Hai-Liang Zhu

Hai-Liang Zhu

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Hai-Liang Zhu

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Synthesis, anticancer activity and molecular docking studies on 1,2-diarylbenzimidazole analogues as anti-tubulin agents.

Bioorg Chem 2019 Nov 26;92:103219. Epub 2019 Aug 26.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.103219DOI Listing
November 2019

Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing piperazine as inhibitors of PI3Kα.

Bioorg Chem 2019 Nov 30;92:103238. Epub 2019 Aug 30.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.103238DOI Listing
November 2019

Tubulin inhibitors binding to colchicine-site: A Review from 2015 to 2019.

Curr Med Chem 2019 Oct 3. Epub 2019 Oct 3.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023. China.

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http://dx.doi.org/10.2174/0929867326666191003154051DOI Listing
October 2019

Advances in pharmacological activities and mechanisms of glycyrrhizic acid.

Curr Med Chem 2019 Oct 11. Epub 2019 Oct 11.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences,Nanjing University. China.

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http://dx.doi.org/10.2174/0929867325666191011115407DOI Listing
October 2019

Introducing Broadened Antibacterial Activity to Rhodanine Derivatives Targeting Enoyl-Acyl Carrier Protein Reductase.

Chem Pharm Bull (Tokyo) 2019 ;67(2):125-129

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University.

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http://dx.doi.org/10.1248/cpb.c18-00663DOI Listing
September 2019

An umbelliferone-derivated fluorescent sensor for selective detection of palladium(II) from palladium(0) in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Sep 15;220:117134. Epub 2019 May 15.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.saa.2019.05.039DOI Listing
September 2019

Design, synthesis and biological evaluation of 2-H pyrazole derivatives containing morpholine moieties as highly potent small molecule inhibitors of APC-Asef interaction.

Eur J Med Chem 2019 Sep 26;177:425-447. Epub 2019 May 26.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.05.056DOI Listing
September 2019

Design, synthesis, biological evaluation of benzoyl amide derivatives containing nitrogen heterocyclic ring as potential VEGFR-2 inhibitors.

Bioorg Med Chem 2019 Sep 4;27(17):3813-3824. Epub 2019 Jul 4.

Zhengzhou Children's Hospital, ZZ 450018, China; State Key Laboratory of Pharmaceutical Biotechnology, NJ 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.07.007DOI Listing
September 2019

A patent review of RAF kinase inhibitors (2010-2018).

Expert Opin Ther Pat 2019 Sep 6;29(9):675-688. Epub 2019 Aug 6.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University , Nanjing , People's Republic of China.

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http://dx.doi.org/10.1080/13543776.2019.1651842DOI Listing
September 2019

Recent progress in the small-molecule fluorescent probes for the detection of sulfur dioxide derivatives (HSO/SO).

Free Radic Biol Med 2019 Sep 13;145:42-60. Epub 2019 Sep 13.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.09.007DOI Listing
September 2019

Discovery of novel oxoindolin derivatives as atypical dual inhibitors for DNA Gyrase and FabH.

Bioorg Chem 2019 Sep 21;93:103309. Epub 2019 Sep 21.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.103309DOI Listing
September 2019

Research Progress of Glycyrrhizic Acid on Antiviral Activity.

Mini Rev Med Chem 2019 ;19(10):826-832

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, No. 163 Xianlin Road, Nanjing 210023, China.

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http://dx.doi.org/10.2174/1389557519666190119111125DOI Listing
August 2019

A patent review of BRAF inhibitors: 2013-2018.

Expert Opin Ther Pat 2019 Aug 13;29(8):595-603. Epub 2019 Jul 13.

a Henan provincial key laboratory of children's genetics and metabolic diseases, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital , Zhengzhou 450018 , China.

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http://dx.doi.org/10.1080/13543776.2019.1640680DOI Listing
August 2019

Imaging Dynamic Peroxynitrite Fluxes in Epileptic Brains with a Near-Infrared Fluorescent Probe.

Adv Sci (Weinh) 2019 Aug 11;6(15):1900341. Epub 2019 Jun 11.

School of Chemistry and Materials Science Nanjing Normal University Wenyuan Road 1 Nanjing 210046 China.

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http://dx.doi.org/10.1002/advs.201900341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685465PMC
August 2019

Development of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates bearing sulfonylpiperazine as antitumor inhibitors targeting PI3Kα.

