Gyorgy Hajnoczky

Gyorgy Hajnoczky

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Gyorgy Hajnoczky

Publications by authors named "Gyorgy Hajnoczky"

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Perturbed mitochondria-ER contacts in live neurons that model the amyloid pathology of Alzheimer's disease.

Authors:
Pamela V Martino Adami Zuzana Nichtová David B Weaver Adam Bartok Thomas Wisniewski Drew R Jones Sonia Do Carmo Eduardo M Castaño A Claudio Cuello György Hajnóczky Laura Morelli

J Cell Sci 2019 Oct 22;132(20). Epub 2019 Oct 22.

Laboratory of Brain Aging and Neurodegeneration, Fundación Instituto Leloir, IIBBA-CONICET, Av. Patricias Argentinas 435, C1405BWE Ciudad Autónoma de Buenos Aires, Argentina

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http://dx.doi.org/10.1242/jcs.229906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826005PMC
October 2019

Mitochondrial calcium exchange links metabolism with the epigenome to control cellular differentiation.

Authors:
Alyssa A Lombardi Andrew A Gibb Ehtesham Arif Devin W Kolmetzky Dhanendra Tomar Timothy S Luongo Pooja Jadiya Emma K Murray Pawel K Lorkiewicz György Hajnóczky Elizabeth Murphy Zoltan P Arany Daniel P Kelly Kenneth B Margulies Bradford G Hill John W Elrod

Nat Commun 2019 10 4;10(1):4509. Epub 2019 Oct 4.

Center for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA.

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http://dx.doi.org/10.1038/s41467-019-12103-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778142PMC
October 2019

Dysregulation of Mitochondrial Ca Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1.

Authors:
Valentina Debattisti Adam Horn Raghavendra Singh Erin L Seifert Marshall W Hogarth Davi A Mazala Kai Ting Huang Rita Horvath Jyoti K Jaiswal György Hajnóczky

Cell Rep 2019 Oct;29(5):1274-1286.e6

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.09.063DOI Listing
October 2019

IP receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.

Authors:
Adam Bartok David Weaver Tünde Golenár Zuzana Nichtova Máté Katona Száva Bánsághi Kamil J Alzayady V Kaye Thomas Hideaki Ando Katsuhiko Mikoshiba Suresh K Joseph David I Yule György Csordás György Hajnóczky

Nat Commun 2019 08 19;10(1):3726. Epub 2019 Aug 19.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1038/s41467-019-11646-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700175PMC
August 2019

Redox regulation of ER and mitochondrial Ca signaling in cell survival and death.

Authors:
Suresh K Joseph David M Booth Michael P Young György Hajnóczky

Cell Calcium 2019 May 16;79:89-97. Epub 2019 Feb 16.

MitoCare, Department of Pathology and Cell Biology, Thomas Jefferson University, Philadelphia, PA, 19107, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01434160173019
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http://dx.doi.org/10.1016/j.ceca.2019.02.006DOI Listing
May 2019

Coming together to define membrane contact sites.

Authors:
Luca Scorrano Maria Antonietta De Matteis Scott Emr Francesca Giordano György Hajnóczky Benoît Kornmann Laura L Lackner Tim P Levine Luca Pellegrini Karin Reinisch Rosario Rizzuto Thomas Simmen Harald Stenmark Christian Ungermann Maya Schuldiner

Nat Commun 2019 03 20;10(1):1287. Epub 2019 Mar 20.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel.

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http://dx.doi.org/10.1038/s41467-019-09253-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427007PMC
March 2019

Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells.

Authors:
Suresh K Joseph Michael P Young Kamil Alzayady David I Yule Mehboob Ali David M Booth György Hajnóczky

J Biol Chem 2018 11 18;293(45):17464-17476. Epub 2018 Sep 18.

From the MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.

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http://dx.doi.org/10.1074/jbc.RA118.005624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231128PMC
November 2018

MICU1 Confers Protection from MCU-Dependent Manganese Toxicity.

Authors:
Jennifer Wettmarshausen Valerie Goh Kai-Ting Huang Daniela M Arduino Utkarsh Tripathi Anja Leimpek Yiming Cheng Alexandros A Pittis Toni Gabaldón Dejana Mokranjac György Hajnóczky Fabiana Perocchi

Cell Rep 2018 11;25(6):1425-1435.e7

Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum München, 85764 Neuherberg, Germany; Department of Biochemistry, Gene Center Munich, Ludwig-Maximilians Universität München, 81377 Munich, Germany; Munich Cluster for Systems Neurology, 81377 Munich, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183161
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http://dx.doi.org/10.1016/j.celrep.2018.10.037DOI Listing
November 2018

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca Flux and Sensitivity to Ru360.

