Publications by authors named "Haifeng Li"

361 Publications

DEEMD-SPP: A Novel Framework for Emotion Recognition Based on EEG Signals.

Front Psychiatry 2022 27;13:885120. Epub 2022 Apr 27.

School of Computer Science and Technology, Faculty of Computing, Harbin Institute of Technology, Harbin, China.

Electroencephalography (EEG) is one of the most widely-used biosignal capturing technology for investigating brain activities, cognitive diseases, and affective disorders. To understand the underlying principles of brain activities and affective disorders using EEG data, one of the fundamental tasks is to accurately identify emotions from EEG signals, which has attracted huge attention in the field of affective computing. To improve the accuracy and effectiveness of emotion recognition based on EEG data, previous studies have successfully developed numerous feature extraction methods and classifiers. Among them, ensemble empirical mode decomposition (EEMD) is an efficient signal decomposition technique for extracting EEG features. It can alleviate the mode-mixing problem by adding white noise to the source signal. However, there remain some issues when applying this method to recognition tasks. As the added noise cannot be filtered completely, spurious modes are generated due to the residual noise. Therefore, it is crucial to perform intrinsic mode function (IMF) selection to find the most valuable IMF components that represent brain activities. Furthermore, the number of decomposed IMFs is various to different original signals, thus how to unify feature dimensions needs better solutions. To solve these issues, we propose a novel forecasting framework, named DEEMD-SPP, to identify emotions from EEG signals, based on the combination of denoising ensemble empirical mode decomposition (DEEMD) and Spatial Pyramid Pooling Network (SPP-Net). First, DEEMD is proposed to decompose the EEG signals, which effectively eliminates residual noise in the IMFs and selects the most valuable IMFs. Second, time-domain and frequency-domain features are extracted from the selected IMFs. Finally, SPP-net is employed as the classifier to recognize emotions, which can effectively transform various-sized feature maps into fixed-sized feature vectors through the pyramid pooling layer. The experimental results demonstrate that our proposed DEEMD-SPP framework can effectively reduce the effect of spike-in white noise, accurately extract EEG features, and significantly improve the performance of emotion recognition.
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http://dx.doi.org/10.3389/fpsyt.2022.885120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091650PMC
April 2022

How Chinese children's filial piety beliefs affect their parents' life satisfaction and loneliness.

Psych J 2022 May 13. Epub 2022 May 13.

School of Psychology, Fujian Normal University, Fuzhou, China.

Filial piety (or xiao) is a unique Chinese culture that affects older adults' life satisfaction and loneliness. Guided by the dual filial piety model and socioemotional selectivity theory, this study explores how adult children's filial piety beliefs affect their parent's life satisfaction and loneliness. A total of 350 pairs of parent-child data were collected through a parent-child pair design. Results show that emotional support provided by adult children and emotional support perceived by parents (i.e., the transmission of emotional support) fully mediated the relationship between children's reciprocal filial piety belief and parents' life satisfaction and loneliness, and partially mediated the relationship between children's authoritarian filial piety belief and parents' life satisfaction and loneliness. However, instrumental support provided by adult children and instrumental support perceived by parents (i.e., the transmission of instrumental support) had no such mediating roles in the relationship between adult children's filial piety beliefs and parents' life satisfaction and loneliness. This finding suggests that to improve parental well-being, adult Chinese children should cultivate their filial piety and pay close attention to their parents' emotional needs.
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http://dx.doi.org/10.1002/pchj.558DOI Listing
May 2022

Effects of α lipoic acid combined with olmesartan medoxomil on blood glucose and oxidation indicators in patients with diabetic nephropathy: A protocol for a parallel, randomized, double-blind, controlled clinical trial.

Medicine (Baltimore) 2022 Apr 29;101(17):e29080. Epub 2022 Apr 29.

Wuwei People's Hospital, Wuwei, Gansu Province, China.

Background: Diabetic nephropathy (DN) is a common microvascular complication of diabetes, which poses a serious threat to the health and life of patients. There is evidence that both α lipoic acid and olmesartan medoxomil have positive effects in the treatment of DN, but whether the 2 have synergistic effects and the effects on blood glucose and oxidation indicators are controversial.

Methods: This is a prospective parallel, randomized, double-blind, placebo-controlled trial to study the effects of α lipoic acid in combination with olmesartan medoxomil on blood glucose and oxidation indicators in patients with DN. Participants will be randomly assigned to a treatment group, which will receive α lipoic acid dispersive tablets combined with olmesartan medoxomil tablets, or a control group, which will receive olmesartan medoxomil tablets combined with placebo for 4 weeks, followed up for 12 weeks. Observation indicators include: glycemic indicators [fasting blood glucose, 2 hours postprandial blood glucose and glycosylated hemoglobin], the oxidation indicators [serum glutathione, superoxide dismutase, malondialdehyde, 8-hydroxydeox-yguanosine], and adverse reactions. Finally, SPASS 22.0 software will be used for statistical analysis of the data.

Discussion: This study will evaluate the effects of α lipoic acid combined with olmesartan medoxomil on blood glucose and oxidation indicators in patients with DN. The results of this study will provide a reference for the clinical use of α lipoic acid combined with olmesartan medoxomil in the treatment of DN.

Trial Registration: OSF Registration number: DOI 10.17605/OSF.IO/VJWXS.
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http://dx.doi.org/10.1097/MD.0000000000029080DOI Listing
April 2022

Contrast-enhanced ultrasound improves the potency of fine-needle aspiration in thyroid nodules with high inadequate risk.

BMC Med Imaging 2022 05 2;22(1):83. Epub 2022 May 2.

Department of Medical Ultrasonic, Laboratory of Novel Optoacoustic (Ultrasonic) Imaging, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, China.

Background: This study aims to determine the clinical value of contrast enhanced ultrasound (CEUS) for fine-needle aspiration (FNA) of high inadequate risky thyroid nodules.