Eur J Med Chem 2019 Aug 18;182:111630. Epub 2019 Aug 18.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.111630DOI Listing
August 2019

Discovery of novel bacterial FabH inhibitors (Pyrazol-Benzimidazole amide derivatives): Design, synthesis, bioassay, molecular docking and crystal structure determination.

Eur J Med Chem 2019 Jun 14;171:209-220. Epub 2019 Mar 14.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234193024
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http://dx.doi.org/10.1016/j.ejmech.2019.03.026DOI Listing
June 2019

Design, synthesis and biological evaluation of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates containing sulfonamido as potential PI3Kα inhibitors.

Bioorg Med Chem 2019 Jun 15;27(11):2261-2267. Epub 2019 Apr 15.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.04.021DOI Listing
June 2019

Design, synthesis, and biological evaluation of 2,3-diphenyl-cycloalkyl pyrazole derivatives as potential tubulin polymerization inhibitors.

Chem Biol Drug Des 2019 May 20. Epub 2019 May 20.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1111/cbdd.13565DOI Listing
May 2019

Discovery and development of novel rhodanine derivatives targeting enoyl-acyl carrier protein reductase.

Bioorg Med Chem 2019 Apr 21;27(8):1509-1516. Epub 2019 Feb 21.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.02.043DOI Listing
April 2019

A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe.

Eur J Med Chem 2019 Feb 17;163:896-910. Epub 2018 Dec 17.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183106
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http://dx.doi.org/10.1016/j.ejmech.2018.12.030DOI Listing
February 2019

Synthesis, biological evaluation and molecular docking of benzimidazole grafted benzsulfamide-containing pyrazole ring derivatives as novel tubulin polymerization inhibitors.

Bioorg Med Chem 2019 02 23;27(3):502-515. Epub 2018 Dec 23.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183167
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http://dx.doi.org/10.1016/j.bmc.2018.12.031DOI Listing
February 2019

Optimization techniques for novel c-Met kinase inhibitors.

Expert Opin Drug Discov 2019 Jan 5;14(1):59-69. Epub 2018 Dec 5.

b State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences , Nanjing University , Nanjing , China.

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http://dx.doi.org/10.1080/17460441.2019.1551355DOI Listing
January 2019

Dihydropyrazothiazole derivatives as potential MMP-2/MMP-8 inhibitors for cancer therapy.

Bioorg Med Chem Lett 2018 12 3;28(23-24):3816-3821. Epub 2018 May 3.

Department of Pesticide Science, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183039
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http://dx.doi.org/10.1016/j.bmcl.2018.05.004DOI Listing
December 2018

Identification and Biological Evaluation of Novel Type II B-Raf Inhibitors.

ChemMedChem 2018 12 8;13(23):2558-2566. Epub 2018 Nov 8.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, P.R. China.

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http://doi.wiley.com/10.1002/cmdc.201800574
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http://dx.doi.org/10.1002/cmdc.201800574DOI Listing
December 2018

Optimization of substituted cinnamic acyl sulfonamide derivatives as tubulin polymerization inhibitors with anticancer activity.

Bioorg Med Chem Lett 2018 12 25;28(23-24):3634-3638. Epub 2018 Oct 25.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183084
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http://dx.doi.org/10.1016/j.bmcl.2018.10.037DOI Listing
December 2018

A fluorescent sensor for discrimination of HSA from BSA through selectivity evolution.

Anal Chim Acta 2018 Dec 8;1043:123-131. Epub 2018 Sep 8.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, China; Institute of Chemistry and Biomedical Science, Nanjing University, Nanjing, 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2018.09.010DOI Listing
December 2018

A new selective fluorescence probe with a quinoxalinone structure (QP-1) for cysteine and its application in live-cell imaging.

Talanta 2018 Nov 20;189:629-635. Epub 2018 Jul 20.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00399140183077
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http://dx.doi.org/10.1016/j.talanta.2018.07.064DOI Listing
November 2018

Isoliquiritigenin (ISL) and its formulations: potential antitumor agents.

Curr Med Chem 2018 Nov 11. Epub 2018 Nov 11.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023. China.

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http://dx.doi.org/10.2174/0929867325666181112091700DOI Listing
November 2018

Developing potential Helicobacter pylori urease inhibitors from novel oxoindoline derivatives: Synthesis, biological evaluation and in silico study.

