Publications by authors named "H T Li"

76,462 Publications

Health effects of air pollutant mixtures on overall mortality among the elderly population using Bayesian kernel machine regression (BKMR).

Chemosphere 2021 Jul 17;286(Pt 1):131566. Epub 2021 Jul 17.

Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. Electronic address:

It is well documented that fine particles matter (PM), ozone (O), and nitrogen dioxide (NO) are associated with a range of adverse health outcomes. However, most epidemiologic studies have focused on understanding their additive effects, despite that individuals are exposed to multiple air pollutants simultaneously that are likely correlated with each other. Therefore, we applied a novel method - Bayesian Kernel machine regression (BKMR) and conducted a population-based cohort study to assess the individual and joint effect of air pollutant mixtures (PM, O, and NO) on all-cause mortality among the Medicare population in 15 cities with 656 different ZIP codes in the southeastern US. The results suggest a strong association between pollutant mixture and all-cause mortality, mainly driven by PM. The positive association of PM with mortality appears stronger at lower percentiles of other pollutants. An interquartile range change in PM concentration was associated with a significant increase in mortality of 1.7 (95% CI: 0.5, 2.9), 1.6 (95% CI: 0.4, 2.7) and 1.4 (95% CI: 0.1, 2.6) standard deviations (SD) when O and NO were set at the 25th, 50th, and 75th percentiles, respectively. BKMR analysis did not identify statistically significant interactions among PM, O, and NO. However, since the small sub-population might weaken the study power, additional studies (in larger sample size and other regions in the US) are in need to reinforce the current finding.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131566DOI Listing
July 2021

Inhibition of CtBP-regulated proinflammatory gene transcription attenuates psoriatic skin inflammation.

J Invest Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Department of Dermatology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address:

Psoriasis is a chronic immune-mediated disease characterized by excessive proliferation of epidermal keratinocytes and increased immune cell infiltration to the skin. Although it is well known that psoriasis pathogenesis is driven by aberrant production of proinflammatory cytokines, the mechanisms underlying the imbalance between proinflammatory and anti-inflammatory cytokine expression are incompletely understood. Here we report that the transcriptional coregulators C-terminal-binding protein (CtBP) 1 and 2 can transactivate a common set of proinflammatory genes both in the skin of imiquimod-induced mouse psoriasis model and in human keratinocytes and macrophages stimulated by imiquimod. We find that mice overexpressing CtBP1 in epidermal keratinocytes display severe skin inflammation phenotypes with increased expression of Th1 and Th17 cytokines. We also find that the expression of CtBPs and CtBP target genes is elevated both in human psoriatic lesions and in the mouse imiquimod psoriasis model. Moreover, we were able to demonstrate that topical treatment with a peptidic inhibitor of CtBP effectively suppresses the CtBP-regulated proinflammatory gene expression and thus attenuates psoriatic inflammation in the imiquimod mouse model. Together, our findings suggest new strategies for therapeutic modulation of the immune response in inflammatory skin diseases.
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http://dx.doi.org/10.1016/j.jid.2021.06.029DOI Listing
July 2021

Renovation priorities for old residential districts based on resident satisfaction: An application of asymmetric impact-performance analysis in Xi'an, China.

PLoS One 2021 22;16(7):e0254372. Epub 2021 Jul 22.

School of Management, Xi'an University of Architecture and Technology, Xi'an, China.

China is currently designing a regional economic layout for high-quality urban development, shifting its focus from the primary stage of beautifying cities to the next stage of profound urbanization aiming at strengthening industry. This is of high importance given that the urbanization rate of permanent residents by the end of 2019 was 60.60%, according to the National Bureau of Statistics of China. In the face of various factors such as the need to economize the intensive use of resources, urban stock development, and the need for urban constructions to maintain harmony with the surrounding ecosystem, regeneration has emerged as an efficient means to repurpose old residential districts. It conforms to the policy of stock planning and is one of the important methods to ensure the sustainable development of a city. Prioritizing the right attributes in renovation is one of the critical steps in the regeneration of old residential districts-instead of merely focusing on their selection and scoring by experts, more attention should be paid to the resident satisfaction (or the lack thereof) arising from them. Therefore, in this study, we have proposed a collaborative approach that requires communities to prioritize the appropriate aspects in urban renewal. This study employed the three-factor theory of customer satisfaction, to investigate the five attributes namely geographical location, infrastructure, traffic, residential management, and living facilities, of satisfaction and dissatisfaction of residents in the old city. This includes 327 samples based on the residents of Yanta old town in Xi'an. The asymmetric impact-performance analysis technique was used to explore, and quantify the asymmetric relationship between the attributes of old residential districts, and residents' satisfaction. The results proved that attributes were divided into three: excitement factors, performance, and basic factors, based on the asymmetric influence of attributes on residents' satisfaction. Residential management was into excitement factors, living facilities were categorized into basic factors, and the remaining three attributes were categorized into performance factors. The satisfaction of the residents regarding the renovation was maximized by comprehensively considering the performance of given attributes, adjusting the improvement strategies of each attribute, and further determining the focus of the renovation of the old residential districts. Simultaneously, it helped planners make more rational choices in urban renewal and sustainable development.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254372PLOS
July 2021

The effect of VAV3 polymorphisms on thyroid cancer.

