Gyorgy Hajnoczky

Gyorgy Hajnoczky

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Publications by authors named "Gyorgy Hajnoczky"

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Perturbed mitochondria-ER contacts in live neurons that model the amyloid pathology of Alzheimer's disease.

J Cell Sci 2019 Oct 22;132(20). Epub 2019 Oct 22.

Laboratory of Brain Aging and Neurodegeneration, Fundación Instituto Leloir, IIBBA-CONICET, Av. Patricias Argentinas 435, C1405BWE Ciudad Autónoma de Buenos Aires, Argentina

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http://dx.doi.org/10.1242/jcs.229906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826005PMC
October 2019

Dysregulation of Mitochondrial Ca Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.

Cell Rep 2019 Oct;29(5):1274-1286.e6

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.09.063DOI Listing
October 2019

Redox regulation of ER and mitochondrial Ca signaling in cell survival and death.

Cell Calcium 2019 May 16;79:89-97. Epub 2019 Feb 16.

MitoCare, Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01434160173019
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http://dx.doi.org/10.1016/j.ceca.2019.02.006DOI Listing
May 2019

Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells.

J Biol Chem 2018 11 18;293(45):17464-17476. Epub 2018 Sep 18.

From the MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.

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http://dx.doi.org/10.1074/jbc.RA118.005624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231128PMC
November 2018

MICU1 Confers Protection from MCU-Dependent Manganese Toxicity.

Cell Rep 2018 11;25(6):1425-1435.e7

Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Department of Biochemistry, Gene Center Munich, Ludwig-Maximilians Universität München, 81377 Munich, Germany; Munich Cluster for Systems Neurology, 81377 Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183161
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http://dx.doi.org/10.1016/j.celrep.2018.10.037DOI Listing
November 2018

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca Flux and Sensitivity to Ru360.

Mol Cell 2018 11 25;72(4):778-785.e3. Epub 2018 Oct 25.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183075
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http://dx.doi.org/10.1016/j.molcel.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251499PMC
November 2018

Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism.

Cell Death Dis 2018 10 9;9(10):1028. Epub 2018 Oct 9.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://www.nature.com/articles/s41419-018-1070-3
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http://dx.doi.org/10.1038/s41419-018-1070-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177459PMC
October 2018

Endoplasmic Reticulum-Mitochondrial Contactology: Structure and Signaling Functions.

Trends Cell Biol 2018 07 24;28(7):523-540. Epub 2018 Mar 24.

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005738PMC
July 2018

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses.

Nat Cell Biol 2018 07 27;20(7):755-765. Epub 2018 Jun 27.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://www.nature.com/articles/s41556-018-0133-0
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http://dx.doi.org/10.1038/s41556-018-0133-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716149PMC
July 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Mitochondrial Nanotunnels.

Trends Cell Biol 2017 11 19;27(11):787-799. Epub 2017 Sep 19.

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Department of Neurology, The Merritt Center and Columbia Translational Neuroscience Initiative, Columbia University Medical Center, New York, NY, USA; Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2017.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749270PMC
November 2017

ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak.

Cell Rep 2017 Nov;21(6):1667-1680

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710826PMC
November 2017

MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans.

EMBO Mol Med 2017 07;9(7):967-984

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA

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http://dx.doi.org/10.15252/emmm.201607058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494519PMC
July 2017

Intracellular Ca Sensing: Its Role in Calcium Homeostasis and Signaling.

Mol Cell 2017 Jun;66(6):780-788

MitoCare Center for Mitochondrial Imaging Research and Diagnostics and Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657234PMC
June 2017

Choosing proper fluorescent dyes, proteins, and imaging techniques to study mitochondrial dynamics in mammalian cells.

Biophys Rep 2017 24;3(4):64-72. Epub 2017 Mar 24.

Department of Pathology, MitoCare Center, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 USA.

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http://dx.doi.org/10.1007/s41048-017-0037-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719805PMC
March 2017

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity.

Proc Natl Acad Sci U S A 2017 01 17;114(5):E859-E868. Epub 2017 Jan 17.

MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107;

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http://dx.doi.org/10.1073/pnas.1617288114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293028PMC
January 2017

Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION.

J Biol Chem 2016 Dec 25;291(50):26126-26137. Epub 2016 Oct 25.

From the MitoCare Center for Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107,

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http://dx.doi.org/10.1074/jbc.M116.744714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207081PMC
December 2016

VDAC2-specific cellular functions and the underlying structure.

Biochim Biophys Acta 2016 10 23;1863(10):2503-14. Epub 2016 Apr 23.

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092071PMC
October 2016

Subcellular ROS imaging methods: Relevance for the study of calcium signaling.

Cell Calcium 2016 08 4;60(2):65-73. Epub 2016 May 4.

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2016.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996722PMC
August 2016

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface.

Mol Cell 2016 07 7;63(2):240-248. Epub 2016 Jul 7.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.05.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998968PMC
July 2016

MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration.

Nat Commun 2016 Mar 9;7:10955. Epub 2016 Mar 9.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1038/ncomms10955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786880PMC
March 2016

Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.

