Haian Fu

Haian Fu

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Haian Fu

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Acetylation regulates ribonucleotide reductase activity and cancer cell growth.

Nat Commun 2019 Jul 19;10(1):3213. Epub 2019 Jul 19.

Departments of Radiation Oncology, Emory University School of Medicine and Winship Cancer Institute of Emory University, 1365C Clifton Road NE, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1038/s41467-019-11214-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642173PMC
July 2019

Down-regulation of 14-3-3zeta reduces proliferation and increases apoptosis in human glioblastoma.

Cancer Gene Ther 2019 May 9. Epub 2019 May 9.

Department of Pharmacology and Winship Cancer Institute, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1038/s41417-019-0097-7DOI Listing
May 2019

HTiP: High-Throughput Immunomodulator Phenotypic Screening Platform to Reveal IAP Antagonists as Anti-cancer Immune Enhancers.

Cell Chem Biol 2019 Mar 10;26(3):331-339.e3. Epub 2019 Jan 10.

Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456183043
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http://dx.doi.org/10.1016/j.chembiol.2018.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501824PMC
March 2019

Identification of higenamine as a novel α -adrenergic receptor antagonist.

Phytother Res 2019 Mar 15;33(3):708-717. Epub 2019 Jan 15.

Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China.

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http://dx.doi.org/10.1002/ptr.6261DOI Listing
March 2019

Polyethylene-glycol-coated gold nanoparticles improve cardiac function after myocardial infarction in mice.

Can J Physiol Pharmacol 2018 Dec 1;96(12):1318-1327. Epub 2018 Nov 1.

a Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, 100191, China; Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, 100191, China; Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, 100191, China; Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, 100191, China.

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http://www.nrcresearchpress.com/doi/10.1139/cjpp-2018-0227
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http://dx.doi.org/10.1139/cjpp-2018-0227DOI Listing
December 2018

Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1.

J Mol Cell Biol 2018 12;10(6):549-558

Graduate Program in Cancer Biology, Emory University, Atlanta, GA, USA.

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https://academic.oup.com/jmcb/advance-article/doi/10.1093/jm
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http://dx.doi.org/10.1093/jmcb/mjy061DOI Listing
December 2018

Repositioning Dopamine D2 Receptor Agonist Bromocriptine to Enhance Docetaxel Chemotherapy and Treat Bone Metastatic Prostate Cancer.

Mol Cancer Ther 2018 09 15;17(9):1859-1870. Epub 2018 Jun 15.

Molecular Oncology and Biomarkers Program, Georgia Cancer Center, Augusta, Georgia.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-1176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125160PMC
September 2018

Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells in vitro and in vivo by inhibiting the EphA2/Akt signaling pathway.

Oncol Rep 2018 Sep 27;40(3):1339-1347. Epub 2018 Jun 27.

School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing 210023, P.R. China.

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http://dx.doi.org/10.3892/or.2018.6531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072400PMC
September 2018

BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma.

Cell Death Dis 2018 05 1;9(5):458. Epub 2018 May 1.

Department of Laboratory Medicine, Translational Cancer Research, Lund University, Medicon Village, Lund, Sweden.

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http://dx.doi.org/10.1038/s41419-018-0500-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913307PMC
May 2018

Dual gene activation and knockout screen reveals directional dependencies in genetic networks.

Nat Biotechnol 2018 02 15;36(2):170-178. Epub 2018 Jan 15.

Department of Microbiology and Immunology, University of California San Francisco Diabetes Center, WM Keck Center for Noncoding RNAs, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/nbt.4062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072461PMC
February 2018

BRET: NanoLuc-Based Bioluminescence Resonance Energy Transfer Platform to Monitor Protein-Protein Interactions in Live Cells.

Authors:
Xiu-Lei Mo Haian Fu

Methods Mol Biol 2016 ;1439:263-71

Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1007/978-1-4939-3673-1_17DOI Listing
December 2017

Regulation of ASK1 signaling by scaffold and adaptor proteins.

Adv Biol Regul 2017 Dec 16;66:23-30. Epub 2017 Oct 16.

Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University, Atlanta, GA 30322, USA; Graduate Program in Cancer Biology, Emory University, Atlanta, GA 30322, USA; Department of Hematology & Medical Oncology, Emory University, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.jbior.2017.10.003DOI Listing
December 2017

Screening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors.

Assay Drug Dev Technol 2017 Feb/Mar;15(2):53-63

1 Department of Pediatrics Infectious Diseases, Emory University School of Medicine , Atlanta, Georgia .

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http://dx.doi.org/10.1089/adt.2017.777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367911PMC
October 2017

Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.

J Med Chem 2017 09 18;60(17):7244-7255. Epub 2017 Aug 18.

