Publications by authors named "Hai-Jun Wang"

237 Publications

Associations of genetic variants of lysophosphatidylcholine metabolic enzymes with levels of serum lipids.

Pediatr Res 2021 May 2. Epub 2021 May 2.

Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.

Objective: Metabolic disturbance of lysophosphatidylcholine (LPC) is related with dyslipidemia. Therefore, eight single-nucleotide polymorphisms (SNPs) were selected from LPC metabolic enzymes to study their associations with obesity and serum levels of lipids.

Methods: A total of 3305 children were recruited from four independent studies. Eight SNPs of LPC metabolic enzymes were selected and genotyped with the matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). The multivariable linear regression model was applied to detect the associations of eight SNPs with obesity-related phenotypes and levels of lipids in each study. Meta-analyses were used to combine the results of four studies.

Results: Only SNP rs4420638 of APOC-1 gene was associated with serum lipids even after Bonferroni correction. The rs4420638 was positively associated with TC (β = 0.15, P = 8.59 × 10) and low-density-lipoprotein-cholesterol (LDL-C, β = 0.16, P = 9.98 × 10) individually.

Conclusion: The study firstly revealed the association between APOC-1/rs4420638 and levels of serum lipids in Chinese children, providing evidence for susceptible gene variants of dyslipidemia.
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http://dx.doi.org/10.1038/s41390-021-01549-9DOI Listing
May 2021

The effect of the underlying malignancy on short- and medium-term survival of critically ill patients admitted to the intensive care unit: a retrospective analysis based on propensity score matching.

BMC Cancer 2021 Apr 15;21(1):417. Epub 2021 Apr 15.

Department of Intensive Care Unit, National Cancer Center / National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100021, China.

Background: Advances in oncology led to a substantial increase in the number of patients requiring admission to the ICU. It is significant to confirm which cancer critical patients can benefit from the ICU care like noncancer patients.

Methods: An observational retrospective cohort study using intensive care unit (ICU) admissions of Medical Information Mart for Intensive Care III from the Beth Israel Deaconess Medical Center in Boston, MA, USA between 2001 and 2012 was conducted. Propensity score matching was used to reduce the imbalance between two matched cohorts. ICU patients with cancer were compared with those without cancer in terms of patients' characteristics and survival.

Results: There were 38,508 adult patients admitted to ICUs during the period. The median age was 65 years (IQR, 52-77) and 8308 (21.6%) had an underlying malignancy diagnosis. The noncancer group had a significant survive advantage at the point of 28-day, 90-day, 365-day and 1095-day after ICU admission compared with cancer group (P < 0.001 for all) after PSM. Subgroup analysis showed that the diagnosis of malignancy didn't decrease 28-day and 90-day survive when patients' age ≥ 65-year, patients in surgical intensive care unit or cardiac surgery recovery unit or traumatic surgical intensive care unit, elective admissions, patients with renal replacement therapy or vasopressor support (P > 0.05 for all).

Conclusions: Malignancy is a common diagnosis among ICU patients. Patients without cancer have a survive advantage compared with patients with cancer in the short- and medium-term. However, in selected groups, cancer critical patients can benefit from the ICU care service like noncancer patients in the short-term.
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http://dx.doi.org/10.1186/s12885-021-08152-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8051069PMC
April 2021

A sensitive label-free photoelectrochemical aptasensor based on a novel PTB7-Th/HO system with unexpected photoelectric performance for C-reactive protein analysis.

Biosens Bioelectron 2021 Jun 13;181:113162. Epub 2021 Mar 13.

Chongqing Engineering Laboratory of Nanomaterials & Sensor Technologies, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, PR China. Electronic address:

Herein, a sensitive label-free photoelectrochemical (PEC) aptasensor was constructed for C-reactive protein (CRP) analysis based on a novel and efficient poly{4,8-bis[5-(2-ethylhexyl) thiophen-2-yl]benzo[1,2-b:4,5-b']dithiophene-2,6-diyl-alt-3-fluoro-2-[(2-ethylhexyl)carbonyl] thieno[3,4-b]-thiophene-4,6-diyl} (PTB7-Th)/HO system with unexpected photoelectric performance. The proposed PTB7-Th/HO system without any sensitizer could surmount defect of the poor photoelectric conversion efficiency of PTB7-Th, leading to the unexpected 10-fold photocurrent enhancement compared to the common PTB7-Th/PBS system. The strong enhancement effect might originate from the special function of hydrogen peroxide (HO) towards PTB7-Th. On the one hand, HO as electron acceptor could continuously capture photogenerated electrons located at acceptor part of PTB7-Th, which would visibly improve the charge separation efficiency of PTB7-Th and the electron-receiving property of electrolyte solution, thus leading to the obviously enhanced photoelectric conversion efficiency (PCE). More importantly, HO as oxidant could oxidize PTB7-Th to obtain oxidation product of PTB7-Th (OPP) with carbonyl group and carboxyl group, and the electron cloud density in donor part of the OPP was higher than that of PTB7-Th, therefrom producing the stronger electron-donating property and higher photoelectrochemical (PEC) reaction efficiency. As a proof of concept, the proposed PTB7-Th/HO system was successfully applied in the construction of a label-free PEC aptasensor for sensitive analysis of CRP, which performed a wide detection range from 1 pM to 1000 nM with a low detection limit of 0.33 pM. This study demonstrated a novel approach to the rational design of photoelectric conversion system with high PEC performance and provided an inspired tack for the construction of high-efficiency photoelectric devices.
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http://dx.doi.org/10.1016/j.bios.2021.113162DOI Listing
June 2021

Application of 3D printed model for planning the endoscopic endonasal transsphenoidal surgery.

Sci Rep 2021 Mar 5;11(1):5333. Epub 2021 Mar 5.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

The application of 3D printing in planning endoscopic endonasal transsphenoidal surgery is illustrated based on the analysis of patients with intracranial skull base diseases who received treatment in our department. Cranial computed tomography/magnetic resonance imaging data are attained preoperatively, and three-dimensional reconstruction is performed using MIMICS (Materialise, Leuven, Belgium). Models of intracranial skull base diseases are printed using a 3D printer before surgery. The models clearly demonstrate the morphologies of the intracranial skull base diseases and the spatial relationship with adjacent large vessels and bones. The printing time of each model is 12.52-15.32 h, and the cost ranges from 900 to 1500 RMB. The operative approach was planned in vitro, and patients recovered postoperatively well without severe complications or death. In a questionnaire about the application of 3D printing, experienced neurosurgeons achieved scores of 7.8-8.8 out of 10, while unexperienced neurosurgeons achieved scores of 9.2-9.8. Resection of intracranial skull base lesions is demonstrated to be well assisted by 3D printing technique, which has great potential in disclosing adjacent anatomical relationships and providing the required help to clinical doctors in preoperative planning.
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http://dx.doi.org/10.1038/s41598-021-84779-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935876PMC
March 2021

Prevalence of cervicovaginal human papillomavirus infection and genotypes in the pre-vaccine era in China: A nationwide population-based study.

