Guy Salvesen

Guy Salvesen

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Guy Salvesen

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The Proteasome as a Drug Target in the Metazoan Pathogen, .

ACS Infect Dis 2019 Aug 12. Epub 2019 Aug 12.

Center for Discovery and Innovation in Parasitic Diseases , University of California, San Diego , 9500 Gilman Drive , La Jolla , California 92093 , United States.

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http://dx.doi.org/10.1021/acsinfecdis.9b00237DOI Listing
August 2019

Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells.

Cell Death Differ 2019 Jun 17. Epub 2019 Jun 17.

Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.

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http://dx.doi.org/10.1038/s41418-019-0364-zDOI Listing
June 2019

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.

Cell Rep 2019 Jun;27(12):3646-3656.e5

Institute of Virology and Immunology, 3147 Mittelhäusern, Switzerland; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.05.065DOI Listing
June 2019

Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells.

Cell Death Differ 2019 Apr 11. Epub 2019 Apr 11.

NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1038/s41418-019-0329-2DOI Listing
April 2019

Caspase selective reagents for diagnosing apoptotic mechanisms.

Cell Death Differ 2019 Feb 10;26(2):229-244. Epub 2018 May 10.

NCI Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA.

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http://dx.doi.org/10.1038/s41418-018-0110-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329798PMC
February 2019

A primer on caspase mechanisms.

Semin Cell Dev Biol 2018 10 12;82:79-85. Epub 2018 Jan 12.

Graduate Program in Biomedical Sciences, NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2018.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043420PMC
October 2018

Protease Specificity: Towards In Vivo Imaging Applications and Biomarker Discovery.

Trends Biochem Sci 2018 10 7;43(10):829-844. Epub 2018 Aug 7.

Jozef Stefan Institute, Department of Biochemistry and Molecular and Structural Biology, Jamova 39, SI-1000 Ljubljana, Slovenia; Faculty of Chemistry and Chemical Technology, University of Ljubljana, Vecna pot 113, SI-1000 Ljubljana, Slovenia. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2018.07.003DOI Listing
October 2018

Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes.

Sci Rep 2018 Oct 30;8(1):15998. Epub 2018 Oct 30.

Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wyb. Wyspianskiego 27, 50-370, Wroclaw, Poland.

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http://www.nature.com/articles/s41598-018-34476-7
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http://dx.doi.org/10.1038/s41598-018-34476-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207715PMC
October 2018

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes.

Chem Sci 2018 Feb 16;9(8):2113-2129. Epub 2018 Jan 16.

Department of Bioorganic Chemistry , Faculty of Chemistry , Wroclaw University of Technology , Wyb. Wyspianskiego 27 , 50-370 Wroclaw , Poland . Email: ; Email:

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http://dx.doi.org/10.1039/c7sc04303aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896380PMC
February 2018

Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity.

Nat Protoc 2017 Oct 21;12(10):2189-2214. Epub 2017 Sep 21.

Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology, Wroclaw, Poland.

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http://dx.doi.org/10.1038/nprot.2017.091DOI Listing
October 2017

Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils.

J Am Chem Soc 2017 07 18;139(29):10115-10125. Epub 2017 Jul 18.

Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Science and Technology , Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland.

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http://dx.doi.org/10.1021/jacs.7b04394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548316PMC
July 2017

Return of the Ice Age: Caspases Safeguard against Inflammatory Cell Death.

Cell Chem Biol 2017 May;24(5):550-552

Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.05.001DOI Listing
May 2017

Differing Requirements for MALT1 Function in Peripheral B Cell Survival and Differentiation.

J Immunol 2017 02 28;198(3):1066-1080. Epub 2016 Dec 28.

Tumor Microenvironment and Cancer Immunology Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1502518
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http://dx.doi.org/10.4049/jimmunol.1502518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263101PMC
February 2017

Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes.

Cell Chem Biol 2016 08 28;23(8):1023-35. Epub 2016 Jul 28.

Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wyb.Wyspianskiego 27, 50-370 Wroclaw, Poland. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939596PMC
August 2016

Response to Comment on "SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML".

Sci Signal 2016 08 9;9(440):tc2. Epub 2016 Aug 9.

Tumor Microenvironment and Cancer Immunology Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scisignal.aad9777DOI Listing
August 2016

Protease signaling in animal and plant-regulated cell death.

FEBS J 2016 07 31;283(14):2577-98. Epub 2015 Dec 31.

Centre for Research in Agricultural Genomics (CRAG), CSIC-IRTA-UAB-UB, Campus UAB Bellaterra, Barcelona, Spain.

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http://dx.doi.org/10.1111/febs.13616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5606204PMC
July 2016

Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4.

PLoS One 2015 14;10(7):e0132818. Epub 2015 Jul 14.

Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, Wroclaw 50-370, Poland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132818PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501687PMC
April 2016

The Paracaspase MALT1.

Biochimie 2016 Mar 16;122:324-38. Epub 2015 Sep 16.

Program in Cell Death and Survival Networks, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2015.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747852PMC
March 2016

Regulation of Histone Acetylation by Autophagy in Parkinson Disease.

J Biol Chem 2016 Feb 23;291(7):3531-40. Epub 2015 Dec 23.

From the Graduate Program of Biomedical Science, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, the State Key Laboratory of Medical Genetics, Xiangya Medical School, Central South University, Hunan 410078, China, and the Sanford-Burnham Medical Research Institute, La Jolla, California 92037

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http://dx.doi.org/10.1074/jbc.M115.675488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751393PMC
February 2016

Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom.

Toxins (Basel) 2016 Feb 5;8(2):38. Epub 2016 Feb 5.

Biomedical Innovation Department, Scientific Research and High Education Center of Ensenada (CICESE), Carretera Ensenada-Tijuana No 3918 Fracc, Zona Playitas Ensenada C.P. 22860, Baja California, Mexico.

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http://dx.doi.org/10.3390/toxins8020038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773791PMC
February 2016

Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates.

PLoS One 2014 17;9(10):e110539. Epub 2014 Oct 17.

