Publications by authors named "Haifeng Lin"

64 Publications

[Expression of CD44 in Tumor Tissue and Serum of Small Cell Lung Cancer and its Clinical Prognostic Significance].

Zhongguo Fei Ai Za Zhi 2021 Jun 30. Epub 2021 Jun 30.

Department of Oncology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China.

Background: Small cell lung cancer (SCLC) is a highly aggressive malignancy characterized by rapid growth, early metastasis and acquired therapeutic resistance, and the prognosis is extremely poor. Studies have proved that the stem cell marker CD44 is correlated with tumor recurrence and treatment resistance, however, there are limited reports yet concerning on the CD44 expression and its clinical prognostic significance in SCLC patients. The purpose of this study is to investigate the expression of CD44 in tumor tissues as well as serum of SCLC patients and explore its correlation with the clinical characteristics, therapeutic effect and prognosis.

Methods: The tumor tissues and serum samples of 47 newly diagnosed SCLC patients were collected. Immunohistochemistry and enzyme-linked immunosorbent assay were applied to detect CD44. The relationship between CD44 level and the clinical characteristics as well as prognosis of the patients was analyzed.

Results: The stem cell marker CD44 was detectable both in serum sample and tumor tissue of SCLC patients. The positive rate of CD44 in tumor tissue was significantly higher in patients with performance status (PS) 2 than that of patients with PS 0-1 (85.71% vs 30%, P=0.017). Patients were divided in to different groups according to the treatment efficacy. The CD44 immunohistochemical score and serum level in the disease progression group were significantly higher than those in the disease control group, and the differences were statistically significant (P=0.006, P=0.034), Univariate analysis depicted that the progression-free- survival (PFS) of CD44 positive patients was significantly shorter than that of CD44 negative patients (5.23 mon vs 9.03 mon, P=0.036).

Conclusions: The positive expression of CD44 in tumor tissues of pre-treatment SCLC patients is correlated with poor PFS. The clinical significance of CD44 is worthy to be further studied.
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http://dx.doi.org/10.3779/j.issn.1009-3419.2021.104.10DOI Listing
June 2021

Ultrafast thulium-doped fiber laser mode-locked by antimonides.

Opt Express 2021 Apr;29(9):13722-13732

We report, for the first time, the nonlinear absorption at the 2 µm waveband of three Sb-related materials including two Sb compounds, GaSb and InSb, and one Sb alloy, GeSb. These saturable absorbers (SAs) were coated on tapered single mode fibers by the magnetron-sputtering deposition method. By incorporating these SAs into Tm-doped fiber lasers, ultrafast mode-locked solitons could be readily obtained. Stable pulse trains with 922 fs/753 fs/1005 fs pulse durations, 31.35 mW/37.70 mW/16.60 mW output powers, 93 dB/80 dB/92 dB signal-to-noise ratios were achieved with GaSb/InSb/GeSb, respectively. Our findings demonstrate that these materials can be widely used for photonic devices in the 2 µm waveband where ultrafast optical switching and modulating are desired.
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http://dx.doi.org/10.1364/OE.421993DOI Listing
April 2021

Diode-pumped sub-50-fs Kerr-lens mode-locked Yb:GdYCOB laser.

Opt Express 2021 Apr;29(9):13496-13503

We present a sub-50-fs diode-pumped Kerr-lens mode-locked laser employing a novel "mixed" monoclinic Yb:Ca(Gd,Y)O(BO) (Yb:GdYCOB) crystal as a gain medium. Nearly Fourier-limited pulses as short as 43 fs at 1036.7 nm are generated with an average power of 84 mW corresponding to a pulse repetition rate of ∼70.8 MHz. A higher average power of 300 mW was achieved at the expense of the pulse duration (113 fs) corresponding to an optical-to-optical efficiency of 35.8% representing a record-high value for any Yb-doped borate crystal. Non-phase-matched self-frequency doubling is observed in the mode-locked regime with pronounced strong spectral fringes which originate from two delayed green replicas of the fundamental femtosecond pulses in the time domain.
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http://dx.doi.org/10.1364/OE.424769DOI Listing
April 2021

A Fluidic Isolation-Assisted Homogeneous-Flow-Pressure Chip-Solid Phase Extraction-Mass Spectrometry System for Online Dynamic Monitoring of 25-Hydroxyvitamin D Biotransformation in Cells.

Anal Chem 2021 02 14;93(4):2273-2280. Epub 2021 Jan 14.

Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorus Chemistry &Chemical Biology, Tsinghua University, Beijing 100084, China.

It is well known that cell can response to various chemical and mechanical stimuli. Therefore, flow pressure variation induced by sample loading and elution should be small enough to ignore the physical impact on cells when we use a Chip-SPE-MS system for cells. However, most existent Chip-SPE-MS systems ignored the pressure alternation because it is extremely difficult to develop a homogeneous-flow-pressure hyphenated module. Herein, we developed an interesting fluidic isolation-assisted homogeneous-flow-pressure Chip-SPE-MS system and demonstrated that it is adequate for online high-throughput determination and quantification of the 25-hydroxyvitamin D (25(OH)D) biotransformation in different cells. Briefly, the homogeneous ambient flow pressure is achieved by fluidic isolation between the cell culture channel and the SPE column, and an automatic sampling probe could accomplish the sample loading and dispensing to fulfill online pretreatment of the sample. Through this new system, the expression levels of 24,25-dihydroxyvitamin D (24,25(OH)D) can be determined in real time with a detection limit of 2.54 nM. In addition, the results revealed that 25(OH)D metabolic activity differed significantly between normal L-02 cells and cancerous HepG2 cells. Treatment of L-02 cells with a high dose of 25(OH)D was found to increase significant formation of 24,25(OH)D, but this change was not apparent in HepG2 cells. The presented system promises to be a versatile tool for online accurate molecule biotransformation investigation and drug screening processes.
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http://dx.doi.org/10.1021/acs.analchem.0c04147DOI Listing
February 2021

Performance of the MeltPro MTB Assays in the Diagnosis of Drug-Resistant Tuberculosis Using Formalin-Fixed, Paraffin-Embedded Tissues.