Bioorg Med Chem Lett 2018 10 25;28(19):3182-3186. Epub 2018 Aug 25.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.08.025DOI Listing
October 2018

Design, synthesis and biological evaluation of novel ferrocene-pyrazole derivatives containing nitric oxide donors as COX-2 inhibitors for cancer therapy.

Eur J Med Chem 2018 Sep 22;157:909-924. Epub 2018 Aug 22.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.08.048DOI Listing
September 2018

A rapid cell-permeating turn-on probe for sensitive and selective detection of sulfite in living cells.

Org Biomol Chem 2018 09;16(37):8318-8324

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, China.

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http://dx.doi.org/10.1039/c8ob01908hDOI Listing
September 2018

A Review: The Anti-inflammatory, Anticancer, Antibacterial Properties of Four Kinds of Licorice Flavonoids Isolated from Licorice.

Curr Med Chem 2018 Sep 30. Epub 2018 Sep 30.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023. China.

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http://www.eurekaselect.com/165760/article
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http://dx.doi.org/10.2174/0929867325666181001104550DOI Listing
September 2018

Resolution and evaluation of 3-chlorophenyl-3-hydroxypropionylhydroxamic acid as antivirulence agent with excellent eradication efficacy in Helicobacter pylori infected mice.

Eur J Pharm Sci 2018 08 31;121:293-300. Epub 2018 May 31.

National Demonstration Center for Experimental Chemistry Education, Hunan Engineering Laboratory for Analyse and Drugs Development of Ethnomedicine in Wuling Mountains, Jishou University, Jishou 416000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09280987183025
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http://dx.doi.org/10.1016/j.ejps.2018.05.029DOI Listing
August 2018

Design, synthesis, and biological evaluation of pyrazole derivatives containing acetamide bond as potential BRAF inhibitors.

Bioorg Med Chem Lett 2018 08 15;28(14):2382-2390. Epub 2018 Jun 15.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.06.028DOI Listing
August 2018

The synthesis and evaluation of phenoxyacylhydroxamic acids as potential agents for Helicobacter pylori infections.

Bioorg Med Chem 2018 08 4;26(14):4145-4152. Epub 2018 Jul 4.

National Demonstration Center for Experimental Chemistry Education, Hunan Engineering Laboratory for Analyse and Drugs Development of Ethnomedicine in Wuling Mountains, Jishou University, Jishou 416000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.07.003DOI Listing
August 2018

Arylamino containing hydroxamic acids as potent urease inhibitors for the treatment of Helicobacter pylori infection.

Eur J Med Chem 2018 Aug 2;156:126-136. Epub 2018 Jul 2.

National Demonstration Center for Experimental Chemistry Education, Hunan Engineering Laboratory for Analyse and Drugs Development of Ethnomedicine in Wuling Mountains, Jishou University, Jishou, 416000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.06.065DOI Listing
August 2018

Design and biological evaluation of novel hybrids of 1, 5-diarylpyrazole and Chrysin for selective COX-2 inhibition.

Bioorg Med Chem 2018 08 18;26(14):4264-4275. Epub 2018 Jul 18.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896183079
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http://dx.doi.org/10.1016/j.bmc.2018.07.022DOI Listing
August 2018

Novel nicotinoyl pyrazoline derivates bearing N-methyl indole moiety as antitumor agents: Design, synthesis and evaluation.

Eur J Med Chem 2018 Aug 17;156:722-737. Epub 2018 Jul 17.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.07.044DOI Listing
August 2018

Design and biological evaluation of novel triaryl pyrazoline derivatives with dioxane moiety for selective BRAF inhibition.

Eur J Med Chem 2018 Jul 19;155:725-735. Epub 2018 Jun 19.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, China; Institute of Chemistry and BioMedical Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.06.043DOI Listing
July 2018

Design, synthesis, and biological evaluation of new B-Raf kinase inhibitors.

Bioorg Med Chem 2018 05 26;26(9):2372-2380. Epub 2018 Mar 26.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2018.03.038DOI Listing
May 2018

Naphthoquinones: A continuing source for discovery of therapeutic antineoplastic agents.

Chem Biol Drug Des 2018 03 28;91(3):681-690. Epub 2017 Nov 28.

State Key Laboratory of Pharmaceutical Biotechnology, Institute of Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing, China.

