Publications by authors named "Hai-bo Wang"

295 Publications

The hospitalization burden of inflammatory bowel disease in China: a nationwide study from 2013 to 2018.

Therap Adv Gastroenterol 2022 13;15:17562848221102307. Epub 2022 Jun 13.

Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, No. 58 Zhongshan Second Road, Guangzhou 510080, P.R. China.

Background: The past decade has witnessed a dramatic increase in the number of patients with inflammatory bowel disease (IBD) in China. The nationwide burden of hospitalization remains unclear, however. We aimed to address this gap by conducting analysis using a nationwide database.

Methods: Population-based hospitalization rates from 2013 to 2018 were calculated by extrapolating the number of patients in the database to the national level. Surgical rates, annual hospital charges, and length of stay were also used for quantification of hospitalization burden. The Poisson regression analysis and the Cochran-Armitage trend test were conducted to analyze temporal trends as expressed as annual percentage of change (APC) with 95% confidential intervals (CIs).

Results: From 2013 to 2018, the hospitalization rates for Crohn's disease (CD) and ulcerative colitis (UC) in China increased from 2.20 (95% CI = 2.17-2.22) to 3.62 (3.59-3.65) per 100,000 inhabitants ( < 0.0001) with an APC of 10.68% (6.00-15.36%) and from 6.24 (6.20-6.28) to 8.29 (8.23-8.33) per 100,000 inhabitants ( < 0.0001) with an APC of 5.73% (2.32-9.15%), respectively. Surgical rates decreased from 7.96% (7.29-8.63%) to 5.56% (5.11-6.00%) for CD patients ( < 0.0001) with APC of -6.30% (-11.33 to -1.27%) and from 3.54% (3.26-3.82%) to 2.52% (2.32-2.72%) for UC patients ( < 0.0001) with APC of -6.35% (-16.21 to 3.51). In 2018, there were estimated 166,000 IBD patients hospitalized costing a total of $426.37 million ($149.91 + $276.46 million) across the entire China.

Conclusion: The population-based hospitalization rate of IBD increased, whereas the surgical rate decreased from 2013 to 2018 in China.
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http://dx.doi.org/10.1177/17562848221102307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201315PMC
June 2022

Trends and sex differences in atrial fibrillation hospitalization and catheter ablation at tertiary hospitals in China from 2013 to 2016.

J Geriatr Cardiol 2022 Apr;19(4):292-300

Department of Cardiology, Peking University First Hospital, Beijing, China.

Background: Catheter ablation for atrial fibrillation (AF) is commonly performed worldwide. However, the clinical characteristics of hospitalized patients with AF and national trends in catheter ablation at tertiary hospitals in China remain unreported.

Methods: This study used the Chinese national database (Hospital Quality Monitoring System) from 2013 to 2016, which is a mandatory database that collects the front page of patients' medical records for hospital accreditation, to describe the clinical characteristics of patients with AF as an overall cohort and as subgroups divided by catheter ablation and sex.

Results: Of 597,919 AF patients first admitted, 57,983 patients underwent catheter ablation [56,384 cases (97.2%) of radiofrequency ablation and 1599 cases (2.8%) of cryoablation] at 746 tertiary hospitals. Nearly 10% of patients hospitalized with AF at tertiary hospitals in China underwent catheter ablation, and the percentage of patients undergoing catheter ablation was on the rise between 2013 and 2016, and the number of cases increased by 2.5 times. Compared with AF patients who did not undergo catheter ablation, those who did were younger, more frequently male, and had fewer baseline comorbidities. Although the overall CHADSVASc score revealed over half of the patients were high-risk, patients who underwent catheter ablation were mostly low-risk (71.2% of males and 59.1% of females). Considering in-hospital adverse events, the overall pericardial tamponade and all-cause death incidences were 0.2% (0.6% in the ablation group) and 1.2% (0.1% in the ablation group), respectively; both of which were higher in females than males.

Conclusions: In this study, AF patients who underwent catheter ablation were relatively young, had a low thrombosis risk, and had few comorbidities and adverse events. Females were older and experienced more complications than males.
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http://dx.doi.org/10.11909/j.issn.1671-5411.2022.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068587PMC
April 2022

Gastric bronchogenic cyst misdiagnoses as a gastrointestinal stromal tumor pre-operative: A case report.

Asian J Surg 2022 May 5. Epub 2022 May 5.

Department of General Surgery, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200011, China. Electronic address:

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http://dx.doi.org/10.1016/j.asjsur.2022.04.067DOI Listing
May 2022

Should we tolerate biased critiques in cardiothoracic surgery journals?

J Thorac Cardiovasc Surg 2022 May 5. Epub 2022 May 5.

Division of Cardiothoracic Surgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.

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http://dx.doi.org/10.1016/j.jtcvs.2022.03.033DOI Listing
May 2022

Deeds Speak Louder than Biased Critiques.

Ann Thorac Surg 2022 May 4. Epub 2022 May 4.

Division of Cardiothoracic Surgery Department of Surgery The Chinese University of Hong Kong Prince of Wales Hospital Hong Kong, China. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2022.04.032DOI Listing
May 2022

Transcriptome Analysis of Apples in High-Temperature Treatments Reveals a Role of MdLBD37 in the Inhibition of Anthocyanin Accumulation.

Int J Mol Sci 2022 Mar 29;23(7). Epub 2022 Mar 29.

National Key Laboratory of Crop Biology, National Research Center for Apple Engineering and Technology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an 271018, China.

