Publications by authors named "Haico van Attikum"

72Publications

Functional Characterization of Variants of Uncertain Significance: Toward Cancer Risk and Therapy Response Prediction.

Front Mol Biosci 2020 16;7:169. Epub 2020 Sep 16.

Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.

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http://dx.doi.org/10.3389/fmolb.2020.00169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7525363PMC
September 2020

DNA double-strand break repair: Putting zinc fingers on the sore spot.

Semin Cell Dev Biol 2020 Sep 19. Epub 2020 Sep 19.

Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2020.09.003DOI Listing
September 2020

A genetic interaction map centered on cohesin reveals auxiliary factors involved in sister chromatid cohesion in .

J Cell Sci 2020 May 22;133(10). Epub 2020 May 22.

Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, Netherlands

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http://dx.doi.org/10.1242/jcs.237628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325435PMC
May 2020

Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription.

J Biol Chem 2019 12 7;294(52):20122-20134. Epub 2019 Nov 7.

Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands

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http://dx.doi.org/10.1074/jbc.RA119.010302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937567PMC
December 2019

Bon voyage: A transcriptional journey around DNA breaks.

DNA Repair (Amst) 2019 10 7;82:102686. Epub 2019 Aug 7.

Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333ZC, Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2019.102686DOI Listing
October 2019

PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells.

Trends Cell Biol 2019 10 14;29(10):820-834. Epub 2019 Aug 14.

Leiden University Medical Center, Department of Human Genetics, Einthovenweg 20, 2333 ZC Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2019.07.008DOI Listing
October 2019

The CHD6 chromatin remodeler is an oxidative DNA damage response factor.

Nat Commun 2019 01 16;10(1):241. Epub 2019 Jan 16.

Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Departments of Biochemistry & Molecular Biology and/or Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.

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http://dx.doi.org/10.1038/s41467-018-08111-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335469PMC
January 2019

Meta-analysis of DNA double-strand break response kinetics.

Nucleic Acids Res 2017 Dec;45(22):12625-12637

Department of Medical Biology and Laboratory of Experimental Oncology and Radiobiology (LEXOR), Cancer Center Amsterdam, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.

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http://dx.doi.org/10.1093/nar/gkx1128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728399PMC
December 2017

Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 Mice.

Mol Ther Nucleic Acids 2017 Sep 29;8:232-242. Epub 2017 Jun 29.

Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.06.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504086PMC
September 2017

DNA repair goes hip-hop: SMARCA and CHD chromatin remodellers join the break dance.

Philos Trans R Soc Lond B Biol Sci 2017 Oct;372(1731)

Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands

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http://rstb.royalsocietypublishing.org/lookup/doi/10.1098/rs
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http://dx.doi.org/10.1098/rstb.2016.0285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577463PMC
October 2017

Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3.

Sci Rep 2016 10 12;6:35200. Epub 2016 Oct 12.

Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, 2333ZA Leiden, The Netherlands.

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http://www.nature.com/articles/srep35200
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http://dx.doi.org/10.1038/srep35200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059676PMC
October 2016

A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.

Mol Cell 2016 08 21;63(3):514-25. Epub 2016 Jul 21.

Division of Genetics, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA; Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA; The Cancer Cell Map Initiative. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5209245PMC
August 2016

Functional Analysis of Missense Variants in the Putative Breast Cancer Susceptibility Gene XRCC2.

Hum Mutat 2016 09 17;37(9):914-25. Epub 2016 Jun 17.

Department of Human Genetics, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands.

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http://dx.doi.org/10.1002/humu.23019DOI Listing
September 2016

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.

Nucleic Acids Res 2016 Apr 15;44(6):2976. Epub 2015 Dec 15.

Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands

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http://dx.doi.org/10.1093/nar/gkv1480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824094PMC
April 2016

Spatiotemporal regulation of posttranslational modifications in the DNA damage response.

EMBO J 2016 Jan 1;35(1):6-23. Epub 2015 Dec 1.

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://emboj.embopress.org/cgi/doi/10.15252/embj.201592595
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http://dx.doi.org/10.15252/embj.201592595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717999PMC
January 2016

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.

Nucleic Acids Res 2015 Aug 22;43(14):6919-33. Epub 2015 Jun 22.

Department of Human Genetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands

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http://dx.doi.org/10.1093/nar/gkv613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538816PMC
August 2015

Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair.