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http://doi.wiley.com/10.1111/cbdd.13141
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http://dx.doi.org/10.1111/cbdd.13141DOI Listing
March 2018

Design of potent B-Raf inhibitors by multiple copy simulation search strategy.

Chem Biol Drug Des 2018 02 15;91(2):567-574. Epub 2017 Dec 15.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1111/cbdd.13121DOI Listing
February 2018

FAK inhibitors in Cancer, a patent review.

Expert Opin Ther Pat 2018 02 13;28(2):139-145. Epub 2017 Dec 13.

a State Key Laboratory of Pharmaceutical Biotechnology , Nanjing University , Nanjing P. R. China.

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https://www.tandfonline.com/doi/full/10.1080/13543776.2018.1
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http://dx.doi.org/10.1080/13543776.2018.1414183DOI Listing
February 2018

Identification of new shikonin derivatives as STAT3 inhibitors.

Biochem Pharmacol 2017 12 21;146:74-86. Epub 2017 Oct 21.

State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing 210023, China; Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952173063
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http://dx.doi.org/10.1016/j.bcp.2017.10.009DOI Listing
December 2017

Identification of nitroimidazole-oxime derivatives targeting the polo-box domain of polo-like kinase 1.

Bioorg Med Chem 2017 12 28;25(24):6581-6588. Epub 2017 Oct 28.

Elion Nature Biological Technology Co., Ltd, Nanjing 210046, PR China.

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http://dx.doi.org/10.1016/j.bmc.2017.10.035DOI Listing
December 2017

Identification of novel 1-indolyl acetate-5-nitroimidazole derivatives of combretastatin A-4 as potential tubulin polymerization inhibitors.

Biochem Pharmacol 2017 08 27;137:10-28. Epub 2017 Apr 27.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.04.026DOI Listing
August 2017

Synthesis of novel hybrids of pyrazole and coumarin as dual inhibitors of COX-2 and 5-LOX.

Bioorg Med Chem Lett 2017 08 8;27(16):3653-3660. Epub 2017 Jul 8.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China; Elion Nature Biological Technology Co., Ltd, 16 Hengtong Road, Nanjing 210038, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.07.020DOI Listing
August 2017

Synthesis, molecular docking and biological evaluation of 1-phenylsulphonyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as novel potential tubulin assembling inhibitors.

Chem Biol Drug Des 2017 07 15;90(1):112-118. Epub 2017 Feb 15.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1111/cbdd.12932DOI Listing
July 2017

Synthesis and Biological Evaluation of Glycyrrhetic Acid Derivatives as Potential VEGFR2 Inhibitors.

ChemMedChem 2017 07 27;12(13):1087-1096. Epub 2017 Jun 27.

Nanjing Institute for the Comprehensive Utilization of Wild Plants, Nanjing, 210042, P.R. China.

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http://dx.doi.org/10.1002/cmdc.201700271DOI Listing
July 2017

Synthesis and evaluation of adenosine containing 3-arylfuran-2(5H)-ones as tyrosyl-tRNA synthetase inhibitors.

Eur J Med Chem 2017 Jun 30;133:62-68. Epub 2017 Mar 30.

College of Chemistry and Chemical Engineering, Hunan Engineering Laboratory for Analyse and Drugs Development of Ethnomedicine in Wuling Mountains, Jishou University, Jishou 416000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.03.074DOI Listing
June 2017

Tyrosyl-tRNA synthetase inhibitors: a patent review.

Expert Opin Ther Pat 2017 May 9;27(5):557-564. Epub 2017 Jan 9.

a State Key Laboratory of Pharmaceutical Biotechnology , Nanjing University , Nanjing , PR China.

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http://dx.doi.org/10.1080/13543776.2017.1273350DOI Listing
May 2017

Identification of novel B-Raf inhibitors employing FBDD strategy.

Biochem Pharmacol 2017 05 4;132:63-76. Epub 2017 Mar 4.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.02.022DOI Listing
May 2017

Discovery of a series of 1,3,4-oxadiazole-2(3H)-thione derivatives containing piperazine skeleton as potential FAK inhibitors.

Bioorg Med Chem 2017 05 19;25(9):2593-2600. Epub 2017 Mar 19.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China; Jiangsu Naique Biological Engineering Technology Company Limited, Zhenjiang 212415, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.03.038DOI Listing
May 2017

Recent Advances in the Design and Synthesis of c-Met Inhibitors as Anticancer Agents (2014-Present).