Sanford Burnham Medical Research Institute, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110539PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201543PMC
December 2015

Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi.

J Biol Chem 2015 Nov 7;290(47):28231-44. Epub 2015 Oct 7.

From the Department of Biochemistry and Molecular and Structural Biology, Jožef Stefan Institute, Jamova Cesta 39, SI-1000 Ljubljana, Slovenia, the Centre of Excellence for Integrated Approaches in Chemistry and Biology of Proteins, Jamova Cesta 39, SI-1000 Ljubljana, Slovenia, the Faculty of Chemistry and Chemical Technology, University of Ljubljana, Jamova Cesta 39, SI-1000 Ljubljana, Slovenia

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.687764
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http://dx.doi.org/10.1074/jbc.M115.687764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653680PMC
November 2015

Small Molecule Active Site Directed Tools for Studying Human Caspases.

Chem Rev 2015 Nov 9;115(22):12546-629. Epub 2015 Nov 9.

Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology , Wyb. Wyspianskiego 27, 50-370 Wroclaw, Poland.

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http://dx.doi.org/10.1021/acs.chemrev.5b00434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610424PMC
November 2015

Regulated cell death: signaling and mechanisms.

Annu Rev Cell Dev Biol 2014 13;30:337-56. Epub 2014 Aug 13.

Genentech Inc., South San Francisco, California 94080; email:

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http://dx.doi.org/10.1146/annurev-cellbio-100913-013226DOI Listing
June 2015

SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML.

Sci Signal 2015 Jun 9;8(380):ra56. Epub 2015 Jun 9.

Cell Death and Survival Networks Program, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1126/scisignal.aaa3929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603552PMC
June 2015

Caspase enzymology and activation mechanisms.

Methods Enzymol 2014 ;544:161-78

Program in Cell Death and Survival Networks, NCI Designated Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-417158-9.00007-8DOI Listing
February 2015

Probes to monitor activity of the paracaspase MALT1.

Chem Biol 2015 Jan 31;22(1):139-47. Epub 2014 Dec 31.

Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304901PMC
January 2015

Functions of caspase 8: the identified and the mysterious.

Semin Immunol 2014 Jun 21;26(3):246-52. Epub 2014 May 21.

Department of Molecular Biology and Biochemistry, Institute for Immunology, University of California, Irvine, CA 92697, USA. Electronic address:

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http://dx.doi.org/10.1016/j.smim.2014.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099255PMC
June 2014

A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids.

Amino Acids 2014 May 27;46(5):1313-20. Epub 2014 Feb 27.

Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370, Wrocław, Poland.

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http://dx.doi.org/10.1007/s00726-014-1694-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984412PMC
May 2014

Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation.

J Biol Chem 2014 May 8;289(22):15544-53. Epub 2014 Apr 8.

the Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30 387 Krakow, Poland, the Malopolska Centre of Biotechnology, 30 387 Krakow, Poland

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http://dx.doi.org/10.1074/jbc.M113.507616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140910PMC
May 2014

Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling.

Proc Natl Acad Sci U S A 2014 Feb 3;111(7):2518-23. Epub 2014 Feb 3.

Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wroclaw 50-370, Poland.

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http://dx.doi.org/10.1073/pnas.1318548111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932852PMC
February 2014

Caspase substrates and inhibitors.

Cold Spring Harb Perspect Biol 2013 Aug 1;5(8):a008680. Epub 2013 Aug 1.

Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, 50-370 Wrocław, Poland.

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http://dx.doi.org/10.1101/cshperspect.a008680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721276PMC
August 2013

Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP.

ACS Chem Biol 2013 Apr 5;8(4):725-32. Epub 2013 Feb 5.

Program in Apoptosis and Cell Death and NCI Designated Cancer Center, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1021/cb3005512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953502PMC
April 2013

Activity, specificity, and probe design for the smallpox virus protease K7L.

J Biol Chem 2012 Nov 25;287(47):39470-9. Epub 2012 Sep 25.

Program in Apoptosis and Cell Death Research, Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.388678
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http://dx.doi.org/10.1074/jbc.M112.388678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501048PMC
November 2012

X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP.

J Mol Biol 2012 Sep 16;422(4):495-507. Epub 2012 Jun 16.

Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne, VIC 3800, Australia.

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http://dx.doi.org/10.1016/j.jmb.2012.06.006DOI Listing
September 2012

Highlight: the universe of proteolytic networks and mechanisms.

Biol Chem 2012 Sep;393(9):841

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http://dx.doi.org/10.1515/hsz-2012-0262DOI Listing
September 2012

Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis.

J Biol Chem 2012 Jun 23;287(25):21142-51. Epub 2012 Apr 23.

Institute of Pharmacology, University of Bern, CH-3010 Bern, Switzerland.

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http://dx.doi.org/10.1074/jbc.M111.306399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375537PMC
June 2012

Mousing around with caspases and IAPs.

Biochem J 2012 Apr;443(2):e1-2

Programs in Cell Death and Inflammation Research, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1042/BJ20120402DOI Listing
April 2012

Guidelines for the use and interpretation of assays for monitoring autophagy.

