acid (HA) (2 mg L). This aggregation was attributed to the elongated morphology of GTNPs, which contributed to surface heterogeneity. The GTNPs and FHNPs mixtures rapidly coagulated, particularly under the surface-charge disequilibrium caused by an increase in negative charges or IS. Hetero-aggregation increased with increase in the GTNPs ratio, indicating that the elongated GTNPs dominated the coagulation of the Fe mineral nanoparticle mixture, which was attributed to the surface heterogeneity and high probability collisions between the GTNPs. Although DLVO neglects the influence of heterogeneity on the nanoparticle surfaces, SEM revealed that hetero-aggregation of GTNPs and FHNPs occurred. The results obtained in this study provide novel and valuable insights into the behaviors of GTNPs and FHNPs mixtures and suggest that during the gradual transformation of FHNPs to GTNPs in soil or aquatic environments, the hetero-aggregation of GTNPs and FHNPs may be enhanced, thus promoting contaminant immobilization.
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http://dx.doi.org/10.1016/j.scitotenv.2020.141536DOI Listing
December 2020

Pure dysgerminoma of the ovary: CT and MRI features with pathological correlation in 13 tumors.

J Ovarian Res 2020 Jun 17;13(1):71. Epub 2020 Jun 17.

Department of Radiology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.

Background: To investigate the spectrum of CT and MRI findings of dysgerminoma of the ovary.

Methods: CT and MRI imaging of 12 patients with 13 histologically proven dysgerminomas of the ovary were retrospectively reviewed. Patients ages ranged from 6 ~ 27 years (mean, 17.2 years). Two observers evaluated the following CT and MRI features of the tumor by consensus: (i) location, shape, and size; (ii) attenuation, T2 signal intensity, and ADC value; (iii) patterns of contrast enhancement; (iv) presence of fibrovascular septa; (v) presence of necrosis, hemorrhage, and calcification; (vi) presence of "ovarian vascular pedicle" sign. We also noted the extent or stage of the tumors.

Results: 75% lesions arised in the right ovary. Bilateral ovaries were involved in one case. Tumors displayed as a purely or predominantly solid mass (mean size, 17.0 ± 7.8 cm). Ten tumors were shaped multilobulated. The mean ADC value of lesions was 0.830 ± 0.154 × 10 mm/s. Characteristic fibrovascular septa were observed in all lesions. Among them, classic septa were present in 69% lesions. They were thin, hypointense on T2WI with a linear intense enhancement indicating the blood vessels in septa. Due to the stromal edema, fibrovascular septa may become thick even amorphous in shape, hyperintense on T2WI and even low attenuation on CT with a slight enhancement except for a bright blood vessel on the edge. Massive necrosis was observed only in one lesion. Calcification was present in 3 of the 5 tumors on CT. "Ovarian vascular pedicle" sign was present in 12 lesions. Lymphadenopathy, retroperitoneal spread, and distant metastases combined with an implantation in Douglas' cul-de-sac were present in one patient respectively.

Conclusion: On CT and MR images, ovarian dysgerminoma often appears as a large solid mass. The edematous condition of characteristic fibrovascular septa can be well displayed by imaging which then can guide the radiologists to make an accurate diagnosis. Calcifications often occur in the tumor. Nonspecific low ADC value and "ovarian vascular pedicle" sign may narrow the differential diagnosis.
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http://dx.doi.org/10.1186/s13048-020-00674-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301981PMC
June 2020

MRI-Based Machine Learning for Differentiating Borderline From Malignant Epithelial Ovarian Tumors: A Multicenter Study.

J Magn Reson Imaging 2020 09 11;52(3):897-904. Epub 2020 Feb 11.

Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China.

Background: Preoperative differentiation of borderline from malignant epithelial ovarian tumors (BEOT from MEOT) can impact surgical management. MRI has improved this assessment but subjective interpretation by radiologists may lead to inconsistent results.

Purpose: To develop and validate an objective MRI-based machine-learning (ML) assessment model for differentiating BEOT from MEOT, and compare the performance against radiologists' interpretation.

Study Type: Retrospective study of eight clinical centers.

Population: In all, 501 women with histopathologically-confirmed BEOT (n = 165) or MEOT (n = 336) from 2010 to 2018 were enrolled. Three cohorts were constructed: a training cohort (n = 250), an internal validation cohort (n = 92), and an external validation cohort (n = 159).

Field Strength/sequence: Preoperative MRI within 2 weeks of surgery. Single- and multiparameter (MP) machine-learning assessment models were built utilizing the following four MRI sequences: T -weighted imaging (T WI), fat saturation (FS), diffusion-weighted imaging (DWI), apparent diffusion coefficient (ADC), and contrast-enhanced (CE)-T WI.