Methods: During April 2018 and April 2021, consecutive 3748 thyroid nodules underwent FNA were retrospectively analyzed. CEUS guided FNA (CEUS-FNA) was applied in 115 nodules with high inadequate risk in Lingnan Campus. Ten nodules underwent CEUS-FNA presented non-enhancing, and would be further analyzed independently. Other 105 partial or total enhancing nodules were included as CEUS-FNA group, and 210 nodules with high inadequate risk in Tianhe Campus were match as the US-FNA control group. FNA specimens were collected for liquid-based preparation. Cytological results were classified following the Bethesda System for Reporting Thyroid Cytopathology.

Results: The overall FNA specimen inadequate rate in our center was 6.6%. All of the ten non-enhancing nodules under CEUS have an inadequate result in cytopathological analyzes. The subsequent postoperative pathology and follow-up ultrasonography showed the non-enhancing nodules were benign or stable without further malignant features. Total specimen inadequate rate of high inadequate risk thyroid nodules in CEUS-FNA group was significantly lower than US-FNA group (6.7% vs. 16.7%, P = 0.014). Further stratified analyzed shown that FNA under US guidance, the inadequate rates in cystic, predominantly cystic, predominantly solid and solid sub-groups were 28.1%, 17.1%, 10.0% and 9.2% (P = 0.019). In contrast, the inadequate rates in cystic, predominantly cystic, predominantly solid and solid sub-groups were 7.4%, 6.7%, 5.6% and 6.7% (P = 0.996) in CEUS-FNA group.

Conclusions: CEUS can improve the specimen adequacy of FNA in high inadequate risk thyroid nodules by avoiding unnecessary FNAs of the non-enhancing nodules, and accurately locating the viable tissue and precise guidance in real-time. CEUS is a recommend modality for FNA guidance of high inadequate risk thyroid nodules.
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http://dx.doi.org/10.1186/s12880-022-00805-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9063232PMC
May 2022

Multidimensional Information Network Big Data Mining Algorithm Relying on Finite Element Analysis.

Authors:
Haifeng Li

Comput Intell Neurosci 2022 11;2022:7156715. Epub 2022 Apr 11.

Dalian Jiaotong University, Dalian, Liaoning 116028, China.

In recent years, with the rapid development of the Internet, online social networks have been continuously integrated with traditional interpersonal networks and research on information dissemination in social networks has gradually increased. This article studies and analyzes the multidimensional information network big data mining algorithm based on the finite element analysis method. This paper firstly introduces the finite element analysis and calculation process, a finite element data mining simulation application software management system will integrate current data, calculation, and background data into one, then analyzes the data mining clustering algorithm, and conducts an experimental exploration of the influential node mining algorithm in complex networks. The experimental results show that the LIC algorithm is better than the CC algorithm, the DC algorithm, and the BC algorithm; its overall performance is improved by 30%, and the effect is better. The LIC algorithm can effectively and quickly determine the influential nodes, which is helpful for social network analysis.
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http://dx.doi.org/10.1155/2022/7156715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017521PMC
April 2022

A CT-based radiomics model to predict subsequent brain metastasis in patients with ALK-rearranged non-small cell lung cancer undergoing crizotinib treatment.

Thorac Cancer 2022 Apr 18. Epub 2022 Apr 18.

State Key Laboratory of Oncology in South China, Guangzhou, China.

Background: Brain metastasis (BM) comprises the most common reason for crizotinib failure in patients with anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). We hypothesize that its occurrence could be predicted by a computed tomography (CT)-based radiomics model, therefore, allowing for selection of enriched patient populations for prevention therapies.

Methods: A total of 75 eligible patients were enrolled from Sun Yat-sen University Cancer Center between June 2014 and September 2019. The primary endpoint was brain metastasis-free survival (BMFS), estimated from the initiation of crizotinib to the date of the occurrence of BM. Patients were randomly divided into two cohorts for model training (n = 51) and validation (n = 24), respectively. A radiomics signature was constructed based on features extracted from chest CT before crizotinib treatment. Clinical model was developed using the Cox proportional hazards model. Log-rank test was performed to describe the difference of BMFS risk.

Results: Patients with low radiomics score had significantly longer BMFS than those with higher, both in the training cohort (p = 0.019) and validation cohort (p = 0.048). The nomogram combining smoking history and the radiomics signature showed good performance for the estimation of BMFS, both in the training (concordance index [C-index], 0.762; 95% confidence interval [CI], 0.663-0.861) and validation cohort (C-index, 0.724; 95% CI, 0.601-0.847).

Conclusion: We have developed a CT-based radiomics model to predict subsequent BM in patients with non-brain metastatic NSCLC undergoing crizotinib treatment. Selection of an enriched patient population at high BM risk will facilitate the design of clinical trials or strategies to prevent BM.
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http://dx.doi.org/10.1111/1759-7714.14386DOI Listing
April 2022

Application and thinking of minimally invasive transforaminal lumbar interbody fusion in degenerative lumbar diseases.

Ann Transl Med 2022 Mar;10(6):272

Department of Orthopedics Center (Spinal Surgery Ward), Yan'an Hospital of Kunming City, Kunming, China.

Background: This study sought to investigate the clinical efficacy and safety of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in the treatment of lumbar degenerative diseases.

Methods: The clinical data of 55 patients with lumbar degenerative diseases treated at our hospital from January 2018 to January 2020 were analyzed retrospectively. Of the 55 patients, 35 who underwent MIS-TLIF were included in the MIS-TLIF group, and 20 who underwent posterior lumbar interbody fusion (PLIF) were included in the PLIF group. The visual analogue scale (VAS) score, Oswestry disability index (ODI) score, operation time, incision length, intraoperative bleeding, postoperative drainage, postoperative landing time, postoperative hospital stay, postoperative interbody fusion rate, and complications were compared between the two groups.

Results: The patients in both groups were followed-up for at least 1.5 years (range, 18-30 months; with an average of 27.5±2.6 months). There was no significant difference in the operation time, incision length, intraoperative bleeding, VAS score for low back and leg pain, ODI score, interbody fusion rate, hospitalization expenses, and complication rate between the two groups (P>0.05). One patient had nail failure in the MIS-TLIF group, 1 patient in each group had nerve root irritation, and 1 patient in each group had superficial incision infection and local suture dehiscence. The postoperative drainage volume, postoperative landing time, and postoperative hospital stay of the MIS-TLIF group were less than those of the PLIF group (P<0.05).