Department of Pathology and Laboratory Medicine ‡Department of Pharmacology, Emory Chemical Biology Discovery Center Emory University School of Medicine Atlanta, Georgia 30322, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871875PMC
September 2017

2-Deoxyglucose Suppresses ERK Phosphorylation in LKB1 and Ras Wild-Type Non-Small Cell Lung Cancer Cells.

PLoS One 2016 29;11(12):e0168793. Epub 2016 Dec 29.

Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, P.R. China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168793PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5198974PMC
July 2017

Study on Inhibitory Effect of MaiMenDong Decoction and WeiJing Decoction Combination with Cisplatin on NCI-A549 Xenograft in Nude Mice and Its Mechanism.

J Cancer 2017 23;8(13):2449-2455. Epub 2017 Jul 23.

Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

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http://dx.doi.org/10.7150/jca.17720DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595074PMC
July 2017

AKT1, LKB1, and YAP1 Revealed as MYC Interactors with NanoLuc-Based Protein-Fragment Complementation Assay.

Mol Pharmacol 2017 04 13;91(4):339-347. Epub 2017 Jan 13.

Department of Pharmacology and Emory Chemical Biology Discovery Center (X.M., Q.Q., A.A.I., Q.N., Y.L., J.H., R.G., S.B., M.A.J., Y.D., H.F.) and Department of Biomedical Informatics (L.A.D.C.), Emory University School of Medicine, Atlanta, Georgia; Departments of Hematology and Medical Oncology (F.R.K., H.F.) and Pathology and Laboratory Medicine (C.S.M.) and Winship Cancer Institute, Emory University, Atlanta, Georgia; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China (Y.L.); and Department of Biomedical Engineering, Emory University School of Medicine/Georgia Institute of Technology, Atlanta, Georgia (L.A.D.C.)

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http://dx.doi.org/10.1124/mol.116.107623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363710PMC
April 2017

Aurora kinase A interacts with H-Ras and potentiates Ras-MAPK signaling.

Oncotarget 2017 Apr;8(17):28359-28372

Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, GA, USA.

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http://dx.doi.org/10.18632/oncotarget.15049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438655PMC
April 2017

Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment.

Cancer Cell 2016 10 22;30(4):623-636. Epub 2016 Sep 22.

Division of Hematology/Oncology, Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University School of Medicine, 1760 Haygood Drive, Atlanta, GA 30322, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079537PMC
http://dx.doi.org/10.1016/j.ccell.2016.08.015DOI Listing
October 2016

Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy in A549 cells.

Int J Oncol 2016 Jul 10;49(1):316-24. Epub 2016 May 10.

Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, P.R. China.

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http://dx.doi.org/10.3892/ijo.2016.3514DOI Listing
July 2016

Enabling systematic interrogation of protein-protein interactions in live cells with a versatile ultra-high-throughput biosensor platform.

J Mol Cell Biol 2016 06 16;8(3):271-81. Epub 2015 Nov 16.

Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, GA 30322, USA Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA

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https://academic.oup.com/jmcb/article-lookup/doi/10.1093/jmc
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http://dx.doi.org/10.1093/jmcb/mjv064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937889PMC
June 2016

LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion.

Mol Biol Cell 2016 Apr 10;27(7):1069-84. Epub 2016 Feb 10.

Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, GA 30322

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http://dx.doi.org/10.1091/mbc.E15-08-0569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814216PMC
April 2016

Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases.

J Biol Chem 2016 Feb 8;291(6):2631-46. Epub 2015 Dec 8.

From the Departments of Biochemistry, the Winship Cancer Institute, Emory University, Atlanta, Georgia 30322

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http://dx.doi.org/10.1074/jbc.M115.698449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742734PMC
February 2016

Transcriptional regulation of YWHAZ, the gene encoding 14-3-3ζ.

PLoS One 2014 1;9(4):e93480. Epub 2014 Apr 1.

Department of Pharmacology, Emory University, Atlanta, Georgia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093480PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972145PMC
December 2015

Downregulation of urea transporter UT-A1 activity by 14-3-3 protein.

Am J Physiol Renal Physiol 2015 Jul 20;309(1):F71-8. Epub 2015 May 20.

Renal Division, Department of Medicine, Emory University, School of Medicine, Atlanta, Georgia; Department of Physiology, Emory University, School of Medicine, Atlanta, Georgia; and

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http://ajprenal.physiology.org/content/ajprenal/309/1/F71.fu
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http://ajprenal.physiology.org/content/ajprenal/early/2015/0
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http://ajprenal.physiology.org/lookup/doi/10.1152/ajprenal.0
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http://dx.doi.org/10.1152/ajprenal.00546.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490382PMC
July 2015

Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog.

PLoS One 2014 30;9(9):e107876. Epub 2014 Sep 30.

