Holger Kirsten

Holger Kirsten

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Holger Kirsten

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A catalog of genetic loci associated with kidney function from analyses of a million individuals.

Authors:
Matthias Wuttke Yong Li Man Li Karsten B Sieber Mary F Feitosa Mathias Gorski Adrienne Tin Lihua Wang Audrey Y Chu Anselm Hoppmann Holger Kirsten Ayush Giri Jin-Fang Chai Gardar Sveinbjornsson Bamidele O Tayo Teresa Nutile Christian Fuchsberger Jonathan Marten Massimiliano Cocca Sahar Ghasemi Yizhe Xu Katrin Horn Damia Noce Peter J van der Most Sanaz Sedaghat Zhi Yu Masato Akiyama Saima Afaq Tarunveer S Ahluwalia Peter Almgren Najaf Amin Johan Ärnlöv Stephan J L Bakker Nisha Bansal Daniela Baptista Sven Bergmann Mary L Biggs Ginevra Biino Michael Boehnke Eric Boerwinkle Mathilde Boissel Erwin P Bottinger Thibaud S Boutin Hermann Brenner Marco Brumat Ralph Burkhardt Adam S Butterworth Eric Campana Archie Campbell Harry Campbell Mickaël Canouil Robert J Carroll Eulalia Catamo John C Chambers Miao-Ling Chee Miao-Li Chee Xu Chen Ching-Yu Cheng Yurong Cheng Kaare Christensen Renata Cifkova Marina Ciullo Maria Pina Concas James P Cook Josef Coresh Tanguy Corre Cinzia Felicita Sala Daniele Cusi John Danesh E Warwick Daw Martin H de Borst Alessandro De Grandi Renée de Mutsert Aiko P J de Vries Frauke Degenhardt Graciela Delgado Ayse Demirkan Emanuele Di Angelantonio Katalin Dittrich Jasmin Divers Rajkumar Dorajoo Kai-Uwe Eckardt Georg Ehret Paul Elliott Karlhans Endlich Michele K Evans Janine F Felix Valencia Hui Xian Foo Oscar H Franco Andre Franke Barry I Freedman Sandra Freitag-Wolf Yechiel Friedlander Philippe Froguel Ron T Gansevoort He Gao Paolo Gasparini J Michael Gaziano Vilmantas Giedraitis Christian Gieger Giorgia Girotto Franco Giulianini Martin Gögele Scott D Gordon Daniel F Gudbjartsson Vilmundur Gudnason Toomas Haller Pavel Hamet Tamara B Harris Catharina A Hartman Caroline Hayward Jacklyn N Hellwege Chew-Kiat Heng Andrew A Hicks Edith Hofer Wei Huang Nina Hutri-Kähönen Shih-Jen Hwang M Arfan Ikram Olafur S Indridason Erik Ingelsson Marcus Ising Vincent W V Jaddoe Johanna Jakobsdottir Jost B Jonas Peter K Joshi Navya Shilpa Josyula Bettina Jung Mika Kähönen Yoichiro Kamatani Candace M Kammerer Masahiro Kanai Mika Kastarinen Shona M Kerr Chiea-Chuen Khor Wieland Kiess Marcus E Kleber Wolfgang Koenig Jaspal S Kooner Antje Körner Peter Kovacs Aldi T Kraja Alena Krajcoviechova Holly Kramer Bernhard K Krämer Florian Kronenberg Michiaki Kubo Brigitte Kühnel Mikko Kuokkanen Johanna Kuusisto Martina La Bianca Markku Laakso Leslie A Lange Carl D Langefeld Jeannette Jen-Mai Lee Benjamin Lehne Terho Lehtimäki