Conclusions: Compared to PLIF, the use of MIS-TLIF in the treatment of lumbar degenerative diseases has a number of advantages, including more complete intraoperative hemostasis, less postoperative drainage, earlier landing, and faster discharge, and also significantly improves postoperative lumbar discomfort.
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http://dx.doi.org/10.21037/atm-22-401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011304PMC
March 2022

Growth charts of brain morphometry for preschool children.

Neuroimage 2022 Jul 14;255:119178. Epub 2022 Apr 14.

Laboratory of Psychological Health and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key laboratory of Psychotic disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China; Institute of Psychological and Behavioral Sciences, Shanghai Jiao Tong University, Shanghai, China. Electronic address:

Brain development from 1 to 6 years of age anchors a wide range of functional capabilities and carries early signs of neurodevelopmental disorders. However, quantitative models for depicting brain morphology changes and making individualized inferences are lacking, preventing the identification of early brain atypicality during this period. With a sample size of 285, we characterized the age dependence of the cortical thickness and subcortical volume in neurologically normal children and constructed quantitative growth charts of all brain regions for preschool children. While the cortical thickness of most brain regions decreased with age, the entorhinal and parahippocampal regions displayed an inverted-U shape of age dependence. Compared to the cortical thickness, the normalized volume of subcortical regions exhibited more divergent trends, with some regions increasing, some decreasing, and some displaying inverted-U-shaped trends. The growth curve models for all brain regions demonstrated utilities in identifying brain atypicality. The percentile measures derived from the growth curves facilitate the identification of children with developmental speech and language disorders with an accuracy of 0.875 (area under the receiver operating characteristic curve: 0.943). Our results fill the knowledge gap in brain morphometrics in a critical development period and provide an avenue for individualized brain developmental status evaluation with demonstrated sensitivity. The brain growth charts are shared with the public (http://phi-group.top/resources.html).
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http://dx.doi.org/10.1016/j.neuroimage.2022.119178DOI Listing
July 2022

Effects of double vs triple injection on block dynamics for ultrasound-guided intertruncal approach to the supraclavicular brachial plexus block in patients undergoing upper limb arteriovenous access surgery: study protocol for a double-blinded, randomized controlled trial.

Trials 2022 Apr 12;23(1):295. Epub 2022 Apr 12.

Department of Anesthesiology, Guangdong Provincial People's Hospital, and Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People's Republic of China.

Background: Ultrasound-guided intertruncal approach (IA) has been proposed to be an alternative and promising approach to the supraclavicular block (SCB), in which double injection (DI) of local anesthetics (LA) is sequentially administered between intertruncal planes. We would like to apply a refined injection technique, named triple injection (TI) technique, based on the 3 separate compartments visualized by ultrasound. The aim of this study is to compare the percentage of patients with complete sensory blockade at 20 min of DI vs TI technique, when they are applied in patients undergoing upper limb arteriovenous access surgery.

Methods: This study is a prospective parallel-group randomized controlled trial. A total of 86 end-stage renal disease patients will be randomly allocated to receive IA-SCB using either DI or TI technique with identical LA (0.5% ropivacaine 24 mL). The primary outcome is the percentage of patients with complete sensory blockade of all 4 terminal nerves (median, ulnar, radial, and musculocutaneous nerves) of the brachial plexus measured at 20 min after injection. The secondary outcomes will consist of the sensory or motor blockade of all individual nerves, onset times, performance time, diaphragmatic paralysis, surgical anesthesia, and adverse events.

Discussion: It is expected that ultrasound-guided IA-SCB with the TI technique results in better block dynamic in patients undergoing upper limb arteriovenous access surgery.

Trial Registration: Chinese Clinical Trial Registry ChiCTR2100045075 .
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http://dx.doi.org/10.1186/s13063-022-06260-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9006596PMC
April 2022

Unifying Obstacle Detection, Recognition, and Fusion Based on the Polarization Color Stereo Camera and LiDAR for the ADAS.

Sensors (Basel) 2022 Mar 23;22(7). Epub 2022 Mar 23.

Research Center for Humanoid Sensing, Zhejiang Lab, Hangzhou 311100, China.

The perception module plays an important role in vehicles equipped with advanced driver-assistance systems (ADAS). This paper presents a multi-sensor data fusion system based on the polarization color stereo camera and the forward-looking light detection and ranging (LiDAR), which achieves the multiple target detection, recognition, and data fusion. The You Only Look Once v4 (YOLOv4) network is utilized to achieve object detection and recognition on the color images. The depth images are obtained from the rectified left and right images based on the principle of the epipolar constraints, then the obstacles are detected from the depth images using the MeanShift algorithm. The pixel-level polarization images are extracted from the raw polarization-grey images, then the water hazards are detected successfully. The PointPillars network is employed to detect the objects from the point cloud. The calibration and synchronization between the sensors are accomplished. The experiment results show that the data fusion enriches the detection results, provides high-dimensional perceptual information and extends the effective detection range. Meanwhile, the detection results are stable under diverse range and illumination conditions.
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http://dx.doi.org/10.3390/s22072453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9003213PMC
March 2022

A nationwide survey of 20 legacy brominated flame retardants in indoor dust from China: continuing occurrence, national distribution, and implication for human exposure.

Environ Sci Pollut Res Int 2022 Apr 4. Epub 2022 Apr 4.

Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.