Authors:
Melanie Paillard György Csordás Kai-Ting Huang Peter Várnai Suresh K Joseph György Hajnóczky

Mol Cell 2018 11 25;72(4):778-785.e3. Epub 2018 Oct 25.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765183075
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http://dx.doi.org/10.1016/j.molcel.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251499PMC
November 2018

Mitochondrial fusion and Bid-mediated mitochondrial apoptosis are perturbed by alcohol with distinct dependence on its metabolism.

Authors:
Shamim Naghdi William S Slovinsky Muniswamy Madesh Emanuel Rubin György Hajnóczky

Cell Death Dis 2018 10 9;9(10):1028. Epub 2018 Oct 9.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://www.nature.com/articles/s41419-018-1070-3
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http://dx.doi.org/10.1038/s41419-018-1070-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177459PMC
October 2018

Endoplasmic Reticulum-Mitochondrial Contactology: Structure and Signaling Functions.

Authors:
György Csordás David Weaver György Hajnóczky

Trends Cell Biol 2018 07 24;28(7):523-540. Epub 2018 Mar 24.

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2018.02.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005738PMC
July 2018

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses.

Authors:
Verónica Eisner Martin Picard György Hajnóczky

Nat Cell Biol 2018 07 27;20(7):755-765. Epub 2018 Jun 27.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://www.nature.com/articles/s41556-018-0133-0
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http://dx.doi.org/10.1038/s41556-018-0133-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6716149PMC
July 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

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http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Mitochondrial Nanotunnels.

Authors:
Amy E Vincent Doug M Turnbull Veronica Eisner György Hajnóczky Martin Picard

Trends Cell Biol 2017 11 19;27(11):787-799. Epub 2017 Sep 19.

Division of Behavioral Medicine, Department of Psychiatry, Columbia University Medical Center, New York, NY, USA; Department of Neurology, The Merritt Center and Columbia Translational Neuroscience Initiative, Columbia University Medical Center, New York, NY, USA; Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2017.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5749270PMC
November 2017

ROS Control Mitochondrial Motility through p38 and the Motor Adaptor Miro/Trak.

Authors:
Valentina Debattisti Akos A Gerencser Masao Saotome Sudipto Das György Hajnóczky

Cell Rep 2017 Nov;21(6):1667-1680

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.10.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710826PMC
November 2017

Recessive mutations in MSTO1 cause mitochondrial dynamics impairment, leading to myopathy and ataxia.

Authors:
Alessia Nasca Chiara Scotton Irina Zaharieva Marcella Neri Rita Selvatici Olafur Thor Magnusson Aniko Gal David Weaver Rachele Rossi Annarita Armaroli Marika Pane Rahul Phadke Anna Sarkozy Francesco Muntoni Imelda Hughes Antonella Cecconi György Hajnóczky Alice Donati Eugenio Mercuri Massimo Zeviani Alessandra Ferlini Daniele Ghezzi

Hum Mutat 2017 08 6;38(8):970-977. Epub 2017 Jun 6.

Molecular Neurogenetics Unit, Foundation IRCCS Neurological Institute Besta, Milan, Italy.

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http://dx.doi.org/10.1002/humu.23262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575512PMC
August 2017

MSTO1 is a cytoplasmic pro-mitochondrial fusion protein, whose mutation induces myopathy and ataxia in humans.

Authors:
Aniko Gal Peter Balicza David Weaver Shamim Naghdi Suresh K Joseph Péter Várnai Tibor Gyuris Attila Horváth Laszlo Nagy Erin L Seifert Maria Judit Molnar György Hajnóczky

EMBO Mol Med 2017 07;9(7):967-984

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA

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http://dx.doi.org/10.15252/emmm.201607058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494519PMC
July 2017

Intracellular Ca Sensing: Its Role in Calcium Homeostasis and Signaling.

Authors:
Rafaela Bagur György Hajnóczky

Mol Cell 2017 Jun;66(6):780-788

MitoCare Center for Mitochondrial Imaging Research and Diagnostics and Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2017.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657234PMC
June 2017

Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca Signals Is Controlled by the Stoichiometry of MICU1/2 and MCU.

