Gwyn T Williams

Gwyn T Williams

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Gwyn T Williams

Gwyn T Williams

Publications by authors named "Gwyn T Williams"

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The hormone response element mimic sequence of GAS5 lncRNA is sufficient to induce apoptosis in breast cancer cells.

Oncotarget 2016 Mar;7(9):10104-16

Apoptosis Research Group, School of Life Sciences, Keele University, Keele ST5 5BG, United Kingdom.

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http://dx.doi.org/10.18632/oncotarget.7173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891107PMC
March 2016

Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA.

Genes (Basel) 2015 Jul 7;6(3):484-99. Epub 2015 Jul 7.

School of Life Sciences, Huxley Building, Keele University, Keele ST5 5BG, UK.

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http://dx.doi.org/10.3390/genes6030484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584312PMC
July 2015

Reciprocal regulation of GAS5 lncRNA levels and mTOR inhibitor action in prostate cancer cells.

Prostate 2015 May 3;75(7):693-705. Epub 2015 Feb 3.

School of Life Sciences, Faculty of Natural Sciences and The Institute of Science and Technology in Medicine, Keele University, Keele, Staffordshire, UK.

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http://dx.doi.org/10.1002/pros.22952DOI Listing
May 2015

Role of GAS5 noncoding RNA in mediating the effects of rapamycin and its analogues on mantle cell lymphoma cells.

Clin Lymphoma Myeloma Leuk 2014 Dec 3;14(6):468-73. Epub 2014 Mar 3.

Institute for Science and Technology in Medicine, Huxley Building, Keele University, Keele, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2014.02.011DOI Listing
December 2014

Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.

Nat Commun 2014 Nov 7;5:5395. Epub 2014 Nov 7.

1] Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA [2] Discovery and Developmental Therapeutics, Winship Cancer Institute, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1038/ncomms6395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280027PMC
November 2014

Growth arrest on inhibition of nonsense-mediated decay is mediated by noncoding RNA GAS5.

Biomed Res Int 2013 11;2013:358015. Epub 2013 Nov 11.

Institute for Science and Technology in Medicine and School of Life Sciences, Keele University, Huxley Building, Keele ST5 5BG, UK.

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http://dx.doi.org/10.1155/2013/358015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844204PMC
June 2014

Regulation of apoptosis by long non-coding RNA GAS5 in breast cancer cells: implications for chemotherapy.

Breast Cancer Res Treat 2014 Jun 1;145(2):359-70. Epub 2014 May 1.

Apoptosis Research Group, Institute of Science and Technology in Medicine, School of Life Sciences, Keele University, Huxley Building, Keele, ST5 5BG, UK,

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http://dx.doi.org/10.1007/s10549-014-2974-yDOI Listing
June 2014

Apoptosis suppression by candidate oncogene PLAC8 is reversed in other cell types.

Curr Cancer Drug Targets 2013 Jan;13(1):80-91

Institute for Science and Technology in Medicine, Keele University, Keele, UK.

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January 2013

Are snoRNAs and snoRNA host genes new players in cancer?

Nat Rev Cancer 2012 01 19;12(2):84-8. Epub 2012 Jan 19.

Institute for Science and Technology in Medicine, Huxley Building, Keele University, Keele ST5 5BG, UK.

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http://dx.doi.org/10.1038/nrc3195DOI Listing
January 2012

Candidate tumour suppressor Fau regulates apoptosis in human cells: an essential role for Bcl-G.

Biochim Biophys Acta 2011 Sep 29;1812(9):1146-53. Epub 2011 Apr 29.

Institute of Science and Technology in Medicine, Huxley Building, Keele University, Keele, ST5 5BG, UK.

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http://dx.doi.org/10.1016/j.bbadis.2011.04.009DOI Listing
September 2011

A critical role for non-coding RNA GAS5 in growth arrest and rapamycin inhibition in human T-lymphocytes.

Biochem Soc Trans 2011 Apr;39(2):482-6

Institute for Science and Technology in Medicine and School of Life Sciences, Huxley Building, Keele University, Keele ST5 5BG, UK.

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http://dx.doi.org/10.1042/BST0390482DOI Listing
April 2011

Apoptosis regulators Fau and Bcl-G are down-regulated in prostate cancer.