Assessment: Diagnostic performance of the models was assessed for both whole tumor (WT) and solid tumor (ST) components. Assessment of the performance of the model in discriminating BEOT vs. early-stage MEOT was made. Six radiologists of varying experience also interpreted the MR images.

Statistical Tests: Mann-Whitney U-test: significance of the clinical characteristics; chi-square test: difference of label; DeLong test: difference of receiver operating characteristic (ROC).

Results: The MP-ST model performed better than the MP-WT model for both the internal validation cohort (area under the curve [AUC] = 0.932 vs. 0.917) and external validation cohort (AUC = 0.902 vs. 0.767). The model showed capability in discriminating BEOT vs. early-stage MEOT, with AUCs of 0.909 and 0.920, respectively. Radiologist performance was considerably poorer than both the internal (mean AUC = 0.792; range, 0.679-0.924) and external (mean AUC = 0.797; range, 0.744-0.867) validation cohorts.

Data Conclusion: Performance of the MRI-based ML model was robust and superior to subjective assessment of radiologists. If our approach can be implemented in clinical practice, improved preoperative prediction could potentially lead to preserved ovarian function and fertility for some women.

Level Of Evidence: Level 4.

Technical Efficacy: Stage 2. J. Magn. Reson. Imaging 2020;52:897-904.
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http://dx.doi.org/10.1002/jmri.27084DOI Listing
September 2020

Histogram Analysis Comparison of Monoexponential, Advanced Diffusion-Weighted Imaging, and Dynamic Contrast-Enhanced MRI for Differentiating Borderline From Malignant Epithelial Ovarian Tumors.

J Magn Reson Imaging 2020 07 10;52(1):257-268. Epub 2020 Jan 10.

Department of Radiology, Jinshan Hospital, Fudan University, Shanghai, China.

Background: The accurate preoperative differentiation between borderline and malignant epithelial ovarian tumors (BEOTs vs. MEOTs) is crucial for determining the proper surgical strategy and improving the patient's postoperative quality of life. Several diffusion and perfusion MRI technologies are valuable for the differentiation; however, which is the best remains unclear.

Purpose: To compare the whole solid-tumor volume histogram analysis of diffusion-weighted imaging (DWI), diffusion kurtosis imaging (DKI), intravoxel incoherent motion (IVIM), and dynamic contrast-enhanced MRI (DCE-MRI) in the differentiation of BEOTs vs. MEOTs and to identify the correlations between the perfusion parameters from IVIM and DCE-MRI.

Study Type: Retrospective.

Population: Twenty patients with BEOTs and 42 patients with MEOTs.

Field Strength/sequence: 1.5T/DWI, DKI, and IVIM models fitting from 13 different b factors and 40 phases DCE-MRI.

Assessment: Histogram metrics were derived from the apparent diffusion coefficient (ADC), diffusion kurtosis (K), diffusion coefficient (Dk), pure diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), volume transfer constant (K ), rate constant (k ), and extravascular extracellular volume fraction (v ).

Statistical Tests: The Mann-Whitney U-test and receiver operating characteristic curve were used to determine the best histogram metrics and parameters. Multivariate logistic regression analysis was used to determine the best combined model for each two from the four technologies. Spearman's rank correlation was used to analyze the correlations between the IVIM and DCE-MRI parameters.

Results: ADC, D, Dk, and D* were significantly higher in BEOTs than in MEOTs (P < 0.05). K, K , k , and v were significantly lower in BEOTs than in MEOTs (P < 0.05). The 10th percentile of Dk was the most reliable single metric, with an area under the curve (AUC) of 0.921. Dk combined with K yielded the highest AUC of 0.950. A weak inverse correlation was found between D and K (r = -0.320, P = 0.025) and between D and k (r = -0.267, P = 0.037).

Data Conclusion: The 10th percentile of Dk was the most valuable metric and Dk combined with K had the best performance for differentiating BEOTs from MEOTs. There was no evident link between perfusion-related parameters derived from IVIM and DCE-MRI.

Level Of Evidence: 4 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2020;52:257-268.
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http://dx.doi.org/10.1002/jmri.27037DOI Listing
July 2020

Chemical modification and antioxidant activity of the polysaccharide from Acanthopanax leucorrhizus.

Carbohydr Res 2020 Jan 10;487:107890. Epub 2019 Dec 10.

College of Chemistry & Chemical Engineering, Longdong University, Qingyang, 745000, PR China.