Authors:
Daniel J Klionsky Fabio C Abdalla Hagai Abeliovich Robert T Abraham Abraham Acevedo-Arozena Khosrow Adeli Lotta Agholme Maria Agnello Patrizia Agostinis Julio A Aguirre-Ghiso Hyung Jun Ahn Ouardia Ait-Mohamed Slimane Ait-Si-Ali Takahiko Akematsu Shizuo Akira Hesham M Al-Younes Munir A Al-Zeer Matthew L Albert Roger L Albin Javier Alegre-Abarrategui Maria Francesca Aleo Mehrdad Alirezaei Alexandru Almasan Maylin Almonte-Becerril Atsuo Amano Ravi Amaravadi Shoba Amarnath Amal O Amer Nathalie Andrieu-Abadie Vellareddy Anantharam David K Ann Shailendra Anoopkumar-Dukie Hiroshi Aoki Nadezda Apostolova Giuseppe Arancia John P Aris Katsuhiko Asanuma Nana Y O Asare Hisashi Ashida Valerie Askanas David S Askew Patrick Auberger Misuzu Baba Steven K Backues Eric H Baehrecke Ben A Bahr Xue-Yuan Bai Yannick Bailly Robert Baiocchi Giulia Baldini Walter Balduini Andrea Ballabio Bruce A Bamber Edward T W Bampton Gábor Bánhegyi Clinton R Bartholomew Diane C Bassham Robert C Bast Henri Batoko Boon-Huat Bay Isabelle Beau Daniel M Béchet Thomas J Begley Christian Behl Christian Behrends Soumeya Bekri Bryan Bellaire Linda J Bendall Luca Benetti Laura Berliocchi Henri Bernardi Francesca Bernassola Sébastien Besteiro Ingrid Bhatia-Kissova Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Lawrence H Boise Paolo Bonaldo David L Boone Beat C Bornhauser Karina R Bortoluci Ioannis Bossis Frédéric Bost Jean-Pierre Bourquin Patricia Boya Michaël Boyer-Guittaut Peter V Bozhkov Nathan R Brady Claudio Brancolini Andreas Brech Jay E Brenman Ana Brennand Emery H Bresnick Patrick Brest Dave Bridges Molly L Bristol Paul S Brookes Eric J Brown John H Brumell Nicola Brunetti-Pierri Ulf T Brunk Dennis E Bulman Scott J Bultman Geert Bultynck Lena F Burbulla Wilfried Bursch Jonathan P Butchar Wanda Buzgariu Sergio P Bydlowski Ken Cadwell Monika Cahová Dongsheng Cai Jiyang Cai Qian Cai Bruno Calabretta Javier Calvo-Garrido Nadine Camougrand Michelangelo Campanella Jenny Campos-Salinas Eleonora Candi Lizhi Cao Allan B Caplan Simon R Carding Sandra M Cardoso Jennifer S Carew Cathleen R Carlin Virginie Carmignac Leticia A M Carneiro Serena Carra Rosario A Caruso Giorgio Casari Caty Casas Roberta Castino Eduardo Cebollero Francesco Cecconi Jean Celli Hassan Chaachouay Han-Jung Chae Chee-Yin Chai David C Chan Edmond Y Chan Raymond Chuen-Chung Chang Chi-Ming Che Ching-Chow Chen Guang-Chao Chen Guo-Qiang Chen Min Chen Quan Chen Steve S-L Chen WenLi Chen Xi Chen Xiangmei Chen Xiequn Chen Ye-Guang Chen Yingyu Chen Yongqiang Chen Yu-Jen Chen Zhixiang Chen Alan Cheng Christopher H K Cheng Yan Cheng Heesun Cheong Jae-Ho Cheong Sara Cherry Russ Chess-Williams Zelda H Cheung Eric Chevet Hui-Ling Chiang Roberto Chiarelli Tomoki Chiba Lih-Shen Chin Shih-Hwa Chiou Francis V Chisari Chi Hin Cho Dong-Hyung Cho Augustine M K Choi DooSeok Choi Kyeong Sook Choi Mary E Choi Salem Chouaib Divaker Choubey Vinay Choubey Charleen T Chu Tsung-Hsien Chuang Sheau-Huei Chueh Taehoon Chun Yong-Joon Chwae Mee-Len Chye Roberto Ciarcia Maria R Ciriolo Michael J Clague Robert S B Clark Peter G H Clarke Robert Clarke Patrice Codogno Hilary A Coller María I Colombo Sergio Comincini Maria Condello Fabrizio Condorelli Mark R Cookson Graham H Coombs Isabelle Coppens Ramon Corbalan Pascale Cossart Paola Costelli Safia Costes Ana Coto-Montes Eduardo Couve Fraser P Coxon James M Cregg José L Crespo Marianne J Cronjé Ana Maria Cuervo Joseph J Cullen Mark J Czaja Marcello D'Amelio Arlette Darfeuille-Michaud Lester M Davids Faith E Davies Massimo De Felici John F de Groot Cornelis A M de Haan Luisa De Martino Angelo De Milito Vincenzo De Tata Jayanta Debnath Alexei Degterev Benjamin Dehay Lea M D Delbridge Francesca Demarchi Yi Zhen Deng Jörn Dengjel Paul Dent Donna Denton Vojo Deretic Shyamal D Desai Rodney J Devenish Mario Di Gioacchino Gilbert Di Paolo Chiara Di Pietro Guillermo Díaz-Araya Inés Díaz-Laviada Maria T Diaz-Meco Javier Diaz-Nido Ivan Dikic Savithramma P Dinesh-Kumar Wen-Xing Ding Clark W Distelhorst Abhinav Diwan Mojgan Djavaheri-Mergny Svetlana Dokudovskaya Zheng Dong Frank C Dorsey Victor Dosenko James J Dowling Stephen Doxsey Marlène Dreux Mark E Drew Qiuhong Duan Michel A Duchosal Karen Duff Isabelle Dugail Madeleine Durbeej Michael Duszenko Charles L Edelstein Aimee L Edinger Gustavo Egea Ludwig Eichinger N Tony Eissa Suhendan Ekmekcioglu Wafik S El-Deiry Zvulun Elazar Mohamed Elgendy Lisa M Ellerby Kai Er Eng Anna-Mart Engelbrecht Simone Engelender Jekaterina Erenpreisa Ricardo Escalante Audrey Esclatine Eeva-Liisa Eskelinen Lucile Espert Virginia Espina Huizhou Fan Jia Fan Qi-Wen Fan Zhen Fan Shengyun Fang Yongqi Fang Manolis Fanto Alessandro Fanzani Thomas Farkas Jean-Claude Farré Mathias Faure Marcus Fechheimer Carl G Feng Jian Feng Qili Feng Youji Feng László Fésüs Ralph Feuer Maria E Figueiredo-Pereira Gian Maria Fimia Diane C Fingar Steven Finkbeiner Toren Finkel