Authors:
Melanie Paillard György Csordás Gergö Szanda Tünde Golenár Valentina Debattisti Adam Bartok Nadan Wang Cynthia Moffat Erin L Seifert András Spät György Hajnóczky

Cell Rep 2017 03;18(10):2291-2300

MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.02.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760244PMC
March 2017

Choosing proper fluorescent dyes, proteins, and imaging techniques to study mitochondrial dynamics in mammalian cells.

Authors:
Xingguo Liu Liang Yang Qi Long David Weaver György Hajnóczky

Biophys Rep 2017 24;3(4):64-72. Epub 2017 Mar 24.

Department of Pathology, MitoCare Center, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107 USA.

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http://dx.doi.org/10.1007/s41048-017-0037-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719805PMC
March 2017

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity.

Authors:
Verónica Eisner Ryan R Cupo Erhe Gao György Csordás William S Slovinsky Melanie Paillard Lan Cheng Jessica Ibetti S R Wayne Chen J Kurt Chuprun Jan B Hoek Walter J Koch György Hajnóczky

Proc Natl Acad Sci U S A 2017 01 17;114(5):E859-E868. Epub 2017 Jan 17.

MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107;

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http://dx.doi.org/10.1073/pnas.1617288114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293028PMC
January 2017

Increased mitochondrial nanotunneling activity, induced by calcium imbalance, affects intermitochondrial matrix exchanges.

Authors:
Manuela Lavorato V Ramesh Iyer Williams Dewight Ryan R Cupo Valentina Debattisti Ludovic Gomez Sergio De la Fuente Yan-Ting Zhao Héctor H Valdivia György Hajnóczky Clara Franzini-Armstrong

Proc Natl Acad Sci U S A 2017 01 17;114(5):E849-E858. Epub 2017 Jan 17.

Department of Cell Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1617788113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293110PMC
January 2017

Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION.

Authors:
Erin L Seifert Aniko Gál Michelle G Acoba Qipei Li Lauren Anderson-Pullinger Tunde Golenár Cynthia Moffat Neal Sondheimer Steven M Claypool György Hajnóczky

J Biol Chem 2016 Dec 25;291(50):26126-26137. Epub 2016 Oct 25.

From the MitoCare Center for Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107,

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http://dx.doi.org/10.1074/jbc.M116.744714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207081PMC
December 2016

VDAC2-specific cellular functions and the underlying structure.

Authors:
Shamim Naghdi György Hajnóczky

Biochim Biophys Acta 2016 10 23;1863(10):2503-14. Epub 2016 Apr 23.

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbamcr.2016.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092071PMC
October 2016

Subcellular ROS imaging methods: Relevance for the study of calcium signaling.

Authors:
David M Booth Suresh K Joseph György Hajnóczky

Cell Calcium 2016 08 4;60(2):65-73. Epub 2016 May 4.

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ceca.2016.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996722PMC
August 2016

Redox Nanodomains Are Induced by and Control Calcium Signaling at the ER-Mitochondrial Interface.

Authors:
David M Booth Balázs Enyedi Miklós Geiszt Péter Várnai György Hajnóczky

Mol Cell 2016 07 7;63(2):240-248. Epub 2016 Jul 7.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.05.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4998968PMC
July 2016

MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration.

Authors:
Anil Noronha Antony Melanie Paillard Cynthia Moffat Egle Juskeviciute Jason Correnti Brad Bolon Emanuel Rubin György Csordás Erin L Seifert Jan B Hoek György Hajnóczky

Nat Commun 2016 Mar 9;7:10955. Epub 2016 Mar 9.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1038/ncomms10955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786880PMC
March 2016

Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.

Authors:
Shamim Naghdi Péter Várnai György Hajnóczky

Proc Natl Acad Sci U S A 2015 Oct 28;112(41):E5590-9. Epub 2015 Sep 28.

MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107;

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http://dx.doi.org/10.1073/pnas.1510574112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4611654PMC
October 2015

The mitochondrial phosphate carrier: Role in oxidative metabolism, calcium handling and mitochondrial disease.

Authors:
Erin L Seifert Erzsébet Ligeti Johannes A Mayr Neal Sondheimer György Hajnóczky

Biochem Biophys Res Commun 2015 Aug 16;464(2):369-75. Epub 2015 Jun 16.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.06.031DOI Listing
August 2015

MCUR1 is an essential component of mitochondrial Ca(2+) uptake that regulates cellular metabolism.