A water-soluble polysaccharide (ALP) from Acanthopanax leucorrhizus was chemically modified to obtain two sulfated derivatives (S-ALP1 and S-ALP2), two phosphorylated derivatives (P-ALP1 and P-ALP2) and two acetylated derivatives (A-ALP1 and A-ALP2) with different degree of substitution (DS). Their structures were characterized by chemical and spectral (IR, C NMR and P NMR) analysis, and in vitro antioxidant activity were evaluated by reducing power assay, DPPH• and HO• scavenging assay. The results obtained showed that the modifications were successful, although the molecular weight (Mw) of the ALP derivatives decreased due to slight degradation during the reaction. Physicochemical and antioxidant properties of ALP changed by the chemical modifications, and the type of the substitution group and DS played a decisive role in the antioxidant activity of the derivatives. P-ALP and S-ALP with higher DS displayed stronger antioxidant abilities on scavenging DPPH• and HO•, ferric-reducing power compared with ALP, and exhibited a certain dose-effect relationship, whereas A-ALP were less effective. These results provide a scientific basis for the further studies and utilization of A. leucorrhizus polysaccharides.
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http://dx.doi.org/10.1016/j.carres.2019.107890DOI Listing
January 2020

Outcomes and practice patterns with hemodiafiltration in Shanghai: a longitudinal cohort study.

BMC Nephrol 2019 02 1;20(1):34. Epub 2019 Feb 1.

Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.

Background: Globally, there is increased clinical interest and uptake of hemodiafiltration (HDF) for increased removal of uremic toxins. To date, there has been no epidemiological analysis of HDF in China. We present HDF practice patterns and associated mortality risk in Shanghai.

Methods: This is an observational, prospectively collected, retrospective analysis of 9351 Chinese patients initiating hemodialysis in Shanghai from 2007 to 2014. The primary exposure was hemodialysis sub-modality at inception, classified into hemodiafiltration (HDF) and hemodialysis (HD), with adjustment for concommitant hemoperfusion. The primary outcome was patient mortality. We used Cox proportional hazards regression and Fine and Gray's proportional subhazards regression, with multiple imputation of missing co-variates by the chained equation method, adjusting for demographic and clinical variables.

Results: Overall, patients in the cohort were younger, with a more males, and with a lower body mass index when compared to corresponding non-Asian cohorts. Mortality rate was low although it doubled over the period of observation. HDF utilization increased from 7% of patients in 2007 to 42% of patients in 2014. The majority of patients received HDF once a week. The adjusted hazard ratio of death (95% confidence intervals) for HDF versus HD was 0.85 (0.71-1.03), and corresponding sub-hazard ratio 0.86 (0.71-1.03). There was strong effect modification by age. In those aged 40-60 years, the hazard ratio (95% confidence intervals) was 0.65 (0.45-0.94), and sub-hazard ratio also 0.65 (0.45-0.95).

Conclusions: Our study has certain limitations resulting from the limited number of co-variates available for modelling, missing data for some co-variates, and the lack of verification of data against source documentation. Notwithstanding, there is evidence of clinical benefit from HDF in China, and potential to improve patient outcomes through the greater removal of middle and larger uremic solutes.
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http://dx.doi.org/10.1186/s12882-019-1219-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359843PMC
February 2019

Preparation of polyacrylic acid-grafted-acryloyl/hemicellulose (PAA-g-AH) hybrid films with high oxygen barrier performance.

Carbohydr Polym 2019 Feb 12;205:83-88. Epub 2018 Oct 12.

Liaoning Key Laboratory of Pulp and Papermaking Engineering, Dalian Polytechnic University, Dalian, 116034, Liaoning, China. Electronic address:

Developing high-performance oxygen barrier films using biomass-based materials is crucial for the development of green and sustainable society. Herein, we develop a strategy to synthesize polyacrylic acid-grafted-acryloyl/hemicellulose composites (PAA-g-AH) as film materials with excellent oxygen barrier property. The as-synthesized films were extensively characterized by Fourier transform infrared (FT-IR), scanning electron microscopy (SEM), gel permeation chromatography (GPC), H nuclear magnetic resonance (H NMR), mechanical test, light transmittance and oxygen transmission rate (OTR) measurement. All these testing results showed that the optimum film exhibit great oxygen barrier property with a low OTR value of 0.25 ± 0.01 cm* μm/(m*d*kPa), which was much lower than that of pure PAA film. Moreover, the hybrid films possess well mechanical strength, light transmittance and recycle usage properties. Experimental results indicated that the as-synthesized films have great potential applications in several fields as packaging materials, such as drug, food and electronic products.
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http://dx.doi.org/10.1016/j.carbpol.2018.10.031DOI Listing
February 2019

Self-assembly of cationic amphiphilic cellulose-g-poly (p-dioxanone) copolymers.

Carbohydr Polym 2019 Jan 9;204:214-222. Epub 2018 Oct 9.

State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, No. 100, Martyrs Middle Road, Yuexiu District, Guangzhou, 510070, China.