Kim D Finley Filomena Fiorito Edward A Fisher Paul B Fisher Marc Flajolet Maria L Florez-McClure Salvatore Florio Edward A Fon Francesco Fornai Franco Fortunato Rati Fotedar Daniel H Fowler Howard S Fox Rodrigo Franco Lisa B Frankel Marc Fransen José M Fuentes Juan Fueyo Jun Fujii Kozo Fujisaki Eriko Fujita Mitsunori Fukuda Ruth H Furukawa Matthias Gaestel Philippe Gailly Malgorzata Gajewska Brigitte Galliot Vincent Galy Subramaniam Ganesh Barry Ganetzky Ian G Ganley Fen-Biao Gao George F Gao Jinming Gao Lorena Garcia Guillermo Garcia-Manero Mikel Garcia-Marcos Marjan Garmyn Andrei L Gartel Evelina Gatti Mathias Gautel Thomas R Gawriluk Matthew E Gegg Jiefei Geng Marc Germain Jason E Gestwicki David A Gewirtz Saeid Ghavami Pradipta Ghosh Anna M Giammarioli Alexandra N Giatromanolaki Spencer B Gibson Robert W Gilkerson Michael L Ginger Henry N Ginsberg Jakub Golab Michael S Goligorsky Pierre Golstein Candelaria Gomez-Manzano Ebru Goncu Céline Gongora Claudio D Gonzalez Ramon Gonzalez Cristina González-Estévez Rosa Ana González-Polo Elena Gonzalez-Rey Nikolai V Gorbunov Sharon Gorski Sandro Goruppi Roberta A Gottlieb Devrim Gozuacik Giovanna Elvira Granato Gary D Grant Kim N Green Aleš Gregorc Frédéric Gros Charles Grose Thomas W Grunt Philippe Gual Jun-Lin Guan Kun-Liang Guan Sylvie M Guichard Anna S Gukovskaya Ilya Gukovsky Jan Gunst Asa B Gustafsson Andrew J Halayko Amber N Hale Sandra K Halonen Maho Hamasaki Feng Han Ting Han Michael K Hancock Malene Hansen Hisashi Harada Masaru Harada Stefan E Hardt J Wade Harper Adrian L Harris James Harris Steven D Harris Makoto Hashimoto Jeffrey A Haspel Shin-ichiro Hayashi Lori A Hazelhurst Congcong He You-Wen He Marie-Joseé Hébert Kim A Heidenreich Miep H Helfrich Gudmundur V Helgason Elizabeth P Henske Brian Herman Paul K Herman Claudio Hetz Sabine Hilfiker Joseph A Hill Lynne J Hocking Paul Hofman Thomas G Hofmann Jörg Höhfeld Tessa L Holyoake Ming-Huang Hong David A Hood Gökhan S Hotamisligil Ewout J Houwerzijl Maria Høyer-Hansen Bingren Hu Chien-An A Hu Hong-Ming Hu Ya Hua Canhua Huang Ju Huang Shengbing Huang Wei-Pang Huang Tobias B Huber Won-Ki Huh Tai-Ho Hung Ted R Hupp Gang Min Hur James B Hurley Sabah N A Hussain Patrick J Hussey Jung Jin Hwang Seungmin Hwang Atsuhiro Ichihara Shirin Ilkhanizadeh Ken Inoki Takeshi Into Valentina Iovane Juan L Iovanna Nancy Y Ip Yoshitaka Isaka Hiroyuki Ishida Ciro Isidoro Ken-ichi Isobe Akiko Iwasaki Marta Izquierdo Yotaro Izumi Panu M Jaakkola Marja Jäättelä George R Jackson William T Jackson Bassam Janji Marina Jendrach Ju-Hong Jeon Eui-Bae Jeung Hong Jiang Hongchi Jiang Jean X Jiang Ming Jiang Qing Jiang Xuejun Jiang Xuejun Jiang Alberto Jiménez Meiyan Jin Shengkan Jin Cheol O Joe Terje Johansen Daniel E Johnson Gail V W Johnson Nicola L Jones Bertrand Joseph Suresh K Joseph Annie M Joubert Gábor Juhász Lucienne Juillerat-Jeanneret Chang Hwa Jung Yong-Keun Jung Kai Kaarniranta Allen Kaasik Tomohiro Kabuta Motoni Kadowaki Katarina Kagedal Yoshiaki Kamada Vitaliy O Kaminskyy Harm H Kampinga Hiromitsu Kanamori Chanhee Kang Khong Bee Kang Kwang Il Kang Rui Kang Yoon-A Kang Tomotake Kanki Thirumala-Devi Kanneganti Haruo Kanno Anumantha G Kanthasamy Arthi Kanthasamy Vassiliki Karantza Gur P Kaushal Susmita Kaushik Yoshinori Kawazoe Po-Yuan Ke John H Kehrl Ameeta Kelekar Claus Kerkhoff David H Kessel Hany Khalil Jan A K W Kiel Amy A Kiger Akio Kihara Deok Ryong Kim Do-Hyung Kim Dong-Hou Kim Eun-Kyoung Kim Hyung-Ryong Kim Jae-Sung Kim Jeong Hun Kim Jin Cheon Kim John K Kim Peter K Kim Seong Who Kim Yong-Sun Kim Yonghyun Kim Adi Kimchi Alec C Kimmelman Jason S King Timothy J Kinsella Vladimir Kirkin Lorrie A Kirshenbaum Katsuhiko Kitamoto Kaio Kitazato Ludger Klein Walter T Klimecki Jochen Klucken Erwin Knecht Ben C B Ko Jan C Koch Hiroshi Koga Jae-Young Koh Young Ho Koh Masato Koike Masaaki Komatsu Eiki Kominami Hee Jeong Kong Wei-Jia Kong Viktor I Korolchuk Yaichiro Kotake Michael I Koukourakis Juan B Kouri Flores Attila L Kovács Claudine Kraft Dimitri Krainc Helmut Krämer Carole Kretz-Remy Anna M Krichevsky Guido Kroemer Rejko Krüger Oleg Krut Nicholas T Ktistakis Chia-Yi Kuan Roza Kucharczyk Ashok Kumar Raj Kumar Sharad Kumar Mondira Kundu Hsing-Jien Kung Tino Kurz Ho Jeong Kwon Albert R La Spada Frank Lafont Trond Lamark Jacques Landry Jon D Lane Pierre Lapaquette Jocelyn F Laporte Lajos László Sergio Lavandero Josée N Lavoie Robert Layfield Pedro A Lazo Weidong Le Laurent Le Cam Daniel J Ledbetter Alvin J X Lee Byung-Wan Lee Gyun Min Lee Jongdae Lee Ju-Hyun Lee Michael Lee Myung-Shik Lee Sug Hyung Lee Christiaan Leeuwenburgh Patrick Legembre Renaud Legouis Michael Lehmann Huan-Yao Lei Qun-Ying Lei David A Leib José Leiro John J Lemasters Antoinette Lemoine Maciej S Lesniak Dina Lev Victor V Levenson Beth Levine Efrat Levy Faqiang Li Jun-Lin Li Lian Li Sheng Li Weijie Li Xue-Jun Li Yan-bo Li Yi-Ping Li Chengyu Liang Qiangrong Liang