Coloring in apple fruit due to anthocyanin accumulation is inhibited by high temperature; however, the underlying mechanism remains unclear. In the present study, total anthocyanin and cyanidin 3-galactoside contents were determined and compared between cv. 'Redchief Delicious' apple fruits at 25 °C and 35 °C treatments. The high temperature (35 °C) treatment substantially decreased total anthocyanin and cyanidin 3-galactoside contents. The transcriptomes of 25 °C- and 35 °C-treated apples were analyzed by high-throughput RNA sequencing. A total of 8354 differentially expressed genes (DEGs) were detected at four time points corresponding to the two temperature treatments. The up-regulated DEGs were annotated using GO as well as KEGG databases. A network module of 528 genes (including 21 transcription factors) most associated with the total anthocyanin and cyanidin 3-galactoside contents was constructed by weighted correlation network analysis (WGCNA). In the WGCNA module, we unearthed a LOB domain-containing gene designated as . The expression of was sharply up-regulated by high temperature and negatively correlated with the total anthocyanin and cyanidin 3-galactoside contents. Overexpression of in apple fruit and calli decreased the expression of anthocyanin biosynthetic genes, such as , , , , , and , along with anthocyanin accumulation. Our results suggested that significantly influenced the high-temperature inhibition of anthocyanin accumulation in apples. The findings shed more light on the mechanism of anthocyanin inhibition during high-temperature stress in apples.
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http://dx.doi.org/10.3390/ijms23073766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998508PMC
March 2022

Effects of Breast-Conserving Surgery Combined with Immediate Autologous Fat Grafting on Oncologic Safety, Satisfaction and Psychology in Patients with Breast Cancer: A Retrospective Cohort Study.

Cancer Manag Res 2022 10;14:1113-1124. Epub 2022 Mar 10.

Department of Breast Disease Center, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, People's Republic of China.

Purpose: Autologous fat grafting (AFG) is a technique that can improve the appearance of breasts in surgical patients. There are currently few studies on breast-conserving surgery (BCS) combined with immediate AFG, although we believe that it could achieve satisfactory effects. Therefore, the purpose of this study is to observe the effects of BCS combined with immediate AFG on oncologic safety, satisfaction and psychology of breast cancer patients.

Patients And Methods: We retrospectively collected the data of 85 breast cancer patients from February 2018 to October 2018. After screening, 40 patients in AFG group (AG, BCS combined with immediate AFG) and 40 patients in control group (CG, BCS alone) were finally included in the study. The primary outcomes were the survival, tumor recurrence and metastasis, and BREAST-Q score of patients. The secondary outcomes were short and long-term complications, degree of depression and anxiety of patients.

Results: A total of 80 patients were included in the analysis. There was no significant difference in the clinicopathological data between the two groups (>0.05). The average follow-up time of the two groups was 40.58±2.630 and 40.28±2.679 months. In the analysis of oncologic safety, no patients died in AG and 1 patient died in CG. In addition, there was no significant difference between the two groups in terms of the overall recurrence rate and the distribution of recurrence types (>0.05). As for satisfaction, the BREAST-Q score of AG was significantly higher than that of CG (57.85±4.833 vs 51.93±5.045, <0.001). In the secondary outcomes, there was no short-term complication specified in the study; in the long-term complications, the incidence of calcification in AG was not significantly higher than that in CG (=0.065). In the analysis of depression and anxiety, there was no significant difference between the two groups (>0.05).

Conclusion: BCS combined with immediate AFG can significantly improve patients' satisfaction without increasing the risk of death and tumor recurrence. However, it does not seem to play a role in improving the conditions of depression and anxiety.
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http://dx.doi.org/10.2147/CMAR.S353370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8921672PMC
March 2022

Icarisid II rescues cognitive dysfunction via activation of Wnt/β-catenin signaling pathway promoting hippocampal neurogenesis in APP/PS1 transgenic mice.

Phytother Res 2022 May 1;36(5):2095-2108. Epub 2022 Mar 1.

School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China.

Restoring the compromised neurogenesis has been served as a potential strategy to rescue cognitive dysfunction of Alzheimer's disease (AD). In this study, we explored whether icarisid II (ICS II), a natural product possessing powerful neuroprotection, could recover the neurogenesis dysfunction of APP/PS1 mice, and investigated its underlying mechanisms. Our results showed that oral administration of ICS II could alleviate cognitive injuries of APP/PS1 mice, promote hippocampal neurogenesis, as well as stimulate Wnt/β-catenin signal pathway confirmed by upregulated Wnt-3a, phosphorylated glycogen synthase kinase-3β (p-GSK-3β), and β-catenin. ICS II also depressed mitochondrial fission evidenced by upregulated Mitofusin 1 (Mfn 1) and Mitofusin 2 (Mfn 2), and downregulated mitochondrial fission 1 protein (Fis 1), mitochondrial fission factor (Mff), and phosphorylated dynamin-related protein 1 (p-Drp 1). However, these effects of ICS II were blunted by XAV-939, an inhibitor of Wnt/β-catenin signaling pathway. In summary, our findings revealed that ICS II could improve neurogenesis and inhibit mitochondrial fission via activation of the Wnt/β-catenin signaling pathway, which contributed to cognitive function restoration of APP/PS1 mice. This study discovered a novel mechanism involving neurogenesis regulation underlying the therapeutic effects of ICS II against AD.
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http://dx.doi.org/10.1002/ptr.7430DOI Listing
May 2022

Apple MdMYB306-like inhibits anthocyanin synthesis by directly interacting with MdMYB17 and MdbHLH33.

Plant J 2022 05 21;110(4):1021-1034. Epub 2022 Mar 21.

State Key Laboratory of Crop Biology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai'an, Shandong, 271018, China.

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http://dx.doi.org/10.1111/tpj.15720DOI Listing
May 2022

Glutathione-stabilized copper nanoclusters mediated-inner filter effect for sensitive and selective determination of p-nitrophenol and alkaline phosphatase activity.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Apr 25;271:120948. Epub 2022 Jan 25.

College of Chemistry and Chemical Engineering, Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang Key Laboratory of Functional Nanomaterials for Bioanalysis, Xinyang Normal University, Xinyang 464000, China.

