Guy C Brown

Guy C Brown

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Guy C Brown

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The endotoxin hypothesis of neurodegeneration.

Authors:
Guy C Brown

J Neuroinflammation 2019 Sep 13;16(1):180. Epub 2019 Sep 13.

Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, UK.

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http://dx.doi.org/10.1186/s12974-019-1564-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744684PMC
September 2019

Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts.

Apoptosis 2019 Feb;24(1-2):145-156

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK.

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http://dx.doi.org/10.1007/s10495-018-1506-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373273PMC
February 2019

Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease.

FEBS J 2018 10 29;285(19):3566-3575. Epub 2017 Nov 29.

Department of Biochemistry, University of Cambridge, UK.

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http://doi.wiley.com/10.1111/febs.14323
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http://dx.doi.org/10.1111/febs.14323DOI Listing
October 2018

Neuronal Cell Death.

Physiol Rev 2018 04;98(2):813-880

Hunter Medical Research Institute, University of Newcastle, Callaghan, New South Wales , Australia ; Department of Clinical Neurosciences, University of Cambridge , Cambridge , United Kingdom ; Neuroscience Institute, Lithuanian University of Health Sciences , Kaunas , Lithuania ; and Department of Biochemistry, University of Cambridge , Cambridge , United Kingdom.

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http://www.physiology.org/doi/10.1152/physrev.00011.2017
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http://dx.doi.org/10.1152/physrev.00011.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5966715PMC
April 2018

Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages the Fc domain, resulting in cell death by phagoptosis.

Oncotarget 2017 Sep 15;8(37):60892-60903. Epub 2017 Jun 15.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.18632/oncotarget.18492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617392PMC
September 2017

Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase.

J Immunol 2017 06 12;198(12):4792-4801. Epub 2017 May 12.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom

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http://dx.doi.org/10.4049/jimmunol.1502532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5458330PMC
June 2017

Deciphering microglial diversity in Alzheimer's disease.

Science 2017 06;356(6343):1123-1124

Department of Clinical Neurosciences, Cambridge Institute for Medical Research, Addenbrookes Hospital, Hills Road, Cambridge CB2 0XY, UK.

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http://dx.doi.org/10.1126/science.aan7893DOI Listing
June 2017

Amyloid β induces microglia to phagocytose neurons via activation of protein kinase Cs and NADPH oxidase.

Int J Biochem Cell Biol 2016 12 5;81(Pt B):346-355. Epub 2016 Jun 5.

Department of Biochemistry, University of Cambridge, UK. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S135727251630139
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http://dx.doi.org/10.1016/j.biocel.2016.06.005DOI Listing
December 2016

Activated microglia cause reversible apoptosis of pheochromocytoma cells, inducing their cell death by phagocytosis.

J Cell Sci 2016 Jan 13;129(1):65-79. Epub 2015 Nov 13.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK

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http://dx.doi.org/10.1242/jcs.174631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732292PMC
January 2016

How microglia kill neurons.

Brain Res 2015 Dec 2;1628(Pt B):288-297. Epub 2015 Sep 2.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1016/j.brainres.2015.08.031DOI Listing
December 2015

Living too long: the current focus of medical research on increasing the quantity, rather than the quality, of life is damaging our health and harming the economy.

Authors:
Guy C Brown

EMBO Rep 2015 Feb 18;16(2):137-41. Epub 2014 Dec 18.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.15252/embr.201439518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328740PMC
February 2015

Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis.

FEBS Lett 2014 Aug 6;588(17):2952-6. Epub 2014 Jun 6.

Department of Biochemistry, University of Cambridge, UK. Electronic address:

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http://dx.doi.org/10.1016/j.febslet.2014.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158418PMC
August 2014

Microglial phagocytosis of live neurons.

Nat Rev Neurosci 2014 Apr;15(4):209-16

Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, D-72076 Tübingen, Germany.German Center for Neurodegenerative Diseases (DZNE), D-72076 Tübingen, Germany.

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http://www.nature.com/articles/nrn3710
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http://dx.doi.org/10.1038/nrn3710DOI Listing
April 2014

Inflammation induces multinucleation of Microglia via PKC inhibition of cytokinesis, generating highly phagocytic multinucleated giant cells.

J Neurochem 2014 Mar 30;128(5):650-61. Epub 2013 Oct 30.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://doi.wiley.com/10.1111/jnc.12477
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http://dx.doi.org/10.1111/jnc.12477DOI Listing
March 2014

Deoxyglucose prevents neurodegeneration in culture by eliminating microglia.