Authors:
Karthik Mallilankaraman César Cárdenas Patrick J Doonan Harish C Chandramoorthy Krishna M Irrinki Tünde Golenár György Csordás Priyanka Madireddi Jun Yang Marioly Müller Russell Miller Jill E Kolesar Jordi Molgó Brett Kaufman György Hajnóczky J Kevin Foskett Muniswamy Madesh

Nat Cell Biol 2015 Jul;17(7):953

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http://dx.doi.org/10.1038/ncb3202DOI Listing
July 2015

Trans-mitochondrial coordination of cristae at regulated membrane junctions.

Authors:
Martin Picard Meagan J McManus György Csordás Péter Várnai Gerald W Dorn Dewight Williams György Hajnóczky Douglas C Wallace

Nat Commun 2015 Feb 17;6:6259. Epub 2015 Feb 17.

Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/ncomms7259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332397PMC
February 2015

Mitochondrial Ca(2+) uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity.

Authors:
Hirohito Shimizu Johann Schredelseker Jie Huang Kui Lu Shamim Naghdi Fei Lu Sarah Franklin Hannah Dg Fiji Kevin Wang Huanqi Zhu Cheng Tian Billy Lin Haruko Nakano Amy Ehrlich Junichi Nakai Adam Z Stieg James K Gimzewski Atsushi Nakano Joshua I Goldhaber Thomas M Vondriska György Hajnóczky Ohyun Kwon Jau-Nian Chen

Elife 2015 Jan 15;4. Epub 2015 Jan 15.

Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, United States.

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http://dx.doi.org/10.7554/eLife.04801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293673PMC
January 2015

Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease.

Authors:
Tammy T Nguyen Sang S Oh David Weaver Agnieszka Lewandowska Dane Maxfield Max-Hinderk Schuler Nathan K Smith Jane Macfarlane Gerald Saunders Cheryl A Palmer Valentina Debattisti Takumi Koshiba Stefan Pulst Eva L Feldman György Hajnóczky Janet M Shaw

Proc Natl Acad Sci U S A 2014 Sep 18;111(35):E3631-40. Epub 2014 Aug 18.

Departments of Biochemistry,

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http://dx.doi.org/10.1073/pnas.1402449111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156725PMC
September 2014

Reliance of ER-mitochondrial calcium signaling on mitochondrial EF-hand Ca2+ binding proteins: Miros, MICUs, LETM1 and solute carriers.

Authors:
György Hajnóczky David Booth György Csordás Valentina Debattisti Tünde Golenár Shamim Naghdi Nima Niknejad Melanie Paillard Erin L Seifert David Weaver

Curr Opin Cell Biol 2014 Aug 10;29:133-41. Epub 2014 Jul 10.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, United States.

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http://dx.doi.org/10.1016/j.ceb.2014.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381426PMC
August 2014

Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion.

Authors:
David Weaver Verónica Eisner Xingguo Liu Péter Várnai László Hunyady Atan Gross György Hajnóczky

Mol Cell 2014 Jun 8;54(5):870-8. Epub 2014 May 8.

MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.03.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363113PMC
June 2014

Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling.

Authors:
Verónica Eisner Guy Lenaers György Hajnóczky

J Cell Biol 2014 Apr 21;205(2):179-95. Epub 2014 Apr 21.

MitoCare Center, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107.

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http://dx.doi.org/10.1083/jcb.201312066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003250PMC
April 2014

Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species.

Authors:
Száva Bánsághi Tünde Golenár Muniswamy Madesh György Csordás Satish RamachandraRao Kumar Sharma David I Yule Suresh K Joseph György Hajnóczky

J Biol Chem 2014 Mar 27;289(12):8170-81. Epub 2014 Jan 27.

From the MitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961646PMC
March 2014

Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca²⁺ and reactive oxygen species signaling.

Authors:
Verónica Eisner György Csordás György Hajnóczky

J Cell Sci 2013 Jul 10;126(Pt 14):2965-78. Epub 2013 Jul 10.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1242/jcs.093609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711195PMC
July 2013

MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.

Authors:
György Csordás Tünde Golenár Erin L Seifert Kimberli J Kamer Yasemin Sancak Fabiana Perocchi Cynthia Moffat David Weaver Sergio de la Fuente Perez Roman Bogorad Victor Koteliansky Jeffrey Adijanto Vamsi K Mootha György Hajnóczky

Cell Metab 2013 Jun;17(6):976-87

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.cmet.2013.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722067PMC
June 2013

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.