Proc Natl Acad Sci U S A 2015 Oct 28;112(41):E5590-9. Epub 2015 Sep 28.

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107;

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http://dx.doi.org/10.1073/pnas.1510574112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611654PMC
October 2015

The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease.

Biochem Biophys Res Commun 2015 Aug 16;464(2):369-75. Epub 2015 Jun 16.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.06.031DOI Listing
August 2015

Trans-mitochondrial coordination of cristae at regulated membrane junctions.

Nat Commun 2015 Feb 17;6:6259. Epub 2015 Feb 17.

Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ncomms7259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332397PMC
February 2015

Reliance of ER-mitochondrial calcium signaling on mitochondrial EF-hand Ca2+ binding proteins: Miros, MICUs, LETM1 and solute carriers.

Curr Opin Cell Biol 2014 Aug 10;29:133-41. Epub 2014 Jul 10.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States.

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http://dx.doi.org/10.1016/j.ceb.2014.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381426PMC
August 2014

Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion.

Mol Cell 2014 Jun 8;54(5):870-8. Epub 2014 May 8.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.03.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363113PMC
June 2014

Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling.

J Cell Biol 2014 Apr 21;205(2):179-95. Epub 2014 Apr 21.

MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107.

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http://dx.doi.org/10.1083/jcb.201312066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003250PMC
April 2014

Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species.

J Biol Chem 2014 Mar 27;289(12):8170-81. Epub 2014 Jan 27.

From the MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M113.504159
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http://dx.doi.org/10.1074/jbc.M113.504159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961646PMC
March 2014

Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca²⁺ and reactive oxygen species signaling.

J Cell Sci 2013 Jul 10;126(Pt 14):2965-78. Epub 2013 Jul 10.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1242/jcs.093609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711195PMC
July 2013

Switch from ER-mitochondrial to SR-mitochondrial calcium coupling during muscle differentiation.

Cell Calcium 2012 Nov 10;52(5):355-65. Epub 2012 Jul 10.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.ceca.2012.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607359PMC
November 2012

Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats.

Pflugers Arch 2012 Jul 19;464(1):101-9. Epub 2012 Apr 19.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://link.springer.com/10.1007/s00424-012-1100-4
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http://dx.doi.org/10.1007/s00424-012-1100-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799820PMC
July 2012

Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology.

Mol Cell Endocrinol 2012 Apr 22;353(1-2):109-13. Epub 2011 Nov 22.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.mce.2011.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295916PMC
April 2012

Bid-induced mitochondrial membrane permeabilization waves propagated by local reactive oxygen species (ROS) signaling.

Proc Natl Acad Sci U S A 2012 Mar 5;109(12):4497-502. Epub 2012 Mar 5.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.1118244109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311374PMC
March 2012

Alignment of sarcoplasmic reticulum-mitochondrial junctions with mitochondrial contact points.

Am J Physiol Heart Circ Physiol 2011 Nov 19;301(5):H1907-15. Epub 2011 Aug 19.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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https://www.physiology.org/doi/10.1152/ajpheart.00397.2011
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http://dx.doi.org/10.1152/ajpheart.00397.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774555PMC
November 2011

Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons.

Eur J Neurosci 2011 Mar 24;33(5):831-42. Epub 2011 Jan 24.

Vollum Institute and Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.1111/j.1460-9568.2010.07576.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183752PMC
March 2011

Calcium signalling: fishing out molecules of mitochondrial calcium transport.

Curr Biol 2010 Oct;20(20):R888-91

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.cub.2010.09.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174682PMC
October 2010

VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria.

EMBO Rep 2009 Dec 9;10(12):1341-7. Epub 2009 Oct 9.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Suite 261 JAH, Philadelphia, Pennsylvania 19107, USA.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2009.219
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http://dx.doi.org/10.1038/embor.2009.219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799216PMC
December 2009

SR/ER-mitochondrial local communication: calcium and ROS.

Biochim Biophys Acta 2009 Nov 13;1787(11):1352-62. Epub 2009 Jun 13.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.bbabio.2009.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2738971PMC
November 2009

Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex.

Int J Biochem Cell Biol 2009 Oct 27;41(10):1972-6. Epub 2009 May 27.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.biocel.2009.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742205PMC
October 2009

Fluorometric methods for detection of mitochondrial membrane permeabilization in apoptosis.

Methods Mol Biol 2009 ;559:173-90

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1007/978-1-60327-017-5_13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799828PMC
October 2009

Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics.

EMBO J 2009 Oct 10;28(20):3074-89. Epub 2009 Sep 10.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1038/emboj.2009.255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771091PMC
October 2009

MAM: more than just a housekeeper.

Trends Cell Biol 2009 Feb 12;19(2):81-8. Epub 2009 Jan 12.

Cellular Pathobiology Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health/DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.tcb.2008.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750097PMC
February 2009

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.

Proc Natl Acad Sci U S A 2008 Dec 19;105(52):20728-33. Epub 2008 Dec 19.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.0808953105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634948PMC
December 2008

Uncoupling of ER-mitochondrial calcium communication by transforming growth factor-beta.