Yung-Feng Liao Pawel P Liberski Andrew Lieberman Hyunjung J Lim Kah-Leong Lim Kyu Lim Chiou-Feng Lin Fu-Cheng Lin Jian Lin Jiandie D Lin Kui Lin Wan-Wan Lin Weei-Chin Lin Yi-Ling Lin Rafael Linden Paul Lingor Jennifer Lippincott-Schwartz Michael P Lisanti Paloma B Liton Bo Liu Chun-Feng Liu Kaiyu Liu Leyuan Liu Qiong A Liu Wei Liu Young-Chau Liu Yule Liu Richard A Lockshin Chun-Nam Lok Sagar Lonial Benjamin Loos Gabriel Lopez-Berestein Carlos López-Otín Laura Lossi Michael T Lotze Peter Lőw Binfeng Lu Bingwei Lu Bo Lu Zhen Lu Frédéric Luciano Nicholas W Lukacs Anders H Lund Melinda A Lynch-Day Yong Ma Fernando Macian Jeff P MacKeigan Kay F Macleod Frank Madeo Luigi Maiuri Maria Chiara Maiuri Davide Malagoli May Christine V Malicdan Walter Malorni Na Man Eva-Maria Mandelkow Stéphen Manon Irena Manov Kai Mao Xiang Mao Zixu Mao Philippe Marambaud Daniela Marazziti Yves L Marcel Katie Marchbank Piero Marchetti Stefan J Marciniak Mateus Marcondes Mohsen Mardi Gabriella Marfe Guillermo Mariño Maria Markaki Mark R Marten Seamus J Martin Camille Martinand-Mari Wim Martinet Marta Martinez-Vicente Matilde Masini Paola Matarrese Saburo Matsuo Raffaele Matteoni Andreas Mayer Nathalie M Mazure David J McConkey Melanie J McConnell Catherine McDermott Christine McDonald Gerald M McInerney Sharon L McKenna BethAnn McLaughlin Pamela J McLean Christopher R McMaster G Angus McQuibban Alfred J Meijer Miriam H Meisler Alicia Meléndez Thomas J Melia Gerry Melino Maria A Mena Javier A Menendez Rubem F S Menna-Barreto Manoj B Menon Fiona M Menzies Carol A Mercer Adalberto Merighi Diane E Merry Stefania Meschini Christian G Meyer Thomas F Meyer Chao-Yu Miao Jun-Ying Miao Paul A M Michels Carine Michiels Dalibor Mijaljica Ana Milojkovic Saverio Minucci Clelia Miracco Cindy K Miranti Ioannis Mitroulis Keisuke Miyazawa Noboru Mizushima Baharia Mograbi Simin Mohseni Xavier Molero Bertrand Mollereau Faustino Mollinedo Takashi Momoi Iryna Monastyrska Martha M Monick Mervyn J Monteiro Michael N Moore Rodrigo Mora Kevin Moreau Paula I Moreira Yuji Moriyasu Jorge Moscat Serge Mostowy Jeremy C Mottram Tomasz Motyl Charbel E-H Moussa Sylke Müller Sylviane Muller Karl Münger Christian Münz Leon O Murphy Maureen E Murphy Antonio Musarò Indira Mysorekar Eiichiro Nagata Kazuhiro Nagata Aimable Nahimana Usha Nair Toshiyuki Nakagawa Kiichi Nakahira Hiroyasu Nakano Hitoshi Nakatogawa Meera Nanjundan Naweed I Naqvi Derek P Narendra Masashi Narita Miguel Navarro Steffan T Nawrocki Taras Y Nazarko Andriy Nemchenko Mihai G Netea Thomas P Neufeld Paul A Ney Ioannis P Nezis Huu Phuc Nguyen Daotai Nie Ichizo Nishino Corey Nislow Ralph A Nixon Takeshi Noda Angelika A Noegel Anna Nogalska Satoru Noguchi Lucia Notterpek Ivana Novak Tomoyoshi Nozaki Nobuyuki Nukina Thorsten Nürnberger Beat Nyfeler Keisuke Obara Terry D Oberley Salvatore Oddo Michinaga Ogawa Toya Ohashi Koji Okamoto Nancy L Oleinick F Javier Oliver Laura J Olsen Stefan Olsson Onya Opota Timothy F Osborne Gary K Ostrander Kinya Otsu Jing-hsiung James Ou Mireille Ouimet Michael Overholtzer Bulent Ozpolat Paolo Paganetti Ugo Pagnini Nicolas Pallet Glen E Palmer Camilla Palumbo Tianhong Pan Theocharis Panaretakis Udai Bhan Pandey Zuzana Papackova Issidora Papassideri Irmgard Paris Junsoo Park Ohkmae K Park Jan B Parys Katherine R Parzych Susann Patschan Cam Patterson Sophie Pattingre John M Pawelek Jianxin Peng David H Perlmutter Ida Perrotta George Perry Shazib Pervaiz Matthias Peter Godefridus J Peters Morten Petersen Goran Petrovski James M Phang Mauro Piacentini Philippe Pierre Valérie Pierrefite-Carle Gérard Pierron Ronit Pinkas-Kramarski Antonio Piras Natik Piri Leonidas C Platanias Stefanie Pöggeler Marc Poirot Angelo Poletti Christian Poüs Mercedes Pozuelo-Rubio Mette Prætorius-Ibba Anil Prasad Mark Prescott Muriel Priault Nathalie Produit-Zengaffinen Ann Progulske-Fox Tassula Proikas-Cezanne Serge Przedborski Karin Przyklenk Rosa Puertollano Julien Puyal Shu-Bing Qian Liang Qin Zheng-Hong Qin Susan E Quaggin Nina Raben Hannah Rabinowich Simon W Rabkin Irfan Rahman Abdelhaq Rami Georg Ramm Glenn Randall Felix Randow V Ashutosh Rao Jeffrey C Rathmell Brinda Ravikumar Swapan K Ray Bruce H Reed John C Reed Fulvio Reggiori Anne Régnier-Vigouroux Andreas S Reichert John J Reiners Russel J Reiter Jun Ren José L Revuelta Christopher J Rhodes Konstantinos Ritis Elizete Rizzo Jeffrey Robbins Michel Roberge Hernan Roca Maria C Roccheri Stephane Rocchi H Peter Rodemann Santiago Rodríguez de Córdoba Bärbel Rohrer Igor B Roninson Kirill Rosen Magdalena M Rost-Roszkowska Mustapha Rouis Kasper M A Rouschop Francesca Rovetta Brian P Rubin David C Rubinsztein Klaus Ruckdeschel Edmund B Rucker Assaf Rudich Emil Rudolf Nelson Ruiz-Opazo Rossella Russo Tor Erik Rusten Kevin M Ryan Stefan W Ryter David M Sabatini Junichi Sadoshima Tapas Saha Tatsuya Saitoh Hiroshi Sakagami Yasuyoshi Sakai Ghasem Hoseini Salekdeh Paolo