Authors:
Karthik Mallilankaraman César Cárdenas Patrick J Doonan Harish C Chandramoorthy Krishna M Irrinki Tünde Golenár György Csordás Priyanka Madireddi Jun Yang Marioly Müller Russell Miller Jill E Kolesar Jordi Molgó Brett Kaufman György Hajnóczky J Kevin Foskett Muniswamy Madesh

Nat Cell Biol 2012 Dec 25;14(12):1336-43. Epub 2012 Nov 25.

Department of Biochemistry, Temple University, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1038/ncb2622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3511605PMC
December 2012

Switch from ER-mitochondrial to SR-mitochondrial calcium coupling during muscle differentiation.

Authors:
Muqing Yi David Weaver Verónica Eisner Péter Várnai László Hunyady Jianjie Ma György Csordás György Hajnóczky

Cell Calcium 2012 Nov 10;52(5):355-65. Epub 2012 Jul 10.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.ceca.2012.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607359PMC
November 2012

Mitochondrial morphology and dynamics in hepatocytes from normal and ethanol-fed rats.

Authors:
Sudipto Das Nora Hajnóczky Anil Noronha Antony György Csordás Lawrence D Gaspers Dahn L Clemens Jan B Hoek György Hajnóczky

Pflugers Arch 2012 Jul 19;464(1):101-9. Epub 2012 Apr 19.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799820PMC
July 2012

Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology.

Authors:
György Csordás Peter Várnai Tünde Golenár Shey-Shing Sheu György Hajnóczky

Mol Cell Endocrinol 2012 Apr 22;353(1-2):109-13. Epub 2011 Nov 22.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.mce.2011.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295916PMC
April 2012

Bid-induced mitochondrial membrane permeabilization waves propagated by local reactive oxygen species (ROS) signaling.

Authors:
Cecilia Garcia-Perez Soumya Sinha Roy Shamim Naghdi Xuena Lin Erika Davies György Hajnóczky

Proc Natl Acad Sci U S A 2012 Mar 5;109(12):4497-502. Epub 2012 Mar 5.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.1118244109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311374PMC
March 2012

Alignment of sarcoplasmic reticulum-mitochondrial junctions with mitochondrial contact points.

Authors:
Cecília García-Pérez Timothy G Schneider György Hajnóczky György Csordás

Am J Physiol Heart Circ Physiol 2011 Nov 19;301(5):H1907-15. Epub 2011 Aug 19.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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https://www.physiology.org/doi/10.1152/ajpheart.00397.2011
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November 2011

Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons.

Authors:
Anna Barsukova Alexander Komarov György Hajnóczky Paolo Bernardi Dennis Bourdette Michael Forte

Eur J Neurosci 2011 Mar 24;33(5):831-42. Epub 2011 Jan 24.

Vollum Institute and Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

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http://dx.doi.org/10.1111/j.1460-9568.2010.07576.xDOI Listing
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March 2011

Calcium signalling: fishing out molecules of mitochondrial calcium transport.

Authors:
György Hajnóczky György Csordás

Curr Biol 2010 Oct;20(20):R888-91

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.cub.2010.09.035DOI Listing
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October 2010

Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity.

Authors:
Gilad Twig Xingguo Liu Marc Liesa Jakob D Wikstrom Anthony J A Molina Guy Las Gal Yaniv György Hajnóczky Orian S Shirihai

Am J Physiol Cell Physiol 2010 Aug 5;299(2):C477-87. Epub 2010 May 5.

Evans Biomedical Research Center, Boston University, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1152/ajpcell.00427.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928626PMC
August 2010

Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface.

Authors:
György Csordás Péter Várnai Tünde Golenár Swati Roy George Purkins Timothy G Schneider Tamás Balla György Hajnóczky

Mol Cell 2010 Jul;39(1):121-32

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178184PMC
July 2010

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria.

Authors:
Yehudit Zaltsman Liat Shachnai Natalie Yivgi-Ohana Michal Schwarz Maria Maryanovich Riekelt H Houtkooper Frédéric Maxime Vaz Francesco De Leonardis Giuseppe Fiermonte Ferdinando Palmieri Bernhard Gillissen Peter T Daniel Erin Jimenez Susan Walsh Carla M Koehler Soumya Sinha Roy Ludivine Walter György Hajnóczky Atan Gross

Nat Cell Biol 2010 Jun 2;12(6):553-562. Epub 2010 May 2.