School of life Sciences, Anhui University, Hefei, China; Center for Stem Cell and Translational Medicine, Anhui University, Hefei, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107876PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182433PMC
June 2015

Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways.

J Cancer 2015 23;6(7):623-31. Epub 2015 May 23.

1. The Pre-clinical Medicine College, Nanjing University of Chinese Medicine, Nanjing 210023, China ; 2. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China.

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http://dx.doi.org/10.7150/jca.11291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4466411PMC
June 2015

Interview with Haian Fu, PhD.

Assay Drug Dev Technol 2015 Jun;13(5):249-53

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http://dx.doi.org/10.1089/adt.2015.29004.hfuDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507085PMC
June 2015

High-Throughput HIV-Cell Fusion Assay for Discovery of Virus Entry Inhibitors.

Assay Drug Dev Technol 2015 Apr 14;13(3):155-66. Epub 2015 Apr 14.

1 Division of Pediatric Infectious Diseases, Emory University Children's Center , Atlanta, Georgia .

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http://dx.doi.org/10.1089/adt.2015.639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410757PMC
April 2015

Glycyrrhetinic acid induces G1‑phase cell cycle arrest in human non‑small cell lung cancer cells through endoplasmic reticulum stress pathway.

Int J Oncol 2015 Mar 8;46(3):981-8. Epub 2015 Jan 8.

Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, P.R. China.

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http://dx.doi.org/10.3892/ijo.2015.2819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324580PMC
March 2015

Stress induces p38 MAPK-mediated phosphorylation and inhibition of Drosha-dependent cell survival.

Mol Cell 2015 Feb;57(4):721-734

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502444PMC
February 2015

Synthetic curcumin analog UBS109 inhibits the growth of head and neck squamous cell carcinoma xenografts.

Curr Cancer Drug Targets 2014 ;14(4):380-93

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.

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January 2015

Cables1 complex couples survival signaling to the cell death machinery.

Cancer Res 2015 Jan 31;75(1):147-158. Epub 2014 Oct 31.

Department of Hematology & Medical Oncology and Winship Cancer Institute, Emory University, Atlanta, Georgia 30322.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-0036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617824PMC
January 2015

The Emory Chemical Biology Discovery Center: leveraging academic innovation to advance novel targets through HTS and beyond.

Comb Chem High Throughput Screen 2014 Mar;17(3):290-6

Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.2174/1386207317666140109125415DOI Listing
March 2014

Ligands for glaucoma-associated myocilin discovered by a generic binding assay.

ACS Chem Biol 2014 Feb 9;9(2):517-25. Epub 2013 Dec 9.

School of Chemistry & Biochemistry, Georgia Institute of Technology , 901 Atlantic Drive NW, Atlanta, Georgia 30332-0400, United States.

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http://pubs.acs.org/doi/10.1021/cb4007776
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http://dx.doi.org/10.1021/cb4007776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944078PMC
February 2014

Expression Profiling and Proteomic Analysis of JIN Chinese Herbal Formula in Lung Carcinoma H460 Xenografts.

Evid Based Complement Alternat Med 2013 20;2013:160168. Epub 2013 Aug 20.

College of Basic Medicine and School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, China.

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http://dx.doi.org/10.1155/2013/160168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770002PMC
September 2013

Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma.

Org Biomol Chem 2013 Aug 20;11(29):4757-63. Epub 2013 Jun 20.

Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, Virginia, USA.

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http://dx.doi.org/10.1039/c3ob40595hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089070PMC
August 2013

p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms.

Mol Cell Biol 2013 Jul 22;33(13):2574-85. Epub 2013 Apr 22.

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1128/MCB.01677-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700113PMC
July 2013

Targeting protein-protein interactions as an anticancer strategy.

Trends Pharmacol Sci 2013 Jul 29;34(7):393-400. Epub 2013 May 29.

Department of Pharmacology, Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.tips.2013.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773978PMC
July 2013

A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors.

Assay Drug Dev Technol 2013 Jul 1;11(6):367-81. Epub 2013 Aug 1.

Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1089/adt.2013.507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751221PMC
July 2013

Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.

J Biol Chem 2013 May 27;288(19):13215-24. Epub 2013 Mar 27.

Departments of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322, USA.

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http://www.jbc.org/content/288/19/13215.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M113.463679
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http://dx.doi.org/10.1074/jbc.M113.463679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650361PMC
May 2013

Biological activity evaluation and structure-activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer.

Bioorg Med Chem Lett 2012 Oct 16;22(19):6085-8. Epub 2012 Aug 16.

Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210046, China.

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http://dx.doi.org/10.1016/j.bmcl.2012.08.038DOI Listing
October 2012

Identification of blapsins A and B as potent small-molecule 14-3-3 inhibitors from the insect Blaps japanensis.