Despite the restrictions on polybrominated diphenyl ethers (PBDEs) and hexabromocyclododecanes (HBCDDs), these chemicals are still ubiquitous environmental pollutants. In this study, we measured the concentrations and profiles of 17 PBDE congeners and 3 HBCDD isomers in indoor dust samples collected from 23 provinces and cities across China. The summed concentrations of PBDEs (ΣPBDEs) ranged from 4.19 to 817 ng/g, with an average of 171 ± 184 ng/g. BDE-209 was the most abundant congener. The concentrations of HBCDDs ranged from 6.65 to 1335 ng/g, with an average of 236 ± 324 ng/g. Unlike commercial HBCDD formulations, α-HBCDD was the predominant isomer in the indoor dust samples analyzed. Geographical distributions showed that the concentrations of PBDEs and HBCDDs varied significantly among different regions. Higher PBDE and HBCDD levels were observed in samples from eastern coastal and economically developed regions. Further, we estimated the daily intakes of PBDEs and HBCDDs through the routes of dust ingestion and dust dermal absorption for different age groups. Dust dermal absorption is an unneglectable exposure pathway to PBDEs and HBCDs for the Chinese population. Among the age groups, infants had the highest exposure via dust dermal absorption, and toddlers had the highest exposure via dust ingestion. Compared with the threshold values, the exposure doses of PBDEs and HBCDDs are unlikely to pose significant health concerns for both infants and adults in China. This is the first national survey of PBDEs and HBCDDs in indoor dust samples across China after the restriction.
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http://dx.doi.org/10.1007/s11356-022-19850-3DOI Listing
April 2022

Cascade Upgrading of Biomass-Derived Furfural to γ-Valerolactone Over Zr/Hf-Based Catalysts.

Front Chem 2022 7;10:863674. Epub 2022 Mar 7.

School of Energy Materials and Chemical Engineering, Hefei University, Hefei, China.

Biomass feedstocks are promising candidates of renewable clean energy. The development and utilization of biological energy is in line with the concept of sustainable development and circular economy. As an important platform chemical, γ-valerolactone (GVL) is often used as green solvent and biofuel additive. Regarding this, the efficient synthesis of GVL from biomass derivative furfural (FF) has attracted wide attention recently, However, suitable catalyst with appropriate acid-base sites is required due to the complex reaction progress. In this , the research progress of catalytic synthesis of GVL from furfural by Zr/Hf-based catalysts was reviewed. The different effects of Lewis acid-base and Brønsted acid sites in the catalysts on each steps in the reaction process were discussed firstly. Then the effects of regulation of acid-base sites in the catalysts was also studied. Finally, the advantages and challenges of Zr/Hf-based catalysts in FF converted to GVL system were proposed.
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http://dx.doi.org/10.3389/fchem.2022.863674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8934881PMC
March 2022

Astaxanthin, a carotenoid antioxidant, pretreatment alleviates cognitive deficits in aircraft noised mice by attenuating inflammatory and oxidative damage to the gut, heart and hippocampus.

Biomed Pharmacother 2022 Apr 4;148:112777. Epub 2022 Mar 4.

Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan. Electronic address:

Background: We first explore whether aircraft noise (AN) induces cognitive deficit via inducing oxidative damage in multiple vital organs including intestines, hearts and hippocampus tissues. Second, we explore whether the AN-induced cognitive deficits and inflammatory and oxidative damage to multiple organs can be alleviated by Astaxanthin (AX) pretreatment.

Methods: Cognitive deficits were induced by subjecting the mice to AN 2 h daily for 7 consecutive days. An intragastrical dose of AX emulsifier (at the dose of daily feed intake [6 g] of a mouse three times weekly) was given to mice for consecutive 8 weeks prior to the start of AN. Cognitive functions were evaluated by using passive avoidance apparatus, Y-maze, Morris water maze and novel recognition test. Intestinal permeability was determined by measuring the intestinal clearance of fluorescein-isothiocyante. Evans Blue extravasation assay was used to measure the permeability of blood-brain-barrier. Inflammatory and oxidative damage to multiple organs were determined by measuring several pro-inflammatory cytokines and oxidative stress indicators in intestines; hearts and hippocampus.

Results: Mice treated with AN displayed exacerbated stress reactions, cognitive deficits, gut barrier hyperpermeability, increased upload of lipopolysaccharide translocation, systemic pro-inflammatory cytokines overproduction, blood-brain-barrier hyperpermeability, hippocampal neuroinflammation and increased levels of oxidative stress indicators in intestine, heart and hippocampus. All of the above-mentioned disorders caused by AN were significantly (P < 0.05) reversed by AX.

Conclusions: Our data indicate that AX pretreatment alleviates cognitive deficits in aircraft noised mice by attenuating inflammatory and oxidative damage to intestines, hearts and hippocampal tissues.
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http://dx.doi.org/10.1016/j.biopha.2022.112777DOI Listing
April 2022

All-day thin-lens computational imaging with scene-specific learning recovery.

Appl Opt 2022 Feb;61(4):1097-1105

Modern imaging optics ensures high-quality photography at the cost of a complex optical form factor that deviates from the portability. The drastic development of image processing algorithms, especially advanced neural networks, shows great promise to use thin optics but still faces the challenges of residual artifacts and chromatic aberration. In this work, we investigate photorealistic thin-lens imaging that paves the way to actual applications by exploring several fine-tunes. Notably, to meet all-day photography demands, we develop a scene-specific generative-adversarial-network-based learning strategy and develop an integral automatic acquisition and processing pipeline. Color fringe artifacts are reduced by implementing a chromatic aberration pre-correction trick. Our method outperforms existing thin-lens imaging work with better visual perception and excels in both normal-light and low-light scenarios.
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http://dx.doi.org/10.1364/AO.448155DOI Listing
February 2022

Causal Analysis of Impact Factors of COVID-19 in China.

Procedia Comput Sci 2022 3;199:1483-1489. Epub 2022 Feb 3.

School of Information, Central University of Finance and Economics, Beijing, 102206, China.

Mobility, group awareness, and temperature are considered as the important factors that may impact the increase in confirmed cases of the COVID-19. This paper aims to verify the above factors on the COVID-19 and show the possible confounding factors of each research variable in reality. Based on this, we collected data about the epidemic from January 20, 2020 to February 24, 2021, including the relevant data of 31 provinces and regions in China. Plus, we use the directed acyclic graph (DAG) to show the causal relationship between the above influencing factors and the confirmed daily epidemic cases, and the confounding is estimated based on DAG. The effective adjustment set of factors are used to perform the regression of the total causal effect among the explanatory variables and the confirmed cases of the epidemic using negative binomial regression. Through the comprehensive causal analysis of the decisive factors for the COVID-19, we provide strong evidence for population mobility, group awareness and the impact of weather on the epidemic, and estimates the possible confounding factors in all aspects of society. Incorporating the above factors, we provide suggestions for future decisions on the prevention of large-scale epidemics.
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http://dx.doi.org/10.1016/j.procs.2022.01.189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812091PMC
February 2022

Therapists' Expressions of Agreement in Therapeutic Conversations With Chinese Children With ASD: Strategies, Sequential Positions and Functions.