Am J Clin Pathol 2021 Jun;156(1):34-41

Department of Pathology, Key Laboratory of Head and Neck Molecular Diagnosis Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing, China.

Objectives: The MeltPro MTB assays for detection of resistance to antituberculosis (TB) drugs perform well in genotypic drug susceptibility testing (DST) of clinical samples, but their effectiveness with formalin-fixed, paraffin-embedded (FFPE) tissues is unknown.

Methods: FFPE tissues were obtained from 334 patients with TB. Susceptibility to rifampicin (RIF), isoniazid (INH), and fluoroquinolones was examined using the MeltPro MTB assays, with Xpert MTB/RIF (Xpert) and/or phenotypic DST (pDST) results as references. Samples with discordant results were analyzed by multiplex polymerase chain reaction-targeted amplicon sequencing (MTA-seq).

Results: With pDST as the reference, the MeltPro MTB assays sensitivity for RIF, INH, levofloxacin (LVX), and moxifloxacin (MXF) was 95.00%, 96.00%, 100%, and 100%, respectively, and the specificity was 95.15%, 95.92%, 94.69%, and 89.92%, respectively. Concordance was 99.08% between the MeltPro MTB and Xpert (κ = 0.956) for RIF and 95.12% (κ = 0.834), 95.93% (κ = 0.880), 95.12% (κ = 0.744), and 90.24% (κ = 0.367) between the MeltPro MTB and pDST for RIF, INH, LVX, and MXF, respectively. MTA-seq confirmed the discordancy between the MeltPro MTB and pDST for 26 (89.66%) of 29 samples.

Conclusions: The MeltPro MTB assays rapidly and efficiently predict Mycobacterium tuberculosis resistance to the main first- and second-line anti-TB drugs in FFPE tissues.
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http://dx.doi.org/10.1093/ajcp/aqaa203DOI Listing
June 2021

Assembly and phylogenetic analysis of the complete chloroplast genome of (Rutaceae).

Mitochondrial DNA B Resour 2020 1;5(3):2250-2251. Epub 2020 Jun 1.

College of Engineering, Nanjing Agricultural University, Nanjing, Jiangsu, China.

(), belonging to the family Rutaceae, is usually utilized as a flavoring and acidifying agent for food. This study assembled and characterized the complete chloroplast (cp) genome of . The cp genome was 160,140 bp in length, containing a pair of inverted repeats (IRs, 26,996 bp each), which is separated by a large single-copy (LSC, 87,763 bp) region and a small single copy (SSC, 18,385 bp) region. The cp genome has overall GC content of 38.48% and 135 genes, composing of 90 protein-coding genes, 37 tRNA genes and 8 rRNA genes. Phylogenetic analysis based on 25 cp genomes highly supported that was evolutionarily close to ().
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http://dx.doi.org/10.1080/23802359.2020.1771228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7510620PMC
June 2020

The complete chloroplast genome of .

Mitochondrial DNA B Resour 2019 Nov 18;4(2):4089-4090. Epub 2019 Nov 18.

College of Information Science and Technology, Nanjing Forestry University, Nanjing, Jiangsu, China.

The species of genus are economically and nutritionally important fruits with remarkably high vitamin C content. Here, we assembled and characterized the complete chloroplast (cp) genome sequence of () using Illumina paired-end sequencing data. The cp genome is 157,339 bp in length, including a large single-copy region (LSC) of 88,741 bp, a small single-copy region (SSC) of 20,512 bp, and a pair of 24,043 bp inverted repeat (IR) regions. A total of 131 genes, consisting of 85 protein-coding genes, 38 tRNA genes, and 8 rRNA genes, were annotated in the cp genome. Phylogenetic analysis confirmed the evolutionary position of within the genus .
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http://dx.doi.org/10.1080/23802359.2019.1691949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707750PMC
November 2019

Continuous-wave and SESAM mode-locked operation of the Yb:BiSiO laser.

Opt Express 2021 Jan;29(1):105-110

We demonstrate a comprehensive characterization of the diode-pumped Yb:BiSiO laser operating in the continuous-wave and soliton mode-locked regimes. Pumping with a 650 mW, single-transverse mode, fiber-coupled laser diode, a maximum continuous-wave output power amounted to 213 mW with a slope efficiency up to 57.6%. A broadband wavelength tuning range of more than 70 nm was achieved in CW regime with a fused silica prism. Applying a SESAM as mode locker, nearly transform-limited pulses as short as 113 fs were generated for a maximum average power of 53 mW and a pulse repetition rate of ∼106 MHz. To the best of our knowledge, this is the first report on passively mode-locked operation with the Yb:BiSiO crystal.
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http://dx.doi.org/10.1364/OE.413930DOI Listing
January 2021

Single-walled carbon-nanotube saturable absorber assisted Kerr-lens mode-locked Tm:MgWO laser.

Opt Lett 2020 Nov;45(22):6142-6145

We demonstrate sub-100-fs Kerr-lens mode-locking of a : laser emitting at ∼2µ assisted by a single-walled carbon-nanotube saturable absorber. A maximum average output power of 100 mW is achieved with pulse duration of 89 fs at a pulse repetition rate of ∼86. The shortest pulse duration derived from frequency-resolved optical gating amounts to 76 fs at 2037 nm, corresponding to nearly bandwidth-limited pulses. To the best of our knowledge, these are the shortest pulses generated from any Tm-doped tungstate crystal and the first report on saturable absorber assisted Kerr-lens mode-locking of a Tm laser at ∼2µ.
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http://dx.doi.org/10.1364/OL.411288DOI Listing
November 2020

One-dimensional [email protected]@ZnS-Ni(OH) nano-hybrids with epitaxial heterointerfaces and spatially separated photo-redox sites enabling highly-efficient visible-light-driven H evolution.