Cationic amphiphilic cellulose copolymers were prepared through grafting hydrophobic poly (p-dioxanone) (PPDO) chains onto hydrophilic quaternized cellulose derivatives (QC) via ring-opening polymerization (ROP) reaction, which was performed in 1-butyl-3-methylimidazolium chloride (BmimCl) and using 4-dimethylaminopyridine (DMAP) or 1,8-diazabicyclo (5.4.0) undec-7-ene (DBU) as catalyst. Their chemical structures and physical properties were confirmed by FT-IR, H-, C-, 2D HSQC-NMR, X-ray diffraction (XRD), and thermal stability (TGA) techniques, while self-assembly behavior was characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM) and fluorescence techniques. Both of the sizes and critical micelle concentration (CMC) values of micelles were decreased with increasing grafting contents of PPDO in the copolymers, which were in the ranges of 110-246 nm and 64-253 μg/mL, respectively. The ζ-potentials of micelles were cationic andranged from 39.1 mV to 45.4 mV. The highest encapsulation efficiencyof paclitaxel (PTX) into the micelles was 61.8% and 92.0% of loaded PTX was continuously released from micelles in phosphate buffered saline medium for 36 h.
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http://dx.doi.org/10.1016/j.carbpol.2018.10.020DOI Listing
January 2019

Xylo-oligosaccharides enriched yeast protein feed production from reed sawdust.

Bioresour Technol 2018 Dec 26;270:738-741. Epub 2018 Sep 26.

Liaoning Key Laboratory of Pulp and Papermaking Engineering, Dalian Polytechnic University, Dalian 116034, Liaoning, China. Electronic address:

The aim of this study was to convert the cellulose and hemicellulose, in reed sawdust from the pulp mills, into yeast protein and xylo-oligosaccharide, then functionalize xylo-oligosaccharide as yeast feed. Both synchronous saccharification and fermentation and separate hydrolysis and fermentation of cellulase and Candida utilis were investigated to produce protein feed. By optimizing the fermentation conditions, 6.1 g/L of protein with 76.1% (7.1 g/L) xylo-oligosaccharide as the sugar was obtained. The final glucan and xylan utilization efficiencies in reed sawdust were 85.45% and 91.03%, respectively. Xylo-oligosaccharide enriched yeast protein feed from reed sawdust was thus realized by pretreatment, enzymatic hydrolysis and synchronous saccharification and fermentation.
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http://dx.doi.org/10.1016/j.biortech.2018.09.127DOI Listing
December 2018

Preparation and characterization of thermo-sensitive gel with phenolated alkali lignin.

Sci Rep 2018 09 27;8(1):14450. Epub 2018 Sep 27.

College of Light Industry and Chemical Engineering, Dalian Polytechnic University, Dalian, Liaoning, 116034, China.

Thermo-sensitive gel exhibits great potential industrial application. It has been widely used in tissue repair, drug release and water purification for its property of phase transition in response to external stimuli, reusability and biocompatibility. In this study, a novel lignin-based thermo-sensitive gel was synthesized with alkali lignin by two steps. Firstly, phenolated lignin (PPAL) was synthesized with purified alkali lignin (PAL) catalyzed by sulfuric acid. Subsequently, thermo-sensitive gel was achieved by thermal polymerization of phenolated alkali lignin and N-isopropylacrylamide (NIPAAm). Furthermore, the prepared hydrogels were characterized in terms of thermal behavior, interior morphology and their swelling behavior. Compared with PAL-based gel, the obtained PPAL-based gel exhibits a higher crosslinking density and lower critical solution temperature (LCST) due to the increase of reaction site and smaller space volume of the hydrophobic side groups grafted on NIPAAm. TGA data revealed that thermal stability of gel was enhanced (50% weight loss at ~380 °C) by using lignin as precursor. SEM images showed that a more regular interior morphology, better compressive strength was also found (PPAL0.05, 11.15 KPa). Furthermore, the swelling ratio of PPAL-based gel was lower than that of PAL-based gel due to its more complex structure.
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http://dx.doi.org/10.1038/s41598-018-32672-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160457PMC
September 2018

Application of medical adhesive inhibits intimal hyperplasia involving the downregulation of ERK1/2 and eNOS levels.

Mol Med Rep 2018 Nov 17;18(5):4643-4649. Epub 2018 Sep 17.

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, P.R. China.