J Infect 2021 04 18;82(4):75-83. Epub 2021 Feb 18.

Department of Maternal and Child Health, School of Public Health, Peking University, 38 Xueyuan Road, Haidian District, Beijing 100191, China. Electronic address:

Objective: The HPV vaccine has been licensed in mainland China since 2017. This study aimed to assess the epidemiological characteristics of HPV genotypes in the pre-vaccine era in China.

Methods: We conducted a multicentric population-based study nested in the largest health clinic chain in China. Between January 1, 2017 and December 31, 2017, 427,401women aged 20 years or older with polymerase chain reaction-based HPV genotyping tests were included in the study. The cervicovaginal infection of 14 high-risk HPV genotypes and 9 low-risk genotypes was assessed using adjusted prevalence, multivariable logistic regression, cluster analysis, and heatmap.

Results: HPV prevalence was 15.0% (95% confidence interval [CI]: 14.1-15.9%) in China, with high- and low-risk genotypes being 12.1% (95%CI: 11.4-12.7%) and 5.2% (95%CI: 4.8-5.7%), respectively. The prevalence of HPV genotypes corresponding to bivalent, quadrivalent, and nonavalent vaccines were 2.1%, 2.4%, and 8.3%, respectively, whereas the prevalence of non-vaccine high-risk genotypes was 5.7%. The most common high-risk genotypes were HPV-52 (3.5%), HPV-58 (2.1%), and HPV-16 (1.6%), and the prevalence of HPV-18 (0.6%), HPV-6 (0.1%), and HPV-11 (0.2%) were relatively low. Infection with HPV genotypes differed significantly across age groups and geographic locations.

Conclusion: HPV prevalence was high in the pre-vaccine era in China, and a population-based HPV vaccination strategy is needed in the future.
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http://dx.doi.org/10.1016/j.jinf.2021.02.017DOI Listing
April 2021

Effects of nitrate on phosphorus release from lake sediments.

Water Res 2021 Apr 2;194:116894. Epub 2021 Feb 2.

Department of Bioscience and Arctic Research Centre, Aarhus University, 8600 Silkeborg, Denmark; Sino-Danish Centre for Education and Research, Beijing 100049, China; Limnology Laboratory, Department of Biological Sciences and Centre for Ecosystem Research and implementation, Middle East Technical University, Ankara 06800, Turkey; Institute of Marine Sciences, Middle East Technical University, 33731 Erdemli-Mersin, Turkey. Electronic address:

Phosphorus (P) release from sediment is a key process affecting the effectiveness of eutrophication mitigation. We hypothesized that high nitrate (NO) input may have dual effect on sediment P release: reduce the sediment P release by improving the oxidation of sediment or promote P release by stimulating the growth of phytoplankton and increase the decomposition rates and oxygen consumption at the sediment water interface. To test the effect of different NO concentrations, we conducted a three-month experiment in 15 cement tanks (1 m), with five targeted concentrations of NO: control, 2 mg L, 5 mg L, 10 mg L, and 15 mg L. The results showed that: i) when NO was maintained at high levels: NO≥5-7 mg L (range of median values), there was no effect of NO on net P release from the sediment, likely because the positive effects of NO (increasing oxidation) was counteracted by a promotion of phytoplankton growth. ii) after NO addition was terminated NO dropped sharply to a low level (NO≤0.4 mg L), followed by a minor P release in the low N treatments but a significant P release in the high N treatments, which likely reflect that the inhibition effect of NO on P release decreased, while the promotion effects at high NO concentrations continued. The results thus supported our hypotheses of a dual effect on sediment P release and suggest dose-dependent effect of NO loading on stimulating P release from the sediment, being clear at high NO exceeding 5-7 mg L.
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http://dx.doi.org/10.1016/j.watres.2021.116894DOI Listing
April 2021

Using Anatomic Landmarks to Locate Schöttle's Point Was Accurate Without Fluoroscopy During Medial Patellofemoral Ligament Reconstruction.

Arthroscopy 2021 Feb 1. Epub 2021 Feb 1.

Sports Medicine Department, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, China. Institute of Sports Medicine of Peking University, Beijing, China. Electronic address:

Purpose: The purpose of the present study was to analyze the anatomic landmarks of Schöttle's point and establish a locating method for identification.

Methods: From 2013 to 2016, patients undergoing medial patellofemoral ligament (MPFL) reconstruction for patellofemoral instability were enrolled.

Inclusion Criteria: at least 2 episodes of patellar dislocation.

Exclusion Criteria: previous knee surgeries, open physes, severe trochlear dysplasia, tibial tuberosity lateralization, or patella alta. Group A: From January 2013 to December 2013, preoperative 3-dimensional computed tomography (3D-CT) images were obtained. Anatomic features of Schöttle's point were measured on the 3D-CT images. A Schöttle's point locating method with 2 distinct landmarks was established. Group B: From January 2014 to January 2016, consecutive MPFL reconstructions were performed. The placement of Schöttle's point was following the established method without fluoroscopy. The accuracy of femoral tunnel positions was assessed on the 3D-CT images postoperatively.

Results: CT images of 53 knees were obtained in group A. Forty-seven MPFL reconstructions were performed in group B. No significant difference was found between the 2 groups regarding to demographic characteristics. The intraclass correlation coefficients were excellent for all measures (r = 0.97). In group A, Schöttle's point was 8.1 ± 0.2 mm (95% confidence interval [CI], 7.7-8.5) distal to the apex of the adductor tubercle and 8.0 ± 0.3 mm (95% CI, 7.4-8.6) anterior to the posterior edge. Apex of the adductor tubercle was defined as the most convex point, and posterior edge was defined as the edge of the posteromedial cortex in the transition area between the medial condyle and femoral shaft. In group B, 44 of 47 femoral tunnels (93.6%) were considered localized in the proper zone.

Conclusions: Schöttle's point was approximately 8 mm distal to the apex of the adductor tubercle and 8 mm from the posterior edge. Schöttle's point locating method without fluoroscopy had high accuracy.

Level Of Evidence: Level IV, case series.
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http://dx.doi.org/10.1016/j.arthro.2021.01.041DOI Listing
February 2021

Long-term exposure to ambient air pollution and metabolic syndrome in children and adolescents: A national cross-sectional study in China.

Environ Int 2021 03 19;148:106383. Epub 2021 Jan 19.

Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Background: The prevalence of metabolic syndrome (MetS) rapidly increased over the past decades. However, little evidence exists about the effects of long-term exposure to ambient air pollution on MetS in children and adolescents.

Objective: This study aims to assess the association between long-term ambient air pollution and the prevalence of MetS in a large population of Chinese children and adolescents.