Nanoscale 2020 Oct;12(39):20522-20535

Taishan Scholar Advantage and Characteristic Discipline Team of Eco Chemical Process and Technology, Key Laboratory of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.

Photocatalytic solar-to-fuel conversion has been of great interest in recent years. Nevertheless, the rational structural manipulation of photocatalysts toward an efficient H2 evolution reaction (HER) is still under-developed. In this work, by employing CdS nanowires as the growth substrate, unique one-dimensional (1D) [email protected]@ZnS-Ni(OH)2 heterostructures were first synthesized through the ultrasonic water-bath reaction combined with subsequent hydrothermal and in situ photo-deposition processes. Under the optimized conditions, [email protected]@40ZS-3N with 30 wt% Cd0.5Zn0.5S, 40 wt% ZnS, and 3 wt% Ni(OH)2 achieves a visible-light-driven HER activity as high as 86.79 mmol h-1 g-1 (corresponding to an apparent quantum yield of 22.8% at 420 nm), which is 4 and 119 times higher than that of Pt-decorated [email protected]@40ZS and CdS, respectively. In addition, [email protected]@ZnS-Ni(OH)2 is also endowed with a good stability for H2 production under long-term irradiation. The spatial separation of photo-redox sites and epitaxial heterointerfaces in [email protected]@ZnS-Ni(OH)2 nanowires facilitate the charge transfer and separation effectively, accounting well for their superior photocatalytic capability. The results indicated in this work could benefit the exploitation of high-performance nanostructures for promising photocatalytic applications.
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http://dx.doi.org/10.1039/d0nr04007jDOI Listing
October 2020

Coinfection of High-Risk Human Papillomavirus and Lower Genital Tract Pathogens in the Development of High-Grade Cervical Lesions.

Can J Infect Dis Med Microbiol 2020 30;2020:7640758. Epub 2020 Aug 30.

Laboratory of Gynecologic Oncology, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China.

Purpose: This study investigated the infection status and relationship between other common lower genital tract infectious pathogens and high-risk human papillomavirus (HR-HPV) in the high-grade cervical lesions.

Methods: Overall, 882 patients were enrolled in this retrospective study, of which 339 patients (≥HSIL group) were confirmed with high-grade squamous intraepithelial lesions (HSIL) or cervical squamous cell carcinoma (SCC), while 543 patients (≤LSIL group) were diagnosed with low-grade squamous intraepithelial lesions (LSIL) or normal cervical pathology diagnosis. Cervical swab specimens were tested for HPV, pathogenic bacteria (PB), (UU), (MH), (CT) in both groups.

Results: The infection rates of HR-HPV, PB, UU (at high density), and CT were higher in the ≥HSIL group than in the ≤LSIL group ( < 0.001); however, higher infection rates with MH were not observed ( > 0.05). PB, UU, and CT were associated with HR-HPV infection ( < 0.001). The PB and UU infection rates in the ≥HSIL group were significantly different from those in the ≤LSIL group, regardless of whether there was an HR-HPV infection at the same time ( < 0.05). However, this was not the case for the CT ( > 0.05). Furthermore, 259 pathogenic bacterial strains were detected in 882 cases. The difference in the distribution of pathogenic bacterial flora in the different grades of cervical lesions had no statistical significance, which was prioritized over ( > 0.05).

Conclusion: PB, UU, and CT infection is associated with susceptibility to HR-HPV, HR-HPV coinfection with these pathogens might increase the risk of high-grade cervical lesions, and PB and UU might be independent risk factors for cervical lesions.
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http://dx.doi.org/10.1155/2020/7640758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7477613PMC
August 2020

Low-loss fs-laser-written surface waveguide lasers at >2  µm in monoclinic Tm:MgWO.

Opt Lett 2020 Jul;45(14):4060-4063

Surface channel waveguides (WGs) based on a half-ring (40-60-µm-diameter) depressed-index cladding (type III) geometry are fabricated in monoclinic Tm:MgWO by femtosecond (fs) laser writing at a repetition rate of 1 kHz. The WGs are characterized by confocal laser microscopy and -Raman spectroscopy. A Tm:MgWO WG laser generates 320 mW at ∼2.02µm with a slope efficiency of 64.4%. The WG emits a transverse single-mode and linear polarization (||). A remarkable low loss of <0.1dB/cm is measured for the WG. Vibronic laser emission at ∼2.08µm is also achieved.
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http://dx.doi.org/10.1364/OL.395811DOI Listing
July 2020

A dendrite-free and stable anode for high-performance Li-O batteries by prestoring Li in reduced graphene oxide coated three-dimensional nickel foam.

Chem Commun (Camb) 2020 Jul 10;56(55):7645-7648. Epub 2020 Jun 10.

Key Laboratory of Eco-chemical Engineering, Taishan Scholar Advantage and Characteristic Discipline Team of Eco Chemical Process and Technology, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.

Li-based reduced (r)GO-Ni (Li/rGO-Ni) was prepared by a thermal-infusion method. Li/rGO-Ni based symmetric cells have high cycling stability and small voltage hysteresis at various current densities. Furthermore, the Li/rGO-Ni based Li-O batteries exhibit good performances.
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http://dx.doi.org/10.1039/d0cc03222kDOI Listing
July 2020

Accelerated charge transfer of [email protected] core-shell nano-spheres via decoration of NiP and g-CN toward efficient visible-light-driven H production.

Dalton Trans 2020 May;49(19):6259-6269

Taishan Scholar Advantage and Characteristic Discipline Team of Eco Chemical Process and Technology, Key Laboratory of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China.