Vein graft remains the most broadly applied vascular material in coronary artery bypass surgery. However, the restenosis rate of the vein bridge following angioplasty is high. The present study investigated the effect of medical adhesive on vascular intimal hyperplasia, in addition to the signal transduction mechanism. A total of 36 New Zealand white rabbits were divided into three groups at random, including the normal group, the surgery group and the medical adhesive spray group. Following surgery for transplantation of the left external jugular vein to the ipsilateral common carotid artery for 4 weeks, the thickness and area of the intima and media of the vessel were measured on formalin‑fixed, paraffin wax‑embedded pathological sections using hematoxylin‑eosin staining, and alterations in the expression of proliferating cell nuclear antigen (PCNA), platelet endothelial cell adhesion molecule 1 (PECAM‑1), vascular cell adhesion protein 1 (VCAM‑1), extracellular signal‑regulated kinase (ERK)1/2, and endothelial nitric oxide synthase (eNOS) were detected by immunohistochemical staining, reverse transcription‑quantitative polymerase chain reaction analysis and western blotting. The levels of intimal hyperplasia in the medical adhesive spray group were markedly decreased compared with the surgery group. Consistently, PCNA, PECAM‑1 and VCAM‑1 were underexpressed in the medical adhesive spray group compared with the surgery group. ERK1/2 and eNOS were underexpressed in the medical adhesive spray group compared with the surgery group. Therefore, the application of medical adhesive may inhibit intimal hyperplasia, which may be associated with the restriction of the over‑distension of the vein graft by downregulating the ERK1/2 and eNOS levels, reducing injury to the vascular intima and inhibiting the signaling pathway involved in intimal hyperplasia.
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http://dx.doi.org/10.3892/mmr.2018.9492DOI Listing
November 2018

Observation of local cardiac electrophysiological changes during off-pump coronary artery bypass grafting using epicardial mapping.

Perfusion 2019 03 2;34(2):116-124. Epub 2018 Aug 2.

1 Department of Cardiac Surgery, Capital Medical University Affiliated Anzhen Hospital, Beijing, People's Republic of China.

Objectives: At present, there is no effective method of evaluating the electrophysiological changes in cardiac myocytes during off-pump coronary artery bypass grafting (OPCAB). Therefore, we preliminarily explored the relationship between electrophysiological characteristics and the changes in cardiac function of 24 patients undergoing OPCAB.

Methods: We used the CARTO3 system for epicardial electrophysiological mapping before surgery, during left anterior descending branch anastomosis, diagonal branch anastomosis and after surgery for 24 patients undergoing OPCAB. Data, including local activation time (LAT), bipolar voltage value (BV) and conduction velocity, were processed and analyzed by the system. Intraoperative invasive blood pressure, heart rate and arterial blood gas analysis data were recorded. Continuous electrocardiography (ECG) monitoring was performed three days after surgery. Routine resting myocardial perfusion imaging (MPI) and adenosine stress-gated MPI were performed before surgery. Patients were re-examined before discharge.

Results: By analyzing the change in the LAT value, we found that the order of excitation of local myocardial cells changed after surgery. In addition, the LAT change in myocardial cells closer to the anastomosis was more significant. The earliest pacing point on the left anterior descending (LAD) coronary artery territory map was the third point (from the proximal to distal LAD) before OPCAB, but the earliest pacing point moved down to the fourth point (closer to the anastomosis) after the diagonal (DIA) anastomosis was complete. On the DIA territory map, the earliest pacing point was the fourth point before OPCAB; this moved up to the third point (closer to the anastomosis) after DIA bypass grafting. The voltages of all points were increased after myocardial revascularization. Compared with the preoperative period, the third, fourth and fifth points on the LAD territory map increased significantly after LAD anastomosis was complete (p=0.007, p=0.001, p=0.009, respectively). On the DIA territory map, the voltages of the first, second and third points were remarkably increased after completing the DIA anastomosis compared to before OPCAB and after LAD anastomosis completion (p=0.001, p=0.008, p<0.001 and p=0.006, p=0.032, p=0.002, respectively). The average conduction velocity (ACV) of all mapped points increased after OPCAB compared with before OPCAB (p<0.05). Postoperative resting MPI and adenosine stress-gated MPI showed that left ventricular global systolic function improved, the left ventricular ejection fraction (LVEF) increased significantly (p<0.05) and the left ventricular end systolic volume (LVESV) decreased significantly (p<0.05) compared to the preoperative MPI.

Conclusions: Adequate surgical coronary revascularization could lead to more stable electrical activity of local cardiomyocytes, thus, illustrating the specific mechanism of coronary revascularization for improving the cardiac function from an electrophysiological perspective.
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http://dx.doi.org/10.1177/0267659118787664DOI Listing
March 2019

Gold Nanobipyramids as Dual-Functional Substrates for in Situ "Turn On" Analyzing Intracellular Telomerase Activity Based on Target-Triggered Plasmon-Enhanced Fluorescence.

ACS Appl Mater Interfaces 2018 Aug 6;10(32):26851-26858. Epub 2018 Aug 6.

Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering , Qingdao University of Science and Technology , Qingdao 266042 , P. R. China.