Prostate 2010 Oct;70(14):1513-23

Institute for Science and Technology in Medicine, School of Life Sciences, Keele University, Huxley Building, Keele, UK.

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http://dx.doi.org/10.1002/pros.21186DOI Listing
October 2010

Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor.

Int Immunopharmacol 2010 Sep 4;10(9):1017-21. Epub 2010 Jun 4.

Infection, Immunity and Inflammation Research Group, Institute of Science and Technology in Medicine, Keele University, Keele, Staffordshire, United Kingdom.

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http://dx.doi.org/10.1016/j.intimp.2010.05.014DOI Listing
September 2010

Inhibition of human T-cell proliferation by mammalian target of rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5).

Mol Pharmacol 2010 Jul 26;78(1):19-28. Epub 2010 Apr 26.

Institute for Science and Technology in Medicine and School of Life Sciences, Huxley Building, Keele University, Keele, ST5 5BG, UK.

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http://dx.doi.org/10.1124/mol.110.064055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912054PMC
July 2010

Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.

Breast Cancer Res 2009 11;11(4):R60. Epub 2009 Aug 11.

Institute for Science and Technology in Medicine and School of Life Sciences, Keele University, Huxley Building, Keele ST5 5BG, UK.

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http://dx.doi.org/10.1186/bcr2350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750122PMC
February 2010

FAU regulates carboplatin resistance in ovarian cancer.

Genes Chromosomes Cancer 2010 Jan;49(1):70-7

Institute for Science and Technology in Medicine and School of Life Sciences, Keele University, Keele, UK.

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http://dx.doi.org/10.1002/gcc.20721DOI Listing
January 2010

Protein phosphatase 4 regulates apoptosis in leukemic and primary human T-cells.

Leuk Res 2009 Nov 18;33(11):1539-51. Epub 2009 Jun 18.

Institute for Science and Technology in Medicine and School of Life Sciences, Huxley Building, Keele University, Keele ST5 5BG, UK.

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http://dx.doi.org/10.1016/j.leukres.2009.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734887PMC
November 2009

Preparation and characterization of prostate cell lines for functional cloning studies to identify regulators of apoptosis.

J Androl 2009 May-Jun;30(3):248-58. Epub 2008 Nov 20.

Institute for Science and Technology in Medicine, Keele University, Keele, United Kingdom.

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http://dx.doi.org/10.2164/jandrol.108.005686DOI Listing
July 2009

Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration.

Arthritis Res Ther 2008 1;10(4):R86. Epub 2008 Aug 1.

Centre for Spinal Studies, Robert Jones & Agnes Hunt Orthopaedic & District Hospital NHS Trust, Oswestry, Shropshire, UK.

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http://dx.doi.org/10.1186/ar2466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575634PMC
February 2009

Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells.

Biochim Biophys Acta 2008 Aug 20;1783(8):1490-502. Epub 2008 Mar 20.

Institute for Science and Technology in Medicine, Huxley Building, Keele University, Keele, ST5 5BG, UK.

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http://dx.doi.org/10.1016/j.bbamcr.2008.03.005DOI Listing
August 2008

Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5).

J Cell Sci 2008 Apr;121(Pt 7):939-46

Institute for Science and Technology in Medicine, Huxley Building, Keele University, Keele, ST5 5BG, UK.

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http://dx.doi.org/10.1242/jcs.024646DOI Listing
April 2008

Primary colorectal tumors fail to express the proapoptotic mediator PTAG and its reexpression augments drug-induced apoptosis.

Genes Chromosomes Cancer 2007 Feb;46(2):202-12

Institute of Science and Technology in Medicine, School of Medicine, Keele University, Stoke on Trent, Staffordshire ST4 7QB, UK.

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http://dx.doi.org/10.1002/gcc.20401DOI Listing
February 2007

The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: research update.

ScientificWorldJournal 2006 Dec 28;6:1705-12. Epub 2006 Dec 28.

Institute for Science and Technology in Medicine, Keele University, Keele, Staffs, ST5 5BG, UK.

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http://dx.doi.org/10.1100/tsw.2006.268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1825760PMC
December 2006

Isolation of genes controlling apoptosis through their effects on cell survival.

Gene Ther Mol Biol 2006 Dec;10(B):255-262

Institute for Science and Technology in Medicine, Huxley Building, Keele University, Keele, ST5 5BG, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828370PMC
December 2006

Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes.