Front Psychol 2021 10;12:792167. Epub 2022 Jan 10.

Department of Rehabilitation, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Based on conversations between 10 Chinese children with Autism Spectrum Disorders (ASD) and five therapists in the context of Naturalistic Intervention, this study investigated the therapists' agreement expressions in this typical setting. The study found that (1) the therapists mainly used four agreement strategies: acknowledgment, positive evaluation, repetition and blending. These four strategies could be used individually or in combination. The first three strategies and their combinations were used frequently during the therapeutic conversation. (2) With the major occurrences in the post-expansion position, the agreement expressions in the therapeutic conversation mainly performed three functions, namely, creating a supportive therapeutic relationship, serving as positive reinforcers and implementing interventions pertinent to communication skills. (3) This study proposed that the therapists' preferred use of agreement expressions in the intervention process could be explained by the features of Naturalistic Intervention.
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http://dx.doi.org/10.3389/fpsyg.2021.792167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8785798PMC
January 2022

Reducing number of target lesions for RECIST1.1 to predict survivals in patients with advanced non-small-cell lung cancer undergoing anti-PD1/PD-L1 monotherapy.

Lung Cancer 2021 Dec 31;165:10-17. Epub 2021 Dec 31.

State Key Laboratory of Oncology in South China, Guangzhou, China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China. Electronic address:

Objectives: The Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 provides conventional and standardized response assessment for multiple solid tumors. We investigated the smallest number of target lesions that can be measured without compromising response categorization and survival prediction in patients with advanced non-small-cell lung cancer (aNSCLC) undergoing anti-PD-1/PD-L1 monotherapy.

Material And Methods: 125 aNSCLC patients with at least two measurable lesions undergoing PD-1/PD-L1 inhibitor treatment were retrospectively studied. Tumor measurements allowing up to two lesions per organ and five lesions in total were reviewed. Inter-individual agreement and κ values for inter-method concordance on response status were evaluated based on up to five target lesions versus the largest one through four lesions. C-index was calculated to evaluate the prognostic accuracy of response categorization based on the selected number of target lesions for predicting overall survival (OS). Cox regression analysis was conducted for survival analysis.

Results: The highly consistent response assignment (99.2%) could be obtained when measuring the largest two lesions versus up to five lesions. Using the largest two through four lesions produced κ values of 0.986, 1.000 and 1.000 for response assessment, values significantly higher than those obtained when measuring the largest single lesion (κ = 0.850). C-index for overall survival (OS) was similar when assessing the largest one through five lesions, ranging from 0.646 to 0.654. Cox regression analyses showed that radiological response significantly predicted OS, irrespective of the number of target lesions selected.

Conclusions: Reducing the number of target lesions does not affect OS prediction in aNSCLC patients treated with anti-PD-1/PD-L1 therapy. Considering the high intra-individual and inter-method concordance, using the largest two lesions in total is proposed to assess response.
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http://dx.doi.org/10.1016/j.lungcan.2021.12.015DOI Listing
December 2021

Optimal first-line treatment for platinum-eligible metastatic urothelial carcinoma: Comparison of chemo-immunotherapy, immunotherapy, and chemotherapy- A systematic review and meta-analysis.

Clin Immunol 2022 03 11;236:108927. Epub 2022 Jan 11.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, PR China; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, PR China. Electronic address:

Background: The role of first-line of immunotherapy in metastatic urothelial carcinoma (mUC) remains unclear. This meta-analysis aimed to explore an optimal first-line treatment strategy for mUC patients.

Methods: We carried out a meta-analysis between chemo-immunotherapy, immunotherapy, and chemotherapy in mUC based on randomized trials. The outcomes included overall survival (OS), progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and treatment-related adverse events (AEs). A fixed-effect or random-effects model was adopted depending on between-study heterogeneity.

Results: Three trials involving 3238 patients were included. PD-1/PD-L1 inhibitor plus platinum-based chemotherapy was associated with the improvements of OS (HR, 0.85; 95% CI 0.75-0.99), PFS (HR, 0.80; 95% CI 0.71-0.90) and ORR (OR, 1.32; 95% CI 1.07-1.63) when compared with platinum-based chemotherapy, but not with better DCR (OR, 1.07; 95% CI 0.78-1.46). PD-1/PD-L1 inhibitor alone was associated with worse ORR (OR, 0.38; 95% CI 0.17-0.87) and DCR (OR, 0.20; 95% CI 0.16-0.25) when compared with platinum-based chemotherapy while it did not statistically reduce the risk of mortality (HR 0.97 for entire cohort; 0.90 for PD-L1 high cohort). In safety analyses, the incidence of adverse events (AEs) between regimens showed no difference, but the frequency of AEs of grade 3 or severity was higher in chemo-immunotherapy compared to chemotherapy.

Conclusions: Compared with platinum-based chemotherapy, chemo-immunotherapy is associated with significantly improved PFS, OS, and ORR in the first-line therapy for mUC at the expanse of increased toxicity.
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http://dx.doi.org/10.1016/j.clim.2022.108927DOI Listing
March 2022

Circular RNA hsa_circ_0032683 inhibits the progression of hepatocellular carcinoma by sponging microRNA-338-5p.

Bioengineered 2022 02;13(2):2321-2335

Department of Hepatic-Biliary-Pancreatic Center, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.