Herein, we developed a novel plasmon-enhanced fluorescence (PEF)-based telomerase-responsive nanoprobe for in situ fluorescence "turn on" visualization of telomerase activity in live cells. The as-prepared nanoprobe was composed of a nicked molecular beacon (which contains Cy5.5-labeled hairpin-DNA sequences hybridized with telomerase primers)-functionalized gold nanobipyramids (Au NBPs). Au NBPs were selected as both fluorescence resonance energy-transfer and PEF dual-functional substrates, while DNA was selected to be the precise spacer to manage the interval between the Au NBPs and Cy5.5. On the basis of this target-triggered PEF probe, optimal fluorescence enhancement can be obtained with 49 DNA bases, which was higher than gold nanorods. The proposed method accomplishes sensitive telomerase activity detection down to 23 HeLa cells with a dynamic range of 40-1200 HeLa cells. On the basis of this, in situ fluorescence imaging of telomerase activity in live cells and real-time analysis of the variation in intracellular telomerase activity can be achieved. Moreover, cancer cells and normal cells can also be successfully discriminated even in their co-cultured mixtures, indicating promising potential in clinical diagnoses.
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http://dx.doi.org/10.1021/acsami.8b05447DOI Listing
August 2018

Assessing the effects of rainfall, groundwater downward leakage, and groundwater head differences on the development of cover-collapse and cover-suffosion sinkholes in central Florida (USA).

Sci Total Environ 2018 Dec 5;644:274-286. Epub 2018 Jul 5.

Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, PR China; Center for Hydroscience Analysis, Modeling & Predictive Simulations, Department of Civil, Environmental, and Construction Engineering, University of Central Florida, Orlando, FL, USA.

Cover-collapse and cover-suffosion sinkholes are widely distributed in central Florida (USA) karst terrains and have been recognized as the primary geo-hazard threatening human lives and destroying infrastructure. Previous studies indicated that the development of cover-collapse and cover-suffosion sinkholes in central Florida might be related to hydrologic/hydrogeologic conditions such as rainfall, groundwater downward leakage and groundwater hydraulic head differences (groundwater level differences between the water tables in unconfined aquifer and the potentiometric levels in confined aquifer). Here, a case study in central Florida urban areas is conducted to quantify the effects of rainfall, groundwater downward leakage and groundwater head differences on the development of cover-collapse and cover-suffosion sinkholes in central Florida with a focus on the timing of their occurrences. Results indicate that heavy rainfall/storm(s) and rapid increase of head differences within a relatively short period of time are major factors affecting the timing of sinkhole occurrences, and the spatial variation of groundwater downward leakage rate can be used to generate sinkhole susceptibility zonation maps for serving as a useful indicator of the likelihood of sinkhole development at certain areas. Results caution that the groundwater pumping and mining dewatering rate should be setup properly and the starting time of groundwater pumping and/or mining dewatering should be selected carefully in central Florida, i.e., the activities should be put into abeyance after a heavy rainfall/storm(s) to reduce the probability of sinkhole occurrences.
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http://dx.doi.org/10.1016/j.scitotenv.2018.06.273DOI Listing
December 2018

Effect of dietary intervention treatment on children with iron deficiency anemia in China: a meta-analysis.

Lipids Health Dis 2018 May 10;17(1):108. Epub 2018 May 10.

College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.

Background: Previous studies have shown beneficial effects of dietary approaches for iron deficiency anemia (IDA) control. This study was design to investigate the effect of dietary intervention treatment on children with iron deficiency anemia.

Methods: We performed a systematic review of published dietary interventions effect on IDA treatment through meta-analysis. CBM, CNKI, Wanfang database, EMBASE, VIP, PubMed and Web of science database were searched to identify studies published between January, 1980 and December, 2016. Statistical analysis was performed by Revmen5.2 software.

Results: Initially we retrieved for 373 studies, and then 6 studies with a total of 676 individuals were included in the analysis according to the inclusion and exclusion criteria for meta-analysis. The overall pooled estimate of odds ratio [(OR), 95% confidence intervals (95% CI)] in the dietary intervention on children with iron deficiency anemia was 6.54 (95% CI: 3.48-12.31, Z = 5.82, p<0.001) and funnel plot is symmetric.

Conclusions: Our meta-analysis suggested that dietary interventions are effective in improving the iron deficiency in children with iron deficiency anemia (IDA) and should be considered in the overall strategy of IDA management.
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http://dx.doi.org/10.1186/s12944-018-0749-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944174PMC
May 2018

Dynamic contrast-enhanced MRI versus F-FDG PET/CT: Which is better in differentiation between malignant and benign solitary pulmonary nodules?

Chin J Cancer Res 2018 Feb;30(1):21-30

Department of Radiology, Nantong Tumor Hospital, Nantong University, Nantong 226361, China.