Methods: In 2013, a total of 9,897 children and adolescents aged 10 to 18 years were recruited from seven provinces/municipalities in China. MetS was defined based on the recommendation by the International Diabetes Federation (IDF). Satellite based spatio-temporal models were used to estimate exposure to ambient air pollution (including particles with diameters ≤1.0 µm (PM), ≤2.5 µm (PM), and ≤10 µm (PM), and nitrogen dioxide (NO)). Individual exposure was calculated according to 94 schools addresses. After adjustment for a range of covariates, generalized linear mixed-effects models were utilized to evaluate the associations between air pollutants and the prevalence of MetS and its components. In addition, several stratified analyses were examined according to sex, weight status, outdoor physical activity time, and sugar-sweetened beverages (SSBs) intake.

Results: The prevalence of MetS was 2.8%. The odds ratio of MetS associated with a 10 μg/m increase in PM, PM, PM and NO was 1.20 (95%CI: 0.99, 1.46), 1.31 (95%CI: 1.05, 1.64), 1.32 (95%CI: 1.08, 1.62), and 1.33 (95%CI: 1.03, 1.72), respectively. Regarding the MetS components, we observed associations between all pollutants and abdominal obesity. In addition, long-term PM and NO exposures were associated with the prevalence of elevated fasting blood glucose. Stratified analyses detected that the associations between air pollutants and the prevalence of MetS were stronger in boys (P < 0.05).

Conclusions: We found that long-term exposure to PM, PM, and NO were positively associated with the prevalence of MetS in children and adolescents. Our findings may have certain public health implications for some comprehensive strategy of environment improvement and lifestyles changes in order to reduce the burden of non-communicable disease.
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http://dx.doi.org/10.1016/j.envint.2021.106383DOI Listing
March 2021

Predictors of postoperative biochemical remission in acromegaly.

J Neurooncol 2021 Jan 4;151(2):313-324. Epub 2021 Jan 4.

Center for Pituitary Tumor Surgery, Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Rd, Yuexiu District, Guangzhou, 510080, Guangdong, China.

Purpose: Acromegaly is a rare neuroendocrine condition that can lead to significant morbidity. Despite China's vast population size, studies on acromegaly remain sparse. This study aimed to investigate the clinical characteristics and predictors of biochemical remission after surgery for acromegaly using the China Acromegaly Patient Association (CAPA) database.

Methods: A retrospective nationwide study was conducted using patient-reported data from CAPA database between 1998 and 2018. The principal component analysis (PCA) and logistic regression analysis were employed to determine independent predictors of biochemical remission at 3 months in patients after surgery.

Results: Of the 546 surgical cases (mean age: 36.8 years; 59.5% females), macroadenomas and invasive tumors (Knosp score 3-4) were 83.9% and 64.1%, respectively. Ninety-five percent of patients were treated with endonasal surgery and 36.8% exhibited biochemical remission at 3-months postoperatively. The following independent predictors of biochemical remission were identified: preoperative growth hormone (GH) levels between 12 and 28 μg/L [odds ratio (OR) = 0.58; 95% confidence interval (CI), 0.37-0.92; p = 0.021], preoperative GH levels > 28 μg/L (OR = 0.55; 95% CI, 0.34-0.88; p = 0.013), macroadenoma (OR = 0.56; 95% CI, 0.32-0.96; p = 0.034), giant adenomas (OR = 0.14; 95% CI, 0.05-0.38; p < 0.001), Knosp score 3-4 (OR = 0.37; 95% CI, 0.24-0.57; p < 0.001), and preoperative medication usage (OR = 2.32; 95% CI, 1.46-3.70; p < 0.001).

Conclusions: In this nationwide study spanning over two decades, we highlight that higher preoperative GH levels, large tumor size, and greater extent of tumor invasiveness are associated with a lower likelihood of biochemical remission at 3-months after surgery, while preoperative medical therapy increases the chance of remission.
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http://dx.doi.org/10.1007/s11060-020-03669-4DOI Listing
January 2021

Association between airborne particulate matter and renal function: An analysis of 2.5 million young adults.

Environ Int 2021 02 30;147:106348. Epub 2020 Dec 30.

Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China; National Research Institute for Family Planning, Beijing, China. Electronic address:

Background: Limited studies have examined the impact of airborne particulate matter of 2.5 μm or less (PM) on renal function. No study has examined the effect of PM, which is small enough to reach the blood circulation. We examined whether exposure to PM or PM affected renal function of young Han Chinese.

Method: We included 2,546,047 young adults who were aged 18 to 45 years, being Han ethnicity and had no chronic disease from a Chinese national birth cohort. Serum creatinine (Scr) of each participant was measured during the baseline examination. Estimated glomerular filtration rate (eGFR) were calculated for each participant using the latest Chronic Kidney Disease Epidemiology Collaboration equation. One-year average exposure to PM and PM prior to the health examination for each participant were estimated using machine learning models with satellite remote sensing information. Generalized additive mixed models were used to estimate associations between PM or PM and renal function after adjusting for detailed individual variables.

Results: A 10 μg/m increment in PM exposure was associated with -0.95% (95%CI: -1.04%, -0.87%) difference of eGFR in females and -0.37% (95%CI: -0.44%, -0.31%) in males. For PM, the corresponding difference of eGFR was -0.99% (95%CI: -1.05%, -0.93%) in females and -0.48% (95%CI: -0.53%, -0.43%) in males, respectively. Associations between eGFR and PM were higher in females compared to males (p < 0.05 for interaction test). Association with PM were weaker than that with other fractions included in PM. Participants who worked as farmers, were of normal weight, were not exposed to tobacco smoking, did not drink alcohol, had higher associations between eGFR and PM than their counterparts (p < 0.05 for interaction test).

Conclusion: Exposure to PM and PM was associated with reduced renal function among Han Chinese at reproductive age.
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http://dx.doi.org/10.1016/j.envint.2020.106348DOI Listing
February 2021

Tibial Tubercle Osteotomy May Not Provide Additional Benefit in Treating Patellar Dislocation With Increased Tibial Tuberosity-Trochlear Groove Distance: A Systematic Review.

Arthroscopy 2021 May 24;37(5):1670-1679.e1. Epub 2020 Dec 24.

Knee Surgery Department, Institute of Sports Medicine, Beijing Key Laboratory of Sports Injuries, Peking University Third Hospital, Beijing, China. Electronic address:

Purpose: To examine the indications and outcomes of medial patellofemoral ligament reconstruction (MPFLR) with or without tibial tubercle osteotomy (TTO) in treating recurrent or habitual patellar dislocation with an increased tibial tuberosity-trochlear groove (TT-TG) distance.

Methods: We performed a literature search of the established medical databases Cochrane Central, PubMed-MEDLINE, EMBASE, and Web of Science. The inclusion criteria were as follows: skeletally mature patients with recurrent or habitual patellar dislocation and an increased TT-TG distance, treatment with MPFLR combined with a TTO procedure or isolated MPFLR, and reporting of clinical outcomes and complications. Each study was assessed for quality and the level of evidence. The general characteristics, indications, surgical techniques, TT-TG distance, clinical results, imaging evaluation findings, and complications of each study were recorded.