Recently, several studies have been conducted on circRNA (circular RNA). circRNA regulates gene expression and plays a vital role in the occurrence and development of various tumors. However, the role and mechanism of hsa_circ_0032683 in hepatocellular carcinoma (HCC) is not studied yet. In GEO (Gene Expression Omnibus) database, hsa_circ_0032683 expression was significantly lower in HCC tissues than in normal liver tissues. In vitro and in vivo functional tests revealed that hsa_circ_0032683 could inhibit HCC cells proliferation and promote their apoptosis. Mechanically, hsa_circ_0032683 primarily exists in the cytoplasm and competes with microRNA-338-5p (miR-338-5p) to regulate reticulon 4(RTN4). Our experiments revealed that hsa_circ_0032683 receded the proliferation ability of HCC via ceRNA (competing endogenous RNAs) mechanism, which provided potential biomarkers and therapeutic targets for HCC patients. circRNAs: circular RNA; HCC: hepatocellular carcinoma; RTN4: reticulon 4; ceRNA: competing endogenous RNA; GEO: Gene Expression Omnibus; miRNA: microRNA; CSCD: Cancer-specific circRNA database; CRI: Circular RNA Interactome; TCGA: The Cancer Genome Atlas; qRT-PCR: quantitative real-time PCR; NEK9:NIMA-related kinase nine; CSMD1: CUB and Sushi multiple domains 1; Tob1: transducer of ERBB2, 1; miR: microRNA; sh: short hairpin; WT: wild type; MUT: mutant.
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http://dx.doi.org/10.1080/21655979.2021.2024961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8974012PMC
February 2022

A comparative analysis of clinical characteristics in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) between Wuhan and Zhoushan, China.

Ann Palliat Med 2021 Dec;10(12):12810-12820

Cell and Molecular Biology Laboratory, Zhoushan Hospital, Zhoushan, China.

Background: We aimed to identify any differences in the clinical characteristics of patients treated in Zhoushan Hospital and Wuhan Fourth Hospital, Gutian campus to provide insights into measures to better control the coronavirus disease 2019 (COVID-19) pandemic and treat COVID-19 patients.

Methods: All cases included in this retrospective study from January 10, 2020 to March 15, 2020 were confirmed by laboratory detection of SARS-CoV-2. Data of epidemiological characteristics, clinical characteristics, laboratory results, radiological findings, treatments, and outcomes were obtained from electronic medical records and compared between the patient groups.

Results: A correlation analysis was performed to detect correlations between the serum C-reactive protein (CRP) level and other laboratory findings. COVID-19 patients treated in Wuhan more commonly had fever and shortness of breath, and less commonly had headache compared to those treated in Zhoushan (P=0.002, 0.039, and 0.015, respectively). The period from illness onset to hospitalization in Wuhan was 11.7±7.2 days, which was longer than that in Zhoushan (4.2±3.7 days; P=0.002), whereas the period from illness onset to shortness of breath in Wuhan was 5.4±5.0 days, which was shorter than that in Zhoushan (14.0±5.6 days; P=0.020). Computed tomography scans showed linear opacities, reticulation, and patchy shadows more commonly in cases treated in Wuhan (P=0.016, 0.013, and 0.008, respectively). The mean CRP level in Zhoushan patients was lower than that in Wuhan patients (P<0.001), and the CRP level was correlated with several laboratory findings related to the immune response.

Conclusions: COVID-19 patients treated at Wuhan Fourth Hospital, Gutian campus had more severe symptoms than those treated at Zhoushan Hospital. Earlier in-hospital treatment, as conducted in Zhoushan, may be beneficial in reducing the severity of illness in COVID-19 patients. Additionally, the correlations between the CRP level and indicators of immune function in COVID-19 patients warrant further investigation.
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http://dx.doi.org/10.21037/apm-21-3629DOI Listing
December 2021

Association of Gestational Age at Birth With Subsequent Suspected Developmental Coordination Disorder in Early Childhood in China.

JAMA Netw Open 2021 12 1;4(12):e2137581. Epub 2021 Dec 1.

Department of Psychology, Nottingham Trent University, Nottingham, United Kingdom.

Importance: It remains unknown whether children born at different degrees of prematurity, early term, and post term might have a higher risk of developmental coordination disorder (DCD) compared with completely full-term children (39-40 gestational weeks).

Objective: To differentiate between suspected DCD in children with different gestational ages based on a national representative sample in China.

Design, Setting, And Participants: A retrospective cohort study was conducted in China from April 1, 2018, to December 31, 2019. A total of 152 433 children aged 3 to 5 years from 2403 public kindergartens in 551 cities of China were included in the final analysis. A multilevel regression model was developed to determine the strength of association for different gestational ages associated with suspected DCD when considering kindergartens as clusters.

Main Outcomes And Measures: Children's motor performance was assessed using the Little Developmental Coordination Disorder Questionnaire, completed by their parents. Gestational age was determined according to the mother's medical records and divided into 7 categories: completely full term (39 to 40 weeks' gestation), very preterm (<32 weeks), moderately preterm (32-33 weeks), late preterm (34-36 weeks), early term (37-38 weeks), late term (41 weeks), and post term (>41 weeks).

Results: A total of 152 433 children aged 3 to 5 years (mean [SD] age, 4.5 [0.8] years), including 80 370 boys (52.7%) and 72 063 girls (47.3%), were included in the study. There were 45 052 children (29.6%) aged 3 years, 59 796 (39.2%) aged 4 years, and 47 585 (31.2%) aged 5 years. Children who were born very preterm (odds ratio [OR], 1.35; 95% CI, 1.23-1.48), moderately preterm (OR, 1.18; 95% CI, 1.02-1.36), late preterm (OR, 1.24; 95% CI, 1.16-1.32), early term (OR, 1.11; 95% CI, 1.06-1.16), and post term (OR, 1.17; 95% CI, 1.07-1.27) were more likely to be classified in the suspected DCD category on the Little Developmental Coordination Disorder Questionnaire than completely full-term children after adjusting for the same characteristics. Additionally, there was no association with suspected DCD in younger (aged 3 years) early-term and postterm children by stratified analyses.

Conclusions And Relevance: In this cohort study, every degree of prematurity at birth, early-term birth, and postterm birth were associated with suspected DCD when compared with full-term birth. These findings have important implications for understanding motor development in children born at different gestational ages. Long-term follow-up and rehabilitation interventions should be considered for children born early and post term.
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http://dx.doi.org/10.1001/jamanetworkopen.2021.37581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8672235PMC
December 2021

Integrated formulation design of self-emulsifying drug delivery systems.