Objective: To prospectively compare the discriminative capacity of dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) with that of F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) in the differentiation of malignant and benign solitary pulmonary nodules (SPNs).

Methods: Forty-nine patients with SPNs were included in this prospective study. Thirty-two of the patients had malignant SPNs, while the other 17 had benign SPNs. All these patients underwent DCE-MRI and F-FDG PET/CT examinations. The quantitative MRI pharmacokinetic parameters, including the trans-endothelial transfer constant (K), redistribution rate constant (K), and fractional volume (V), were calculated using the Extended-Tofts Linear two-compartment model. The F-FDG PET/CT parameter, maximum standardized uptake value (SUV), was also measured. Spearman's correlations were calculated between the MRI pharmacokinetic parameters and the SUV of each SPN. These parameters were statistically compared between the malignant and benign nodules. Receiver operating characteristic (ROC) analyses were used to compare the diagnostic capability between the DCE-MRI and F-FDG PET/CT indexes.

Results: Positive correlations were found between K and SUV, and between K and SUV (P<0.05). There were significant differences between the malignant and benign nodules in terms of the K, K and SUV values (P<0.05). The areas under the ROC curve (AUC) of K, K and SUV between the malignant and benign nodules were 0.909, 0.838 and 0.759, respectively. The sensitivity and specificity in differentiating malignant from benign SPNs were 90.6% and 82.4% for K; 87.5% and 76.5% for K; and 75.0% and 70.6% for SUV, respectively. The sensitivity and specificity of K and K were higher than those of SUV, but there was no significant difference between them (P>0.05).

Conclusions: DCE-MRI can be used to differentiate between benign and malignant SPNs and has the advantage of being radiation free.
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http://dx.doi.org/10.21147/j.issn.1000-9604.2018.01.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842230PMC
February 2018

Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients.

JCI Insight 2017 11 16;2(22). Epub 2017 Nov 16.

Division of Nephrology, Vanderbilt University Medical Center (VUMC), Nashville, Tennessee, USA.

Background: Systemic inflammation and muscle wasting are highly prevalent and coexist in patients on maintenance hemodialysis (MHD). We aimed to determine the effects of systemic inflammation on skeletal muscle protein metabolism in MHD patients.

Methods: Whole body and skeletal muscle protein turnover were assessed by stable isotope kinetic studies. We incorporated expressions of E1, E214K, E3αI, E3αII, MuRF-1, and atrogin-1 in skeletal muscle tissue from integrin β1 gene KO CKD mice models.

Results: Among 129 patients with mean (± SD) age 47 ± 12 years, 74% were African American, 73% were male, and 22% had diabetes mellitus. Median high-sensitivity C-reactive protein (hs-CRP) concentration was 13 (interquartile range 0.8, 33) mg/l. There were statistically significant associations between hs-CRP and forearm skeletal muscle protein synthesis, degradation, and net forearm skeletal muscle protein balance (P < 0.001 for all). The associations remained statistically significant after adjustment for clinical and demographic confounders, as well as in sensitivity analysis, excluding patients with diabetes mellitus. In attempting to identify potential mechanisms involved in this correlation, we show increased expressions of E1, E214K, E3αI, E3αII, MuRF-1, and atrogin-1 in skeletal muscle tissue obtained from an animal model of chronic kidney disease.

Conclusion: These data suggest that systemic inflammation is a strong and independent determinant of skeletal muscle protein homeostasis in MHD patients, providing rationale for further studies using anticytokine therapies in patients with underlying systemic inflammation.

Funding: This study was in part supported by NIH grants R01 DK45604 and 1K24 DK62849, the Clinical Translational Science Award UL1-TR000445 from the National Center for Advancing Translational Sciences, the Veterans Administration Merit Award I01 CX000414, the SatelliteHealth Normon Coplon Extramural Grant Program, and the FDA grant 000943.
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http://dx.doi.org/10.1172/jci.insight.95185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752392PMC
November 2017

Journey to the east: Diverse routes and variable flowering times for wheat and barley en route to prehistoric China.

PLoS One 2017 2;12(11):e0187405. Epub 2017 Nov 2.

McDonald Institute for Archaeological Research, University of Cambridge, Cambridge, United Kingdom.