Wolfgang Lieb Su-Chi Lim Lars Lind Cecilia M Lindgren Jun Liu Jianjun Liu Markus Loeffler Ruth J F Loos Susanne Lucae Mary Ann Lukas Leo-Pekka Lyytikäinen Reedik Mägi Patrik K E Magnusson Anubha Mahajan Nicholas G Martin Jade Martins Winfried März Deborah Mascalzoni Koichi Matsuda Christa Meisinger Thomas Meitinger Olle Melander Andres Metspalu Evgenia K Mikaelsdottir Yuri Milaneschi Kozeta Miliku Pashupati P Mishra Karen L Mohlke Nina Mononen Grant W Montgomery Dennis O Mook-Kanamori Josyf C Mychaleckyj Girish N Nadkarni Mike A Nalls Matthias Nauck Kjell Nikus Boting Ning Ilja M Nolte Raymond Noordam Jeffrey O'Connell Michelle L O'Donoghue Isleifur Olafsson Albertine J Oldehinkel Marju Orho-Melander Willem H Ouwehand Sandosh Padmanabhan Nicholette D Palmer Runolfur Palsson Brenda W J H Penninx Thomas Perls Markus Perola Mario Pirastu Nicola Pirastu Giorgio Pistis Anna I Podgornaia Ozren Polasek Belen Ponte David J Porteous Tanja Poulain Peter P Pramstaller Michael H Preuss Bram P Prins Michael A Province Ton J Rabelink Laura M Raffield Olli T Raitakari Dermot F Reilly Rainer Rettig Myriam Rheinberger Kenneth M Rice Paul M Ridker Fernando Rivadeneira Federica Rizzi David J Roberts Antonietta Robino Peter Rossing Igor Rudan Rico Rueedi Daniela Ruggiero Kathleen A Ryan Yasaman Saba Charumathi Sabanayagam Veikko Salomaa Erika Salvi Kai-Uwe Saum Helena Schmidt Reinhold Schmidt Ben Schöttker Christina-Alexandra Schulz Nicole Schupf Christian M Shaffer Yuan Shi Albert V Smith Blair H Smith Nicole Soranzo Cassandra N Spracklen Konstantin Strauch Heather M Stringham Michael Stumvoll Per O Svensson Silke Szymczak E-Shyong Tai Salman M Tajuddin Nicholas Y Q Tan Kent D Taylor Andrej Teren Yih-Chung Tham Joachim Thiery Chris H L Thio Hauke Thomsen Gudmar Thorleifsson Daniela Toniolo Anke Tönjes Johanne Tremblay Ioanna Tzoulaki André G Uitterlinden Simona Vaccargiu Rob M van Dam Pim van der Harst Cornelia M van Duijn Digna R Velez Edward Niek Verweij Suzanne Vogelezang Uwe Völker Peter Vollenweider Gerard Waeber Melanie Waldenberger Lars Wallentin Ya Xing Wang Chaolong Wang Dawn M Waterworth Wen Bin Wei Harvey White John B Whitfield Sarah H Wild James F Wilson Mary K Wojczynski Charlene Wong Tien-Yin Wong Liang Xu Qiong Yang Masayuki Yasuda Laura M Yerges-Armstrong Weihua Zhang Alan B Zonderman Jerome I Rotter Murielle Bochud Bruce M Psaty Veronique Vitart James G Wilson Abbas Dehghan Afshin Parsa Daniel I Chasman Kevin Ho Andrew P Morris Olivier Devuyst Shreeram Akilesh Sarah A Pendergrass Xueling Sim Carsten A Böger Yukinori Okada Todd L Edwards Harold Snieder Kari Stefansson Adriana M Hung Iris M Heid Markus Scholz Alexander Teumer Anna Köttgen Cristian Pattaro