Salomoni Paul M Salvaterra Guy Salvesen Rosa Salvioli Anthony M J Sanchez José A Sánchez-Alcázar Ricardo Sánchez-Prieto Marco Sandri Uma Sankar Poonam Sansanwal Laura Santambrogio Shweta Saran Sovan Sarkar Minnie Sarwal Chihiro Sasakawa Ausra Sasnauskiene Miklós Sass Ken Sato Miyuki Sato Anthony H V Schapira Michael Scharl Hermann M Schätzl Wiep Scheper Stefano Schiaffino Claudio Schneider Marion E Schneider Regine Schneider-Stock Patricia V Schoenlein Daniel F Schorderet Christoph Schüller Gary K Schwartz Luca Scorrano Linda Sealy Per O Seglen Juan Segura-Aguilar Iban Seiliez Oleksandr Seleverstov Christian Sell Jong Bok Seo Duska Separovic Vijayasaradhi Setaluri Takao Setoguchi Carmine Settembre John J Shacka Mala Shanmugam Irving M Shapiro Eitan Shaulian Reuben J Shaw James H Shelhamer Han-Ming Shen Wei-Chiang Shen Zu-Hang Sheng Yang Shi Kenichi Shibuya Yoshihiro Shidoji Jeng-Jer Shieh Chwen-Ming Shih Yohta Shimada Shigeomi Shimizu Takahiro Shintani Orian S Shirihai Gordon C Shore Andriy A Sibirny Stan B Sidhu Beata Sikorska Elaine C M Silva-Zacarin Alison Simmons Anna Katharina Simon Hans-Uwe Simon Cristiano Simone Anne Simonsen David A Sinclair Rajat Singh Debasish Sinha Frank A Sinicrope Agnieszka Sirko Parco M Siu Efthimios Sivridis Vojtech Skop Vladimir P Skulachev Ruth S Slack Soraya S Smaili Duncan R Smith Maria S Soengas Thierry Soldati Xueqin Song Anil K Sood Tuck Wah Soong Federica Sotgia Stephen A Spector Claudia D Spies Wolfdieter Springer Srinivasa M Srinivasula Leonidas Stefanis Joan S Steffan Ruediger Stendel Harald Stenmark Anastasis Stephanou Stephan T Stern Cinthya Sternberg Björn Stork Peter Strålfors Carlos S Subauste Xinbing Sui David Sulzer Jiaren Sun Shi-Yong Sun Zhi-Jun Sun Joseph J Y Sung Kuninori Suzuki Toshihiko Suzuki Michele S Swanson Charles Swanton Sean T Sweeney Lai-King Sy Gyorgy Szabadkai Ira Tabas Heinrich Taegtmeyer Marco Tafani Krisztina Takács-Vellai Yoshitaka Takano Kaoru Takegawa Genzou Takemura Fumihiko Takeshita Nicholas J Talbot Kevin S W Tan Keiji Tanaka Kozo Tanaka Daolin Tang Dingzhong Tang Isei Tanida Bakhos A Tannous Nektarios Tavernarakis Graham S Taylor Gregory A Taylor J Paul Taylor Lance S Terada Alexei Terman Gianluca Tettamanti Karin Thevissen Craig B Thompson Andrew Thorburn Michael Thumm FengFeng Tian Yuan Tian Glauco Tocchini-Valentini Aviva M Tolkovsky Yasuhiko Tomino Lars Tönges Sharon A Tooze Cathy Tournier John Tower Roberto Towns Vladimir Trajkovic Leonardo H Travassos Ting-Fen Tsai Mario P Tschan Takeshi Tsubata Allan Tsung Boris Turk Lorianne S Turner Suresh C Tyagi Yasuo Uchiyama Takashi Ueno Midori Umekawa Rika Umemiya-Shirafuji Vivek K Unni Maria I Vaccaro Enza Maria Valente Greet Van den Berghe Ida J van der Klei Wouter van Doorn Linda F van Dyk Marjolein van Egmond Leo A van Grunsven Peter Vandenabeele Wim P Vandenberghe Ilse Vanhorebeek Eva C Vaquero Guillermo Velasco Tibor Vellai Jose Miguel Vicencio Richard D Vierstra Miquel Vila Cécile Vindis Giampietro Viola Maria Teresa Viscomi Olga V Voitsekhovskaja Clarissa von Haefen Marcela Votruba Keiji Wada Richard Wade-Martins Cheryl L Walker Craig M Walsh Jochen Walter Xiang-Bo Wan Aimin Wang Chenguang Wang Dawei Wang Fan Wang Fen Wang Guanghui Wang Haichao Wang Hong-Gang Wang Horng-Dar Wang Jin Wang Ke Wang Mei Wang Richard C Wang Xinglong Wang Xuejun Wang Ying-Jan Wang Yipeng Wang Zhen Wang Zhigang Charles Wang Zhinong Wang Derick G Wansink Diane M Ward Hirotaka Watada Sarah L Waters Paul Webster Lixin Wei Conrad C Weihl William A Weiss Scott M Welford Long-Ping Wen Caroline A Whitehouse J Lindsay Whitton Alexander J Whitworth Tom Wileman John W Wiley Simon Wilkinson Dieter Willbold Roger L Williams Peter R Williamson Bradly G Wouters Chenghan Wu Dao-Cheng Wu William K K Wu Andreas Wyttenbach Ramnik J Xavier Zhijun Xi Pu Xia Gengfu Xiao Zhiping Xie Zhonglin Xie Da-zhi Xu Jianzhen Xu Liang Xu Xiaolei Xu Ai Yamamoto Akitsugu Yamamoto Shunhei Yamashina Michiaki Yamashita Xianghua Yan Mitsuhiro Yanagida Dun-Sheng Yang Elizabeth Yang Jin-Ming Yang Shi Yu Yang Wannian Yang Wei Yuan Yang Zhifen Yang Meng-Chao Yao Tso-Pang Yao Behzad Yeganeh Wei-Lien Yen Jia-jing Yin Xiao-Ming Yin Ook-Joon Yoo Gyesoon Yoon Seung-Yong Yoon Tomohiro Yorimitsu Yuko Yoshikawa Tamotsu Yoshimori Kohki Yoshimoto Ho Jin You Richard J Youle Anas Younes Li Yu Long Yu Seong-Woon Yu Wai Haung Yu Zhi-Min Yuan Zhenyu Yue Cheol-Heui Yun Michisuke Yuzaki Olga Zabirnyk Elaine Silva-Zacarin David Zacks Eldad Zacksenhaus Nadia Zaffaroni Zahra Zakeri Herbert J Zeh Scott O Zeitlin Hong Zhang Hui-Ling Zhang Jianhua Zhang Jing-Pu Zhang Lin Zhang Long Zhang Ming-Yong Zhang Xu Dong Zhang Mantong Zhao Yi-Fang Zhao Ying Zhao Zhizhuang J Zhao Xiaoxiang Zheng Boris Zhivotovsky Qing Zhong Cong-Zhao Zhou Changlian Zhu Wei-Guo Zhu Xiao-Feng Zhu Xiongwei Zhu Yuangang Zhu Teresa Zoladek Wei-Xing Zong Antonio Zorzano Jürgen Zschocke Brian Zuckerbraun