Acta Pharm Sin B 2021 Nov 5;11(11):3585-3594. Epub 2021 May 5.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau 999078, China.

The drug formulation design of self-emulsifying drug delivery systems (SEDDS) often requires numerous experiments, which are time- and money-consuming. This research aimed to rationally design the SEDDS formulation by the integrated computational and experimental approaches. 4495 SEDDS formulation datasets were collected to predict the pseudo-ternary phase diagram by the machine learning methods. Random forest (RF) showed the best prediction performance with 91.3% for accuracy, 92.0% for sensitivity and 90.7% for specificity in 5-fold cross-validation. The pseudo-ternary phase diagrams of meloxicam SEDDS were experimentally developed to validate the RF prediction model and achieved an excellent prediction accuracy (89.51%). The central composite design (CCD) was used to screen the best ratio of oil-surfactant-cosurfactant. Finally, molecular dynamic (MD) simulation was used to investigate the molecular interaction between excipients and drugs, which revealed the diffusion behavior in water and the role of cosurfactants. In conclusion, this research combined machine learning, central composite design, molecular modeling and experimental approaches for rational SEDDS formulation design. The integrated computer methodology can decrease traditional drug formulation design works and bring new ideas for future drug formulation design.
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http://dx.doi.org/10.1016/j.apsb.2021.04.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642610PMC
November 2021

Exploring the degree of nicotine dependence and willingness to quit smoking in Chinese smoking patients with stroke: A cross-sectional survey.

Medicine (Baltimore) 2021 Dec;100(49):e27715

Linyi City Center Blood Station, Shandong Province 146 Yimeng North Road, Lanshan District, Linyi City, Shangdong, China.

Abstract: Smoking is closely related to the occurrence of stroke. The degree of nicotine dependence and willingness to quit smoking are key factors that determine whether a smoker can successfully quit smoking. Few studies have been conducted on factors affecting the willingness to quit smoking among smokers who suffered from stroke.Although the smoking rate has declined, it is still the main changeable risk factor for cerebrovascular diseases. We aimed to investigate the current status of nicotine dependence and willingness to quit smoking among patients who suffered from stroke. We also clarified factors that affect the willingness to quit smoking among stroke patients and provide evidence for quitting smoking.Convenience sampling methods were used to conduct cross-sectional studies. A questionnaire survey was administered to 215 stroke patients who smoked. A general information questionnaire as well as patient smoking and cessation status questionnaire were used. Nicotine dependence test scale, smoking attitude factor score, and tobacco harm perception scale were applied for investigation. Logistic regression was used to analyze factors related to patients' willingness to quit smoking.Statistically significant differences in willingness to quit smoking were found among stroke patients with different ages, household registration status, education levels, marital status, occupation, smoking attitude, and nicotine dependence (P < .05). About 34.4%, 39.1%, and 26.5% of smoking patients had low, moderate, and severe nicotine dependence, respectively. Logistic analysis showed that compared with other occupations, workers, retirees, farmers, and freelancers compared with other people (0.050, 0.081, 0.053, 0.048) had a negative impact on the willingness to quit smoking among stroke patients. Compared with positive attitudes, negative and neutral smoking attitudes (0.190, 0.048) had a negative impact on the willingness to quit smoking among stroke patients. Compared with high nicotine dependence, low and moderate nicotine dependence (4.628, 2.596) had a positive impact on willingness to quit smoking.Smoking patients in neurology department are more willing to quit smoking (67.9%). Factors such as occupation, smoking attitude, and nicotine dependence should be considered when establishing smoking cessation interventions for stroke smokers.
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http://dx.doi.org/10.1097/MD.0000000000027715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8663880PMC
December 2021

Novel SNX13 Frameshift Variant in an Individual with Developmental Delay.

Cytogenet Genome Res 2021 8;161(10-11):514-519. Epub 2021 Dec 8.

Department of Rehabilitation, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Recently, an increasing number of genes have been associated with global developmental delay (GDD) and intellectual disability (ID). The sorting nexin (SNX) protein family plays multiple roles in protein trafficking and intracellular signaling. SNXs have been reported to be associated with several disorders, including Alzheimer disease and Down syndrome. Despite the growing evidence of an association of SNXs with neurodegeneration, SNX13 deficiency has not been associated with GDD or ID. In this study, we present the case of a 4-year-old boy with brain dysplasia and GDD, including language delay, cognitive delay, and dyskinesia. Exome sequencing revealed a 1-bp homozygous deletion in SNX13 (NM_015132.5: exon8: c.742_743del; p.Tyr248Leufs*20), which caused a frameshift and predicted early termination. Sanger sequencing confirmed that the variant was inherited from his parents respectively. Our findings associate SNX13 variation with GDD for the first time and provide a new GDD candidate gene.
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http://dx.doi.org/10.1159/000520296DOI Listing
March 2022

Association between blood urea nitrogen and 30-day mortality in patients with sepsis: a retrospective analysis.

Ann Palliat Med 2021 Nov;10(11):11653-11663

Department of Nephrology, Shihezi City People's Hospital, Shihezi, China.

Background: Patients with sepsis have a high mortality rate. Rapid and effective risk stratification indicators for sepsis-related death are urgently needed to explored. Blood urea nitrogen (BUN) level can reflect the protein catabolism in the human body and the degree of renal impairment. So it has particular value for the management of septic patients. In this study, we explored the relationship between BUN level and 30-day mortality in patients with sepsis.

Methods: In this retrospective cohort study, a total of 12,713 patients with sepsis from the Medical Information Mart for Intensive Care III (MIMIC-III) database were included. BUN level at admission was retrieved, and the outcome indicator was the 30-day mortality. Multivariate Cox regression analysis and smoothed curve fitting were used to assess the relationship between BUN and 30-day mortality.

Results: A total of 12,713 patients with sepsis were screened. The overall 30-day mortality rate was 20.6%. The multivariate Cox regression model and smoothed curve fitting revealed a nonlinear association between BUN and 30-day mortality. The inflection point occurred at 41.1 mg/dL. The effect size was 1.298 on the left side of the inflection point [hazard ratio (HR) =1.298; 95% confidence interval (CI): 1.224-1.376; P<0.001] and 1.045 on the right side of the inflection point (HR =1.045; 95% CI: 1.016-1.075; P=0.002).