Nat Genet 2019 Jun 31;51(6):957-972. Epub 2019 May 31.

Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.

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http://dx.doi.org/10.1038/s41588-019-0407-xDOI Listing
June 2019

Genetic association study of eight steroid hormones and implications for sexual dimorphism of coronary artery disease.

J Clin Endocrinol Metab 2019 Jun 6. Epub 2019 Jun 6.

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1210/jc.2019-00757DOI Listing
June 2019

Post-mortem in situ stability of serum markers of cerebral damage and acute phase response.

Int J Legal Med 2019 May 30;133(3):871-881. Epub 2018 Aug 30.

Medical Faculty, Institute of Legal Medicine, University of Leipzig, Johannisallee 28, 04103, Leipzig, Germany.

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http://dx.doi.org/10.1007/s00414-018-1925-2DOI Listing
May 2019

Necessity of transnasal gastroscopy in routine diagnostics: a patient-centred requirement analysis.

BMJ Open Gastroenterol 2019 14;6(1):e000264. Epub 2019 Apr 14.

Division of Gastroenterology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1136/bmjgast-2018-000264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506089PMC
April 2019

Association of Human Promoter Variants with the Occurrence of Knee-Osteoarthritis in a Case Control Association Study.

Int J Mol Sci 2019 Mar 19;20(6). Epub 2019 Mar 19.

Experimental Rheumatology Unit, Department of Orthopedics, Jena University Hospital, Waldkrankenhaus 'Rudolf Elle', 07607 Eisenberg, Germany.

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http://dx.doi.org/10.3390/ijms20061382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471183PMC
March 2019

Genome-wide association study identifies inversion in the locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.

Gut 2018 10 28;67(10):1855-1863. Epub 2017 Jul 28.

Department of Molecular and Cell Biology, Center for Exocrine Disorders, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, USA.

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http://gut.bmj.com/lookup/doi/10.1136/gutjnl-2017-314454
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http://dx.doi.org/10.1136/gutjnl-2017-314454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145291PMC
October 2018

Measurement of Cerebral Biomarkers Proving Traumatic Brain Injuries in Post-Mortem Body Fluids.

J Neurotrauma 2018 Sep 6;35(17):2044-2055. Epub 2018 Jul 6.

1 Institute of Legal Medicine, Medical Faculty, University of Leipzig , Leipzig, Germany .

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http://dx.doi.org/10.1089/neu.2017.5441DOI Listing
September 2018

Biomechanical properties of polymer-infiltrated ceramic crowns on one-piece zirconia implants after long-term chewing simulation.

Int J Implant Dent 2018 May 23;4(1):16. Epub 2018 May 23.

Department of Dental Prosthodontics and Materials Science, University of Leipzig, Liebigstraße 12, Haus 1, 04103, Leipzig, Germany.

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http://dx.doi.org/10.1186/s40729-018-0127-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964049PMC
May 2018

Human brain arousal in the resting state: a genome-wide association study.

Mol Psychiatry 2018 Apr 27. Epub 2018 Apr 27.

LIFE - Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1038/s41380-018-0052-2DOI Listing
April 2018

and are putative modulators of dyslexia-related MMR.

Brain Behav 2017 11 18;7(11):e00851. Epub 2017 Oct 18.

Fraunhofer Institute for Cell Therapy and Immunology Leipzig Germany.

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http://dx.doi.org/10.1002/brb3.851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698869PMC
November 2017

Dyslexia risk gene relates to representation of sound in the auditory brainstem.

Dev Cogn Neurosci 2017 04 17;24:63-71. Epub 2017 Jan 17.

Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.dcn.2017.01.008DOI Listing
April 2017

Genome-wide meta-analysis identifies novel loci of plaque burden in carotid artery.

Atherosclerosis 2017 04 24;259:32-40. Epub 2017 Feb 24.

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.02.018DOI Listing
April 2017

Genome-wide association analysis of actigraphic sleep phenotypes in the LIFE Adult Study.

J Sleep Res 2016 12 29;25(6):690-701. Epub 2016 Apr 29.

LIFE-Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1111/jsr.12421DOI Listing
December 2016

Predicting early signs of dyslexia at a preliterate age by combining behavioral assessment with structural MRI.

Neuroimage 2016 Dec 5;143:378-386. Epub 2016 Sep 5.

Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1a, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.neuroimage.2016.09.004DOI Listing
December 2016

NRSN1 associated grey matter volume of the visual word form area reveals dyslexia before school.

Brain 2016 Oct 24;139(Pt 10):2792-2803. Epub 2016 Jun 24.