A simple and highly selective fluorescence biosensor has been exploited for p-nitrophenol (p-NP) and alkaline phosphatase (ALP) activity detection based on the glutathione-stabilized copper nanoclusters (GSH-CuNCs) mediated-inner filter effect (IFE). The GSH-CuNCs were prepared by employing GSH as stabilizer and ascorbic acid (AA) as reductant. The obtained GSH-CuNCs exhibited a strong blue fluorescence emission at 420 nm with an excitation wavelength of 365 nm, which overlapped largely with the absorption spectra of p-nitrophenol (p-NP). Therefore, the luminescence of GSH-CuNCs could be quenched by p-NP through inner filter effect. In addition, ALP catalyzed the substrate p-nitrophenyl phosphate (p-NPP) to form p-nitrophenol (p-NP), which also leading to the fluorescence quenching of GSH-CuNCs. The fluorescent strategy was realized for the sensitive determination of p-NP and ALP activity with the promising limit of detection of 20 nM (for p-NP) and 0.003 mU⋅mL (for ALP). Furthermore, the method could be applied to detect the p-NP content in river water samples and ALP activity in human serum samples.
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http://dx.doi.org/10.1016/j.saa.2022.120948DOI Listing
April 2022

Efficacy and Safety of Albumin-Bound Paclitaxel Compared to Docetaxel as Neoadjuvant Chemotherapy for HER2-Negative Breast Cancer.

Front Oncol 2021 11;11:760655. Epub 2022 Jan 11.

Breast Center, The Affiliated Hospital of Qingdao University, Qingdao, China.

Background: Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) as neoadjuvant chemotherapy (NAC) for breast cancer remains controversial. We conducted a retrospective study to compare the efficacy and safety of nab-paclitaxel with those of docetaxel as neoadjuvant regimens for HER2-negative breast cancer.

Methods: In this retrospective analysis, a total of 159 HER2-negative breast cancer patients who had undergone operation after NAC were consecutively analyzed from May 2016 to April 2018. Patients were classified into the nab-paclitaxel group (n = 79, nab-paclitaxel 260 mg/m, epirubicin 75 mg/m, and cyclophosphamide 500 mg/m) and the docetaxel group (n = 80, docetaxel 75 mg/m, epirubicin 75 mg/m, and cyclophosphamide 500 mg/m) according to the drug they received for neoadjuvant treatment. The efficacy and adverse events were evaluated in the two groups.

Results: The pathological complete response (pCR)(ypT0isN0) rate was significantly higher in the nab-paclitaxel group than in the docetaxel group (36.71% vs 20.00%; = 0.031). The multivariate analysis revealed that therapeutic drugs, lymph node status, and tumor subtype were the most significant factor influencing treatment outcome. At a median follow-up of 47 months, disease-free survival (DFS) was not significantly different in those assigned to nab-paclitaxel compared with docetaxel (82.28% vs 76.25%; = 0.331). The incidence of peripheral sensory neuropathy in the nab-paclitaxel group was higher than that in the docetaxel group (60.76% vs 36.25%; = 0.008), while the incidence of arthralgia was observed more frequently in the docetaxel group (57.50% vs 39.97%; = 0.047).

Conclusions: Compared with docetaxel, nab-paclitaxel achieved a higher pCR rate, especially those patients with triple-negative breast cancer or lymph node negative breast cancer. However, there was no significant difference in DFS between the two groups. This study provides a valuable reference for the management of patients with HER2-negative breast cancer.
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http://dx.doi.org/10.3389/fonc.2021.760655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8787090PMC
January 2022

Efficacy and safety of hospital-based group medical quarantine for dialysis patients exposed to coronavirus disease 2019.

Chin Med J (Engl) 2022 Jan 4. Epub 2022 Jan 4.

Department of Nephrology, Peking University People's Hospital, Beijing 100044, China Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing 100044, China China National Health Development Research Center, Beijing 100044, China Department of Obstetrics and Gynecology, Peking University People's Hospital, Beijing 100044, China Xicheng District Center for Disease Prevention and Control, Beijing 100120, China Urology and Lithotripsy Center, Peking University People's Hospital, Beijing 100044, China Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing 100044, China Department of Orthopedic Oncology, Peking University People's Hospital, Beijing 100044, China Peking University Hepatology Institute and Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University People's Hospital, Beijing 100044, China Department of Infection Prevention & Control, Peking University People's Hospital, Beijing 100044, China Department of Development, Peking University People's Hospital, Beijing 100044, China Department of Clinical Nutrition, Peking University People's Hospital, Beijing 100044, China Department of Medical Affair Administration, Peking University People's Hospital, Beijing 100044, China Department of Continuing Medical Education, Peking University People's Hospital, Beijing 100044, China Logistics Department, Peking University People's Hospital, Beijing 100044, China Administration Office, Peking University People's Hospital, Beijing 100044, China Peking University Clinical Research Institute, Beijing 100191, China.

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http://dx.doi.org/10.1097/CM9.0000000000001862DOI Listing
January 2022

Relationship Between Lifestyle Habits and Health-Related Quality of Life of Recently Diagnosed Breast Cancer Patients: A Comparison Between Younger and Older Women in China.

Front Public Health 2021 14;9:767151. Epub 2021 Dec 14.

Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

The aim of this study was to evaluate the relationship between lifestyle habits and health-related quality of life (HRQoL) among different ages who were initially diagnosed with breast cancer (within the first 2 weeks) and to determine the contribution of lifestyle habits factors on HRQoL. Patients with breast cancer were recruited from 22 hospitals in 11 provinces or municipalities in northern and eastern China. The Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B) was used to measure HRQoL. Chi-square test, ANOVA, and multivariable generalized linear models were conducted to identify the differences in HRQoL between two age groups (age <50 years and ≥50 years) and to evaluate the contribution of lifestyle habits factors on HRQoL of patients with breast cancer. About 1,199 eligible patients with breast cancer were used for analysis. Younger women (aged <50 years) appeared to show lower scores than older women (aged ≥50 years) in HRQoL subscales, including emotional well-being ( = 0.003), functional well-being ( = 0.006), breast cancer subscale ( = 0.038), and FACT-B Total scores ( = 0.028). Tea and alcohol consumption and being very satisfied with sleep and current life were the strongest predictors of higher HRQoL in younger group. Meanwhile, no coffee consumption, frequent participation in physical activities, high sleep satisfaction, and current life satisfaction were the key predictors of higher HRQoL in older women with breast cancer. The relationship of the nine lifestyle habit items with HRQoL differed among younger and older women. The associated variable of low HRQoL can help clinicians take intervention early in order to improve the prognosis of patients with breast cancer.
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http://dx.doi.org/10.3389/fpubh.2021.767151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714764PMC
April 2022

Treatment and Survival Outcomes Associated With Platinum Plus Low-Dose, Long-term Fluorouracil for Metastatic Nasopharyngeal Carcinoma.