Conclusions: There is a nonlinear correlation between BUN and 30-day mortality in patients with sepsis. With 41.1 mg/dL as a cutoff level for BUN, patients have a remarkably different risk of death and should be managed differently.
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http://dx.doi.org/10.21037/apm-21-2937DOI Listing
November 2021

Correction to: Hepatotoxicity associated with PD-1 blockade antibodies in cancer patients co-infected with hepatitis B virus.

Cancer Immunol Immunother 2022 May;71(5):1257

Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.

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http://dx.doi.org/10.1007/s00262-021-03112-1DOI Listing
May 2022

MODENN: A Shallow Broad Neural Network Model Based on Multi-Order Descartes Expansion.

IEEE Trans Pattern Anal Mach Intell 2021 Nov 8;PP. Epub 2021 Nov 8.

Deep neural networks have achieved great success in almost every eld of artificial intelligence. However, several weaknesses keep bothering researchers due to its hierarchical structure, particularly when large-scale parallelism, faster learning, better performance, and high reliability are required. Inspired by the parallel and large-scale information processing structures in the human brain, a shallow broad neural network model is proposed on a specially designed multi-order Descartes expansion operation. Such Descartes expansion acts as an efficient feature extraction method for the network, improve the separability of the original pattern by transforming the raw data pattern into a high-dimensional feature space, the multi-order Descartes expansion space. As a result, a single-layer perceptron network will be able to accomplish the classification task. The multi-order Descartes expansion neural network (MODENN) is thus created by combining the multi-order Descartes expansion operation and the single-layer perceptron together, and its capacity is proved equivalent to the traditional multi-layer perceptron and the deep neural networks. Three kinds of experiments were implemented, the results showed that the proposed MODENN model retains great potentiality in many aspects, including implementability, parallelizability, performance, robustness, and interpretability, indicating MODENN would be an excellent alternative to mainstream neural networks.
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http://dx.doi.org/10.1109/TPAMI.2021.3125690DOI Listing
November 2021

Integrated computer-aided formulation design: A case study of andrographolide/ cyclodextrin ternary formulation.

Asian J Pharm Sci 2021 Jul 3;16(4):494-507. Epub 2021 Jun 3.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau 999078, China.

Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists, which is time-consuming, high cost and waste materials. This research aims to integrate various computational tools, including machine learning, molecular dynamic simulation and physiologically based absorption modeling (PBAM), to enhance andrographolide (AG) /cyclodextrins (CDs) formulation design. The lightGBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy. AG/γ-CD inclusion complexes showed the strongest binding affinity, which was experimentally validated by the phase solubility study. The molecular dynamic simulation was used to investigate the inclusion mechanism between AG and γ-CD, which was experimentally characterized by DSC, FTIR and NMR techniques. PBAM was applied to simulate the behavior of the formulations, which were validated by cell and animal experiments. Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate (TPGS) significantly increased the intracellular uptake of AG in MDCK-MDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers. The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills, respectively. In conclusion, this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility, dissolution rate and bioavailability. The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design.
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http://dx.doi.org/10.1016/j.ajps.2021.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8520056PMC
July 2021

Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance.

Nat Commun 2021 10 21;12(1):6121. Epub 2021 Oct 21.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.

In obesity, macrophages drive a low-grade systemic inflammation (LSI) and insulin resistance (IR). The ribosome biosynthesis protein NOC4 (NOC4) mediates 40 S ribosomal subunits synthesis in yeast. Hereby, we reported an unexpected location and function of NOC4L, which was preferentially expressed in human and mouse macrophages. NOC4L was decreased in both obese human and mice. The macrophage-specific deletion of Noc4l in mice displayed IR and LSI. Conversely, Noc4l overexpression by lentivirus treatment and transgenic mouse model improved glucose metabolism in mice. Importantly, we found that Noc4l can interact with TLR4 to inhibit its endocytosis and block the TRIF pathway, thereafter ameliorated LSI and IR in mice.
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http://dx.doi.org/10.1038/s41467-021-26408-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8531303PMC
October 2021

Role of long intergenic non-protein coding RNA 00152 in pancreatic cancer glycolysis the manipulation of the microRNA-185-5p/Krüppel-like factor 7 axis.

J Cancer 2021 28;12(21):6330-6343. Epub 2021 Aug 28.

Department of Hepato-Pancreatico-Biliary Surgery, Zhongda Hospital Southeast University, Nanjing, 210009, Jiangsu Province, China.

The current study set out to investigate the role of long intergenic non-protein coding RNA (LINC) 00152 in pancreatic cancer (PC) cell glycolysis with the microRNA (miR)-185-5p/Krüppel-like factor 7 (KLF7) axis. Firstly, PC tissues and cells as well as the control ones were collected from 53 PC patients, and assessed for LINC00152 expression patterns. Besides, PC cells with the most differentially expressed LINC00152 were selected for further experiments. When LINC00152 was silenced or overexpressed, PC cell glucose consumption, lactic acid production, adenosine triphosphate and levels of glycolysis-associated enzymes were detected. In addition, the binding relation between LINC00152 and miR-185-5p as well as the target relation between miR-185-5p and KLF7 was clarified and validated. Additionally, xenograft transplantation was performed to confirm the experiments. It was found that LINC00152 was over-expressed in PC, and it predicted a poor prognosis. Besides, LINC00152 knockdown inhibited PC cell glycolysis. Moreover, LINC00152 could specifically targeted miR-185-5p. Meanwhile, LINC00152 exhaustion blocked PC cell glycolysis through the up-regulation of miR-185-5p. Lastly, LINC00152 inhibition targeted miR-185-5p to quench KLF7, therefore suppressing PC cell tumorigenesis and glycolysis. Collectively, our findings indicated that silencing LINC00152 restricted PC cell glycolysis promoting miR-185-5p and reducing KLF7.
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http://dx.doi.org/10.7150/jca.63128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489139PMC
August 2021
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