Development of noble-metal-free photocatalysts for efficient H2 production from sunlight-driven water-splitting has aroused great interest in recent years. Herein, unique [email protected] core-shell nano-spheres decorated with Ni2P and g-C3N4 cocatalysts were prepared for the first time, and they are highly active and stable toward the visible-light-driven (λ > 420 nm) H2 evolution reaction (HER). Noticeably, the optimized [email protected]/g-C3N4 with 50 wt% ZnS, 3 wt% Ni2P, and 8 wt% g-C3N4 ([email protected]/8CN) exhibits a superior HER activity of 55.43 mmol·g-1·h-1, approximately 25 and 18 times higher than those of [email protected] and Pt-decorated [email protected] ([email protected]), respectively. Meanwhile, the corresponding apparent quantum yield (AQY) at 420 nm is as high as 21%. It is revealed that the protective ZnS shell on the CZ0.5S core enhances the photo-stability of the hybrid significantly. Moreover, the synergistic effect of the Ni2P and g-C3N4 cocatalysts leads to the effective transfer and separation of charge carriers. The results presented in this work may pave the way for the ingenious design and fabrication of highly active nano-structures for sufficient solar utilization.
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http://dx.doi.org/10.1039/d0dt00843eDOI Listing
May 2020

Evaluation of PCR-Reverse Dot Blot Human Papillomavirus Genotyping Test in Predicting Residual/Recurrent CIN 2+ in Posttreatment Patients in China.

Cancer Manag Res 2020 1;12:2369-2379. Epub 2020 Apr 1.

Laboratory of Gynecologic Oncology, Fujian Provincial Maternity and Children's Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.

Objective: To assess the clinical value of the PCR-reverse dot blot human papillomavirus genotyping test during follow-up of patients with CIN grade 2 or worse (CIN 2+).

Methods: Four hundred patients with CIN 2+ receiving treatment from January 2008 to January 2017 were included in our study. Postoperative follow-up procedures comprised HPV examination and cervical cytology every 3-6 months for the first 2 years and then followed up every 6-12 months. A pathology examination was performed when there was a positive funding for HPV 16/18 or an abnormal ThinPrep cytology test (TCT) with or without positive for HR-HPV according to the American Society for Coloscopy and Cervical Pathology (ASCCP) guidelines.

Results: The median follow-up period was 27.10±12.47 months (ranging from 3 to 50 months). During follow-up, 12.00% (48/400) of the women developed residual/recurrent disease. The highest risk in CIN 2+ and CIN 3+ residual/recurrence was HPV-16/-18 (hazard ratio (HR)=12.898, 95% CI= 6.849-24.289; HR= 20.726, 95% CI= 9.64-44.562, respectively). Among the different follow-up methods, type-specific (TP) HR-HPV persistent infection showed the highest cumulative incidence risk (CIR) (84.62%, 95% CI=73.29-95.94) and HR (5.38, 95% CI= 2.596-11.149) during the 4-year follow-up period. At the CIN 2+ and CIN 3+ endpoints, TP-HPV testing had relatively high sensitivity (84.62%, 95% CI=73.29-95.94 and 89.28%, 95% CI= 77.83-100.00, respectively) and specificity (78.07%, 95% CI= 72.70-83.44 and 75.73%, 95% CI= 70.30-81.17, respectively). However, at the CIN 2+/CIN 3+ endpoint, TCT follow-up had a sensitivity of 60.42%/62.16% (95% CI=46.58-72.25/46.54-77.79) and specificity of 90.18%/88.72% (95% CI=86.95-93.41/85.35-92.10).

Conclusion: TP HR-HPV follow-up can provide a reliable and sensitive clinical reference for CIN 2+ postoperative patients.
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http://dx.doi.org/10.2147/CMAR.S237490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132552PMC
April 2020

Spectroscopy and high-power laser operation of a monoclinic Yb:MgWO crystal.

Opt Lett 2020 Apr;45(7):1770-1773

Monoclinic (wolframite-type) monotungstate crystals are promising for rare-earth doping. We report polarized room- and low-temperature spectroscopy and efficient high-power laser operation of such a ${{\rm Yb}^{3 + }}{:}\,{{\rm MgWO}_4}$Yb:MgWO crystal featuring high stimulated emission cross section (${\sigma _{\rm SE}}\; = \;{6}.{2}\; \times \;{{10}^{ - 20}}\;{{\rm cm}^2}$σ=6.2×10cm at 1056.7 nm for light polarization ${\rm E}\;||\;{N_m}$E||N), large Stark splitting of the ground state (${765}\;{{\rm cm}^{ - 1}}$765cm), large gain bandwidth (26.1 nm for ${\rm E}\;||\;{N_g}$E||N), and strong Raman response (most intense mode at ${916}\;{{\rm cm}^{ - 1}}$916cm). A diode-pumped ${{\rm Yb}^{3 + }}{:}\,{{\rm MgWO}_4}$Yb:MgWO laser generated 18.2 W at ${\sim}{1056}\;{\rm nm}$∼1056nm with a slope efficiency of ${\sim}{89}\% $∼89% and a linearly polarized laser output.
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http://dx.doi.org/10.1364/OL.389627DOI Listing
April 2020

Variants of Genes are Associated with Liver Cancer Risk in Chinese Li Population.

Onco Targets Ther 2020 28;13:1809-1818. Epub 2020 Feb 28.

Department of Medical Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570311, People's Republic of China.

Background: Liver cancer (LC) is the sixth most common cancer and the second leading cause of cancer mortality worldwide, and its incidence rate is high in China.

Methods: In this study, we aimed to investigate the contribution of (MIR137 Host Gene) polymorphisms to LC risk in a case-control study with 432 LC patients and 430 healthy controls. A logistic recession model was used to evaluate the effects of candidate single nucleotide polymorphisms (SNPs) on LC risk. HaploReg v 4.1 database was conducted to predict the potential functionality of SNPs.