J Neuroinflammation 2014 Mar 26;11:58. Epub 2014 Mar 26.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1186/1742-2094-11-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986974PMC
March 2014

Analysis of microglial production of reactive oxygen and nitrogen species.

Methods Mol Biol 2013 ;1041:103-11

University of Cambridge, Cambridge, UK.

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http://link.springer.com/10.1007/978-1-62703-520-0_12
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http://dx.doi.org/10.1007/978-1-62703-520-0_12DOI Listing
January 2014

In the eye of the storm: mitochondrial damage during heart and brain ischaemia.

FEBS J 2013 Oct 18;280(20):4999-5014. Epub 2013 Jun 18.

Institute of Neurosciences, Lithuanian University of Health Sciences, Kaunas, Lithuania.

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http://dx.doi.org/10.1111/febs.12353DOI Listing
October 2013

Rotenone induces neuronal death by microglial phagocytosis of neurons.

FEBS J 2013 Oct 10;280(20):5030-8. Epub 2013 Jul 10.

Department of Biochemistry, University of Cambridge, UK.

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http://dx.doi.org/10.1111/febs.12401DOI Listing
October 2013

Introduction: Focus on mitochondria.

FEBS J 2013 Oct 23;280(20):4932. Epub 2013 Sep 23.

Institute of Molecular, Cell and Systems Biology, University of Glasgow, UK.

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http://dx.doi.org/10.1111/febs.12504DOI Listing
October 2013

Phagocytosis executes delayed neuronal death after focal brain ischemia.

Proc Natl Acad Sci U S A 2013 Oct 7;110(43):E4098-107. Epub 2013 Oct 7.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1308679110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808587PMC
October 2013

Lactadherin/MFG-E8 is essential for microglia-mediated neuronal loss and phagoptosis induced by amyloid β.

J Neurochem 2013 Aug 22;126(3):312-7. Epub 2013 May 22.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/jnc.12288DOI Listing
August 2013

Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia.

J Biol Chem 2013 Mar 5;288(13):9145-52. Epub 2013 Feb 5.

Department of Biochemistry, University of Cambridge, Cambridge, CB2 1QW, United Kingdom.

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http://dx.doi.org/10.1074/jbc.M112.427880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610987PMC
March 2013

Anthocyanins block ischemia-induced apoptosis in the perfused heart and support mitochondrial respiration potentially by reducing cytosolic cytochrome c.

Int J Biochem Cell Biol 2013 Jan 27;45(1):23-9. Epub 2012 Jul 27.

Institute of Neurosciences, Lithuanian University of Health Sciences, Eiveniu str. 4, LT-50009 Kaunas, Lithuania.

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http://dx.doi.org/10.1016/j.biocel.2012.07.022DOI Listing
January 2013

Primary phagocytosis of neurons by inflamed microglia: potential roles in neurodegeneration.

Front Pharmacol 2012 28;3:27. Epub 2012 Feb 28.

Department of Biochemistry, University of Cambridge Cambridge, UK.

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http://dx.doi.org/10.3389/fphar.2012.00027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288722PMC
October 2012

Eaten alive! Cell death by primary phagocytosis: 'phagoptosis'.

Trends Biochem Sci 2012 Aug 7;37(8):325-32. Epub 2012 Jun 7.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1016/j.tibs.2012.05.002DOI Listing
August 2012

Primary phagocytosis of viable neurons by microglia activated with LPS or Aβ is dependent on calreticulin/LRP phagocytic signalling.

J Neuroinflammation 2012 Aug 13;9:196. Epub 2012 Aug 13.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK.

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http://jneuroinflammation.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/1742-2094-9-196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481398PMC
August 2012

MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation.

J Neurosci 2012 Feb;32(8):2657-66

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1523/JNEUROSCI.4837-11.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312099PMC
February 2012

There is no evidence that mitochondria are the main source of reactive oxygen species in mammalian cells.

Mitochondrion 2012 Jan 15;12(1):1-4. Epub 2011 Feb 15.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1016/j.mito.2011.02.001DOI Listing
January 2012

Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia.

J Biol Chem 2011 Nov 8;286(46):39904-13. Epub 2011 Sep 8.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.267583
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http://dx.doi.org/10.1074/jbc.M111.267583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220594PMC
November 2011

Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death.