Results: Nine studies consisting of 288 knees met the inclusion criteria. The average Coleman score was 71.56 (range, 55-83). The threshold for an increased TT-TG distance ranged from 16 to 20 mm in the included studies. Similar good postoperative outcomes were reported in patients with an increased TT-TG distance treated with MPFLR with versus without a TTO procedure. The mean postoperative Lysholm score ranged from 75.0 to 94.7 (I = 87.6%) in the isolated MPFLR group and from 85.0 to 87.6 (I = 16.3%) in the TTO-with-MPFLR group. Similar postoperative congruence angles were reported in both groups. The postoperative redislocation rate ranged from 0% to 4.2% in the TTO-with-MPFLR group, and no redislocation was found in the isolated MPFLR group. The postoperative apprehension sign was only reported in isolated MPFLR patients.

Conclusions: The outcomes of MPFLR with or without TTO to treat recurrent or habitual patellar dislocation with an increased TT-TG distance appeared similar. However, this study was limited by the considerable heterogeneity, variety of techniques, variety of TT-TG distances, and variability in patella alta and trochlear dysplasia among the included studies.

Level Of Evidence: Level IV, systematic review of Level II to IV studies.
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http://dx.doi.org/10.1016/j.arthro.2020.12.210DOI Listing
May 2021

From silicates to oxonitridosilicates: improving optical anisotropy for phase-matching as ultraviolet nonlinear optical materials.

Chem Commun (Camb) 2021 Jan;57(5):639-642

Department of Physics, Tamkang University, New Taipei City 25137, Taiwan.

Oxonitridosilicates, in which O atoms in SiO4 are partially substituted by N atoms, are proposed to improve optical anisotropies of silicates as UV NLO materials. The optical properties calculation showed that the heteroleptic SiOxN4-x (x = 1-3) tetrahedra have strong polarizability anisotropy and large hyperpolarizability. Accordingly, nine noncentrosymmetric (NCS) oxonitridosilicate crystals collected in the inorganic crystal structural database (ICSD) are evaluated by using the first principles method. Finally, Si2N2O and LiSiON are screened out owing to wide band gaps (6.49 and 6.95 eV), large birefringences (0.102 and 0.060 at 1064 nm), and large SHG coefficients (3.3 and 2.2 times that of d36(KDP)). More importantly, the cation selection and structural characteristics that are beneficial for enhancing the band gap and birefringence are identified. This study provides a novel strategy to design and find UV NLO crystals.
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http://dx.doi.org/10.1039/d0cc07269aDOI Listing
January 2021

Folic Acid Supplementation and the Association between Maternal Airborne Particulate Matter Exposure and Preterm Delivery: A National Birth Cohort Study in China.

Environ Health Perspect 2020 12 18;128(12):127010. Epub 2020 Dec 18.

Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China.

Background: Potential modification of the association between maternal particulate matter (PM) exposure and preterm delivery (PTD) by folic acid (FA) supplementation has not been studied.

Objective: We examined whether FA supplementation could reduce the risk of PTD associated with maternal exposure to PM in ambient air during pregnancy.

Method: In a cohort study covering 30 of the 31 provinces of mainland China in 2014, 1,229,556 primiparas of Han ethnicity were followed until labor. We collected information on their FA supplementation and pregnancy outcomes and estimated each participant's exposure to PM with diameters of (), (), and () using satellite remote-sensing based models. Cox proportional hazard regression models were used to examine interactions between FA supplementation and PM exposures, after controlling for individual characteristics.

Results: Participants who initiated FA prior to pregnancy (38.1%) had a 23% [hazard ratio (95% CI: 0.76, 0.78)] lower risk of PTD than women who did not use preconception FA. Participants with PM concentrations in the highest quartile had a higher risk of PTD [ (95% CI: 1.26, 1.32) for , 1.52 (95% CI: 1.46, 1.58) for , and 1.22 (95% CI: 1.17, 1.27) for ] than those with exposures in the lowest PM quartiles. Estimated associations with a increase in and were significantly lower among women who initiated FA prior to pregnancy [ (95% CI: 1.08, 1.10) for both exposures] than among women who did not use preconception FA [ (95% CI: 1.11, 1.13) for both exposures; ]. The corresponding association was also significantly lower for a increase in [ (95% CI: 1.02, 1.03) for FA before pregnancy vs. 1.04 (95% CI: 1.03, 1.04) for no preconception FA; ].

Conclusion: Our findings require confirmation in other populations, but they suggest that initiating FA supplementation prior to pregnancy may lessen the risk of PTD associated with PM exposure during pregnancy among primiparas of Han ethnicity. https://doi.org/10.1289/EHP6386.
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http://dx.doi.org/10.1289/EHP6386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7747880PMC
December 2020

Expression of apolipoprotein C1 in clear cell renal cell carcinoma: An oncogenic gene and a prognostic marker.

Kaohsiung J Med Sci 2020 Dec 10:e12328. Epub 2020 Dec 10.

Department of Urology, Qilu Hospital,Cheeloo College of Medicine, Shandong University, Jinan, China.

This study aimed to explore whether APOC1 expression has a function in the biological behavior of clear cell renal cell carcinoma (ccRCC) cells and its possible mechanism. Bioinformatics analysis of data TCGA and OnComine was conducted to explore the expression pattern and prognostic value of APOC1, as well as the relationship between APOC1 expression and clinical indicators. Loss- and gain- of APOC1 function assays were carried out to assess the biological functions of APOC1. Western blotting was applied to detect protein expression. We revealed that APOC1 was upregulated in ccRCC tissues. APOC1 expression was related to gender, grade, pathologic-T, pathologic-stage, and pathologic-M in patients with ccRCC. Meanwhile, Kaplan-Meier analysis evidenced that the high APOC1 expression indicated unfavorable outcomes of ccRCC. Functional experiments in vitro revealed that upregulation of APOC1 in UT33A cells promoted cell proliferation, invasion, and migration, while downregulation of APOC1 in 786-O cells had the opposite effect. Furthermore, epithelial mesenchymal transition (EMT) was activated in cells with upregulated APOC1 but inhibited in cells with down-regulated APOC1. Collectively, our data suggested that APOC1 was overexpressed in ccRCC cells and promoted the malignant biological behaviors and EMT of ccRCC cells.
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http://dx.doi.org/10.1002/kjm2.12328DOI Listing
December 2020

Fullerenol as a photoelectrochemical nanoprobe for discrimination and ultrasensitive detection of amplification-free single-stranded DNA.