Endocrine 2021 Jul 22. Epub 2021 Jul 22.

Otorhinolaryngology head and neck surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, China.

Background: The incidence of thyroid cancer is rising rapidly in China, but there are few studies on the risk factors of thyroid cancer in the Chinese Han population.

Methods: We performed this case-control study of 510 patients and 509 controls to for determine the linkage of VAV3 variants (rs17019602, rs7521681, rs4915076, and rs1777451) with thyroid cancer susceptibility by computing the odds ratio (OR) and 95% confidence intervals (CI). Multi-factor dimension reduction (MDR) analysis was conducted to assess interaction of VAV3 genetic variants.

Results: We found that rs7521681 was remarkably related to a higher risk of thyroid cancer (OR = 1.74, p = 0.012), whereas rs4915076 (OR = 0.66, p = 0.001) significantly decreased thyroid cancer susceptibility. Stratified analyses showed that rs4915076 had a protective role in thyroid cancer in both ages >45 years (OR = 0.70, p = 0.017) and age ≤45 years (OR = 0.63, p = 0.007). Rs17019602 could increase the susceptibility of thyroid cancer in men (OR = 4.76, p = 0.049). Rs7521681 was related to an increased risk of thyroid cancer in women (OR = 1.97, p = 0.012). Rs4915076 could protect individuals from thyroid cancer both in men (OR = 0.60, p = 0.031) and women (OR = 0.68, p = 0.010). Moreover, rs4915076 was the best single-locus model to predict thyroid cancer. Interestingly, the interaction model of rs17019602, rs7521681, rs4915076, rs1777451, and age was a candidate gene-environment model.

Conclusion: Our results indicated VAV3 variants were associated with thyroid cancer, which provides a new sight into etiology of thyroid cancer.
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http://dx.doi.org/10.1007/s12020-021-02827-6DOI Listing
July 2021

The Diagnostic Value of Coagulation Indicators and Inflammatory Markers in Distinguishing Between Strangulated and Simple Intestinal Obstruction.

Surg Laparosc Endosc Percutan Tech 2021 Jul 21. Epub 2021 Jul 21.

Prenatal Diagnosis Center Departments of Emergency Radiological Clinical Laboratory, Boai Hospital of Zhongshan Affiliated to Southern Medical University, Zhongshan, Guangdong, China.

Background: Intestinal obstruction with strangulation can be life-threating, and it is critical to make an accurate and timely diagnosis for emergency surgery.

Objective: This was aimed to investigate the value of coagulation indicators and inflammatory markers in distinguishing between strangulated and simple intestinal obstruction.

Materials And Methods: Fifty-four patients with intestinal obstruction were retrospectively studied. The correlation between coagulation indicators and inflammatory markers with intestinal obstruction was analyzed. Receiver operating characteristic curves were created to assess their ability in discriminative diagnosis.

Results: Levels of fibrinogen (Fib), C-reactive protein (CRP), neutrophil ratio, and D-Dimer were significantly greater, while thrombin time was significantly shorter in strangulated intestinal obstruction compared with simple intestinal obstruction. Furthermore, Fib levels in the necrosis subgroup of strangulated intestinal obstruction were significantly higher than those in the ischemia subgroup and simple intestinal obstruction group. The areas under the receiver operating characteristic curve were 0.58 for white blood cells, 0.78 for CRP, and 0.80 for Fib. Using the optimal cutoff values of Fib (3.71 g/L) and CRP (14.54 mg/L), the sensitivity, specificity, positive predictive value, and negative predictive value in discriminating between strangulated intestinal obstruction and simple intestinal obstruction were 51.43%, 100%, 100%, and 52.78% for Fib, and 56.25%, 94.44%, 94.74%, and 54.84% for CRP, respectively.

Conclusions: Fib and CRP demonstrate good performance in predicting strangulation and are indicative of intestinal necrosis and ischemia. The combination of this coagulation indicator and inflammatory marker holds potential for better discrimination between strangulated and simple intestinal obstruction.
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http://dx.doi.org/10.1097/SLE.0000000000000982DOI Listing
July 2021