Results: The results revealed that rs17371457 and rs7554283 in the gene were correlated with an enhanced LC risk under the allele ( = 0.001 and = 0.043, respectively) and genetic models ( < 0.05). When the sample was stratified by gender and age, statistically significant associations were found. Rs9440302, rs17371457 and rs7554283 were associated with an increased the risk of LC among individuals aged >55 years ( < 0.05); rs17371457 was related to higher LC risk in males ( < 0.05). Similarly, the haplotype AG constituted by rs12333983 and rs3735451 significantly increased LC risk in Chinese Li population ( = 0.043). Six SNPs distributed in were successfully predicted as regulatory SNPs with different biological functions.

Conclusion: Our research firstly showed that gene polymorphisms were implicated in LC susceptibility among Chinese Li population.
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http://dx.doi.org/10.2147/OTT.S225669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053808PMC
February 2020

Multifunctional Cellulose Nanocrystals as a High-Efficient Polysulfide Stopper for Practical Li-S Batteries.

ACS Appl Mater Interfaces 2020 Apr 2;12(15):17592-17601. Epub 2020 Apr 2.

Centre for Clean Environment and Energy, Environmental Futures Research Institute, School of Environment and Science, Griffith University, Gold Coast, Queensland 4222, Australia.

Because of the severe shuttle effect of polysulfides, achieving durable Li-S batteries is still a great challenge, especially under practical operation conditions including the high sulfur content, high loading, and high operation temperature. Herein, for the first time, low-cost, eco-friendly, and hydrophilic cellulose nanocrystals (CNCs) are proposed as a multifunctional polysulfide stopper for Li-S batteries with high performance. CNCs display an intrinsically high aspect ratio and a large surface area and contain a large amount of hydroxyl groups offering a facile platform for chemical interactions. Density functional theory calculations suggest that the electron-rich functional groups on CNCs deliver robust binding energies with polysulfides. In this work, CNCs not only firmly confine sulfur and polysulfides in the cathode as a robust binder, but also further hinder polysulfide shuttling to the Li anode as a polysulfide stopper on a separator. Consequently, the as-prepared Li-S batteries demonstrate outstanding cycling performance even under the conditions of high sulfur content of 90 wt % (63 wt % in the cathode), high loading of 8.5 mg cm, and high temperature of 60 °C. These results sufficiently demonstrate that CNCs have significant application potential in Li-S battery technologies.
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http://dx.doi.org/10.1021/acsami.0c00537DOI Listing
April 2020

The Necessity of Anti-Tuberculosis Therapy after Resection of Pulmonary Tuberculous Nodules: A Single Center Retrospective Study.

Ann Thorac Cardiovasc Surg 2020 Aug 27;26(4):190-195. Epub 2019 Nov 27.

Minimally Invasive Treatment Center, Beijing Chest Hospital, Beijing, China.

Purpose: To discuss the necessity of anti-tuberculosis therapy after resection of asymptomatic pulmonary tuberculous nodules: is postoperative anti-tuberculosis therapy is over-treatment?

Methods: This is a single-center retrospective study. Patients with solitary pulmonary nodule (SPN) and diagnosed as tuberculosis by pathology were included. Clinical features are collected. The primary end point is tuberculosis relapse and the secondary is adverse drug reactions. Patients are divided into two groups according to the acceptance of anti-tuberculosis treatment after operation (A: treated; B: untreated). Recurrence is diagnosed by multi-disciplinary discussion. The difference of recurrence rate will be compared and the incidence of adverse drug reactions in Group A will be calculated.

Results: A total of 98 patients were enrolled, 66 in Group A and 32 in Group B. No significant difference between two groups was found in the past history of tuberculosis, erythrocyte sedimentation rate (ESR), T-spot positive rate, and the uptake value of 18F-glucose. No relapse of tuberculosis was found in both groups. The incidence of adverse drug reactions in Group A was 61% (40/66), and the rate of severe adverse reaction was 14% (9/66).

Conclusions: Postoperative recurrence of tuberculosis is rare, anti-tuberculosis treatment seems unnecessary for asymptomatic pulmonary tuberculous nodules. Adverse drug reactions should not be ignored.
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http://dx.doi.org/10.5761/atcs.oa.19-00199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7435138PMC
August 2020

Wildfire Detection Using Sound Spectrum Analysis Based on the Internet of Things.

Sensors (Basel) 2019 Nov 21;19(23). Epub 2019 Nov 21.

College of Information Science and Technology, Nanjing Forestry University, Nanjing 210037, China.

Wildfire is a sudden and hazardous natural disaster. Currently, many schemes based on optical spectrum analysis have been proposed to detect wildfire, but obstacles in forest areas can decrease the efficiency of spectral monitoring, resulting in a wildfire detection system not being able to monitor the occurrence of wildfire promptly. In this paper, we propose a novel wildfire detection system using sound spectrum analysis based on the Internet of Things (IoT), which utilizes a wireless acoustic detection system to probe wildfire and distinguish the difference in the sound between the crown and the surface fire. We also designed a new power supply unit: tree-energy device, which utilizes the biological energy of the living trees to generate electricity. We implemented sound spectrum analysis on the data collected by sound sensors and then combined our classification algorithms. The results describe that the sound frequency of the crown fire is about 0-400 Hz, while the sound frequency of the surface fire ranges from 0 to 15,000 Hz. However, the accuracy of the classification method is affected by some factors, such as the distribution of sensors, the loss of energy in sound transmission, and the delay of data transmission. In the simulation experiments, the recognition rate of the method can reach about 70%.
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http://dx.doi.org/10.3390/s19235093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929188PMC
November 2019

Association between the degree of fibrosis in fibrotic focus and the unfavorable clinicopathological prognostic features of breast cancer.

PeerJ 2019 15;7:e8067. Epub 2019 Nov 15.

Department of Oncology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Objective: To explore the association between the degree of fibrosis in fibrotic focus (FF) and the unfavorable clinicopathological prognostic features of breast cancer.

Methods: A total of 169 cases of breast invasive ductal carcinoma (IDC) were included in the study. Hematoxylin and eosin (H&E) staining was performed in the primary lesion of breast IDC and the degree of fibrosis in tumor-stromal FF was assessed. The association between the degree of fibrosis in FF and the well-known clinicopathologic features of breast cancer was investigated and the influence of the degree of fibrosis in FF on the survival was analyzed.