Biosens Bioelectron 2020 Nov 13;173:112802. Epub 2020 Nov 13.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, PR China. Electronic address:

Traditional approaches for nucleic acids detection require prior amplification of target genes, while nanomaterials-aided DNA biosensors are very magnificent but still suffer from the nanomaterial acquirement and limited sensitivity (above picomolar level). Herein, fullerenol C(OH), a representative fullerene derivative, was employed as a photoelectrochemical (PEC) nanoprobe to achieve discrimination and ultrasensitive detection of amplification-free single-stranded DNA (ssDNA) down to sub-femtomolar level. The bonded hydroxyl groups with intense density endowed fullerenol to directly recognize and capture ssDNA-AuNPs via the hydrogen bonding interactions (H-bonds), leading to a sharply decreased photocurrent with quenching efficiency up to 85%, which could be attributed to the photo-generated electrons on the conduction band of fullerenol (-4.66 eV) preferentially migrating to the Fermi level of AuNPs (-5.1 eV) rather than the electrode. In the presence of target gene (mutant human p53 gene fragment), the H-bonds between fullerenol and ssDNA were competitively depleted during the base pairing process of complete hybridization between ssDNA and target, making double-stranded DNA-AuNPs (dsDNA-AuNPs) depart so that the photocurrent powerfully recovered. On basis of the photocurrent variation before and after target introduction, this proposed simple, rapid and ultrasensitive PEC biosensor for amplification-free target gene detection illustrated a wide liner ranged from 1 fM to 100 pM and a detection limit of 0.338 fM. This work presented an ingenious strategy for the discrimination and ultrasensitive detection of nucleic acids, and the well-designed PEC biosensor was further conducive to the impetus of clinic diagnostics.
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http://dx.doi.org/10.1016/j.bios.2020.112802DOI Listing
November 2020

[Acupuncture of "Zhibian (BL 54) through Shuidao (ST 28)" for female stress urinary incontinence: a randomized controlled trial].

Zhongguo Zhen Jiu 2020 Oct;40(10):1061-4

Third Clinical College of Shanxi University of CM, Jinzhong 030619, China.

Objective: To observe effect of "Zhibian (BL 54) through Shuidao (ST 28)" acupuncture for quality of life of female patients with stress urinary incontinence.

Methods: A total of 90 female patients were randomly divided into an observation group and a control group, 45 cases in each group. The patients in the observation group were treated with "Zhibian (BL 54) through Shuidao (ST 28)" acupuncture method, and the patients in the control group were treated with non-permeable sham acupuncture at Zhibian (BL 54). The needles were retained for 30 min in both groups, once a day, and the treatment was totally given 10 times. The score of urinary incontinence quality of life questionnaire (I-QOL) was recorded before and after treatment and during the follow-up 1 month after treatment in the two groups, and the 1 h urine pad test and the 72 h urination diary card were used to evaluate the 1 h urine leakage and the 24 h urine leakage frequency of the two groups.

Results: After treatment and during follow-up, the I-QOL scores in the observation group were higher than those before treatment (<0.05), and were higher than those in the control group (<0.05). After treatment and during follow-up, the 1 h urine leakage and the 24 h urine leakage frequency in the observation group were lower than those before treatment (<0.05), and less than those in the control group (<0.05).

Conclusion: Acupuncture of "Zhibian (BL 54) through Shuidao (ST 28)" can improve the quality of life of female patients with stress urinary incontinence, and improve the volume and frequency of urine leakage.
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http://dx.doi.org/10.13703/j.0255-2930.20200410-k0005DOI Listing
October 2020

A randomized controlled trial comparing the efficacy of tigecycline versus meropenem in the treatment of postoperative complicated intra-abdominal infections.

Ann Palliat Med 2021 Feb 9;10(2):1262-1275. Epub 2020 Oct 9.

Intensive Care Unit, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: The efficacy and safety of tigecycline in the treatment of complicated intra-abdominal infections (cIAIs) is potentially controversial. Here we conducted the non-inferiority study to assess the efficacy and safety of tigecycline versus meropenem in the treatment of postoperative cIAIs.

Methods: Data of abdominal tumor surgery patients with postoperative cIAIs admitted to intensive care unit (ICU) between October 2017 and December 2019 were collected. A prospective, randomized controlled trial was conducted in which 56 eligible patients with cIAIs randomly received intravenous tigecycline or meropenem for 3 to 14 days. Patients and clinicians were not blinded to the group allocation.

Results: The total of 56 patients were enrolled, which were divided into 2 groups, one group included 30 patients receiving meropenem and another group included 26 receiving tigecycline therapy. The 2 groups were similar at demographic and baseline clinical characteristics. Microorganisms were isolated from 46 of 56 patients (82.14%), with a total of 107 pathogens were cultured in two groups. The two groups had similar distribution of infecting microorganisms. The primary end point was the clinical response at the end-oftherapy (EOT) visit and upon discharge visit and comprehensive efficacy. The clinical success rates were 83.33%, 76.67% for meropenem versus 76.92%, 88.46% for tigecycline at the EOT visit and upon discharge visit (P>0.05), respectively. Comprehensive efficacy did not significantly differ between two groups either. There were no significant differences in 30-day and 60-day all-cause mortality between two groups (P>0.05). The univariable analysis identified that serum albumin at admission ICU, colorectal cancer on oncology type, postoperative abdominal bleeding were the risk factors for 60-day all-cause mortality. The multivariable analysis showed that postoperative abdominal bleeding were independent predictors of 60-day all-cause mortality. Gastrointestinal disorders and antibacterials-induced Fungal Infection were the most frequently reported adverse events (AEs). The incidence of AEs was similar between meropenem and tigecycline groups (P>0.05).

Conclusions: Taken together, the study demonstrated that tigecycline is as effective and safe as meropenem for postoperative cIAIs in abdominal tumors patients. Tigecycline is non-inferior to meropenem.
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http://dx.doi.org/10.21037/apm-20-907DOI Listing
February 2021

Greenness surrounding schools and adiposity in children and adolescents: Findings from a national population-based study in China.

Environ Res 2021 01 4;192:110289. Epub 2020 Oct 4.

Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:

Background: Previous studies have indicated that exposure to green space may benefit human health. However, the available evidence concerning the effects of greenness, especially school-based greenness, on pediatric obesity is scarce.

Objective: To explore the association between school-based greenness and adiposity in children and adolescents in China.

Method: We conducted a nationwide cross-sectional study of 56,620 children and adolescents (aged 6-18 years) in seven provinces/municipalities across China. School-based greenness was assessed using satellite-derived Normalized Difference Vegetation Index (NDVI) and Soil Adjusted Vegetation Index (SAVI) within 100-, 500-, and 1000-m circular buffers around each school's address. Generalized linear mixed regression models were used to estimate associations of greenness with BMI z-scores (zBMI), waist circumference, and prevalent overweight/obesity. We also explored the potential mediating role of ambient air pollution and physical activity in the greenness-adiposity associations.

Result: In the adjusted model, an IQR increase in NDVI was associated with lower zBMI (β: -0.11, 95% confidence interval[CI]: -0.13,-0.09) and waist circumference (β: -0.64, 95%CI: -0.78,-0.50). Consistently, an IQR increase in NDVI, NDVI, NDVI was associated with 7-20% lower odds of overweight/obesity in the adjusted models. Air pollutants mediated 6.5-29.1% of the association between greenness and zBMI. No significant mediation effect was observed for physical activity.