Curr Med Chem 2017 ;24(1):57-64

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.2174/0929867323666161028161441DOI Listing
April 2017

Recent Developments of Metal and Metal Oxide Nanocatalysts in Organic Synthesis.

Mini Rev Med Chem 2016 ;16(16):1303-1320

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China.

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http://dx.doi.org/10.2174/1389557516666160823143243DOI Listing
March 2017

Study of Schiff-Base-Derived with Dioxygenated Rings and Nitrogen Heterocycle as Potential β-Ketoacyl-acyl Carrier Protein Synthase III (FabH) Inhibitors.

Chem Pharm Bull (Tokyo) 2017 ;65(2):178-185

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University.

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http://dx.doi.org/10.1248/cpb.c16-00772DOI Listing
March 2017

Indole-based, Antiproliferative Agents Targeting Tubulin Polymerization.

Curr Top Med Chem 2017 ;17(2):120-137

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China.

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http://dx.doi.org/10.2174/1568026616666160530154812DOI Listing
February 2017

Design, synthesis, and biological evaluation of chrysin derivatives as potential FabH inhibitors.

Chem Biol Drug Des 2017 Jan 10;89(1):136-140. Epub 2016 Nov 10.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China.

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http://dx.doi.org/10.1111/cbdd.12839DOI Listing
January 2017

Synthesis of phenylpiperazine derivatives of 1,4-benzodioxan as selective COX-2 inhibitors and anti-inflammatory agents.

Bioorg Med Chem 2016 11 12;24(21):5626-5632. Epub 2016 Sep 12.

School of Life Sciences, Shandong University of Technology, Zibo 255049, China.

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http://dx.doi.org/10.1016/j.bmc.2016.09.023DOI Listing
November 2016

Synthesis, Molecular Modeling and Biological Evaluation of 4-Alkoxyquinazoline Derivatives as Novel Inhibitors of VEGFR2.

Chem Pharm Bull (Tokyo) 2016 Nov 26;64(11):1570-1575. Epub 2016 Aug 26.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University.

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http://dx.doi.org/10.1248/cpb.c16-00386DOI Listing
November 2016

Discovery of Chromeno[4,3-c]pyrazol-4(2H)-one Containing Carbonyl or Oxime Derivatives as Potential, Selective Inhibitors PI3Kα.

Chem Pharm Bull (Tokyo) 2016 Nov 1;64(11):1576-1581. Epub 2016 Sep 1.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University.

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http://dx.doi.org/10.1248/cpb.c16-00388DOI Listing
November 2016

Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation.

Chem Biol Drug Des 2016 10 24;88(4):592-8. Epub 2016 Jun 24.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1111/cbdd.12793DOI Listing
October 2016

3-Arylpropionylhydroxamic acid derivatives as Helicobacter pylori urease inhibitors: Synthesis, molecular docking and biological evaluation.

Bioorg Med Chem 2016 10 25;24(19):4519-4527. Epub 2016 Jul 25.

College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.07.052DOI Listing
October 2016

Preparations, characterization, and biological features of mononuclear Cu(II) complexes based on hydrazone ligands.

Bioorg Med Chem Lett 2016 10 7;26(20):4925-4929. Epub 2016 Sep 7.

School of Life Sciences, Shandong University of Technology, Zibo 255000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.

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http://dx.doi.org/10.1016/j.bmcl.2016.09.015DOI Listing
October 2016

Design, synthesis and biological evaluation of novel benzo-α-pyrone containing piperazine derivatives as potential BRAF inhibitors.

Bioorg Med Chem Lett 2016 10 3;26(20):4983-4991. Epub 2016 Sep 3.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.09.003DOI Listing
October 2016

A Quinoline-Based Ratiometric and Reversible Fluorescent Probe for Cadmium Imaging in Living Cells.

Chem Pharm Bull (Tokyo) 2016 30;64(1):27-33. Epub 2015 Oct 30.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University.

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http://dx.doi.org/10.1248/cpb.c15-00579DOI Listing
September 2016

Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis.

Bioorg Med Chem Lett 2016 08 16;26(15):3491-8. Epub 2016 Jun 16.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.06.037DOI Listing
August 2016

Fatty acid binding protein (FABP) inhibitors: a patent review (2012-2015).

