Publications by authors named "Guy M Lenk"

36Publications

VAC14 Gene-Related Parkinsonism-Dystonia With Response to Deep Brain Stimulation.

Mov Disord Clin Pract 2019 Jul 21;6(6):494-497. Epub 2019 Jun 21.

Department of Neurology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA.

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http://dx.doi.org/10.1002/mdc3.12797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660234PMC
July 2019

The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation.

J Cell Sci 2019 02 28;132(5). Epub 2019 Feb 28.

Structure and Membrane Compartments, Institut Curie, Paris Sciences & Lettres Research University, Centre National de la Recherche Scientifique, UMR144, 75005 Paris, France

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http://dx.doi.org/10.1242/jcs.229500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432708PMC
February 2019

Protective role of the lipid phosphatase Fig4 in the adult nervous system.

Hum Mol Genet 2018 07;27(14):2443-2453

Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.

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https://academic.oup.com/hmg/article/27/14/2443/4983966
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http://dx.doi.org/10.1093/hmg/ddy145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030899PMC
July 2018

Rescue of neurodegeneration in the Fig4 null mouse by a catalytically inactive FIG4 transgene.

Hum Mol Genet 2016 Jan 24;25(2):340-7. Epub 2015 Nov 24.

Department of Human Genetics, Department of Neurology, University of Michigan, 4909 Buhl, Ann Arbor, MI 48109-5618, USA.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddv480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706117PMC
January 2016

Response.

Neuromuscul Disord 2015 Apr 29;25(4):360. Epub 2014 Dec 29.

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http://dx.doi.org/10.1016/j.nmd.2014.12.008DOI Listing
April 2015

Whole exome sequencing identifies three recessive FIG4 mutations in an apparently dominant pedigree with Charcot-Marie-Tooth disease.

Neuromuscul Disord 2014 Aug 4;24(8):666-70. Epub 2014 May 4.

Institute for Neuroscience and Muscle Research, The Children's Hospital at Westmead, Sydney, Australia; Discipline of Paediatrics and Child Health, The University of Sydney, Sydney, Australia.

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http://dx.doi.org/10.1016/j.nmd.2014.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096049PMC
August 2014

Role of the phosphoinositide phosphatase FIG4 gene in familial epilepsy with polymicrogyria.

Neurology 2014 Mar 5;82(12):1068-75. Epub 2014 Mar 5.

From INSERM (S.B., B.D., B.O.A.B., P.C., J.R., E.N., K.H.E.H., E.L.), U1127; Sorbonne Universités, UPMC Univ Paris 06 (S.B., B.D., B.O.A.B., P.C., J.R., E.N., K.H.E.H., E.L.), UM 75; CNRS (S.B., B.D., B.O.A.B., P.C., J.R., E.N., K.H.E.H., E.L.), UMR 7225, ICM, Paris, ICM, (S.B., B.D., B.O.A.B., P.C., J.R., E.N., K.H.E.H., E.L.) Paris, F-75013 Paris, France; Department of Human Genetics (G.M.L., P.A.L., C.J.F., M.H.M.), University of Michigan, Ann Arbor; Service de Neurophysiologie Clinique (B.O.A.B.), Hôpital des Spécialités, Centre Hospitalier Ibn Sina Rabat, Morocco; Genetics and Pathophysiology of Neurodevelopmental and Neuromuscular Diseases (K.P.), Cochin Institute, Paris; GenoScreen (C.H., S.F.), Lille, France; Neuroscience Department (R.G.), Children's Hospital A. Meyer, University of Florence and IRCCS Stella Maris, Pisa, Italy; Laboratoire de Neurogénétique (K.H.E.H.), Ecole Pratique des Hautes Etudes, Paris; and Département de Génétique et de Cytogénétique (E.L.), AP-HP Groupe hospitalier Pitié-Salpêtrière, Paris, France.

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http://dx.doi.org/10.1212/WNL.0000000000000241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962989PMC
March 2014

Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.

Methods Enzymol 2014 ;534:245-60

Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-397926-1.00014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059992PMC
July 2014

Murine Fig4 is dispensable for muscle development but required for muscle function.

Skelet Muscle 2013 Sep 1;3(1):21. Epub 2013 Sep 1.

Department of Pediatrics, University of Michigan Medical Center, Ann Arbor, MI 48109-2200, USA.

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http://dx.doi.org/10.1186/2044-5040-3-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844516PMC
September 2013

C9ORF72 expansion in a family with bipolar disorder.

Bipolar Disord 2013 May 1;15(3):326-32. Epub 2013 Apr 1.

Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor, MI 48109-5618, USA.

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http://dx.doi.org/10.1111/bdi.12063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660726PMC
May 2013

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.

Proc Natl Acad Sci U S A 2012 Oct 9;109(43):17472-7. Epub 2012 Oct 9.

Departments of Cell and Developmental Biology, Division of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1203106109
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http://dx.doi.org/10.1073/pnas.1203106109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491506PMC
October 2012

Binding sites for ETS family of transcription factors dominate the promoter regions of differentially expressed genes in abdominal aortic aneurysms.

Circ Cardiovasc Genet 2009 Dec 19;2(6):565-72. Epub 2009 Oct 19.

Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan,USA.

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http://dx.doi.org/10.1161/CIRCGENETICS.108.843854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3089770PMC
December 2009

PtdIns(3,5)P2 and autophagy in mouse models of neurodegeneration.

Autophagy 2010 Jan 13;6(1):170-1. Epub 2010 Jan 13.

Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859463PMC
http://dx.doi.org/10.4161/auto.6.1.10626DOI Listing
January 2010

Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.

Hum Mol Genet 2009 Dec 29;18(24):4868-78. Epub 2009 Sep 29.

Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109-5618, USA.

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https://academic.oup.com/hmg/article-lookup/doi/10.1093/hmg/
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http://dx.doi.org/10.1093/hmg/ddp460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778378PMC
December 2009

Basic research studies to understand aneurysm disease.

Drug News Perspect 2008 Apr;21(3):142-8

Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

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April 2008

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.

Nat Genet 2008 Feb 6;40(2):217-24. Epub 2008 Jan 6.

deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.72DOI Listing
February 2008

Integration of expression profiles and genetic mapping data to identify candidate genes in intracranial aneurysm.

Physiol Genomics 2007 Dec 18;32(1):45-57. Epub 2007 Sep 18.

Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00015.2007DOI Listing
December 2007

Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms.

BMC Genomics 2007 Jul 16;8:237. Epub 2007 Jul 16.

Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, USA.

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http://dx.doi.org/10.1186/1471-2164-8-237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934369PMC
July 2007

Global expression profiles in human normal and aneurysmal abdominal aorta based on two distinct whole genome microarray platforms.

Ann N Y Acad Sci 2006 Nov;1085:360-2

Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 3317 Gordon H. Scott Hall of Basic Medical Sciences, 540 E. Canfield Ave., Detroit, MI 48201, USA.

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http://dx.doi.org/10.1196/annals.1383.041DOI Listing
November 2006