Conclusion: Higher school-based greenness levels were associated with lower zBMI, waist circumference, and lower odds of overweight and obesity in children and adolescents. Ambient air pollutants may partially mediate the greenness-adiposity associations.
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http://dx.doi.org/10.1016/j.envres.2020.110289DOI Listing
January 2021

The individual and joint effects of maternal 25(OH)D deficiency and gestational diabetes on infant birth size.

Nutr Metab Cardiovasc Dis 2020 11 11;30(12):2398-2405. Epub 2020 Aug 11.

Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. Electronic address:

Background And Aims: To examine the independent effect of maternal serum 25-hydroxyvitamin D [25(OH)D] deficiency and its joint effect with gestational diabetes mellitus (GDM) on infant birth size.

Methods And Results: This retrospective cohort study was conducted in 15,724 mother-offspring dyads in Beijing, China between 2016 and 2017. Outcomes included infant birth weight Z-score (adjusted for gestational age and sex) and large for gestational age (LGA). Exposures were maternal 25(OH)D concentrations. Linear and logistic regression models were used to assess the associations of exposures with continuous and binary outcomes, respectively. Exposure-outcome associations were not observed when analyzing 25(OH)D concentrations continuously or in quartiles (P > 0.05); however, mothers with severely deficient 25(OH)D concentrations (n = 307) had a decreased risk of LGA compared with those with sufficient 25(OH)D concentrations (≥30.0 ng/mL; n = 5400) (adjusted odds ratio (OR): 0.63; 95% confidence interval (CI): 0.42, 0.93). Compared to mothers with no 25(OH)D deficiency (≥20.0 ng/mL) and no GDM (n = 7975), those with both 25(OH)D deficiency and GDM (n = 1090) had 0.15 (95% CI: 0.09, 0.21) higher infant birth weight Z-score and a higher risk of LGA (OR: 1.29; 95% CI: 1.09, 1.52). Maternal 25(OH)D deficiency and GDM had additive interaction on the risk of LGA (relative risk due to interaction: 0.18).

Conclusion: Mothers with severely deficient 25(OH)D might have a decreased risk of LGA. However, the joint effect of maternal 25(OH)D deficiency and GDM might increase the risk of LGA. Our findings have clinical and public health implications and provide potential directions for future studies.
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http://dx.doi.org/10.1016/j.numecd.2020.07.046DOI Listing
November 2020

Novel Single-Enzyme-Assisted Dual Recycle Amplification Strategy for Sensitive Photoelectrochemical MicroRNA Assay.

Anal Chem 2020 11 12;92(21):14550-14557. Epub 2020 Oct 12.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China.

Herein, a novel single-enzyme-assisted dual recycle amplification strategy based on T7 exonuclease (T7 Exo) and a strand-displacement reaction (SDR) was designed to fabricate a photoelectrochemical (PEC) biosensor for sensitive microRNA-141 (miRNA-141) detection with the use of laminar bismuth tungstate (BiWO) as photoactive material. Compared with a traditional enzyme-assisted dual recycle amplification strategy, the presented method could effectively refrain the enzyme interference reaction, reduce environmental sensitivity, and save cost. Here, hairpin DNA1 (H1) decorated on magnetic beads (MB) hybridized with target miRNA-141 to form an H1/miRNA-141 heteroduplex. With the introduction of hairpin DNA2 (H2)-labeled SiO (H2-SiO), SDR was triggered between H2-SiO and H1, thus miRNA-141 was displaced from the H1/miRNA-141 heteroduplex and an H1/H2-SiO duplex was formed, realizing the reuse of the target. In the presence of T7 Exo, the H1/H2-SiO duplex was digested with the release of output DNA-SiO. To enhance the target conversion rate, H1-MB was intactly released and cycled, which could initiate more T7 Exo digestion and free abundant output DNA-SiO. Through such a process, a tiny miRNA-141 could induce substantial output DNA-SiO, effectively improving the target amplification efficiency and detection sensitivity of a PEC biosensor. Furthermore, BiWO was modified on an electrode to provide a superior initial PEC signal due to its excellent electronic transformation capacity. With the introduction of output DNA-SiO, the hairpin structure of H3 on the electrode was opened, making SiO close to the electrode surface, which significantly decreases the PEC signal. This work first established the PEC biosensor featuring a single-enzyme-assisted dual recycle amplification process for sensitive detection of biomarkers.
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http://dx.doi.org/10.1021/acs.analchem.0c02752DOI Listing
November 2020

Exposure to ambient air pollution and blood lipids in children and adolescents: A national population based study in China.

Environ Pollut 2020 Nov 15;266(Pt 3):115422. Epub 2020 Aug 15.

Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. Electronic address:

Few studies have explored the links of air pollution and childhood lipid profiles and dyslipidemias. We aimed to explore this topic in Chinese children and adolescents. This study included 12,814 children aged 7-18 years who participated in a national survey in 2013. Satellite-based spatial-temporal model was used to predict 3-y (2011-2013) average particles with diameters ≤ 1.0 μm (PM), ≤2.5 μm (PM), ≤10 μm (PM), and nitrogen dioxide (NO) concentrations. Generalized linear mixed models were employed to evaluate the relationships of air pollution and total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and dyslipidemias. Every 10 μg/m increase in PM, PM, PM, and NO was related to increases of 6.20% [95% confidence interval (CI): 2.44, 10.10], 5.31% (95%CI: 0.41, 10.44), 3.49% (95%CI: 0.97, 6.08), and 5.25% (95%CI: 1.56, 9.07) in TC, respectively. The odds ratio of hypercholesterolemia associated with a 10 μg/m increase in PM, PM, and NO was 2.15 (95%CI: 1.27, 3.65), 1.70 (95%CI: 1.12, 2.60), and 1.43 (95%CI: 1.05, 1.93), respectively. No associations were found for air pollution and other blood lipids. Long-term PM, PM, PM, and NO exposures were positively associated with TC levels and risk of hypercholesterolemia in children and adolescents.
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http://dx.doi.org/10.1016/j.envpol.2020.115422DOI Listing
November 2020

The Smartphone-Assisted Intervention Improved Perception of Nutritional Status among Middle School Students.

Int J Environ Res Public Health 2020 08 15;17(16). Epub 2020 Aug 15.

Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China.