1 Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1a, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1093/brain/aww153DOI Listing
October 2016

Comparing performance of modern genotype imputation methods in different ethnicities.

Sci Rep 2016 10 4;6:34386. Epub 2016 Oct 4.

Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16-18, 04107 Leipzig, Germany.

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http://dx.doi.org/10.1038/srep34386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048136PMC
October 2016

Improved prediction of complex diseases by common genetic markers: state of the art and further perspectives.

Hum Genet 2016 Mar 2;135(3):259-72. Epub 2016 Feb 2.

Department of Cell Therapy, Fraunhofer Institute for Cell Therapy and Immunology, Perlickstraße 1, Leipzig, Germany.

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http://dx.doi.org/10.1007/s00439-016-1636-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759222PMC
March 2016

High acceptance of an early dyslexia screening test involving genetic analyses in Germany.

Eur J Hum Genet 2016 Feb 3;24(2):178-82. Epub 2015 Jun 3.

Department of Cell Therapy, Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany.

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http://dx.doi.org/10.1038/ejhg.2015.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717194PMC
February 2016

Genetic variants of lipase activity in chronic pancreatitis.

Gut 2016 Jan 26;65(1):184-5. Epub 2015 Mar 26.

Division of Gastroenterology and Rheumatology, Department of Internal Medicine, Neurology and Dermatology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1136/gutjnl-2015-309521DOI Listing
January 2016

Working-memory endophenotype and dyslexia-associated genetic variant predict dyslexia phenotype.

Cortex 2015 Oct 22;71:291-305. Epub 2015 Jul 22.

Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

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http://dx.doi.org/10.1016/j.cortex.2015.06.029DOI Listing
October 2015

Genetic dyslexia risk variant is related to neural connectivity patterns underlying phonological awareness in children.

Neuroimage 2015 Sep 12;118:414-21. Epub 2015 Jun 12.

Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstraße 1a, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.neuroimage.2015.06.024DOI Listing
September 2015

Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood.

PLoS Genet 2015 Sep 24;11(9):e1005510. Epub 2015 Sep 24.

LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig Germany; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1005510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581711PMC
September 2015

A stereotaxic, population-averaged T1w ovine brain atlas including cerebral morphology and tissue volumes.

Front Neuroanat 2015 4;9:69. Epub 2015 Jun 4.

Department of Cell Therapy, Fraunhofer Institute for Cell Therapy and Immunology Leipzig, Germany ; Translational Centre for Regenerative Medicine, University of Leipzig Leipzig, Germany ; Neurovascular Regulation Laboratory at Neuroscience Center, Massachusetts General Hospital and Harvard Medical School Charlestown, MA, USA.

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http://dx.doi.org/10.3389/fnana.2015.00069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455244PMC
June 2015

Cellular adhesion gene SELP is associated with rheumatoid arthritis and displays differential allelic expression.

PLoS One 2014 22;9(8):e103872. Epub 2014 Aug 22.

Fraunhofer Institute for Celltherapy and Immunology (IZI), Leipzig, Germany; LIFE - Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany; Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Universität Leipzig, Leipzig, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103872PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141704PMC
May 2015

Three gangliogliomas: results of GTG-banding, SKY, genome-wide high resolution SNP-array, gene expression and review of the literature.

Neuropathology 2015 Apr 6;35(2):148-57. Epub 2014 Nov 6.

Department of Neurosurgery, University of Leipzig, Leipzig, Germany; Translational Centre for Regenerative Medicine (TRM), University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1111/neup.12176DOI Listing
April 2015

Complexin2 modulates working memory-related neural activity in patients with schizophrenia.

Eur Arch Psychiatry Clin Neurosci 2015 Mar 9;265(2):137-45. Epub 2014 Oct 9.

Department of Child and Adolescent Psychiatry, Faculty of Medicine Carl Gustav Carus of the Technische Universität Dresden, Fetscherstr. 74, 01307, Dresden, Germany.

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http://dx.doi.org/10.1007/s00406-014-0550-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342303PMC
March 2015

Comprehensive high-resolution genomic profiling and cytogenetics of two pediatric and one adult medulloblastoma.