Autophagy 2012 Apr;8(4):445-544

Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.4161/auto.19496DOI Listing
April 2012

S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors.

Biochimie 2012 Mar 7;94(3):704-10. Epub 2011 Nov 7.

Division of Medicinal Chemistry and Microbiology, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.

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http://dx.doi.org/10.1016/j.biochi.2011.10.014DOI Listing
March 2012

Mitochondrial pathway of apoptosis is ancestral in metazoans.

Proc Natl Acad Sci U S A 2012 Mar 13;109(13):4904-9. Epub 2012 Mar 13.

Apoptosis and Cell Death Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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March 2012

An optimized activity-based probe for the study of caspase-6 activation.

Chem Biol 2012 Mar;19(3):340-52

Cancer Biology Program, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305-5324, USA.

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March 2012

Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate.

Biochim Biophys Acta 2012 Jan 16;1824(1):113-22. Epub 2011 Jun 16.

Program of Apoptosis and Cell Death Research, Sanford-Burnham Institute, La Jolla, CA 92037, USA.

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January 2012

RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts.

Mol Cell 2011 Oct;44(1):9-16

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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October 2011

Snapshot: caspases.

Cell 2011 Oct;147(2):476-476.e1

Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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October 2011

N-terminomics: a high-content screen for protease substrates and their cleavage sites.

Methods Mol Biol 2011 ;753:243-55

Department of Pharmacology, University of California San Diego, La Jolla, CA 92037, USA.

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September 2011

Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity.

Proc Natl Acad Sci U S A 2011 Sep 29;108(37):15312-7. Epub 2011 Aug 29.

Department of Molecular Biology and Biochemistry, Institute for Immunology, University of California, Irvine, CA 92697, USA.

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September 2011

The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases.

J Biol Chem 2011 Mar 19;286(12):10238-47. Epub 2011 Jan 19.

Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060478PMC
March 2011

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.

Nature 2011 Mar 2;471(7338):363-7. Epub 2011 Mar 2.

Dept. of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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March 2011

FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity.

Biochem J 2011 Feb;433(3):447-457

Program in Apoptosis and Cell Death Research, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024219PMC
February 2011

Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress.

Proc Natl Acad Sci U S A 2011 Feb 18;108(5):1749-50. Epub 2011 Jan 18.

Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

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February 2011

Divide and die another day.

Curr Opin Cell Biol 2010 Dec 23;22(6):764-5. Epub 2010 Sep 23.

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December 2010

Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4).

Autophagy 2010 Oct 19;6(7):936-47. Epub 2010 Oct 19.

Sanford-Burnham Medical Research Institute, Program on Apoptosis and Cell Death Research, La Jolla, CA, USA.

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http://dx.doi.org/10.4161/auto.6.7.13075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039740PMC
October 2010

Regulation of the Apaf-1-caspase-9 apoptosome.