Expert Opin Ther Pat 2016 Jul 10;26(7):767-76. Epub 2016 May 10.

a State Key Laboratory of Pharmaceutical Biotechnology , Nanjing University , Nanjing , P. R. China.

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http://dx.doi.org/10.1080/13543776.2016.1182500DOI Listing
July 2016

Synthesis and Biological Evaluation of 1-Methyl-1H-indole-Pyrazoline Hybrids as Potential Tubulin Polymerization Inhibitors.

ChemMedChem 2016 07 9;11(13):1446-58. Epub 2016 May 9.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210023, P.R. China.

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http://dx.doi.org/10.1002/cmdc.201600137DOI Listing
July 2016

Design, biological evaluation and 3D QSAR studies of novel dioxin-containing triaryl pyrazoline derivatives as potential B-Raf inhibitors.

Bioorg Med Chem 2016 07 12;24(13):3052-3061. Epub 2016 May 12.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.05.012DOI Listing
July 2016

Synthesis, crystal structures, molecular docking, and in vitro biological activities of transition metals with 4-(2,3-dichlorophenyl)piperazine-1-carboxylic acid.

Bioorg Med Chem Lett 2016 07 19;26(14):3295-3299. Epub 2016 May 19.

School of Life Sciences, Shandong University of Technology, Zibo 255049, People's Republic of China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China.

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http://dx.doi.org/10.1016/j.bmcl.2016.05.051DOI Listing
July 2016

Telomerase inhibitors: a patent review (2010-2015).

Expert Opin Ther Pat 2016 Jun 12;26(6):679-88. Epub 2016 May 12.

a State Key Laboratory of Pharmaceutical Biotechnology , Nanjing University , Nanjing , People's Republic of China.

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http://dx.doi.org/10.1080/13543776.2016.1181172DOI Listing
June 2016

Design, biological evaluation and 3D QSAR studies of novel dioxin-containing pyrazoline derivatives with thiourea skeleton as selective HER-2 inhibitors.

Sci Rep 2016 06 8;6:27571. Epub 2016 Jun 8.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, China.

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http://dx.doi.org/10.1038/srep27571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897788PMC
June 2016

Synthesis and Biological Evaluation of Novel Aryl-2H-pyrazole Derivatives as Potent Non-purine Xanthine Oxidase Inhibitors.

Chem Pharm Bull (Tokyo) 2015 3;63(8):603-7. Epub 2015 Jun 3.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University.

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http://dx.doi.org/10.1248/cpb.c15-00282DOI Listing
May 2016

Synthesis of dihydropyrazole sulphonamide derivatives that act as anti-cancer agents through COX-2 inhibition.

Pharmacol Res 2016 Feb 23;104:86-96. Epub 2015 Dec 23.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210046, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.phrs.2015.12.025DOI Listing
February 2016

Design, synthesis and biological evaluation of pyrazolyl-nitroimidazole derivatives as potential EGFR/HER-2 kinase inhibitors.

Bioorg Med Chem Lett 2016 Jan 14;26(2):677-683. Epub 2015 Nov 14.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, 163 Xianlin Road, Nanjing 210023, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.11.040DOI Listing
January 2016

(E)-1,3-diphenyl-1H-pyrazole derivatives containing O-benzyl oxime moiety as potential immunosuppressive agents: Design, synthesis, molecular docking and biological evaluation.

Eur J Med Chem 2016 Jan 15;108:586-593. Epub 2015 Dec 15.

College of Plant Protection, Anhui Agricultural University, Hefei 230036, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.12.020DOI Listing
January 2016

Synthesis, Biological Evaluation, and Docking of Dihydropyrazole Sulfonamide Containing 2-hydroxyphenyl Moiety: A Series of Novel MMP-2 Inhibitors.

Chem Biol Drug Des 2015 Dec 14;86(6):1405-10. Epub 2015 Jul 14.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China.

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http://dx.doi.org/10.1111/cbdd.12604DOI Listing
December 2015

Discovery of new 4-alkoxyquinazoline-based derivatives as potent VEGFR2 inhibitors.

Chem Biol Drug Des 2015 Nov 23;86(5):1323-9. Epub 2015 Jun 23.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, China.