Pathol Res Pract 2013 Sep 4;209(9):541-7. Epub 2013 Jul 4.

Translational Centre for Regenerative Medicine (TRM), University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1016/j.prp.2013.06.001DOI Listing
September 2013

Differential allelic expression of IL13 and CSF2 genes associated with asthma.

Genet Mol Biol 2012 Jul 2;35(3):567-74. Epub 2012 Aug 2.

Translational Centre for Regenerative Medicine, Universität Leipzig, Leipzig,Germany. ; Fraunhofer Institute for Cell Therapy and Immunology, Leipzig, Germany.

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http://dx.doi.org/10.1590/S1415-47572012005000055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459404PMC
July 2012

Detection of novel genomic aberrations in anaplastic astrocytomas by GTG-banding, SKY, locus-specific FISH, and high density SNP-array.

Pathol Res Pract 2012 Jun 8;208(6):325-30. Epub 2012 May 8.

Translational Centre for Regenerative Medicine (TRM) and Medical Faculty, Universität Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1016/j.prp.2012.03.010DOI Listing
June 2012

Comparison of scoring methods for the detection of causal genes with or without rare variants.

BMC Proc 2011 Nov 29;5 Suppl 9:S49. Epub 2011 Nov 29.

Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Universität Leipzig, Härtelstrasse 16-18, 04107 Leipzig, Germany.

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http://dx.doi.org/10.1186/1753-6561-5-S9-S49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3287886PMC
November 2011

High resolution genomic profiling and classical cytogenetics in a group of benign and atypical meningiomas.

Cancer Genet 2011 Oct;204(10):541-9

Translational Centre for Regenerative Medicine (TRM), Department of Neurosurgery, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1016/j.cancergen.2011.10.007DOI Listing
October 2011

Intracranial hemangiopericytoma: Case study with cytogenetics and genome wide SNP-A analysis.

Pathol Res Pract 2011 May 9;207(5):310-6. Epub 2011 Feb 9.

Translational Centre for Regenerative Medicine, Faculty of Medicine, University of Leipzig, Philipp-Rosenthal Str. 55, 04103 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.prp.2010.12.010DOI Listing
May 2011

No association between systemic sclerosis and C77G polymorphism in the human PTPRC (CD45) gene.

J Rheumatol 2008 Sep 15;35(9):1817-9. Epub 2008 Jul 15.

Institute of Clinical Immunology and Transfusion Medicine,University of Leipzig, Leipzig, Germany.

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September 2008

Cytogenetic and molecular biological characterization of an adult medulloblastoma.

Cancer Genet Cytogenet 2007 Oct;178(2):104-13

Biotechnical-Biomedical Center (BBZ) and Institute of Clinical Immunology and Transfusion Medicine, Faculty of Medicine, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1016/j.cancergencyto.2007.06.005DOI Listing
October 2007

Robustness of single-base extension against mismatches at the site of primer attachment in a clinical assay.

J Mol Med (Berl) 2007 Apr 8;85(4):361-9. Epub 2006 Dec 8.

IKIT/BBZ, Faculty of Medicine, Center for Biotechnology and Biomedicine, University of Leipzig, Johannisallee 30, 04103, Leipzig, Germany.

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http://dx.doi.org/10.1007/s00109-006-0129-2DOI Listing
April 2007

Comprehensive cytogenetic characterization of an esthesioneuroblastoma.

Cancer Genet Cytogenet 2007 Mar;173(2):89-96

Biotechnical-Biomedical Centre (BBZ) and Institute of Clinical Immunology and Transfusion Medicine, Faculty of Medicine, University of Leipzig, Johannisallee 30, Leipzig D-04103, Germany.

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http://dx.doi.org/10.1016/j.cancergencyto.2006.09.024DOI Listing
March 2007

CalcDalton: a tool for multiplex genotyping primer design for single-base extension reactions using cleavable primers.

Biotechniques 2006 Feb;40(2):158, 160, 162

University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.2144/000112115DOI Listing
February 2006