Department of Biological Regulation, The Weizmann Institute of Science, Rehovot 76100, Israel.

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June 2010

VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria.

Authors:
Soumya Sinha Roy Amy M Ehrlich William J Craigen György Hajnóczky

EMBO Rep 2009 Dec 9;10(12):1341-7. Epub 2009 Oct 9.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Suite 261 JAH, Philadelphia, Pennsylvania 19107, USA.

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December 2009

SR/ER-mitochondrial local communication: calcium and ROS.

Authors:
György Csordás György Hajnóczky

Biochim Biophys Acta 2009 Nov 13;1787(11):1352-62. Epub 2009 Jun 13.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.bbabio.2009.06.004DOI Listing
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November 2009

Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex.

Authors:
Xingguo Liu György Hajnóczky

Int J Biochem Cell Biol 2009 Oct 27;41(10):1972-6. Epub 2009 May 27.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.biocel.2009.05.013DOI Listing
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October 2009

Fluorometric methods for detection of mitochondrial membrane permeabilization in apoptosis.

Authors:
Soumya Sinha Roy György Hajnóczky

Methods Mol Biol 2009 ;559:173-90

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799828PMC
October 2009

Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics.

Authors:
Xingguo Liu David Weaver Orian Shirihai György Hajnóczky

EMBO J 2009 Oct 10;28(20):3074-89. Epub 2009 Sep 10.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1038/emboj.2009.255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771091PMC
October 2009

MAM: more than just a housekeeper.

Authors:
Teruo Hayashi Rosario Rizzuto Gyorgy Hajnoczky Tsung-Ping Su

Trends Cell Biol 2009 Feb 12;19(2):81-8. Epub 2009 Jan 12.

Cellular Pathobiology Section, Cellular Neurobiology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health/DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA.

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http://dx.doi.org/10.1016/j.tcb.2008.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750097PMC
February 2009

Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death.

Authors:
Soumya Sinha Roy Muniswamy Madesh Erika Davies Bruno Antonsson Nika Danial György Hajnóczky

Mol Cell 2009 Feb;33(3):377-88

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662194PMC
February 2009

Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.

Authors:
Masao Saotome Dzhamilja Safiulina György Szabadkai Sudipto Das Asa Fransson Pontus Aspenstrom Rosario Rizzuto György Hajnóczky

Proc Natl Acad Sci U S A 2008 Dec 19;105(52):20728-33. Epub 2008 Dec 19.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.0808953105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634948PMC
December 2008

Uncoupling of ER-mitochondrial calcium communication by transforming growth factor-beta.

Authors:
Pál Pacher Kumar Sharma György Csordás Yanqing Zhu György Hajnóczky

Am J Physiol Renal Physiol 2008 Nov 23;295(5):F1303-12. Epub 2008 Jul 23.

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1152/ajprenal.90343.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584912PMC
November 2008

Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle.

Authors:
Cecilia García-Pérez György Hajnóczky György Csordás

J Biol Chem 2008 Nov 12;283(47):32771-80. Epub 2008 Sep 12.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M803385200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395082PMC
November 2008

Calcium, mitochondria and apoptosis studied by fluorescence measurements.

Authors:
Soumya Sinha Roy György Hajnóczky

Methods 2008 Nov 21;46(3):213-23. Epub 2008 Oct 21.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Suite 253 JAH, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.ymeth.2008.09.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799833PMC
November 2008

High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling.

Authors:
András Spät Gergo Szanda György Csordás György Hajnóczky

Cell Calcium 2008 Jul 19;44(1):51-63. Epub 2008 Feb 19.

Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.

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http://dx.doi.org/10.1016/j.ceca.2007.11.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662195PMC
July 2008

Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts.

Authors:
Hua Zhang Sudipto Das Quan-Zhen Li Ioannis Dragatsis Joyce Repa Scott Zeitlin György Hajnóczky Ilya Bezprozvanny

BMC Neurosci 2008 Apr 15;9:38. Epub 2008 Apr 15.

Department of Physiology, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1186/1471-2202-9-38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2377268PMC
April 2008

Calcium signalling and mitochondrial motility.

Authors:
György Hajnóczky Masao Saotome György Csordás David Weaver Muqing Yi

Novartis Found Symp 2007 ;287:105-17; discussion 117-21

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1002/9780470725207.ch8DOI Listing
January 2008

IP3 receptors in cell survival and apoptosis: Ca2+ release and beyond.

