Publications by authors named "H H Van der Zee"

145 Publications

Identifying Unmet Care Needs and Important Treatment Attributes in the Management of Hidradenitis Suppurativa: A Qualitative Interview Study.

Patient 2021 Aug 9. Epub 2021 Aug 9.

Department of Health Services Research, Care and Public Health Research Institute (CAPHRI), Faculty of Health, Medicine and Life Sciences, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

Background And Objective: Hidradenitis suppurativa (HS) is an inflammatory skin disease with a profound effect on patients' quality of life. The patient's journey to manage HS is often complex and unsuccessful, which motivates the aim of this research to gain insight into unmet needs and relevant treatment considerations from the perspective of patients and healthcare professionals (HCPs).

Methods: Individual semi-structured interviews were conducted with patients and HCPs experienced in treating HS to understand the perceived unmet care needs and to identify important treatment attributes. Prioritization of the five most important treatment attributes allowed elicitation of their relative importance.

Results: Interviews with 12 patients and 16 HCPs revealed 16 areas of unmet needs either related to treatment outcomes or the care process and 13 important treatment attributes. The most frequently reported unmet needs by patients and HCPs were lacking quality-of-life improvement, low treatment effectiveness, inadequate pain control, low disease awareness, and delayed diagnosis. Patients expressed unique concerns relating to pain management, access to HS specialists, and wound care guidance and costs, which HCPs did not. Treatment attributes related to effectiveness were considered most important by patients and HCPs. Patients additionally emphasized a strong preference for improved pain management.

Conclusions: Current HS treatments and care processes leave patients and HCPs with a high level of unmet need. It is critical to consider patients' and HCPs' perspectives when designing appropriate HS care as perceived unmet needs differ. Further quantitative preference elicitation studies are needed to assess the trade-offs between important care needs and treatment attributes.
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http://dx.doi.org/10.1007/s40271-021-00539-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349666PMC
August 2021

Clinical Implementation of Biologics and Small Molecules in the Treatment of Hidradenitis Suppurativa.

Drugs 2021 Aug 20;81(12):1397-1410. Epub 2021 Jul 20.

Department of Dermatology, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.

Hidradenitis suppurativa (HS) is a chronic, recurrent, auto-inflammatory skin disease originating from the hair follicles. The typical inflammatory nodules, abscesses, and draining sinus tracts (tunnels) are characterized by a massive influx of neutrophils, macrophages, B-cells, plasma cells, T helper (Th)1, Th17 cells and upregulation of pro-inflammatory cytokines such as IL-1, IL-17, IL-12/23, and TNF-α. Over the last decades, several clinical trials evaluated the clinical efficacy of different biologics targeting these pro-inflammatory cytokines, in particular TNF-α and IL-1. However, adalimumab is still the only registered drug for HS. This review discusses biologics and small molecules with high level of evidence for their clinical application, provides guidance on when and how to use these biologics and small molecules in clinical practice, and elaborates on the combination with medical and surgical treatment options beyond the current guidelines. Furthermore this review provides an overview of potential biologics and small molecules currently under investigation for novel targets in HS such as IL-36, C5a, Janus kinase family members, CD-40, LTA4 and CXCR1/2.
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http://dx.doi.org/10.1007/s40265-021-01566-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352818PMC
August 2021

No Evident Systemic Terminal Complement Pathway Activation in Hidradenitis Suppurativa.

J Invest Dermatol 2021 Jul 9. Epub 2021 Jul 9.

Department of Pathology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jid.2021.03.037DOI Listing
July 2021

Hidradenitis suppurativa - Body-Mass-Index zu Beginn der Erkrankung.

J Dtsch Dermatol Ges 2021 Mar;19(3):437-439

Department of Dermatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/ddg.14433_gDOI Listing
March 2021

Body mass index at the onset of hidradenitis suppurativa.

J Dtsch Dermatol Ges 2021 03 11;19(3):437-439. Epub 2021 Feb 11.

Department of Dermatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1111/ddg.14433DOI Listing
March 2021
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