J Immunol 2011 Apr 14;186(8):4973-83. Epub 2011 Mar 14.

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.1003600DOI Listing
April 2011

Nitric oxide and neuronal death.

Authors:
Guy C Brown

Nitric Oxide 2010 Nov 12;23(3):153-65. Epub 2010 Jun 12.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom.

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http://dx.doi.org/10.1016/j.niox.2010.06.001DOI Listing
November 2010

The principle of sufficiency and the evolution of control: using control analysis to understand the design principles of biological systems.

Authors:
Guy C Brown

Biochem Soc Trans 2010 Oct;38(5):1210-4

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1042/BST0381210DOI Listing
October 2010

Inflammatory neurodegeneration and mechanisms of microglial killing of neurons.

Mol Neurobiol 2010 Jun 2;41(2-3):242-7. Epub 2010 Mar 2.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK.

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http://link.springer.com/10.1007/s12035-010-8105-9
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http://dx.doi.org/10.1007/s12035-010-8105-9DOI Listing
June 2010

Dependence of leukemic cell proliferation and survival on H2O2 and L-arginine.

Free Radic Biol Med 2009 Apr 11;46(8):1211-20. Epub 2009 Feb 11.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/j.freeradbiomed.2009.02.001DOI Listing
April 2009

The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance.

J Bioenerg Biomembr 2008 Oct 7;40(5):533-9. Epub 2008 Oct 7.

Department of Biological Sciences, University of Essex, Colchester, UK.

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http://link.springer.com/10.1007/s10863-008-9166-6
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http://dx.doi.org/10.1007/s10863-008-9166-6DOI Listing
October 2008

Regulation of apoptosis by the redox state of cytochrome c.

Biochim Biophys Acta 2008 Jul-Aug;1777(7-8):877-81. Epub 2008 Apr 3.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1016/j.bbabio.2008.03.024DOI Listing
August 2008

Arachidonate and NADPH oxidase synergise with iNOS to induce death in macrophages: mechanisms of inflammatory degeneration.

Pharmacol Rep 2006 ;58 Suppl:96-102

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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December 2007

Nitric oxide from neuronal nitric oxide synthase sensitises neurons to hypoxia-induced death via competitive inhibition of cytochrome oxidase.

J Neurochem 2007 Oct 10;103(1):346-56. Epub 2007 Jul 10.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1471-4159.2007.04765.xDOI Listing
October 2007

Mitochondrial regulation of caspase activation by cytochrome oxidase and tetramethylphenylenediamine via cytosolic cytochrome c redox state.

J Biol Chem 2007 Oct 9;282(43):31124-30. Epub 2007 Aug 9.

Institute for Biomedical Research, Kaunas University of Medicine, Eiveniu 4, Kaunas LT 50009, Lithuania.

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http://dx.doi.org/10.1074/jbc.M700322200DOI Listing
October 2007

Nitric oxide and mitochondrial respiration in the heart.

Cardiovasc Res 2007 Jul 3;75(2):283-90. Epub 2007 Apr 3.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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https://academic.oup.com/cardiovascres/article-lookup/doi/10
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http://dx.doi.org/10.1016/j.cardiores.2007.03.022DOI Listing
July 2007

Nitric oxide and mitochondria.

Authors:
Guy C Brown

Front Biosci 2007 Jan 1;12:1024-33. Epub 2007 Jan 1.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom.

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http://dx.doi.org/10.2741/2122DOI Listing
January 2007

Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide.

J Neurochem 2006 Oct 31;99(2):596-607. Epub 2006 Jul 31.

European Centre for the Validation of Alternative Methods, ECVAM, European Commission Joint Research Centre, Ispra, VA, Italy.

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http://dx.doi.org/10.1111/j.1471-4159.2006.04085.xDOI Listing
October 2006

S-nitrosothiol inhibition of mitochondrial complex I causes a reversible increase in mitochondrial hydrogen peroxide production.

Biochim Biophys Acta 2006 May-Jun;1757(5-6):562-6. Epub 2006 Mar 23.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1016/j.bbabio.2006.02.014DOI Listing
September 2006

Nitric oxide stimulates PC12 cell proliferation via cGMP and inhibits at higher concentrations mainly via energy depletion.

Nitric Oxide 2006 May 21;14(3):238-46. Epub 2005 Nov 21.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S108986030500150
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http://dx.doi.org/10.1016/j.niox.2005.10.002DOI Listing
May 2006

Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase.