Am J Physiol Renal Physiol 2008 Nov 23;295(5):F1303-12. Epub 2008 Jul 23.

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1152/ajprenal.90343.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584912PMC
November 2008

Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle.

J Biol Chem 2008 Nov 12;283(47):32771-80. Epub 2008 Sep 12.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M803385200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395082PMC
November 2008

Calcium, mitochondria and apoptosis studied by fluorescence measurements.

Methods 2008 Nov 21;46(3):213-23. Epub 2008 Oct 21.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Suite 253 JAH, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.ymeth.2008.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799833PMC
November 2008

High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling.

Cell Calcium 2008 Jul 19;44(1):51-63. Epub 2008 Feb 19.

Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

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http://dx.doi.org/10.1016/j.ceca.2007.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662195PMC
July 2008

Calcium signalling and mitochondrial motility.

Novartis Found Symp 2007 ;287:105-17; discussion 117-21

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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January 2008

IP3 receptors in cell survival and apoptosis: Ca2+ release and beyond.

Apoptosis 2007 May;12(5):951-68

Department of Pathology & Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.

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http://link.springer.com/10.1007/s10495-007-0719-7
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May 2007

Cell signaling. Mitochondrial longevity pathways.

Science 2007 Feb;315(5812):607-9

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1126/science.1138825DOI Listing
February 2007

Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis.

Cell Calcium 2006 Nov-Dec;40(5-6):553-60. Epub 2006 Oct 30.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.ceca.2006.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692319PMC
January 2007

Ca2+-dependent control of the permeability properties of the mitochondrial outer membrane and voltage-dependent anion-selective channel (VDAC).

J Biol Chem 2006 Jun 5;281(25):17347-58. Epub 2006 Apr 5.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M600906200DOI Listing
June 2006

Visualization of binding and transcytosis of botulinum toxin by human intestinal epithelial cells.

J Pharmacol Exp Ther 2005 Dec 6;315(3):1028-35. Epub 2005 Sep 6.

Department of Medicine, Jefferson Medical College, Room 314-JAH, 1020 Locust Street, Philadelphia, PA 19107, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.105.09221
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December 2005

Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins.

J Pharmacol Exp Ther 2005 Sep 3;314(3):1013-22. Epub 2005 Jun 3.

Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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September 2005

RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death.

Alcohol Clin Exp Res 2005 Sep;29(9):1749-52

Thomas Jefferson University (JBH, GH), Department of Pathology, Anatomy and Cell Biology, Philadelphia, PA 19107-6799, USA.

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http://dx.doi.org/10.1097/01.alc.0000179318.48376.cdDOI Listing
September 2005

Mitochondria and endoplasmic reticulum: the lethal interorganelle cross-talk.

J Bioenerg Biomembr 2005 Jun;37(3):191-206

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1007/s10863-005-6600-xDOI Listing
June 2005

Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization.

Alcohol Clin Exp Res 2005 May;29(5):693-701

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1097/01.alc.0000163493.45344.7aDOI Listing
May 2005

Control of calcium signal propagation to the mitochondria by inositol 1,4,5-trisphosphate-binding proteins.

J Biol Chem 2005 Apr 11;280(13):12820-32. Epub 2005 Jan 11.

Department of Pathology, Anatomy & Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M411591200DOI Listing
April 2005

Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit.

J Cell Biol 2004 Nov 15;167(4):661-72. Epub 2004 Nov 15.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1083/jcb.200406038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172592PMC
November 2004

Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells.

Am J Physiol Renal Physiol 2003 Dec 22;285(6):F1258-70. Epub 2003 Jul 22.

Dorrance Hamilton Research Laboratories, Division of Nephrology, Department of Medicine, Thomas Jefferson University, Suite 353, Jeff Alumni Hall, 1020 Locust Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1152/ajprenal.00145.2003DOI Listing
December 2003

Plasticity of mitochondrial calcium signaling.

J Biol Chem 2003 Oct 7;278(43):42273-82. Epub 2003 Aug 7.

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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October 2003

Calcium signaling and apoptosis.

Biochem Biophys Res Commun 2003 May;304(3):445-54

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/s0006-291x(03)00616-8DOI Listing
May 2003

Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130.

J Biol Chem 2002 Jul 17;277(30):27412-22. Epub 2002 May 17.

Endocrinology and Reproduction Research Branch, NICHD/National Institutes of Health, 49 Convent Drive, Bldg. 49, Bethesda, MD 20892, USA.

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July 2002

TGF-beta-induced Ca(2+) influx involves the type III IP(3) receptor and regulates actin cytoskeleton.

Am J Physiol Renal Physiol 2002 May;282(5):F910-20

Dorrance Hamilton Laboratory, Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1152/ajprenal.00252.2001DOI Listing
May 2002

tcBid promotes Ca(2+) signal propagation to the mitochondria: control of Ca(2+) permeation through the outer mitochondrial membrane.

EMBO J 2002 May;21(9):2198-206

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125984PMC
May 2002

Ca2+ marks: miniature calcium signals in single mitochondria driven by ryanodine receptors.

Proc Natl Acad Sci U S A 2002 Feb;99(4):2380-5

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.032423699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122373PMC
February 2002