J Cell Biol 2014 Dec;207(6):717-33

Robson DNA Science Centre, Southern Alberta Cancer Research Institute; and Department of Biochemistry and Molecular Biology and Department of Oncology, Cumming School of Medicine; University of Calgary, Calgary, Alberta T2N 4N1, Canada Robson DNA Science Centre, Southern Alberta Cancer Research Institute; and Department of Biochemistry and Molecular Biology and Department of Oncology, Cumming School of Medicine; University of Calgary, Calgary, Alberta T2N 4N1, Canada Robson DNA Science Centre, Southern Alberta Cancer Research Institute; and Department of Biochemistry and Molecular Biology and Department of Oncology, Cumming School of Medicine; University of Calgary, Calgary, Alberta T2N 4N1, Canada

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http://dx.doi.org/10.1083/jcb.201405077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274264PMC
December 2014

Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.

Mol Cell 2015 Jan 18;57(2):273-89. Epub 2014 Dec 18.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland; Faculty of Sciences, University of Basel, 4056 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706562PMC
January 2015

Remodeling and spacing factor 1 (RSF1): a rising star in DNA repair.

Epigenomics 2014 Jun;6(3):261-5

Leiden University Medical Center, Department of Human Genetics, Einsteinweg 20, 2333ZC Leiden, The Netherlands.

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http://dx.doi.org/10.2217/epi.14.16DOI Listing
June 2014

A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.

Cell Rep 2013 Dec 19;5(6):1714-24. Epub 2013 Dec 19.

Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.11.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136507PMC
December 2013

Touching base with PARPs: moonlighting in the repair of UV lesions and double-strand breaks.

Trends Biochem Sci 2013 Jun 4;38(6):321-30. Epub 2013 Apr 4.

Department of Toxicogenetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://www.cell.com/trends/biochemical-sciences/pdf/S0968-00
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http://dx.doi.org/10.1016/j.tibs.2013.03.002DOI Listing
June 2013

The chromatin response to DNA breaks: leaving a mark on genome integrity.

Annu Rev Biochem 2013 14;82:55-80. Epub 2013 Feb 14.

Department of Toxicogenetics, Leiden University Medical Center, 2333 ZC Leiden, The Netherlands.

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http://dx.doi.org/10.1146/annurev-biochem-061809-174504DOI Listing
November 2013

Dissection of DNA damage responses using multiconditional genetic interaction maps.

Mol Cell 2013 Jan 27;49(2):346-58. Epub 2012 Dec 27.

Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, the Netherlands.

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http://dx.doi.org/10.1016/j.molcel.2012.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633480PMC
January 2013

Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling.

J Cell Sci 2013 Feb 21;126(Pt 4):889-903. Epub 2012 Dec 21.

Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.

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http://dx.doi.org/10.1242/jcs.109413DOI Listing
February 2013

SWI/SNF complex in disorder: SWItching from malignancies to intellectual disability.

Epigenetics 2012 Nov 25;7(11):1219-24. Epub 2012 Sep 25.

Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.4161/epi.22299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499322PMC
November 2012

The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection.

Nature 2012 Sep 9;489(7417):581-4. Epub 2012 Sep 9.

Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.

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http://dx.doi.org/10.1038/nature11353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493121PMC
September 2012

Close encounters of the RNF8th kind: when chromatin meets DNA repair.

Curr Opin Cell Biol 2012 Jun 29;24(3):439-47. Epub 2012 Mar 29.

Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.ceb.2012.03.008DOI Listing
June 2012

NuRD alert! NuRD regulates the DNA damage response.

Epigenomics 2011 Apr;3(2):133-5

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http://dx.doi.org/10.2217/epi.10.79DOI Listing
April 2011

Chromatin and the DNA damage response: the cancer connection.

Mol Oncol 2011 Aug 3;5(4):349-67. Epub 2011 Jul 3.

Department of Cell and Molecular Biology, Karolinska Institutet, von Eulers väg 3, S-17177 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.molonc.2011.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528312PMC
August 2011

Improved functional overview of protein complexes using inferred epistatic relationships.

BMC Syst Biol 2011 May 23;5:80. Epub 2011 May 23.

School of Computer Science and Informatics, University College Dublin, Ireland.

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http://dx.doi.org/10.1186/1752-0509-5-80DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117733PMC
May 2011

The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage.

J Cell Biol 2010 Sep 30;190(5):741-9. Epub 2010 Aug 30.

Department of Toxicogenetics, Leiden University Medical Center, Leiden 2300RC, Netherlands.

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http://dx.doi.org/10.1083/jcb.201001048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2935570PMC
September 2010

Mapping genomic targets of DNA helicases by chromatin immunoprecipitation in Saccharomyces cerevisiae.

Methods Mol Biol 2010 ;587:113-26

Department of Biochemistry and Molecular Biology, Southern Alberta Cancer Research Institute, University of Calgary, Calgary, AB, Canada.

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http://link.springer.com/10.1007/978-1-60327-355-8_8
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http://dx.doi.org/10.1007/978-1-60327-355-8_8DOI Listing
May 2010

Genome-wide association data reveal a global map of genetic interactions among protein complexes.