Results: Tumor size >2 cm ( = 0.023), vascular invasion ( = 0.011), lymphatic vessel invasion ( < 0.001) and HER-2+ ( = 0.032) were positively correlated with the degree of fibrosis in FF in breast IDC. The result of multivariate analysis showed that lymphatic vessel invasion was the only independent correlation factor of high fibrosis in FF in breast IDC (OR = 3.82, 95% CI[1.13 ∼ 12.82],  = 0.031). The Nottingham prognostic index (NPI) of high fibrosis in FF was significantly higher than that of mild and moderate fibrosis in FF in the no vascular infiltration subgroup, the no nerve infiltration subgroup, and the Luminal A subgroup (P = 0.014, 0.039, and 0.018; respectively).

Conclusions: The high fibrosis in FF is closely associated with the strong invasiveness and the high malignancy of breast IDC. The degree of fibrosis in FF might be considered as a very practical and meaningful pathological feature of breast cancer.
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http://dx.doi.org/10.7717/peerj.8067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859872PMC
November 2019

Assembly and phylogenetic analysis of the complete chloroplast genome sequence of .

Mitochondrial DNA B Resour 2019 Oct 21;4(2):3679-3680. Epub 2019 Oct 21.

College of Engineering, Nanjing Agricultural University, Nanjing, Jiangsu, China.

The complete chloroplast (cp) genome sequence of () was sequenced and assembled into a circular genome of 156,728 bp length using Illumina paired-end data. The cp genome composed of a pair of 24,090 bp inverted repeat (IR) regions separated by a large single copy region (LSC) of 88,256 bp and a small single copy region (SSC) of 20,292 bp. Additionally, a total of 131 genes, including 85 protein-coding genes, 38 tRNA genes and 8 rRNA genes, were identified in the cp genome. Phylogenetic analysis showed that was evolutionarily close to other two kiwifruits and .
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http://dx.doi.org/10.1080/23802359.2019.1678423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7707611PMC
October 2019

Alteration of intracellular metabolome in osteosarcoma stem cells revealed by liquid chromatography-tandem mass spectrometry.

Talanta 2019 Nov 23;204:6-12. Epub 2019 May 23.

Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, MOE Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, China. Electronic address:

Cancer stem cells (CSCs) are the origin of many malignant tumours, including osteosarcoma that mainly affects adolescents and is accompanied by a poor prognosis. However, little is known about the intrinsic biological information of osteosarcoma stem cells, particularly for the metabolomics features. Hence, an ultra-high performance liquid chromatography coupled with tandem Q-Exactive Orbitrap mass spectrometer (UHPLC-QE-MS)-based metabolomics approach was developed to investigate the metabolism changes in the human osteosarcoma (HOS) cell line in order to understand its possible mechanism. HMDB, METLIN and m/z Cloud databases were used to identify the metabolic markers. Additionally, the compounds were further identified using standards of the metabolites. Comparing HOS-CSCs with non-CSCs, 154 different metabolites were identified in both the positive and negative modes. Based on the clearly distinct metabolites, the changed metabolic pathways were analysed using MetaboAnalyst. The top five altered pathways included alanine, aspartate and glutamate metabolism; arginine and proline metabolism; glutathione metabolism; cysteine and methionine metabolism; and the citrate cycle (TCA cycle). The downregulation of the TCA cycle and elevation of oxidized glutathione levels suggested a decline of mitochondrial metabolism, while most of the amino acid metabolisms were upregulated. Further biological experiments including an analysis of mitochondrial activity confirmed the above hypotheses that were deduced from metabolomics results. These findings not only enhance our understanding of the altered metabolome in osteosarcoma stem cells but also demonstrate the great potential of such a metabolomics method based on UHPLC-QE-MS in large-scale cell studies.
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http://dx.doi.org/10.1016/j.talanta.2019.05.088DOI Listing
November 2019

Selective Fabrication of Nanowires with High Aspect Ratios Using a Diffusion Mixing Reaction System for Applications in Temperature Sensing.

Anal Chem 2019 06 22;91(11):7346-7352. Epub 2019 May 22.

Department of Applied Chemistry, Graduate School of Urban Environmental Sciences , Tokyo Metropolitan University , Minamiohsawa , Hachioji, Tokyo 192-0397 , Japan.

The selective fabrication of highly ordered nanowires with high aspect ratios was of low reproducibility, which remains a challenge for laboratory research. In this paper, we report a novel approach for selective fabrication of conductive nanowires on a solid surface via diffusion mixing reaction system formed by a chemical pen. The nanoscale-mixing region was achieved by appropriately adjusting the viscosity of the solution and other parameters with the aid of dyes functioned as a flow boundary indicator. Finite element simulations and analysis were performed to understand the generation of mixing regions and guide the improvement of the chemical pen design. Under the optimal parameters, high aspect ratio silver nanowires (aspect ratio ≈ 1800) were obtained. Silver nanowire arrays with uniform width, gradient width and complex patterns were successfully fabricated. The theoretical value of the temperature coefficient of resistance (TCR) for silver was 0.0038 Ω/°C. A single silver wire temperature sensor with 7-fold increase in temperature coefficient resistance (0.0261 Ω/°C) was fabricated to show the advantages of the chemical pen in the fabrication of nanosensors. With the freedom of the region, simple operability and applicability, the chemical pen was expected to a potential and advanced method for selective nanomodification and processing on subcellular interfaces.
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http://dx.doi.org/10.1021/acs.analchem.9b01122DOI Listing
June 2019

Association between IL-1R2 polymorphisms and lung cancer risk in the Chinese Han population: A case-control study.

Mol Genet Genomic Med 2019 05 20;7(5):e644. Epub 2019 Mar 20.

Department of Medical Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.