Misperception of nutritional status is common and hinders the progress of childhood obesity prevention. This study aimed to examine the effectiveness of a smartphone-assisted intervention to improve student and parental perception of students' nutritional status (underweight, normal weight, overweight, obese). We conducted a parallel-group controlled trial with a non-randomized design in three junior middle schools of Beijing, China in 2019. One school was allocated to the intervention group and two schools to the control group. A total of 573 students (aged 13.1 ± 0.4 years) participated in the trial. The 3-month intervention included three components: health education sessions for students and parents, regular monitoring of students' weight, and the provision of feedback via a smartphone application. Schools in the control group continued their usual practice. Primary outcomes included the student and parental accurate perception of students' nutritional status. The percentage of students' accurate perception of their own nutritional status in the intervention group increased from 49.0% to 59.2% from baseline to three months, whereas it decreased from 64.1% to 58.1% in the control group; the adjusted odds ratio (OR) between the two groups was 1.71 (95% confidence interval (CI): 1.13, 2.59). The intervention did not significantly improve parental perception of students' nutritional status ( > 0.05). The study findings provided a brief approach for improving perception of nutritional status among middle school students.
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http://dx.doi.org/10.3390/ijerph17165932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7459995PMC
August 2020

Better assessments of greenhouse gas emissions from global fish ponds needed to adequately evaluate aquaculture footprint.

Sci Total Environ 2020 Dec 25;748:141247. Epub 2020 Jul 25.

Department of Biology, Federal University of Juiz de Fora, Juiz de Fora 36036-900, Brazil.

While providing protein for a fast-growing human population, the ongoing boom in global aquaculture comes with environmental costs. Particularly, the intense greenhouse gas (GHG) emissions reported for several aquaculture systems are a source of concern. Still, we argue that actual emissions could be multiple times higher than currently thought. Most studies supporting existing estimates solely rely on measurements of water-atmosphere diffusive fluxes of GHG, whereas methane (CH) and nitrous oxide (NO) emissions during drainage and refilling and CH bubbles emerging from sediments are largely ignored. Yet, abundant evidence for similar aquatic ecosystems suggests that these largely unaccounted emission pathways may be responsible for a large share of annual GHG emissions. Uncertainties from overlooking important emission pathways may have serious consequences, including incorrect advice on mitigation strategies and overly optimistic assessments of the GHG footprint of cultured freshwater fish. To ensure a low-carbon future for global aquaculture, we contend that GHG assessments in fish-farming ponds must extend beyond the focus on diffusive water-atmosphere fluxes and include all emission pathways and possible carbon burial in the sediment. In parallel, we call for a better understanding of the biological, microbiological and physical drivers of aquaculture emissions to effectively support mitigation strategies to minimize the footprint of this nutritionally valuable protein source.
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http://dx.doi.org/10.1016/j.scitotenv.2020.141247DOI Listing
December 2020

Ambient temperature and the risk of preterm birth: A national birth cohort study in the mainland China.

Environ Int 2020 09 22;142:105851. Epub 2020 Jun 22.

National Human Genetic Resources Center, Beijing, China; National Research Institute for Family Planning, Beijing, China. Electronic address:

Background: Little is known about the effect of ambient temperature on preterm birth, especially for the trimester-specific effects.

Objective: To evaluate whether exposure to relatively low or high temperature during pregnancy is associated with increasing risk of preterm birth or not.

Method: We analysed the data of a birth cohort with 1,281,859 singleton pregnancies during 2013-2014 and matched the home address of each pregnant women to the model based daily meteorological and air pollution data. Then we used the Cox proportional hazard regression models with random effect to estimate the non-linear associations between exposure to relatively low or high temperature at each trimester of pregnancy and the risk of preterm birth, after controlling for air pollution and individual-level covariates.

Finding: The overall preterm birth rate was 8.1% (104,493 preterm births). Exposure to relatively low or high temperatures during the entire pregnancy significantly increase the risk of preterm birth, with hazard ratios (HRs) [95% confidence intervals (CIs)] of 1.03 (95%CI: 1.02, 1.04) for relatively low (9.1 ℃, the 5th percentile) temperature and 1.55 (95%CI: 1.48, 1.61) for relatively high (23.0 ℃, the 95th percentile) temperature in comparison with the thresholds (12.0 ℃). Pregnant women at the early pregnancy (the 1 and 2 trimester) are more susceptible to high temperatures while pregnant women at the late pregnancy (the 3 trimester) are more susceptible to low temperatures.

Conclusion: These findings provide new evidence that exposure to relatively low or high temperatures during pregnancy increases the risk of preterm birth, which can serve as scientific evidence for prevention of preterm birth.
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http://dx.doi.org/10.1016/j.envint.2020.105851DOI Listing
September 2020

The association of the glucokinase rs4607517 polymorphism with gestational diabetes mellitus and its interaction with sweets consumption in Chinese women.

Public Health Nutr 2020 Jun 2:1-7. Epub 2020 Jun 2.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

Objective: To identify the association of the glucokinase gene (GCK) rs4607517 polymorphism with gestational diabetes mellitus (GDM) and determine whether sweets consumption could interact with the polymorphism on GDM in Chinese women.

Design: We conducted a case-control study at a hospital including 1015 participants (562 GDM cases and 453 controls). We collected the data of pre-pregnancy BMI, sweets consumption and performed genotyping of the GCK rs4607517 polymorphism. Logistic regression was performed to test the association between the rs4607517 polymorphism and GDM, and the stratified analyses by sweets consumption were conducted, using an additive genetic model.

Setting: A case-control study of women at a hospital in Beijing, China.

Participants: One thousand and fifteen Chinese women.

Results: The GCK rs4607517 A allele was significantly associated with GDM (OR 1·35, 95 % CI 1·03, 1·77; P = 0·028). Furthermore, stratified analyses showed that the A allele increased the risk of GDM only in women who had a habitual consumption of sweet foods (sweets consumption ≥ once per week) (OR 1·61, 95 % CI 1·17, 2·21; P = 0·003). Significant interaction on GDM was found between the rs4607517 A allele and sweets consumption (P = 0·004).

Conclusions: This study for the first time reported the interaction between the GCK rs4607517 polymorphism and sweets consumption on GDM. The results provided novel evidence for risk assessment and personalised prevention of GDM.
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http://dx.doi.org/10.1017/S1368980020000609DOI Listing
June 2020

Combined Effect of Maternal Vitamin D Deficiency and Gestational Diabetes Mellitus on Trajectories of Ultrasound-Measured Fetal Growth: A Birth Cohort Study in Beijing, China.

J Diabetes Res 2020 30;2020:4231892. Epub 2020 Mar 30.

Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China.

Objective: Few studies have examined whether maternal 25(OH)D deficiency and gestational diabetes mellitus (GDM) jointly affect fetal growth. We aimed to examine the separate and combined effects of maternal 25(OH)D deficiency and GDM on trajectories of fetal growth.

Methods: We established a birth cohort (2016-2017) with 10,913 singleton pregnancies in Tongzhou Maternal and Child Health Hospital of Beijing, China. Maternal 25(OH)D deficiency (serum 25(OH)D concentration < 20.0 ng/mL) was detected, and GDM was diagnosed at 24~28 gestational weeks. Fetal growth was assessed by longitudinal ultrasound measurements of estimated fetal weight (EFW) and abdominal circumference (AC) from 28 gestational weeks to delivery, both of which were standardized as gestational-age-adjusted -score. A -means algorithm was used to cluster the longitudinal measurements (trajectories) of fetal growth. Logistic regression models were used for estimating exposure-outcome associations and additive interactions.