PLoS Genet 2009 Dec 24;5(12):e1000782. Epub 2009 Dec 24.

Department of Bioengineering, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1371/journal.pgen.1000782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788232PMC
December 2009

Crosstalk between histone modifications during the DNA damage response.

Trends Cell Biol 2009 May 1;19(5):207-17. Epub 2009 Apr 1.

Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, the Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S096289240900060
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http://dx.doi.org/10.1016/j.tcb.2009.03.001DOI Listing
May 2009

Regulation of nuclear positioning and dynamics of the silent mating type loci by the yeast Ku70/Ku80 complex.

Mol Cell Biol 2009 Feb 1;29(3):835-48. Epub 2008 Dec 1.

Laboratoire de Biologie Moléculaire Eucaryote, Bâtiment IBCG, Université de Toulouse, Toulouse, France.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01009-08
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http://dx.doi.org/10.1128/MCB.01009-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630671PMC
February 2009

The processing of double-strand breaks and binding of single-strand-binding proteins RPA and Rad51 modulate the formation of ATR-kinase foci in yeast.

J Cell Sci 2007 Dec 14;120(Pt 23):4209-20. Epub 2007 Nov 14.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1242/jcs.018366DOI Listing
December 2007

Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks.

EMBO J 2007 Sep 30;26(18):4113-25. Epub 2007 Aug 30.

Division of Epigenetics, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1038/sj.emboj.7601835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230671PMC
September 2007

Chromatin at the crossroads. Meeting on signalling to chromatin epigenetics.

EMBO Rep 2006 Dec 27;7(12):1206-10. Epub 2006 Oct 27.

Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Western Infirmary, Glasgow G11 6NT, UK.

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http://embor.embopress.org/cgi/doi/10.1038/sj.embor.7400834
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http://dx.doi.org/10.1038/sj.embor.7400834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794706PMC
December 2006

Yeast (Saccharomyces cerevisiae).

Methods Mol Biol 2006 ;344:465-73

Institute of Biology, Department of Molecular and Developmental Genetics, Leiden University, Clusius Laboratory, Leiden, The Netherlands.

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http://dx.doi.org/10.1385/1-59745-131-2:465DOI Listing
February 2007

The histone code at DNA breaks: a guide to repair?

Nat Rev Mol Cell Biol 2005 Oct;6(10):757-65

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058, Basel, Switzerland.

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http://www.nature.com/articles/nrm1737
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http://dx.doi.org/10.1038/nrm1737DOI Listing
October 2005

ATP-dependent chromatin remodeling and DNA double-strand break repair.

Cell Cycle 2005 Aug 2;4(8):1011-4. Epub 2005 Aug 2.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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https://www.tandfonline.com/doi/full/10.4161/cc.4.8.1887
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http://dx.doi.org/10.4161/cc.4.8.1887DOI Listing
August 2005

Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair.

Cell 2004 Dec;119(6):777-88

University of Geneva, Department of Molecular Biology and NCCR Frontiers in Genetics Program, Quai Ernest Ansermet 30, CH-1211 Geneva 4, Switzerland.

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http://dx.doi.org/10.1016/j.cell.2004.11.033DOI Listing
December 2004

The Arabidopsis AtLIG4 gene is required for the repair of DNA damage, but not for the integration of Agrobacterium T-DNA.

Nucleic Acids Res 2003 Jul;31(14):4247-55

Institute of Biology, Leiden University, Clusius Laboratory, Wassenaarseweg 64, 2333 AL, Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165973PMC
http://dx.doi.org/10.1093/nar/gkg458DOI Listing
July 2003

Genetic requirements for the targeted integration of Agrobacterium T-DNA in Saccharomyces cerevisiae.

Nucleic Acids Res 2003 Feb;31(3):826-32

Institute of Molecular Plant Sciences, Leiden University, Clusius Laboratory, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC149203PMC
http://dx.doi.org/10.1093/nar/gkg183DOI Listing
February 2003

Increased telomere length and hypersensitivity to DNA damaging agents in an Arabidopsis KU70 mutant.

Nucleic Acids Res 2002 Aug;30(15):3395-400

Institute of Molecular Plant Sciences, Sectie 2A, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC137071PMC
http://dx.doi.org/10.1093/nar/gkf445DOI Listing
August 2002

Insertional mutagenesis in yeasts using T-DNA from Agrobacterium tumefaciens.

Yeast 2002 Apr;19(6):529-36

Institute for Molecular Plant Sciences, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands.

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http://doi.wiley.com/10.1002/yea.858
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http://dx.doi.org/10.1002/yea.858DOI Listing
April 2002