Background: Interleukin-1 receptor 2 (IL-1R2), as an anti-inflammatory cytokine, is involved in the pathogenesis and progression of lung cancer. However, the role of IL-1R2 polymorphisms in patients with lung cancer has yet to be fully elucidated.

Methods: Six single-nucleotide polymorphisms (SNPs) in IL-1R2 were genotyped in 259 patients and 346 healthy controls. We used the chi-squared test, genetic model analysis, Haploview analysis, and multifactor dimensionality reduction (MDR) to evaluate the potential association between IL-1R2 polymorphisms and lung cancer susceptibility. Bioinformatics analyses were conducted to analyze the expression level of IL-1R2 and its association with the overall survival of lung cancer.

Results: Our results found that rs3218977-GG was associated with a decreased risk of lung cancer (odds ratio [OR] = 0.39; 95% confidence interval [CI]: 0.17-0.87; p = 0.023), and rs2072472 had a significant risk-increasing effect in the dominant model (AG + GG vs. AA: OR = 1.54; 95% CI: 1.09-2.20; p = 0.015). The MDR model also revealed that rs2072472 is the most influential risk factor of lung cancer (testing accuracy = 0.543; cross-validation consistency = 10/10; p = 0.032). In addition, our results indicated that the IL-1R2 mRNA level was downregulated in lung cancer patients, whereas the high expression of IL-1R2 was related to a poor prognosis in lung cancer.

Conclusions: Our results suggest that genetic variants of IL-1R2 may play a role in lung cancer susceptibility. Further population and functional validations of our findings are warranted.
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http://dx.doi.org/10.1002/mgg3.644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503014PMC
May 2019

On-site sampling of inorganic contamination on the metal surface and analysis with capillary electrophoresis.

J Sep Sci 2019 Apr 8;42(8):1593-1599. Epub 2019 Mar 8.

Department of Chemistry, Beijing Key Laboratory of Microanalytical Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, P. R. China.

Pipes are the primary structural elements used for transporting fluid in various industries. The most common damage mechanism is corrosion, which occurs in pipes surface of turbine. The corrosive compounds for pipes are inorganic ion (Na , Cl , NH , NO , etc.) and grinding oil. For rapid and quantitative detection of inorganic ions on site, more reliable and reproducible analytical methods are demanded. A highly efficient solid-liquid sampling collection system is introduced in this work. Papering on the sample surface, inorganic cations and anions were simultaneously collected and analyzed by capillary electrophoresis with indirect ultraviolet detection. As a result, five cations (Na , K , NH , Ca , Mg ) and three anions (Cl , NO , SO ) were completely separated. The efficiency of the sampling and ability of capillary electrophoresis analysis were presented by the determination of trace-level (mg/m ) contaminants. The recoveries of cations and anions on the paper from metal surface were between 86.6 and 107.2%, and the relative standard deviations were less than 12.85%.
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http://dx.doi.org/10.1002/jssc.201800916DOI Listing
April 2019

The Impact of 3'UTR Polymorphism rs859 on Lung Carcinoma Susceptibility among Chinese Han Individuals.

Biomed Res Int 2018 24;2018:8305745. Epub 2018 Dec 24.

Department of Medical Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570311, China.

Lung carcinoma is the most common cancer and cause of cancer deaths among both males and females in China. Previously, genetic variants located in gene untranslated region have been well established as interfering factors in mRNA translation and confirmed playing critical roles in lung oncogenesis. However, the correlation between polymorphisms in gene 3' untranslated region and lung cancer risk is less reported in China Han population. In this study, polymorphisms in 3'-untranslated region of , , and were determined in 322 lung cancer patients and 384 healthy controls with the usage of Sequenom MassARRAY. The correlation between selected variants and lung cancer risk was examined by unconditional logistic regression analysis with or without adjustments for age, gender, smoking status, and alcohol drinking status. Additionally, stratification analysis was applied to detect the associations of SNPs with lung cancer in different subgroups. As the results, significant relationships were found between rs859 and lung cancer susceptibility in recessive model (OR= 0.65, 95% CI: 0.44-0.96, = 0.029) and log-additive model (OR= 0.76, 95% CI: 0.60-0.96, = 0.019). Moreover, adjusted stratified analysis also revealed the important effects of rs859 on lung cancer risk among individuals aged older than 50, males, and nondrinkers. rs859 showed statistically significant evidence associated with susceptibility to lung adenocarcinoma and lung small cell carcinoma in Chinese Han population as well. Our research demonstrated that genetic variant rs859 of 3'UTR was associated with lung cancer risk in Chinese Han population and the result might be exploited as a new biomarker for lung cancer assessment and prevention.
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http://dx.doi.org/10.1155/2018/8305745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323476PMC
May 2019

Unique 1D Cd Zn [email protected] /NiO Nanohybrids: Highly Efficient Visible-Light-Driven Photocatalytic Hydrogen Evolution via Integrated Structural Regulation.

Small 2019 Jul 15;15(29):e1804115. Epub 2019 Jan 15.

Key Lab of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China.

Development of noble-metal-free photocatalysts for highly efficient sunlight-driven water splitting is of great interest. Nevertheless, for the photocatalytic H evolution reaction (HER), the integrated regulation study on morphology, electronic band structures, and surface active sites of catalyst is still minimal up to now. Herein, well-defined 1D Cd Zn [email protected] /NiO hybrid nanostructures with enhanced activity and stability for photocatalytic HER are prepared. Interestingly, the band alignments, exposure of active sites, and interfacial charge separation of Cd Zn [email protected] /NiO are optimized by tuning the Zn-doping content as well as the growth of defect-rich O-MoS layer and NiO nanoparticles, which endow the hybrids with excellent HER performances. Specifically, the visible-light-driven (>420 nm) HER activity of Cd Zn [email protected] /NiO with 15% Zn-doping and 0.2 wt% O-MoS (CZ S-0.2M-NiO ) in lactic acid solution (66.08 mmol h g ) is about 25 times that of Pt loaded CZ S, which is further increased to 223.17 mmol h g when using Na S/Na SO as the sacrificial agent. Meanwhile, in Na S/Na SO solution, the CZ S-0.2M-NiO sample demonstrates an apparent quantum yield of 64.1% at 420 nm and a good stability for HER under long-time illumination. The results presented in this work can be valuable inspirations for the exploitation of advanced materials for energy-related applications.
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http://dx.doi.org/10.1002/smll.201804115DOI Listing
July 2019

Cribriform pattern in lung invasive adenocarcinoma correlates with poor prognosis in a Chinese cohort.