Results: We identified two distinct trajectories of fetal growth, and the faster one resembling the 90 centile curve in the reference population was classified as excessive fetal growth. Maternal 25(OH)D deficiency and GDM were independently associated with an increased risk of excessive fetal growth. The combination of maternal 25(OH)D deficiency and GDM was associated with an increased risk of excessive fetal growth assessed by EFW -score (odds ratio (OR): 1.36; 95% confidence interval (CI): 1.15~1.62) and AC -score (OR (95% CI): 1.32 (1.11~1.56)), but the relative excess risks attributable to interaction were nonsignificant ( > 0.05).

Conclusion: Maternal 25(OH)D deficiency and GDM may jointly increase the risk of excessive fetal growth. Interventions for pregnancies with GDM may be more beneficial for those with 25(OH)D deficiency than those without regarding risk of excessive fetal growth, if confirmed in a large sample.
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http://dx.doi.org/10.1155/2020/4231892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149432PMC
February 2021

The associations of specific school- and individual-level characteristics with obesity among primary school children in Beijing, China.

Public Health Nutr 2020 07 13;23(10):1838-1845. Epub 2020 Apr 13.

Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.

Objective: We aimed to investigate the associations between school-level characteristics and obesity among Chinese primary school children with consideration of individual-level characteristics.

Design: This cross-sectional study was conducted in 2015/2016. School-level characteristics were assessed using an interviewer-administered school questionnaire, and a 'school-based obesity prevention index' was further developed. Individual-level characteristics were collected by self-administered questionnaires. Objectively measured height and weight of students were collected, and obesity status was classified according to the International Obesity Task Force criteria for Asian children. Generalised linear mixed models were used to estimate the associations among the school- and individual-level characteristics and obesity of students.

Setting: Thirty-seven primary schools from an urban and a rural district of Beijing, China.

Participants: School staffs, 2201 students and their parents.

Results: The school-based obesity prevention index involved the number of health professionals, availability of students' health records, monitoring students' nutrition status, frequency of health education activities, reporting achievements of obesity prevention activities to parents, duration of physical activity during school time and availability of playground equipment. The prevalence of obesity was lower in schools with the higher index value compared with that in schools with the lower index value (OR 0·56; 95 % CI 0·40, 0·79). Some individual-level characteristics were negatively associated with childhood obesity: liking sports, duration of screen time ≤2 h/d, perceived lower eating speed, parental non-overweight/obesity.

Conclusions: Irrespective of individual-level characteristics, the specific school-level characteristics had a cumulative effect on obesity among Chinese primary school children. Further school-based obesity intervention should consider these characteristics simultaneously.
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http://dx.doi.org/10.1017/S1368980019004592DOI Listing
July 2020

Letter: Strategies for Prevention and Control of 2019 Novel Coronavirus Infection Among Medical Staff.

Neurosurgery 2020 07;87(1):E57-E62

Department of Neurosurgery Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan, Hubei P.R. China.

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http://dx.doi.org/10.1093/neuros/nyaa117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184454PMC
July 2020

Long-term exposure to airborne particulate matter of 1 μm or less and blood pressure in healthy young adults: A national study with 1.2 million pregnancy planners.

Environ Res 2020 05 19;184:109113. Epub 2020 Feb 19.

National Research Institute for Family Planning, Beijing, China; National Center for Human Genetic Resources, Beijing, China. Electronic address:

No evidence exists concerning the effect of airborne particulate matter of 1 μm or less (PM) on blood pressure of young adults planning for pregnancy. We collected health examination information of about 1.2 million couples (aged 18-45 years) from a national birth cohort in China from Jan 1, 2013 to Oct 1, 2014 and matched their home address to daily PM and PM concentrations, which were predicted by remote sensing information. Generalized additive mixed models were used to analyze associations between long-term exposure to PM and blood pressure, after controlling for individual factors. A 10 μg/m increase in PM was associated with increased systolic blood pressure (SBP) for 0.26 (95%CI: 0.24, 0.29) mmHg in females and 0.29 (95%CI: 0.26, 0.31) mmHg in males, respectively. PM was also associated with increased DBP for 0.22 (95%CI: 0.20, 0.23) mmHg in females and 0.17 (95%CI: 0.15, 0.19) mmHg in males, respectively. Similar effects on blood pressure were found for PM, meanwhile, the effect of PM on SBP increased with the scale of PM included in PM (p for interaction term <0.01). In summary, long-term exposure to PM as well as PM was associated with increased SBP and DBP of Chinese young adults planning for pregnancy.
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http://dx.doi.org/10.1016/j.envres.2020.109113DOI Listing
May 2020

Association between convenience stores near schools and obesity among school-aged children in Beijing, China.

BMC Public Health 2020 Jan 31;20(1):150. Epub 2020 Jan 31.

Department of Maternal and Child Health, School of Public Health, Peking University, No.38 Xueyuan Rd, Beijing, 100191, China.

Background: Food environments have rapidly changed over the past years in China and children have more access to unhealthy food in convenience stores near schools. Since the studies on the association between convenience stores near schools and obesity had inconsistent results and no similar study in China, we conducted a study on the association in Beijing of China, which will provide scientific evidence for the intervention of childhood obesity.

Methods: The study included 2201 students at grade 4 of 37 primary schools in Dongcheng or Miyun district of Beijing. The food environment data was acquired from AMAP, the free web-based geospatial service provider. The numbers of convenience stores were captured within the 800-m network buffer near schools using Geographic Information System. The weight and height of each student were measured by trained health professionals. Students' dietary and physical behaviors and other information associated with obesity were collected with questionnaires for students and their parents. The generalized linear mixed model (GLMM) was used to analyze the data.

Results: The average age of the students was 10.2 years (Standard Deviation (SD) = 0.33). The prevalence of obesity in students was 14.9%. The median number of convenience stores within the 800-m network buffer near schools was 24 in two districts. The number of convenience stores near each school varied from 5 to 67 (median: 25) in Dongcheng district and from 1 to 57 (median: 22) in Miyun district. After adjusting for the confounding factors at the family and individual levels, the association between convenience stores and childhood obesity was statistically significant. Additional ten convenience stores near schools were associated with an increased risk of obesity (Odds Ratio (OR) = 1.13, 95% confidence interval (CI): 1.03,1.24, P = 0.011). Compared with less than 24 convenience stores near schools, the students with more than or equal to 24 convenience stores near schools had an increased risk of obesity (OR = 1.49, 95% CI: 1.09, 2.03, P = 0.013).

Conclusion: The students with more convenience stores near their schools had an increased risk of obesity. The findings provided evidence for developing public health policy to restrict the number of convenience stores near schools to prevent and control childhood obesity.
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http://dx.doi.org/10.1186/s12889-020-8257-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995088PMC
January 2020