JAMA Netw Open 2021 12 1;4(12):e2138444. Epub 2021 Dec 1.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.

Importance: The treatment of metastatic nasopharyngeal carcinoma (mNPC) is a major challenge because of drug resistance and the toxic effects of chemotherapy.

Objective: To evaluate the survival and toxicity outcomes and safety associated with the use of a modified low-dose fluorouracil protocol compared with standard regimens recommended in current guidelines for treatment of mNPC.

Design, Setting, And Participants: This retrospective cohort study was based on data retrieved from electronic medical records from Sun Yat-sen University Cancer Center in China for 1397 patients with mNPC diagnosed from January 1, 2006, to December 31, 2017. Data analyses were conducted from October 1, 2020, to May 1, 2021.

Exposures: Patients received chemotherapy, including platinum plus low-dose, long-term fluorouracil (PFLL); cisplatin plus standard dose, short-term fluorouracil (PFSS); cisplatin plus gemcitabine (GP); cisplatin plus taxane (TP); and cisplatin plus taxane plus fluorouracil (TPF).

Main Outcomes And Measures: The main outcomes included overall survival (OS); subsequent-line, treatment-free survival (sTFS), defined as the period from metastasis to the date requiring subsequent-line treatment or death; and the survival to toxicity ratio (STR), defined as person-year rate of OS divided by person-year rate of severe hematologic toxic effects. Cox regression models were used to compare the outcomes of patients receiving PFLL vs other regimens, adjusting for baseline characteristics.

Results: Of 1397 patients with mNPC included in this study (1152 men; median age, 46 years [range, 18-70 years]) 134 received PFLL, 203 received GP, 330 received PFSS, 366 received TP, and 364 received TPF. A total of 764 patients died (75 in treatment group PFLL; 107 in group GP; 204 in group PFSS; 207 in group TP; and 171 in group TPF), and 979 patients had subsequent-line treatment or died, whichever occurred first (PFLL, 77; GP, 144; PFSS, 262; TP, 269; and TPF, 227). The median follow-up was 46.9 months (IQR, 25.4-82.4 months), and the 5-year OS rate among patients who received PFLL was 25.4% (95% CI, 16.7%-38.8%), which was not significantly different from that among patients who did not receive PFLL (30.2%; 95% CI, 27.1%-33.5%; P = .13) or who received GP (25.1%; 95% CI, 18.1%-35.0%; P = .81), PFSS (23.6%; 95% CI, 18.5%-30.0%; P = .80), or TP (28.1%; 95% CI, 22.8%-34.7%; P = .99) but was lower than that for patients who received TPF (40.4%; 95% CI, 34.7%-47.1%; P = .001). The 5-year sTFS among patients who received PFLL (24.1%; 95% CI, 15.4%-37.6%) was significantly higher than that among patients who did not receive PFLL (18.5%; 95% CI, 16.1%-21.3%; P = .005) or who received GP (14.3%; 95% CI, 9.1%-22.5%; P = .001) but similar to that for patients who received TPF (28.0%; 95% CI, 23.0%-34.0%; P = .74). The STR of PFLL was 0.81, substantially better than that of GP (0.41) and TPF (0.65).

Conclusions And Relevance: The results of this cohort study suggest that, compared with the use of standard treatment regimens, administration of PFLL was associated with similar OS but prolonged sTFS. PFLL also had better STR than other regimens, which could indicate less severe toxic effects. Thus, PFLL may be an option for first-line treatment of mNPC.
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http://dx.doi.org/10.1001/jamanetworkopen.2021.38444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8669524PMC
December 2021

Achieving WHO's Goal for Reducing Cesarean Section Rate in a Chinese Hospital.

Front Med (Lausanne) 2021 22;8:774487. Epub 2021 Nov 22.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

To address the worldwide dramatically increased Cesarean section (CS) rate in the past decades, WHO has recommended the CS rate should not be higher than 10-15%. Whether it is achievable remains unknown. We collected the data of delivery from 2008 to 2017 in two typical regional hospitals in China: Longhua Hospital (national policies rigorously implemented) and Dongguan Hospital (national policies not rigorously implemented). We compared between the two hospitals the 10 years trend in annual rate of CS, standardized by age, education level, parity, and CS history, against the time of issuing relevant national, local, and hospital policies. In 10 years, 42,441 women in Longhua and 36,935 women in Dongguan have given birth. China's first national policy on CS reduction was issued in 2010 and the formal relaxation of one-child policy was issued in 2015-2016. In Longhua, the standardized annual CS rate was around 35% in 2008-2009, which declined sharply since 2010 down to 13.1% in 2016 ( < 0.001) and then leveled off. In contrast, in Dongguan, the rate stayed around 25% at the beginning, increased to 36% in 2011, decreased sharply to 27% in 2012, and leveled off until 2015 ( < 0.001), and then bounced back to 35% in 2017. The proportion of women with the history of CS increased significantly in the two hospitals (both roughly from 6% before 2010 to 20% after 2015). Analyses stratified by modified Robson classification showed that CS rates reduced in all risk classes of delivery women in Longhua but only in the Robson class 2 group in Dongguan. Major complications did not differ by hospital. With vigorously implementing national policies at micro levels, the WHO-recommended CS rate could be achieved without increase in major complications.
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http://dx.doi.org/10.3389/fmed.2021.774487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8645788PMC
November 2021

Quantum-illumination-inspired active single-pixel imaging with structured illumination.