Authors:
Suresh K Joseph György Hajnóczky

Apoptosis 2007 May;12(5):951-68

Department of Pathology & Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.

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http://link.springer.com/10.1007/s10495-007-0719-7
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May 2007

Cell signaling. Mitochondrial longevity pathways.

Authors:
György Hajnóczky Jan B Hoek

Science 2007 Feb;315(5812):607-9

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1126/science.1138825DOI Listing
February 2007

Mitochondrial calcium signalling and cell death: approaches for assessing the role of mitochondrial Ca2+ uptake in apoptosis.

Authors:
György Hajnóczky György Csordás Sudipto Das Cecilia Garcia-Perez Masao Saotome Soumya Sinha Roy Muqing Yi

Cell Calcium 2006 Nov-Dec;40(5-6):553-60. Epub 2006 Oct 30.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1016/j.ceca.2006.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692319PMC
January 2007

Structural and functional features and significance of the physical linkage between ER and mitochondria.

Authors:
György Csordás Christian Renken Péter Várnai Ludivine Walter David Weaver Karolyn F Buttle Tamás Balla Carmen A Mannella György Hajnóczky

J Cell Biol 2006 Sep 18;174(7):915-21. Epub 2006 Sep 18.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://www.jcb.org/lookup/doi/10.1083/jcb.200604016
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064383PMC
September 2006

Ca2+-dependent control of the permeability properties of the mitochondrial outer membrane and voltage-dependent anion-selective channel (VDAC).

Authors:
György Báthori György Csordás Cecilia Garcia-Perez Erika Davies György Hajnóczky

J Biol Chem 2006 Jun 5;281(25):17347-58. Epub 2006 Apr 5.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M600906200DOI Listing
June 2006

Visualization of binding and transcytosis of botulinum toxin by human intestinal epithelial cells.

Authors:
Chowdhury R Ahsan György Hajnóczky Andrew B Maksymowych Lance L Simpson

J Pharmacol Exp Ther 2005 Dec 6;315(3):1028-35. Epub 2005 Sep 6.

Department of Medicine, Jefferson Medical College, Room 314-JAH, 1020 Locust Street, Philadelphia, PA 19107, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.105.09221
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December 2005

Proliferative signaling by store-operated calcium channels opposes colon cancer cell cytostasis induced by bacterial enterotoxins.

Authors:
Shiva Kazerounian Giovanni M Pitari Fawad J Shah Glen S Frick Muniswamy Madesh Inez Ruiz-Stewart Stephanie Schulz Gyorgy Hajnóczky Scott A Waldman

J Pharmacol Exp Ther 2005 Sep 3;314(3):1013-22. Epub 2005 Jun 3.

Division of Clinical Pharmacology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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September 2005

RSA 2004: combined basic research satellite symposium - session three: alcohol and mitochondrial metabolism: at the crossroads of life and death.

Authors:
Gyongyi Szabo Jan B Hoek Victor Darley-Usmar Gyorgy Hajnoczky Thomas Knudsen Daria Mochly-Rosen Sam Zakhari

Alcohol Clin Exp Res 2005 Sep;29(9):1749-52

Thomas Jefferson University (JBH, GH), Department of Pathology, Anatomy and Cell Biology, Philadelphia, PA 19107-6799, USA.

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http://dx.doi.org/10.1097/01.alc.0000179318.48376.cdDOI Listing
September 2005

Mitochondria and endoplasmic reticulum: the lethal interorganelle cross-talk.

Authors:
Ludivine Walter György Hajnóczky

J Bioenerg Biomembr 2005 Jun;37(3):191-206

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1007/s10863-005-6600-xDOI Listing
June 2005

Alcohol and mitochondria in cardiac apoptosis: mechanisms and visualization.

Authors:
György Hajnóczky Christopher J Buzas Pál Pacher Jan B Hoek Emanuel Rubin

Alcohol Clin Exp Res 2005 May;29(5):693-701

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1097/01.alc.0000163493.45344.7aDOI Listing
May 2005

Control of calcium signal propagation to the mitochondria by inositol 1,4,5-trisphosphate-binding proteins.

Authors:
Xuena Lin Péter Várnai György Csordás András Balla Takeharu Nagai Atsushi Miyawaki Tamás Balla György Hajnóczky

J Biol Chem 2005 Apr 11;280(13):12820-32. Epub 2005 Jan 11.