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http://dx.doi.org/10.1111/cbdd.12596DOI Listing
November 2015

Combined Molecular Docking, 3D-QSAR, and Pharmacophore Model: Design of Novel Tubulin Polymerization Inhibitors by Binding to Colchicine-binding Site.

Chem Biol Drug Des 2015 Oct 20;86(4):731-45. Epub 2015 Mar 20.

College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210073, China.

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http://dx.doi.org/10.1111/cbdd.12545DOI Listing
October 2015

Sulfonamide derivatives containing dihydropyrazole moieties selectively and potently inhibit MMP-2/MMP-9: Design, synthesis, inhibitory activity and 3D-QSAR analysis.

Bioorg Med Chem Lett 2015 Oct 14;25(20):4664-71. Epub 2015 Aug 14.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.08.026DOI Listing
October 2015

Adenosine analogs as inhibitors of tyrosyl-tRNA synthetase: Design, synthesis and antibacterial evaluation.

Bioorg Med Chem 2015 Oct 11;23(20):6602-11. Epub 2015 Sep 11.

College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896153004
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http://dx.doi.org/10.1016/j.bmc.2015.09.018DOI Listing
October 2015

Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents.

Bioorg Med Chem 2015 Sep 4;23(18):6148-56. Epub 2015 Aug 4.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.07.075DOI Listing
September 2015

Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold.

Eur J Med Chem 2015 Sep 14;102:631-8. Epub 2015 Aug 14.

College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.08.025DOI Listing
September 2015

Discovery of a series of novel phenylpiperazine derivatives as EGFR TK inhibitors.

Sci Rep 2015 Sep 9;5:13934. Epub 2015 Sep 9.

School of Life Sciences, Shandong University of Technology, Zibo, China.

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http://dx.doi.org/10.1038/srep13934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563558PMC
September 2015

Synthesis, molecular docking and biological evaluation of 3-arylfuran-2(5H)-ones as anti-gastric ulcer agent.

Bioorg Med Chem 2015 Aug 21;23(15):4860-5. Epub 2015 May 21.

College of Chemistry and Chemical Engineering, Jishou University, Jishou 416000, PR China; State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.05.026DOI Listing
August 2015

Synthesis and evaluation of N-analogs of 1,2-diarylethane as Helicobacter pylori urease inhibitors.

Bioorg Med Chem 2015 Aug 14;23(15):4508-13. Epub 2015 Jun 14.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.06.014DOI Listing
August 2015

Synthesis, biological evaluation, and molecular docking studies of novel 1-benzene acyl-2-(1-methylindol-3-yl)-benzimidazole derivatives as potential tubulin polymerization inhibitors.

Eur J Med Chem 2015 Jun 21;99:125-37. Epub 2015 May 21.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.05.021DOI Listing
June 2015

Design, synthesis, biological evaluation and molecular modeling of dihydropyrazole sulfonamide derivatives as potential COX-1/COX-2 inhibitors.

Bioorg Med Chem Lett 2015 May 22;25(9):1947-51. Epub 2015 Mar 22.

Department of Plastic and Burn Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 21003, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.03.022DOI Listing
May 2015

Design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors.

Eur J Med Chem 2015 Apr 3;94:447-57. Epub 2015 Mar 3.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Science, Nanjing University, Nanjing 210093, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.02.058DOI Listing
April 2015

Discovery of phenylpiperazine derivatives as IGF-1R inhibitor with potent antiproliferative properties in vitro.

Bioorg Med Chem Lett 2015 Mar 13;25(5):1067-71. Epub 2015 Jan 13.

School of Life Sciences, Shandong University of Technology, Zibo 255049, Shandong Province, PR China.

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http://dx.doi.org/10.1016/j.bmcl.2015.01.011DOI Listing
March 2015

6,7-Dihydrobenzo[f]benzo[4,5]imidazo[1,2-d][1,4]oxazepine derivatives as selective inhibitors of PI3Kα.

Bioorg Med Chem 2015 Mar 7;23(6):1231-40. Epub 2015 Feb 7.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896150007
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http://dx.doi.org/10.1016/j.bmc.2015.01.052DOI Listing
March 2015

Synthesis, biological evaluation and 3D-QSAR studies of novel 5-phenyl-1H-pyrazol cinnamamide derivatives as novel antitubulin agents.

Eur J Med Chem 2015 Mar 14;93:291-9. Epub 2015 Feb 14.

State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.02.018DOI Listing
March 2015