Bioorg Med Chem Lett 2012 Jun 12;22(12):4179-81. Epub 2012 Apr 12.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.

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http://dx.doi.org/10.1016/j.bmcl.2012.04.027DOI Listing
June 2012

14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function.

FEBS Lett 2012 Apr 23;586(8):1111-9. Epub 2012 Mar 23.

School of Life Sciences, Anhui University, Hefei, Anhui 230039, China.

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http://doi.wiley.com/10.1016/j.febslet.2012.03.018
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http://dx.doi.org/10.1016/j.febslet.2012.03.018DOI Listing
April 2012

Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C kinases.

J Biol Chem 2012 Feb 3;287(9):6113-27. Epub 2012 Jan 3.

Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1074/jbc.M111.293605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307261PMC
February 2012

A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin.

J Biomol Screen 2011 Sep 21;16(8):836-44. Epub 2011 Jun 21.

The Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://journals.sagepub.com/doi/10.1177/1087057111411088
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http://dx.doi.org/10.1177/1087057111411088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677475PMC
September 2011

14-3-3 proteins as potential therapeutic targets.

Semin Cell Dev Biol 2011 Sep 1;22(7):705-12. Epub 2011 Oct 1.

Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.semcdb.2011.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3207012PMC
September 2011

A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.

Assay Drug Dev Technol 2011 Aug 11;9(4):382-93. Epub 2011 Mar 11.

Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1089/adt.2010.0292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148108PMC
August 2011

Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication.

J Virol 2011 Jul 20;85(13):6381-9. Epub 2011 Apr 20.

McIntyre Medical Sciences Building, Rm. 810, 3655 Promenade Sir William Osler, McGill University, Montreal, Quebec, Canada H3G 1Y6.

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http://dx.doi.org/10.1128/JVI.00078-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126520PMC
July 2011

14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination.

Nat Struct Mol Biol 2010 Sep 22;17(9):1124-35. Epub 2010 Aug 22.

Institute for Immunology, School of Medicine and School of Biological Sciences, University of California, Irvine, California, USA.

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http://dx.doi.org/10.1038/nsmb.1884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645988PMC
September 2010

Trichoderone, a novel cytotoxic cyclopentenone and cholesta-7, 22-diene-3 beta, 5 alpha, 6 beta-triol, with new activities from the marine-derived fungus Trichoderma sp.

J Ind Microbiol Biotechnol 2010 Mar;37(3):245-52

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 510663 Guangzhou, People's Republic of China.

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http://link.springer.com/10.1007/s10295-009-0667-z
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http://dx.doi.org/10.1007/s10295-009-0667-zDOI Listing
March 2010

14-3-3{eta} Amplifies Androgen Receptor Actions in Prostate Cancer.

Clin Cancer Res 2009 Dec;15(24):7571-7581

Authors' Affiliations: Departments of Pediatrics (Laboratories for Reproductive Biology), Surgery (Division of Urology) and Pathology and Laboratory Medicine, Biochemistry and Biophysics, and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina; Department of Urologic Oncology, Roswell Park Cancer Institute, and Department of Urology, University at Buffalo School of Medicine and Biotechnology, Buffalo, New York; and Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-1976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795092PMC
December 2009

Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins.

Biochem Biophys Res Commun 2009 Nov 2;389(3):455-60. Epub 2009 Sep 2.

Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.08.165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311924PMC
November 2009

Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.

J Biol Chem 2009 Sep 10;284(36):24512-25. Epub 2009 Jul 10.

Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1074/jbc.M109.026237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782043PMC
September 2009

14-3-3zeta mediates resistance of diffuse large B cell lymphoma to an anthracycline-based chemotherapeutic regimen.

J Biol Chem 2009 Aug 12;284(33):22379-89. Epub 2009 Jun 12.

Department of Molecular and Cellular Medicine, The Texas A&M Health Science Center, College Station, Texas 77840-1114, USA.

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http://dx.doi.org/10.1074/jbc.M109.022418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755960PMC
August 2009

Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening.

Mol Cancer Ther 2009 Mar 24;8(3):563-70. Epub 2009 Feb 24.

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, 201 Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727710PMC
March 2009

How does arrestin assemble MAPKs into a signaling complex?

J Biol Chem 2009 Jan 10;284(1):685-95. Epub 2008 Nov 10.

Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA.

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http://dx.doi.org/10.1074/jbc.M806124200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610502PMC
January 2009

Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy.

Cancer Biol Ther 2008 Dec 8;7(12):1952-8. Epub 2008 Dec 8.

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762753PMC
http://dx.doi.org/10.4161/cbt.7.12.6944DOI Listing
December 2008

Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation.

Cancer Res 2008 Sep;68(18):7409-18

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562339PMC
September 2008