Today, farmers in many regions of eastern Asia sow their barley grains in the spring and harvest them in the autumn of the same year (spring barley). However, when it was first domesticated in southwest Asia, barley was grown between the autumn and subsequent spring (winter barley), to complete their life cycles before the summer drought. The question of when the eastern barley shifted from the original winter habit to flexible growing schedules is of significance in terms of understanding its spread. This article investigates when barley cultivation dispersed from southwest Asia to regions of eastern Asia and how the eastern spring barley evolved in this context. We report 70 new radiocarbon measurements obtained directly from barley grains recovered from archaeological sites in eastern Eurasia. Our results indicate that the eastern dispersals of wheat and barley were distinct in both space and time. We infer that barley had been cultivated in a range of markedly contrasting environments by the second millennium BC. In this context, we consider the distribution of known haplotypes of a flowering-time gene in barley, Ppd-H1, and infer that the distributions of those haplotypes may reflect the early dispersal of barley. These patterns of dispersal resonate with the second and first millennia BC textual records documenting sowing and harvesting times for barley in central/eastern China.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187405PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667820PMC
December 2017

Off-Pump Semicircular Annuloplasty: Effective Treatment of Concurrent Moderate Aortic Regurgitation.

Ann Thorac Surg 2017 Jul;104(1):e97-e99

Department of Cardiac Surgery, Beijing An Zhen Hospital, Capital Medical University, Beijing, China. Electronic address:

The treatment of aortic regurgitation (AR) in patients undergoing off-pump coronary artery bypass grafting (CABG) is a difficult problem. Aortic valve repair has become a promising therapy for AR. Various annuloplasty approaches have been used and have gained satisfactory results. Thus we adopted off-pump semicircular annuloplasty to treat concurrent moderate AR in 12 high-risk patients. Early follow-up results showed that this way is simple, safe, and effective.
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http://dx.doi.org/10.1016/j.athoracsur.2017.01.090DOI Listing
July 2017

Human paleodiet and animal utilization strategies during the Bronze Age in northwest Yunnan Province, southwest China.

PLoS One 2017 22;12(5):e0177867. Epub 2017 May 22.

MOE Key Laboratory of Western China's Environmental System, College of Earth Environmental Sciences, Lanzhou University, Lanzhou, Gansu Province, China.

Reconstructing ancient diets and the use of animals and plants augment our understanding of how humans adapted to different environments. Yunnan Province in southwest China is ecologically and environmentally diverse. During the Neolithic and Bronze Age periods, this region was occupied by a variety of local culture groups with diverse subsistence systems and material culture. In this paper, we obtained carbon (δ13C) and nitrogen (δ15N) isotopic ratios from human and faunal remains in order to reconstruct human paleodiets and strategies for animal exploitation at the Bronze Age site of Shilinggang (ca. 2500 Cal BP) in northwest Yunnan Province. The δ13C results for human samples from Shilinggang demonstrate that people's diets were mainly dominated by C3-based foodstuffs, probably due to both direct consumption of C3 food and as a result of C3 foddering of consumed animals. Auxiliary C4 food signals can also be detected. High δ15N values indicate that meat was an important component of the diet. Analysis of faunal samples indicates that people primarily fed pigs and dogs with human food waste, while sheep/goats and cattle were foddered with other food sources. We compare stable isotope and archaeobotanical data from Shilinggang with data from other Bronze Age sites in Yunnan to explore potential regional variation in subsistence strategies. Our work suggests that people adopted different animal utilization and subsistence strategies in different parts of Yunnan during the Bronze Age period, probably as local adaptations to the highly diversified and isolated environments in the region.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177867PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439680PMC
September 2017

Collagen External Scaffolds Mitigate Intimal Hyperplasia and Improve Remodeling of Vein Grafts in a Rabbit Arteriovenous Graft Model.

Biomed Res Int 2017 19;2017:7473437. Epub 2017 Apr 19.

Department of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

. The aim of this study was to test the effects of collagen external scaffold (CES) in intimal hyperplasia of vein grafts and explore its underlying mechanisms. . Thirty-six New Zealand white rabbits were randomized into no-graft group, graft group, and CES group. The rabbit arteriovenous graft model was established. In CES group, the vein graft was wrapped around with CES. The hemodynamic parameters of vein grafts were measured intraoperatively and 4 weeks after operation by ultrasonic examination. Histological characteristics of vein grafts were also evaluated 4 weeks later. The mRNA and protein levels of proliferating cell nuclear antigen (PCNA), active cleaved-caspase-3 (ClvCasp-3), and smooth muscle 22 alpha (SM22) were measured 4 weeks later by quantitative real-time PCR and western blot. . CES significantly improved the hemodynamic stability of vein grafts, with higher blood velocity and blood flow. Similarly, CES also markedly mitigated intimal hyperplasia and inhibited dilatation of vein grafts. In CES group, the upexpression of PCNA and ClvCasp-3 and the downexpression of SM22 were inhibited. . CES exerts beneficial effects in mitigating intimal hyperplasia and improving remodeling of autogenous vein grafts, which may be associated with reducing the proliferation and apoptosis and preserving the phenotype of VSMCs.
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http://dx.doi.org/10.1155/2017/7473437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414509PMC
February 2018