Appl Opt 2021 Nov;60(32):10151-10159

Quantum-illumination-inspired single-pixel imaging (QII-SPI) or computational ghost imaging protocol is proposed to improve image quality in the presence of strong background and stray light. According to the reversibility of the optical path, a digital micro-mirror device acts as a structured light modulator and a spatial light filter simultaneously, which can effectively eliminate 50% of stray light. Accompanied by a 6 dB gain of detection signal-to-noise ratio under an equivalent loss condition, our scheme only requires a simple and minor modification on the placement of the single-pixel detector based on the original SPI system. Since QII-SPI will obtain almost the same reconstruction results as the passive SPI technology in principle, one can, therefore, adjust the placement position of the detector, without exchanging the relative position of the detector and the light source to realize the flexible conversion of the SPI system from active to passive. Also, this work initially discusses the influence of relative coherence time on Hadamard-based SPI driven by a thermal source. This work brings new insights into the optical path design of the SPI technology, paving the way for the practical application of active SPI in stray light environments.
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http://dx.doi.org/10.1364/AO.438642DOI Listing
November 2021

Neoadjuvant Chemotherapy in Synchronous Bilateral Breast Cancer With Different HER2 Types.

Am J Ther 2021 Nov-Dec 01;28(6):e769-e772

Department of Breast Center, Affiliated Hospital of Qingdao University, Shandong Province, China.

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http://dx.doi.org/10.1097/MJT.0000000000000895DOI Listing
January 2022

Turning waste into treasure: chicken eggshell membrane derived fluorescent carbon nanodots for the rapid and sensitive detection of Hg and glutathione.

Analyst 2021 Nov 22;146(23):7250-7256. Epub 2021 Nov 22.

College of Chemistry and Chemical Engineering, Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang Key Laboratory of Functional Nanomaterials for Bioanalysis, Xinyang Normal University, Xinyang 464000, PR China.

Herein, a green, economical, and waste-utilization approach is reported for the synthesis of water-soluble carbon nanodots (C-Dots) with a high fluorescence quantum yield of 19.5%. As a common protein-rich waste, eggshell membrane was selected as a cost-effective and ideal precursor to prepare C-Dots using the microwave method. The as-prepared C-Dots showed a maximum emission at 375 nm with an excitation wavelength at 235 nm. The fluorescent C-Dots were adopted as a sensitive probe for the rapid detection of Hg and glutathione (GSH) based on the fluorescence off and on (turn-off-on) strategy. This was ascribed to the fact that Hg could effectively quench the fluorescence of the C-Dots and GSH was able to prevent fluorescence quenching owing to the specific binding between Hg and GSH. The designed method exhibited a high sensitivity and selectivity towards the detection of Hg and GSH. Under the optimized conditions, the method showed a good linear relationship with Hg concentration in the range from 100 nM to 50 μM with a detection limit of 32.0 nM. For GSH detection, it displayed a linear range from 50 nM to 10 μM with a detection limit of 9.8 nM. Moreover, this method was successfully applied to detect GSH in human serum samples. The eggshell derived fluorescent C-Dots pave the way for economical environmental and biological analyses.
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http://dx.doi.org/10.1039/d1an01582fDOI Listing
November 2021

Ghost panorama using a convex mirror.

Opt Lett 2021 Nov;46(21):5389-5392

Computational ghost imaging or single-pixel imaging enables the image formation of an unknown scene using a lens-free photodetector. In this Letter, we present a computational panoramic ghost imaging system that can achieve a full-color panorama using a single-pixel photodetector, where a convex mirror performs the optical transformation of the engineered Hadamard-based circular illumination pattern from unidirectionally to omnidirectionally. To our best knowledge, it is the first time to propose the concept of ghost panoramas and realize preliminary experimentations. It is foreseeable that ghost panoramas will have more advantages in imaging and detection in many extreme conditions (e.g., scattering/turbulence and unconventional spectra), as well as broad application prospects.
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http://dx.doi.org/10.1364/OL.441938DOI Listing
November 2021

Long-Term Effect of Early Post-operative Transcutaneous Electrical Stimulation on Voiding Function After Radical Hysterectomy: A Multicenter, Randomized, Controlled Trial.

Front Med (Lausanne) 2021 30;8:677029. Epub 2021 Sep 30.

Department of OB/Gyn, Peking University People's Hospital, Beijing, China.

Post-radical-hysterectomy (RH) patients suffer from a series of problems resulting from neurovascular injury, such as bladder dysfunction, which reduce their quality of life. We have designed this study to evaluate the efficacy of transcutaneous electrical stimulation (TENS) on patient rehabilitation after RH for early cervical cancer. A total of 97 patients were enrolled in a randomized-controlled trial (from January 2015 to December 2019) involving 7 medical centers nationwide. Patients were assigned to either the intervention group ( = 46), or the control group ( = 51). TENS was given to patients in the intervention group from the 7 day after surgery for a total of 14-21 days. The control group received no TENS. Primary outcomes were measured for residual urine volume and recovery of urination function. Secondary outcomes were measures for urodynamics (UDS), pelvic floor electromyography function examination (PFEmF), and quality of life (QoL). Residual urine volume and improvement in the rate of urination were found to show no significant differences on the 14, 21, and 28 days after surgery. The maximum flow rate (Qmax) in the intervention group was significantly higher than that in the control group on the 28 day, but there were no significant differences in average flow rate, voiding time, time to Qmax, muscle fiber strength, muscle fiber fatigue, and the abnormal rate of A3 reflection on the 28 day and the 3 mo., as well as in the QoL at 3 mo., 6 mo., and 12 mo. after surgery. Our study showed no sufficient evidence to prove that TENS under the trialed parameters could improve the subject's voiding function, PFEmF, and QOL after RH. This has provided valuable data for rehabilitation after RH. www.ClinicalTrials.gov, identifier: NCT02492542.
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http://dx.doi.org/10.3389/fmed.2021.677029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514959PMC
September 2021

Research on the prognosis of different types of microvessels in bladder transitional cell carcinoma.

World J Clin Cases 2021 Sep;9(25):7381-7390

Department of Urology Surgery, Dalian Municipal Friendship Hospital, Dalian 116001, Liaoning Province, China.

Background: At present, there is controversy on the role of microvessel density (MVD) in tumors as a prognostic indicator of bladder transitional cell carcinoma (BTCC). However, the MVD in tumors is simply classified based on the expression of several different vascular markers, which has not been related to analytical research on the prognosis of patients with BTCC.