Pathol Res Pract 2019 Feb 12;215(2):347-353. Epub 2018 Dec 12.

Department of Pathology, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China. Electronic address:

The 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) lung adenocarcinoma classification and the following 2015 WHO classification have both been validated for their predictive values of histologic subtypes for prognosis. We sought to investigate the clinicopathological and prognostic significance of the cribriform pattern in lung adenocarcinomas. Histologic subtypes were evaluated in 395 patients who underwent complete resection for invasive lung adenocarcinomas between 2011 and 2013. Cribriform pattern was correlated with clinicopathological factors as well as molecular and survival data. One hundred and thirty cases (33%) were present with cribriform pattern (5-100%; mean ± SD, 24% ± 22%). Thirty two (8%) of those were reclassified into cribriform predominant tumors. Presence of cribriform pattern (≥5%) was significantly associated with lymph/vascular invasion (P<0.001), nodal positivity (P = 0.003), higher T stage(P = 0.005) and higher TNM stage (P = 0.001). Cribriform pattern (≥10%) was highly associated with worse disease-free survival (DFS) and overall survival (OS) (mean DFS: 42.6 months, P < 0.001; mean OS: 64.1 months, P = 0.012). The DFS or OS for cribriform predominant tumors was similar to that for solid or micropapillary tumors. In multivariate analysis, cribriform pattern (≥10%) or cribriform predominant subtype was an independent predictor for DFS. Cribriform pattern was a specific pattern compared to other acinar patterns, presenting with more aggressive behavior. Moreover, presence of cribriform pattern was a strong predictor for worse prognosis and should be considered a high grade pattern. Our study provides further evidence for cribriform pattern to be acknowledged as an independent subtype in the future classification.
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http://dx.doi.org/10.1016/j.prp.2018.12.014DOI Listing
February 2019

Association of plasma apolipoprotein CIII, high sensitivity C-reactive protein and tumor necrosis factor-α contributes to the clinical features of coronary heart disease in Li and Han ethnic groups in China.

Lipids Health Dis 2018 Jul 27;17(1):176. Epub 2018 Jul 27.

Department of Pharmacology, School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, 571199, Hainan Province, China.

Background: Apolipoprotein CIII (apoCIII) is an independent risk for coronary heart disease (CHD). In this study, we investigated the associations among plasma apoCIII, hs-CRP and TNF-α levels and their roles in the clinical features of CHD in the Li and Han ethnic groups in China.

Methods: A cohort of 474 participants was recruited (238 atherosclerotic patients and 236 healthy controls) from the Li and Han ethnic groups. Blood samples were obtained to evaluate apoCIII, TNF-α, hs-CRP and lipid profiles. Chi-squared, t-tests, and Kruskal-Wallis or Wilcoxon-Mann-Whitney tests, Pearson or Spearman correlation tests and multiple unconditional logistic regression were employed to analyze lipid profiles and variations in plasma apoCIII, TNF-α, hs-CRP in subgroups of CHD and their contributions to CHD using SPSS version 20.0 software.

Results: Compared to healthy participants, unfavorable lipid profiles were identified in CHD patients with enhanced systolic pressure, diastolic pressure, fasting blood sugar (FBS), TG, TC, LDL-C, apoB, Lp(a) (P < 0.05, TC and Lp(a); P < 0.01, FBS, TG, LDL-C, apoB); and lower HDL-C and apoAI (P < 0.05). Plasma apoCIII, TNF-α and hs-CRP levels were higher in CHD individuals (16.77 ± 5.98 mg/dL vs. 10.91 ± 4.97 mg/dL; 17.23 ± 6.34 pg/mL vs. 9.49 ± 3.88 pg/mL; 9.55 ± 7.32 mg/L vs. 2.14 ± 1.56 mg/L; P < 0.01 vs. healthy participants). Identical patterns were obtained in the Li and Han groups (16.46 ± 6.08 mg/dL vs. 11.72 ± 5.16 mg/dL; 15.71 ± 5.52 pg/mL vs. 9.74 ± 4.31 pg/mL; 8.21 ± 7.09 mg/L vs. 2.15 ± 1.51 mg/L in Li people; 17.05 ± 5.90 mg/dL vs. 10.07 ± 4.63 mg/dL; 18.59 ± 6.73 pg/mL vs. 9.23 ± 3.38 pg/mL; 10.75 ± 7.44 mg/L vs. 2.12 ± 1.63 mg/L in Han people; P < 0.01). Paired comparisons of subgroups with stable angina, unstable angina, and acute myocardial infarction (AMI) revealed significant variation in plasma levels of apoCIII, TNF-α and hs-CRP (P < 0.01), but not among subgroups with mild, moderate and severe stenosis (P > 0.05). Plasma apoCIII, TNF-α and hs-CRP contributed to the development of CHD (OR = 2.554, 7.252, 6.035, P < 0.01) with paired correlations in CHD patients (apoCIII vs. TNF-α, r = 0.425; apoCIII vs. hs-CRP, r = 0.319; TNF-α vs. hs-CRP, r = 0.400, P < 0.01).

Conclusions: Association among plasma apoCIII, hs-CRP and TNF-α interacts with unfavorable lipid profiles to contribute to the clinical features of CHD with stable angina, unstable angina, and AMI in the Li and Han ethnic groups in China.
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http://dx.doi.org/10.1186/s12944-018-0830-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6064080PMC
July 2018
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