Publications by authors named "Gyorgy Hajnoczky"

88Publications

Molecular pathophysiology of human MICU1-deficiency.

Authors:
Nicolai Kohlschmidt Miriam Elbracht Artur Czech Martin Häusler Vietxuan Phan Ana Töpf Kai-Ting Huang Adam Bartok Katja Eggermann Stephanie Zippel Thomas Eggermann Erik Freier Claudia Groß Hanns Lochmüller Rita Horvath György Hajnóczky Joachim Weis Andreas Roos

Neuropathol Appl Neurobiol 2021 Jan 11. Epub 2021 Jan 11.

Department of Neuropediatrics, Centre for Neuromuscular Disorders in Children, University Hospital Essen, University of Duisburg-Essen, 45122, Essen, Germany.

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January 2021

Pharmacological inhibition of the mitochondrial Ca uniporter: Relevance for pathophysiology and human therapy.

Authors:
Katalin Márta Prottoy Hasan Macarena Rodríguez-Prados Melanie Paillard György Hajnóczky

J Mol Cell Cardiol 2020 Oct 6. Epub 2020 Oct 6.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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October 2020

Dysregulation of RyR Calcium Channel Causes the Onset of Mitochondrial Retrograde Signaling.

Authors:
Anindya Roy Chowdhury Satish Srinivasan György Csordás György Hajnóczky Narayan G Avadhani

iScience 2020 Aug 15;23(8):101370. Epub 2020 Jul 15.

Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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August 2020

Dysregulation of Mitochondrial Ca Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.

Authors:
Valentina Debattisti Adam Horn Raghavendra Singh Erin L Seifert Marshall W Hogarth Davi A Mazala Kai Ting Huang Rita Horvath Jyoti K Jaiswal György Hajnóczky

Cell Rep 2019 10;29(5):1274-1286.e6

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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October 2019

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.

Authors:
Alyssa A Lombardi Andrew A Gibb Ehtesham Arif Devin W Kolmetzky Dhanendra Tomar Timothy S Luongo Pooja Jadiya Emma K Murray Pawel K Lorkiewicz György Hajnóczky Elizabeth Murphy Zoltan P Arany Daniel P Kelly Kenneth B Margulies Bradford G Hill John W Elrod

Nat Commun 2019 10 4;10(1):4509. Epub 2019 Oct 4.

Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.

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October 2019

Perturbed mitochondria-ER contacts in live neurons that model the amyloid pathology of Alzheimer's disease.

Authors:
Pamela V Martino Adami Zuzana Nichtová David B Weaver Adam Bartok Thomas Wisniewski Drew R Jones Sonia Do Carmo Eduardo M Castaño A Claudio Cuello György Hajnóczky Laura Morelli

J Cell Sci 2019 10 22;132(20). Epub 2019 Oct 22.

Laboratory of Brain Aging and Neurodegeneration, Fundación Instituto Leloir, IIBBA-CONICET, Av. Patricias Argentinas 435, C1405BWE Ciudad Autónoma de Buenos Aires, Argentina

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October 2019

IP receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.

Authors:
Adam Bartok David Weaver Tünde Golenár Zuzana Nichtova Máté Katona Száva Bánsághi Kamil J Alzayady V Kaye Thomas Hideaki Ando Katsuhiko Mikoshiba Suresh K Joseph David I Yule György Csordás György Hajnóczky

Nat Commun 2019 08 19;10(1):3726. Epub 2019 Aug 19.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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August 2019

Coming together to define membrane contact sites.

Authors:
Luca Scorrano Maria Antonietta De Matteis Scott Emr Francesca Giordano György Hajnóczky Benoît Kornmann Laura L Lackner Tim P Levine Luca Pellegrini Karin Reinisch Rosario Rizzuto Thomas Simmen Harald Stenmark Christian Ungermann Maya Schuldiner

Nat Commun 2019 03 20;10(1):1287. Epub 2019 Mar 20.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel.

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March 2019

Redox regulation of ER and mitochondrial Ca signaling in cell survival and death.

Authors:
Suresh K Joseph David M Booth Michael P Young György Hajnóczky

Cell Calcium 2019 05 16;79:89-97. Epub 2019 Feb 16.

MitoCare, Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.

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May 2019

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca Flux and Sensitivity to Ru360.

Authors:
Melanie Paillard György Csordás Kai-Ting Huang Peter Várnai Suresh K Joseph György Hajnóczky

Mol Cell 2018 11 25;72(4):778-785.e3. Epub 2018 Oct 25.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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November 2018

MICU1 Confers Protection from MCU-Dependent Manganese Toxicity.

Authors:
Jennifer Wettmarshausen Valerie Goh Kai-Ting Huang Daniela M Arduino Utkarsh Tripathi Anja Leimpek Yiming Cheng Alexandros A Pittis Toni Gabaldón Dejana Mokranjac György Hajnóczky Fabiana Perocchi

Cell Rep 2018 11;25(6):1425-1435.e7

Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Department of Biochemistry, Gene Center Munich, Ludwig-Maximilians Universität München, 81377 Munich, Germany; Munich Cluster for Systems Neurology, 81377 Munich, Germany. Electronic address:

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November 2018

Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism.

Authors:
Shamim Naghdi William S Slovinsky Muniswamy Madesh Emanuel Rubin György Hajnóczky

Cell Death Dis 2018 10 9;9(10):1028. Epub 2018 Oct 9.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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October 2018

Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells.

Authors:
Suresh K Joseph Michael P Young Kamil Alzayady David I Yule Mehboob Ali David M Booth György Hajnóczky

J Biol Chem 2018 11 18;293(45):17464-17476. Epub 2018 Sep 18.

From the MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.

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November 2018

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses.

Authors:
Verónica Eisner Martin Picard György Hajnóczky

Nat Cell Biol 2018 07 27;20(7):755-765. Epub 2018 Jun 27.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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July 2018

Endoplasmic Reticulum-Mitochondrial Contactology: Structure and Signaling Functions.

Authors:
György Csordás David Weaver György Hajnóczky

Trends Cell Biol 2018 07 24;28(7):523-540. Epub 2018 Mar 24.

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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July 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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March 2018

Choosing proper fluorescent dyes, proteins, and imaging techniques to study mitochondrial dynamics in mammalian cells.

Authors:
Xingguo Liu Liang Yang Qi Long David Weaver György Hajnóczky

Biophys Rep 2017 24;3(4):64-72. Epub 2017 Mar 24.

Department of Pathology, MitoCare Center, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 USA.

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March 2017

ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak.

Authors:
Valentina Debattisti Akos A Gerencser Masao Saotome Sudipto Das György Hajnóczky

Cell Rep 2017 Nov;21(6):1667-1680

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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November 2017

Mitochondrial Nanotunnels.

Authors:
Amy E Vincent Doug M Turnbull Veronica Eisner György Hajnóczky Martin Picard

Trends Cell Biol 2017 11 19;27(11):787-799. Epub 2017 Sep 19.

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Department of Neurology, The Merritt Center and Columbia Translational Neuroscience Initiative, Columbia University Medical Center, New York, NY, USA; Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY 10032, USA. Electronic address:

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November 2017

Intracellular Ca Sensing: Its Role in Calcium Homeostasis and Signaling.

Authors:
Rafaela Bagur György Hajnóczky

Mol Cell 2017 Jun;66(6):780-788

MitoCare Center for Mitochondrial Imaging Research and Diagnostics and Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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June 2017