Aim: To explore the classification of blood vessels in tumors and studied the relationship between MVD and the prognosis of patients with BTCC.

Methods: The tissue mass was detected by tissue microarray and immunohistochemical analysis with monoclonal antibodies against CD31, CD34, CD105, and vascular smooth muscle actin to investigate the MVD in BTCC. The measurement data are expressed as the mean ± SD. The difference between the groups was analyzed by the -test, the counting data were analyzed by test. The Kaplan-Meier survival curve was estimated by the product-limit method. The log-rank time-series test was employed to compare the tumor-free survival curves.

Results: The MVD was closely related to the pathological grade, invasive depth, and prognosis of BTCC. Significant differences were found between grade I and grade II, grade II and grade III, superficial and invasive type, and the tumor-free survival group and the recurrence or metastasis group ( < 0.01). Multivariate analysis showed that undifferentiated MVD was an independent prognostic factor for patient survival time. An inverse correlation between undifferentiated tumor MVD and differentiated tumor MVD in BTCC was also shown.

Conclusion: The classification of blood vessels in BTCC could act as an important prognostic indicator and may also be of great significance in the treatment of cancer.
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http://dx.doi.org/10.12998/wjcc.v9.i25.7381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464470PMC
September 2021

Comparison of clinical outcomes of tracheotomy in patients with acute cervical spinal cord injury at different timing.

Clin Neurol Neurosurg 2021 11 16;210:106947. Epub 2021 Sep 16.

Department of Intensive Care Unit, Affiliated Haian Hospital of Nantong University, Nantong 226001, China. Electronic address:

Respiratory failure is the leading cause of early death after acute CSCI. Tracheotomy is an effective approach to reduce mortality and improve the clinical outcomes. However, the optimal timing for tracheotomy remains controversial. Hence, the study aimed to compare the clinical outcomes of tracheotomy in patients with acute cervical spinal cord injury (CSCI) at different timing. A retrospectively review was performed of acute CSCI patients who underwent tracheotomy in the intensive care unit of Haian Hospital between January 2014 and June 2019. 124 CSCI patients were included and stratified into three groups based on the timing of tracheotomy: early group (≤4 days from initial intubation), medium group (4-10 days from initial intubation), and late group (≥10 days from initial intubation). The clinical outcomes and functional outcomes were analyzed. No significant intergroup differences in baseline characteristics were observed. The late group needed significantly longer duration of mechanical ventilation, longer ICU stay, and suffered higher ICU mortality, higher pneumonia after tracheotomy than the early and medium groups. More patients in the early and medium groups successfully weaned from mechanical ventilation. The early and medium groups achieved better improvement of JOA and NDI scores than the late group at one year after surgery and at the final follow-up. Early to medium term tracheotomy may lead to better clinical and functional outcomes in patients with acute CSCI who require prolonged mechanical ventilation.
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http://dx.doi.org/10.1016/j.clineuro.2021.106947DOI Listing
November 2021

Using random forest to detect multiple inherited metabolic diseases simultaneously based on GC-MS urinary metabolomics.

Talanta 2021 Dec 19;235:122720. Epub 2021 Jul 19.

Yuncheng Maternal and Child Health Hospital, Yuncheng, Shanxi, 044000, PR China.

Inborn errors of metabolism, also known as inherited metabolic diseases (IMDs), are related to genetic mutations and cause corresponding biochemical metabolic disorder of newborns and even sudden infant death. Timely detection and diagnosis of IMDs are of great significance for improving survival of newborns. Here we propose a strategy for simultaneously detecting six types of IMDs via combining GC-MS technique with the random forest algorithm (RF). Clinical urine samples from IMD and healthy patients are analyzed using GC-MS for acquiring metabolomics data. Then, the RF model is established as a multi-classification tool for the GC-MS data. Compared with the models built by artificial neural network and support vector machine, the results demonstrated the RF model has superior performance of high specificity, sensitivity, precision, accuracy, and matthews correlation coefficients on identifying all six types of IMDs and normal samples. The proposed strategy can afford a useful method for reliable and effective identification of multiple IMDs in clinical diagnosis.
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http://dx.doi.org/10.1016/j.talanta.2021.122720DOI Listing
December 2021

Effects of Decompressive Cervical Surgery on Blood Pressure in Cervical Spondylosis Patients With Hypertension: A Time Series Cohort Study.

Int J Spine Surg 2021 Aug 15;15(4):683-691. Epub 2021 Jul 15.

Peking University Clinical Research Institute, Peking University First Hospital, Beijing, China.

Background: The blood pressure of cervical spondylosis (CS) patients with hypertension often returns to normal after decompressive cervical surgery (DCS). However, the effect of DCS on the blood pressure of patients with CS has not been rigorously studied.

Methods: We recruited 50 consecutive CS patients with hypertension from 2014-2017 and investigated the changes in blood pressure after DCS using a time series design. Ambulatory blood pressure monitoring (ABPM) was performed at 3 and 0 days before DCS and at 30 and 90 days after DCS. The primary outcome was mean 24-hour systolic blood pressure (SBP). Secondary outcomes included mean 24-hour diastolic blood pressure (DBP), office blood pressure, and the percentage of patients on antihypertensive medication. Paired test was used for assessing the changes in blood pressure over time and a McNemar test was used for comparison among different medication groups.

Results: The mean 24-hour SBP did not vary significantly among 4 time points (134.5 ± 14.7, 132.8 ± 14.7, 131.5 ± 13.3, and 133.2 ± 14.6, respectively; = .42). The mean 24-hour DBP showed a similar trend. However, mean office SBP/DBP decreased significantly from 142.5/82.0 mm Hg before surgery to 127.3/76.6 mm Hg after surgery (both < .01). The corresponding percentage of patients on antihypertensive medication decreased significantly, from 84% to 54% ( < .01).

Conclusions: This study confirmed previous findings of reduction in office blood pressure associated with DCS among CS patients with hypertension. However, this was not confirmed by multiple-time series of 24-hour ABPM.

Level Of Evidence: 3.
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http://dx.doi.org/10.14444/8090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8375702PMC
August 2021

L-Histidine-DNA interaction: a strategy for the improvement of the fluorescence signal of poly(adenine) DNA-templated gold nanoclusters.