J Cell Sci 2010 Oct;123(Pt 19):3209-14

Division of Pharmacology and Toxicology, College of Pharmacy, and Center for Molecular and Cellular Toxicology, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712-0125, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939798PMC
October 2010

Activation and specificity of human caspase-10.

Biochemistry 2010 Sep;49(38):8307-15

Program in Apoptosis and Cell Death Research, Sanford-BurnhamMedical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1021/bi100968mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943529PMC
September 2010

Emerging principles in protease-based drug discovery.

Nat Rev Drug Discov 2010 Sep;9(9):690-701

Program in Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974563PMC
September 2010

Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death.

Mol Cell 2010 Jul;39(2):184-95

Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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July 2010

Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis.

Clin Exp Metastasis 2010 Apr 12;27(4):217-31. Epub 2010 Mar 12.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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April 2010

Identification of very potent inhibitor of human aminopeptidase N (CD13).

Bioorg Med Chem Lett 2010 Apr 4;20(8):2497-9. Epub 2010 Mar 4.

Division of Medicinal Chemistry and Microbiology, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego, Wroclaw, Poland.

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http://dx.doi.org/10.1016/j.bmcl.2010.02.111DOI Listing
April 2010

Transferring death: a role for tRNA in apoptosis regulation.

Mol Cell 2010 Mar;37(5):591-2

Program in Apoptosis and Cell Death Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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March 2010

Vaccinia virus protein F1L is a caspase-9 inhibitor.

J Biol Chem 2010 Feb 18;285(8):5569-80. Epub 2009 Dec 18.

Sanford-Burnham Medical Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M109.078113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820784PMC
February 2010

Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors.

J Biol Chem 2010 Jan 30;285(5):3310-8. Epub 2009 Nov 30.

Apoptosis and Cell Death Research Program, the Burnham Institute for Medical Research, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M109.060418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823418PMC
January 2010

A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis.

Biochem J 2009 Dec 10;424(3):335-45. Epub 2009 Dec 10.

Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC 27695, USA.

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http://dx.doi.org/10.1042/BJ20090825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805924PMC
December 2009

Structural and kinetic determinants of protease substrates.

Nat Struct Mol Biol 2009 Oct 20;16(10):1101-8. Epub 2009 Sep 20.

Apoptosis and Cell Death Research Program at the Burnham Institute for Medical Research, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nsmb.1668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4042863PMC
October 2009

Structure of the Fas/FADD complex: a conditional death domain complex mediating signaling by receptor clustering.

Cell Cycle 2009 Sep 30;8(17):2723-7. Epub 2009 Sep 30.

The Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788920PMC
http://dx.doi.org/10.4161/cc.8.17.9399DOI Listing
September 2009

Human caspases: activation, specificity, and regulation.

J Biol Chem 2009 Aug 26;284(33):21777-81. Epub 2009 May 26.

Program in Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.R800084200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755903PMC
August 2009

The CULt of caspase-8 ubiquitination.

Cell 2009 May;137(4):604-6

Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.cell.2009.04.052DOI Listing
May 2009

Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1.

Mol Cell 2009 Mar;33(5):570-80

Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

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http://dx.doi.org/10.1016/j.molcel.2009.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668917PMC
March 2009

The Fas-FADD death domain complex structure unravels signalling by receptor clustering.

Nature 2009 Feb 31;457(7232):1019-22. Epub 2008 Dec 31.

Program in Apoptosis and Cell Death Research, The Burnham Institute for Medical Research, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/nature07606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661029PMC
February 2009

Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis.

J Biol Chem 2009 Jan 11;284(2):862-71. Epub 2008 Nov 11.

Department of Pediatrics, Biomedical Sciences Graduate Program, Laboratory of Signal Transduction, University of California, San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1074/jbc.M804632200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613605PMC
January 2009

DeSUMOylating enzymes--SENPs.

IUBMB Life 2008 Nov;60(11):734-42

Program in Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1002/iub.113DOI Listing
November 2008

Proteolytic needles in the cellular haystack.

Nat Chem Biol 2008 Nov;4(11):651-2

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http://dx.doi.org/10.1038/nchembio1108-651DOI Listing
November 2008

Caspase assays: identifying caspase activity and substrates in vitro and in vivo.

Methods Enzymol 2008 ;446:351-67

Program in Apoptosis and Cell Death Research, The Burnham Institute for Medical Research, La Jolla, California, USA.

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http://dx.doi.org/10.1016/S0076-6879(08)01621-2DOI Listing
August 2008

Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function.

J Biol Chem 2008 Jul 5;283(28):19499-510. Epub 2008 May 5.

Program in Apoptosis and Cell Death Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1074/jbc.M800331200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443678PMC
July 2008

Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues.

J Biol Chem 2008 Jul 9;283(27):19140-50. Epub 2008 May 9.

Department of Biochemistry, Molecular and Structural Biology, J. Stefan Institute, Sl-1000 Ljubljana, Slovenia.

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http://www.jbc.org/content/283/27/19140.full.pdf
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http://dx.doi.org/10.1074/jbc.M802513200DOI Listing
July 2008

Caspase mechanisms.

Adv Exp Med Biol 2008 ;615:13-23

Program on Apoptosis and Cell Death, Burnham Institute for Medical Research, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/978-1-4020-6554-5_2DOI Listing
May 2008

Apoptotic caspase activation and activity.

Methods Mol Biol 2008 ;414:191-220

The Burnham Institute for Medical Research, La Jolla, CA, USA.

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http://dx.doi.org/10.1007/978-1-59745-339-4_15DOI Listing
February 2008

Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family.

Biochem J 2008 Jan;409(2):461-9

Apoptosis and Cell Death Research Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1042/BJ20070940DOI Listing
January 2008

Expression, purification, and characterization of caspases.

Curr Protoc Protein Sci 2003 Feb;Chapter 21:Unit 21.13

The Burnham Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1002/0471140864.ps2113s30DOI Listing
February 2003

Caspases.

Curr Protoc Protein Sci 2002 Feb;Chapter 21:Unit 21.8

The Burnham Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1002/0471140864.ps2108s26DOI Listing
February 2002