Exp Cell Res 2006 Jun 20;312(10):1745-52. Epub 2006 Mar 20.

School of Life Sciences, Keele University, Keele ST5 5BG, UK.

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http://dx.doi.org/10.1016/j.yexcr.2006.02.009DOI Listing
June 2006

Functional expression cloning reveals a central role for the receptor for activated protein kinase C 1 (RACK1) in T cell apoptosis.

J Leukoc Biol 2005 Aug 3;78(2):503-14. Epub 2005 May 3.

School of Life Sciences, Keele University, Keele, ST5 5BG, UK.

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http://dx.doi.org/10.1189/jlb.0205070DOI Listing
August 2005

Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression.

Oncogene 2004 Dec;23(58):9419-26

School of Life Sciences, Keele University, Keele, ST5 5BG, UK.

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http://dx.doi.org/10.1038/sj.onc.1208048DOI Listing
December 2004

The role of apoptosis in non-mammalian host-parasite relationships.

Symp Soc Exp Biol 2004 (55):13-44; discussion 243-5

School of Life Sciences, Keele University, Staffordshire, United Kingdom.

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November 2004

Isolation and characterization of a novel pituitary tumor apoptosis gene.

Mol Endocrinol 2004 Jul 22;18(7):1827-39. Epub 2004 Apr 22.

Institute for Science and Technology in Medicine, Medical Research Unit, School of Postgraduate Medicine, Keele University, North Staffordshire Hospital, Stoke-on-Trent ST4 7QB, United Kingdom.

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http://dx.doi.org/10.1210/me.2004-0087DOI Listing
July 2004

The use of gene function to identify the rate-limiting steps controlling cell fate.

Cancer Immunol Immunother 2004 Mar 13;53(3):160-5. Epub 2004 Jan 13.

School of Life Sciences, Keele University, ST5 5BG, Keele, UK.

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http://dx.doi.org/10.1007/s00262-003-0476-6DOI Listing
March 2004

Apoptosis gene hunting using retroviral expression cloning: identification of vacuolar ATPase subunit E.

ScientificWorldJournal 2003 Mar 17;3:51-8. Epub 2003 Mar 17.

School of Life Sciences, Keele University, Keele, Staffordshire, ST5 5BG, England.

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http://dx.doi.org/10.1100/tsw.2003.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974873PMC
March 2003

Apoptosis in the malaria protozoan, Plasmodium berghei: a possible mechanism for limiting intensity of infection in the mosquito.

Int J Parasitol 2002 Aug;32(9):1133-43

Centre for Applied Entomology and Parasitology, Keele University, Staffordshire ST5 5BG, UK.

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http://dx.doi.org/10.1016/s0020-7519(02)00087-5DOI Listing
August 2002

RBM5/LUCA-15--tumour suppression by control of apoptosis and the cell cycle?

ScientificWorldJournal 2002 Jul 4;2:1885-90. Epub 2002 Jul 4.

School of Life Sciences, Keele University, Keele, Staffs, ST5 5BG, UK.

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http://dx.doi.org/10.1100/tsw.2002.859DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009235PMC
July 2002

Complete cDNA sequence of SAP-like pentraxin from Limulus polyphemus: implications for pentraxin evolution.

J Mol Biol 2002 Feb;316(3):583-97

School of Life Sciences, Keele University, Keele, Staffordshire, ST5 5BG, UK.

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http://dx.doi.org/10.1006/jmbi.2001.5356DOI Listing
February 2002

Regulation of T-Cell Apoptosis by Sequences Encoded at the Luca-15 Candidate Tumour Suppressor Locus.

ScientificWorldJournal 2001 15;1:38. Epub 2001 Nov 15.

School of Life Sciences, Keele University, Staffordshire, U.K. ST5 5BG, UK.

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http://dx.doi.org/10.1100/tsw.2001.145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084202PMC
November 2001

Apoptosis Gene Hunting Using Retroviral Expression Cloning.

ScientificWorldJournal 2001 23;1:33. Epub 2001 Oct 23.

School of Life Sciences, Keele University, Keele, Staffs, ST5 5BG, England.

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http://dx.doi.org/10.1100/tsw.2001.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083997PMC
October 2001