Mikrochim Acta 2021 05 26;188(6):198. Epub 2021 May 26.

College of Chemistry and Chemical Engineering, Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang Normal University, Xinyang, 464000, People's Republic of China.

An interesting phenomenon is described that the fluorescence signal of poly(adenine) (A) DNA-templated gold nanoclusters (AuNCs) is greatly improved in the presence of L-histidine by means of L-histidine-DNA interaction. The modified nanoclusters display strong fluorescence emission with excitation/emission maxima at 290/475 nm. The fluorescence quantum yield (QY) is improved from 1.9 to 6.5%. Fluorescence enhancement is mainly ascribed to the L-histidine-DNA interaction leading to conformational changes of the poly(A) DNA template, which offer a better microenvironment to protect AuNCs. The assay enables L-histidine to be determined with good sensitivity and a linear response that covers the 1 to 50 nM L-histidine concentration range with a 0.3 nM limit of detection. The proposed method has been applied to the determination of imidazole-containing drugs in pharmaceutical samples. A turn-on fluorescent method has been designed for the sensitive detection of L-histidine as well as imidazole-containing drugs on the basis of the L-histidine-DNA interaction.
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http://dx.doi.org/10.1007/s00604-021-04853-7DOI Listing
May 2021

A comparison of non-intubated video-assisted thoracic surgery with spontaneous ventilation and intubated video-assisted thoracic surgery: a meta-analysis based on 14 randomized controlled trials.

J Thorac Dis 2021 Mar;13(3):1624-1640

Department of Thoracic Surgery, Affiliated Hospital of Hebei University, Baoding, China.

Background: Video-assisted thoracic surgery (VATS) generally involves endotracheal intubation under general anesthesia. However, inevitably, this may cause intubation-related complications and prolong the postoperative recovery process. Gradually, non-intubated video-assisted thoracic surgery (NIVATS) is increasingly being utilized. However, its safety and efficacy remain controversial.

Methods: Randomized controlled trials (RCTs) published up to August 2020 were selected from the Cochrane Library, Web of Science, PubMed, Embase, and ClinicalTrials.gov databases and included in this study according to the inclusion criteria. Two reviewers screened these RCTs and independently extracted the relevant data. After assessing the risk of bias in these RCTs, a meta-analysis was performed using Review Manager 5.3. Pooled data were meta-analyzed using a random-effects model.

Results: Meta-analysis data demonstrated that the mean difference (MD) in the length of hospital stay between non-intubated patients and intubated patients was -1.41 days, with a 95% confidence interval (CI) of -2.47 to -0.34 (P=0.01). The visual analogue scale (VAS) score between the two groups showed a MD of -0.34 (95% CI: -0.58 to -0.10; P=0.006). Patients who underwent NIVATS presented with lower rates of overall complications [odds ratio (OR) 0.41; 95% CI: 0.25 to 0.67; P=0.0004], air leak (OR 0.45; 95% CI: 0.24 to 0.87; P=0.02), pharyngeal discomfort (OR 0.08; 95% CI: 0.04 to 0.17; P<0.00001), hoarseness (OR 0.06; 95% CI: 0.02 to 0.21; P<0.00001), and gastrointestinal reactions (OR 0.23; 95% CI: 0.10 to 0.53; P=0.0005) compared to intubated patients. The anesthesia satisfaction scores in the NIVATS group were significantly higher than those of the VATS group (MD 0.50; 95% CI: 0.12 to 0.88; P=0.009). However, there were no statistically significant differences in the length of operation time (MD 0.90 hours; 95% CI: -0.23 to 2.03; P=0.12) and surgical field satisfaction (1 point) (OR 0.73; 95% CI: 0.34 to 1.59; P=0.43) between the two groups.

Conclusions: NIVATS is a safe and feasible form of intervention that can reduce the postoperative pain and complications of various systems and shorten hospital stay duration without prolonging the operation time.
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http://dx.doi.org/10.21037/jtd-20-3039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8024812PMC
March 2021

Associations Between Elevated Systolic Blood Pressure and Outcomes in Critically Ill Patients: A Retrospective Cohort Study and Propensity Analysis.

Shock 2021 10;56(4):557-563

First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, China.

Introduction: Studies have shown nonlinear relationships between systolic blood pressure (SBP) and outcomes, with increased risk observed at both low and high blood pressure levels. However, the relationships between cumulative times at different SBP levels and outcomes in critically ill patients remain unclear. We hypothesized that an appropriate SBP level is associated with a decrease in adverse outcomes after intensive care unit (ICU) admission.

Methods: This study was a retrospective analysis of data from the Medical Information Mart for Intensive Care (MIMIC) III database, which includes more than 1,000,000 SBP records from 12,820 patients. Associations of cumulative times at four SBP ranges (<100 mm Hg, 100-120 mm Hg, 120-140 mm Hg, and ≥140 mm Hg) with mortality (12-, 3-, 1-month mortality and in-hospital mortality) were evaluated. Restricted cubic splines and multivariable Cox regression models were employed to assess associations between mortality and cumulative times at SBP levels (4 levels: <2, 2-12, 12-36, and ≥36 h) over 72 h of ICU admission. Additionally, 120 mm Hg to 140 mm Hg was subdivided into <12 h (Group L) and ≥12 h (Group M) subsets and subjected to propensity-score matching and subgroup analyses.

Results: At 120 mm Hg to 140 mm Hg, level-4 SBP was associated with lower adjusted risks of mortality at 12 months (OR, 0.71; CI, 0.61-0.81), 3 months (OR, 0.72; CI, 0.61-0.85), and 1 month (OR, 0.61; CI, 0.48-0.79) and in the hospital (OR, 0.71; CI, 0.58-0.88) than level-1 SBP. The cumulative times at the other 3 SBP ranges (<100 mm Hg, 100-120 mm Hg, and ≥140 mm Hg) were not independent risk predictors of prognosis. Furthermore, Group M had lower 12-month mortality than Group L, which remained in the propensity-score matched and subgroup analyses.