J Immunol 2006 Jan;176(2):1046-52

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.176.2.1046DOI Listing
January 2006

Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation.

J Neurochem 2005 Nov 2;95(4):1132-43. Epub 2005 Sep 2.

European Centre for the Validation of Alternative Methods (ECVAM), European Commission Joint Research Centre, Ispra, Italy.

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http://dx.doi.org/10.1111/j.1471-4159.2005.03422.xDOI Listing
November 2005

Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration.

J Neuroinflammation 2005 Sep 12;2:20. Epub 2005 Sep 12.

Biochemistry Department, University of Cambridge, Cambridge, CB2 1QW, UK.

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http://dx.doi.org/10.1186/1742-2094-2-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1232863PMC
September 2005

Nitric oxide from inducible nitric oxide synthase sensitizes the inflamed aorta to hypoxic damage via respiratory inhibition.

Shock 2005 Apr;23(4):319-23

Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, United Kingdom.

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http://dx.doi.org/10.1097/01.shk.0000156672.36439.2dDOI Listing
April 2005

Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death.

J Neurosci Res 2005 Jan 1-15;79(1-2):208-15

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, United Kingdom.

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http://dx.doi.org/10.1002/jnr.20285DOI Listing
March 2005

Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols.

Biochim Biophys Acta 2004 Jul;1658(1-2):44-9

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1016/j.bbabio.2004.03.016DOI Listing
July 2004

Nitric oxide-induced cell death of cerebrocortical murine astrocytes is mediated through p53- and Bax-dependent pathways.

J Neurochem 2004 May;89(4):812-21

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02395.xDOI Listing
May 2004

Nitric oxide induces apoptosis via hydrogen peroxide, but necrosis via energy and thiol depletion.

Free Radic Biol Med 2003 Dec;35(11):1457-68

Department of Biochemistry, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1016/j.freeradbiomed.2003.08.003DOI Listing
December 2003

S-nitrosothiol-induced rapid cytochrome c release, caspase activation and mitochondrial permeability transition in perfused heart.

Biochem Pharmacol 2003 Oct;66(8):1513-9

Institute for Biomedical Research, Kaunas University of Medicine, Kaunas, Lithuania.

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http://dx.doi.org/10.1016/s0006-2952(03)00506-9DOI Listing
October 2003

Nitric oxide and calcium together inactivate mitochondrial complex I and induce cytochrome c release.

J Mol Cell Cardiol 2003 Jul;35(7):803-9

Institute for Biomedical Research, Kaunas University of Medicine, Eiveniu 4, LT-3007, Kaunas, Lithuania.

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http://dx.doi.org/10.1016/s0022-2828(03)00137-8DOI Listing
July 2003

Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria.

Mol Neurobiol 2003 Jun;27(3):325-55

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1385/MN:27:3:325DOI Listing
June 2003

Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia.

J Mol Cell Cardiol 2003 Apr;35(4):357-66

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1016/s0022-2828(03)00005-1DOI Listing
April 2003

Mitochondria in apoptosis of ischemic heart.

FEBS Lett 2003 Apr;541(1-3):1-5

Department of Biochemistry, University of Cambridge, UK.

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http://dx.doi.org/10.1016/s0014-5793(03)00278-3DOI Listing
April 2003

Cell biology. NO says yes to mitochondria.

Authors:
Guy C Brown

Science 2003 Feb;299(5608):838-9

Department of Biochemistry, Cambridge University, Cambridge CB2 1QW, UK.

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http://dx.doi.org/10.1126/science.1082028DOI Listing
February 2003

Nitric oxide inhibition of mitochondrial respiration and its role in cell death.

Free Radic Biol Med 2002 Dec;33(11):1440-50

Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom.

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http://dx.doi.org/10.1016/s0891-5849(02)01112-7DOI Listing
December 2002

Different pathways for iNOS-mediated toxicity in vitro dependent on neuronal maturation and NMDA receptor expression.

J Neurochem 2002 Jul;82(2):269-82

Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1046/j.1471-4159.2002.00973.xDOI Listing
July 2002

Stimulation of the NADPH oxidase in activated rat microglia removes nitric oxide but induces peroxynitrite production.

J Neurochem 2002 Jan;80(1):73-80

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB1 2QW, UK.

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http://dx.doi.org/10.1046/j.0022-3042.2001.00675.xDOI Listing
January 2002