Department of Pathology, Anatomy & Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1074/jbc.M411591200DOI Listing
April 2005

Control of mitochondrial motility and distribution by the calcium signal: a homeostatic circuit.

Authors:
Muqing Yi David Weaver György Hajnóczky

J Cell Biol 2004 Nov 15;167(4):661-72. Epub 2004 Nov 15.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1083/jcb.200406038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172592PMC
November 2004

Involvement of transforming growth factor-beta in regulation of calcium transients in diabetic vascular smooth muscle cells.

Authors:
Kumar Sharma Leo Deelman Muniswamy Madesh Bernd Kurz Emilio Ciccone Senthuran Siva Taishan Hu Yanqing Zhu Lewei Wang Robert Henning Xinliang Ma Gyorgy Hajnoczky

Am J Physiol Renal Physiol 2003 Dec 22;285(6):F1258-70. Epub 2003 Jul 22.

Dorrance Hamilton Research Laboratories, Division of Nephrology, Department of Medicine, Thomas Jefferson University, Suite 353, Jeff Alumni Hall, 1020 Locust Street, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1152/ajprenal.00145.2003DOI Listing
December 2003

Plasticity of mitochondrial calcium signaling.

Authors:
György Csordás György Hajnóczky

J Biol Chem 2003 Oct 7;278(43):42273-82. Epub 2003 Aug 7.

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1074/jbc.M305248200DOI Listing
October 2003

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice.

Authors:
Julie M Jones Pinaki Datta Srinivasa M Srinivasula Weizhen Ji Sanjeev Gupta ZhiJia Zhang Erika Davies György Hajnóczky Thomas L Saunders Margaret L Van Keuren Teresa Fernandes-Alnemri Miriam H Meisler Emad S Alnemri

Nature 2003 Oct 8;425(6959):721-7. Epub 2003 Oct 8.

Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109-0618, USA.

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October 2003

Calcium signaling and apoptosis.

Authors:
György Hajnóczky Erika Davies Muniswamy Madesh

Biochem Biophys Res Commun 2003 May;304(3):445-54

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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May 2003

Inositol lipid binding and membrane localization of isolated pleckstrin homology (PH) domains. Studies on the PH domains of phospholipase C delta 1 and p130.

Authors:
Péter Várnai Xuena Lin Sang Bong Lee Galina Tuymetova Tzvetanka Bondeva Andras Spät Sue Goo Rhee György Hajnóczky Tamas Balla

J Biol Chem 2002 Jul 17;277(30):27412-22. Epub 2002 May 17.

Endocrinology and Reproduction Research Branch, NICHD/National Institutes of Health, 49 Convent Drive, Bldg. 49, Bethesda, MD 20892, USA.

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July 2002

TGF-beta-induced Ca(2+) influx involves the type III IP(3) receptor and regulates actin cytoskeleton.

Authors:
Tracy A McGowan Muniswamy Madesh Yanqing Zhu Lewei Wang Mark Russo Leo Deelman Rob Henning Suresh Joseph Gyorgy Hajnoczky Kumar Sharma

Am J Physiol Renal Physiol 2002 May;282(5):F910-20

Dorrance Hamilton Laboratory, Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://dx.doi.org/10.1152/ajprenal.00252.2001DOI Listing
May 2002

tcBid promotes Ca(2+) signal propagation to the mitochondria: control of Ca(2+) permeation through the outer mitochondrial membrane.

Authors:
György Csordás Muniswamy Madesh Bruno Antonsson György Hajnóczky

EMBO J 2002 May;21(9):2198-206

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1093/emboj/21.9.2198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125984PMC
May 2002

Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization.

Authors:
Muniswamy Madesh Bruno Antonsson Srinivasa M Srinivasula Emad S Alnemri György Hajnóczky

J Biol Chem 2002 Feb 6;277(7):5651-9. Epub 2001 Dec 6.

Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

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http://www.jbc.org/content/277/7/5651.full.pdf
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http://dx.doi.org/10.1074/jbc.M108171200DOI Listing
February 2002

Ca2+ marks: miniature calcium signals in single mitochondria driven by ryanodine receptors.

Authors:
Pál Pacher Andrew P Thomas György Hajnóczky

Proc Natl Acad Sci U S A 2002 Feb;99(4):2380-5

Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1073/pnas.032423699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122373PMC
February 2002