Conclusions: SBP at 120 mm Hg to 140 mm Hg was associated with decreased adverse outcomes. Randomized trials are required to determine whether the outcomes in critically ill patients improve with early maintenance of a SBP level at 120 mm Hg to 140 mm Hg.
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http://dx.doi.org/10.1097/SHK.0000000000001774DOI Listing
October 2021

XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi-center study.

Cancer Med 2021 04 18;10(8):2752-2762. Epub 2021 Mar 18.

Department of Breast Surgery, Yantai Yuhuangding Hospital, Yantai, China.

Background: X-ray repair cross-complementary 5 (XRCC5) and 6 (XRCC6) are critical for DNA repair. Few studies have assessed their association with breast cancer risk, and related gene-environment interactions remain poorly understood. This study aimed to determine the influence of XRCC5/6 polymorphisms on breast cancer risk, and their interactions with cigarette smoking, alcohol consumption, and sleep satisfaction.

Methods: The study included 1039 patients with breast cancer and 1040 controls. Four single-nucleotide polymorphisms of XRCC5 and two of XRCC6 were genotyped. Information about smoking, alcohol consumption, and sleep satisfaction was collected through questionnaires. Odds ratios (OR) and related 95% confidence intervals (95% CI) were assessed using unconditional logistic regression models. Gene-environment interactions were analyzed using logistic regression with multiplicative interaction models.

Results: XRCC5 rs16855458 was associated with increased breast cancer risk in the co-dominant (p  = 0.003) and dominant (CA + AA vs. CC, OR = 1.29, 95% CI = 1.07-1.56, p = 0.008) genetic models after Bonferroni correction. The CG + GG genotype of XRCC6 rs2267437 was associated with an increased risk of estrogen receptor-negative/progesterone receptor-negative (ER-/PR-) breast cancer (CG + GG vs. CC: OR = 1.54, 95% CI = 1.12-2.13, p = 0.008) after Bonferroni correction. Moreover, an antagonistic interaction between XRCC5 rs16855458 and alcohol consumption (p  = 0.017), and a synergistic interaction between XRCC6 rs2267437 and sleep satisfaction were associated with breast cancer risk (p  = 0.0497). However, these interactions became insignificant after Bonferroni correction.

Conclusion: XRCC5 rs16855458 was associated with breast cancer risk, and XRCC6 rs2267437 was associated with the risk of ER-/PR- breast cancer. Breast cancer risk associated with XRCC5 and XRCC6 polymorphisms might vary according to alcohol consumption and sleep satisfaction, respectively, and merit further investigation.
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http://dx.doi.org/10.1002/cam4.3847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8026916PMC
April 2021

Preventing forgery attacks in computational ghost imaging or disabling ghost imaging in a "spatiotemporal" scattering medium with weighted multiplicative signals.

Appl Opt 2021 Feb;60(5):1092-1098

The ghost imaging (GI) approach is an intriguing and promising image acquisition technique that can transmit high-quality image information in a scattering environment. In this paper, we focus on two concerns recently emerged in the GI modality: one is the vulnerability to forgery attacks in GI-based optical encryption [Opt. Lett.45, 3917 (2020)OPLEDP0146-959210.1364/OL.392424], and the other is the potential threat of GI to personal privacy regarding non-invasive imaging [Opt. Express28, 17232 (2020)OPEXFF1094-408710.1364/OE.391788]. The core idea is to recommend introducing weighted multiplicative signals [Opt. Express27, 36505 (2019)OPEXFF1094-408710.1364/OE.27.036505] into the computational GI system, whether on the transmitting end or the receiving end. At the transmitting end, the random multiplicative signal can be used as an additional key that can reduce the possibility of forgery attacks, thereby increasing image transmission security. On the receiving end, the introduction of a random multiplicative signal to a spatial scattering medium makes it a "spatiotemporal" scattering medium, whose transmittance changes with time. Further, the spatiotemporal scattering medium can disable direct imaging and GI at the same time with low cost, thereby having great potential in privacy protection in daily lives.
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http://dx.doi.org/10.1364/AO.415608DOI Listing
February 2021

Chronic Respiratory Diseases and the Outcomes of COVID-19: A Nationwide Retrospective Cohort Study of 39,420 Cases.

J Allergy Clin Immunol Pract 2021 07 6;9(7):2645-2655.e14. Epub 2021 Mar 6.

State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.

Background: Chronic respiratory diseases (CRD) are common among patients with coronavirus disease 2019 (COVID-19).

Objectives: We sought to determine the association between CRD (including disease overlap) and the clinical outcomes of COVID-19.

Methods: Data of diagnoses, comorbidities, medications, laboratory results, and clinical outcomes were extracted from the national COVID-19 reporting system. CRD was diagnosed based on International Classification of Diseases-10 codes. The primary endpoint was the composite outcome of needing invasive ventilation, admission to intensive care unit, or death within 30 days after hospitalization. The secondary endpoint was death within 30 days after hospitalization.

Results: We included 39,420 laboratory-confirmed patients from the electronic medical records as of May 6, 2020. Any CRD and CRD overlap was present in 2.8% and 0.2% of patients, respectively. Chronic obstructive pulmonary disease (COPD) was most common (56.6%), followed by bronchiectasis (27.9%) and asthma (21.7%). COPD-bronchiectasis overlap was the most common combination (50.7%), followed by COPD-asthma (36.2%) and asthma-bronchiectasis overlap (15.9%). After adjustment for age, sex, and other systemic comorbidities, patients with COPD (odds ratio [OR]: 1.71, 95% confidence interval [CI]: 1.44-2.03) and asthma (OR: 1.45, 95% CI: 1.05-1.98), but not bronchiectasis, were more likely to reach to the composite endpoint compared with those without at day 30 after hospitalization. Patients with CRD were not associated with a greater likelihood of dying from COVID-19 compared with those without. Patients with CRD overlap did not have a greater risk of reaching the composite endpoint compared with those without.

Conclusion: CRD was associated with the risk of reaching the composite endpoint, but not death, of COVID-19.
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http://dx.doi.org/10.1016/j.jaip.2021.02.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935669PMC
July 2021
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